graduate student
Ufa, Ufa, Russian Federation
UDK 616 Патология. Клиническая медицина
GRNTI 76.29 Клиническая медицина
OKSO 31.05.03 Стоматология
BBK 566 Стоматология
Dental diseases are a frequent manifestation of disorders of adaptive reactions, since the negative impact on the immune status of cadets is reflected in changes in the microflora of the oral cavity and periodontal [2, 5, 7, 9]. The goal is to improve the therapeutic and preventive measures of inflammatory periodontal diseases caused by a disorder of adaptive reactions in cadets of the departmental institute. Matherials and methods. The group of the examined consisted of 171 people – cadets of 1–4 courses of the Ufa Law Institute of the Ministry of Internal Affairs of the Russian Federation in the Republic of Bashkortostan, aged 18–23 years. The study consisted of psychological testing, determination of the state of their vegetative reactions and cortisol content in saliva, molecular genetic determination of the composition of frequently occurring periodontopathogenic bacteria of the dentoalveolar furrow and enzyme immunoassay of the content of cytokines in the oral fluid of proinflammatory, cellular regulatory and immunosuppressive action. Results. The antimicrobial effect of the course application of supravival applications of dental gel Phagodent, together with Glycine, is manifested by a decrease in the frequency of detection of periodontal pathogenic bacteria - Tanerella forsythia and Aggregatibacter actinomycetemcomitans in persons with periodontal diseases not associated with a disorder of adaptive reactions. The use of supramural applications of dental gel is accompanied by a significant decrease in the level of IL-4, IL-12, IL-1ß, TFR-β in the oral fluid of persons with a disorder of adaptive reactions and periodontal inflammation. Conclusion. After the use of dental gel Phagodent and Glycine, there was a 4-fold decrease in the possibility of recurrence of periodontal diseases, the frequency of detection of Aggregatibacter actinomycetemcomitans in the microflora of the dental sulcus decreased by 66% of the frequency and Tannerella forsythia – by 30%, a decrease in the levels of IL-4, IL-12, IL-1ß, TFR-β in the oral fluid in the group with disorder of adaptive reactions and periodontal inflammation, as well as IL-10, TNF-α and IL-1β in the group without disorder, but with periodontal inflammation.
periodontopathogens, interleukins, dental gel, glycine, cadets
1. Aver'yanov S.V., Gulyaeva O.A., Il'chigulova O.E. i dr. Sravnenie effektivnosti nemedikamentoznyh metodov v komplekse podderzhivayuschey parodontal'noy terapii. Problemy stomatologii. 2017;1:51-54. [S.V. Averyanov, O.A. Gulyaeva, O.E. Ilchigulova et al. Comparison of the effectiveness of non-drug methods in the complex of supportive periodontal therapy. Actual problems in dentistry. 2017;1:51-54. (In Russ.)]. https://www.elibrary.ru/item.asp?id = 29256722
2. Bazarnyy V.V., Polushina L.G., Maksimova A.Yu., Svetlakova E.N., Mandra Yu.V. Patogeneticheskoe obosnovanie novyh podhodov k ocenke sostoyaniya tkaney polosti rta pri hronicheskom generalizovannom parodontite. Problemy stomatologii. 2018;14;4:14-18. [V.V. Bazarny, L.G. Polushina, A.Yu. Maksimova, E.N. Svetlakova, Yu.V. Mandra. Pathogenetic justification of new approaches to assessing the state of oral tissues in chronic generalized periodontitis. Actual problems in dentistry. 2018;14;4:14-18. (In Russ.)]. https://elibrary.ru/item.asp?id = 36777701
3. Vasil'eva N.A., Bulgakova A.I., Imel'baeva E.A. i dr. Osobennosti lokal'nogo immuniteta polosti rta pri tradicionnoy terapii vospalitel'nyh zabolevaniy parodonta. Problemy stomatologii. 2018;14(3):11-16. [N.A. Vasilyeva, A.I. Bulgakova, E.A. Imelbaeva et al. Features of local immunity of the oral cavity in traditional therapy of inflammatory periodontal diseases. Actual problems in dentistry. 2018;14(3):11-16. (In Russ.)]. https://www.elibrary.ru/item.asp?id = 36458685
4. Gileva O.S. Konservativno-profilakticheskaya stomatologiya: sovremennye trendy razvitiya. Permskiy medicinskiy zhurnal. 2018;35(6):61-72. [O.S. Gileva. Conservative-preventive dentistry: modern development trends. Perm Medical Journal. 2018;35(6):61-72. (In Russ.)]. https://www.elibrary.ru/item.asp?id = 36686183
5. Davtyan G.A., Spiridonova S.A., Uspenskaya O.A., Shevchenko E.A. Izmenenie gormonal'nogo fona u lic s hronicheskim generalizovannym parodontitom. Endodontiya Today. 2019;17(4):16-20. [G.A. Davtyan, S.A. Spiridonova, O.A. Uspenskaya, E.A. Shevchenko. Changes in hormonal levels in persons with chronic generalized periodontitis. Endodontics Today. 2019;17(4):16-20. (In Russ.)]. https://www.elibrary.ru/item.asp?id = 41669675
6. Red. Uspenskaya O.A., Zhuleva E.N. Zabolevaniya slizistoy obolochki polosti rta. Uchebnoe posobie. Nizhniy Novgorod : Izdatel'stvo Nizhegorodskoy gosudarstvennoy medicinskoy akademii. 2017:504. [Eds. O.A. Uspenskaya, E.N. Zhuleva. Diseases of the oral mucosa. Textbook. N. Novgorod : Publishing house of the Nizhny Novgorod State Medical Academy. 2017:504. (In Russ.)]. https://www.books-up.ru/ru/book/zabolevaniya-slizistoj-obolochki-polosti-rta-12969472/
7. Kuznecova N.S., Kabirova M.F., Gerasimova L.P., Haybullina R.R., Kogina E.N., Miftahova Z.K. Pokazateli gemodinamiki tkaney parodonta u lic molodogo vozrasta v sostoyanii psihoemocional'nogo napryazheniya. Problemy stomatologii. 2018;14;1:37-42. [N.S. Kuznetsova, M.F. Kabirova, L.P. Gerasimova, R.R. khaybullina, E.N. Kogina, Z.K. Miftakhova. Indicators of hemodynamics of periodontal tissues in young people in a state of psychoemotional stress. Actual problems in dentistry. 2018;14;1:37-42. (In Russ.)]. https://elibrary.ru/item.asp?id = 32840687
8. Kraynov S.V., Mihal'chenko V.F., Yakovlev A.T. i dr. «Glubina parodontal'nogo karmana» ili «velichina poteri prikrepleniya», kakoy parametr vybrat' v gerontostomatologii. Problemy stomatologii. 2017;4:9-14. [S.V. Krainov, V.F. Mikhalchenko, A.T. Yakovlev et al. "The Depth of the periodontal pocket" or "value of loss of attachment" which option to choose gerontechnology? Actual problems in dentistry. 2017;4:9-14. (In Russ.)]. https://www.elibrary.ru/item.asp?id = 30638213
9. Lyubomirskiy G.B. Analiz funkcional'nyh pokazateley sostoyaniya parodonta u pacientov s hronicheskim generalizovannym parodontitom v dinamike lazeroterapii. Aspirantskiy vestnik Povolzh'ya. 2018;5-6:152-161. [G.B. Lyubomirsky. Analysis of functional indicators of periodontal condition in patients with chronic generalized periodontitis in the dynamics of laser therapy. Postgraduate Bulletin of the Volga region. 2018;5-6:152-161. (In Russ.)]. https://www.elibrary.ru/item.asp?id = 37266765
10. Mamedov R.M., Sadygova N.N., Ibragimova L.K. Optimizaciya metodov profilaktiki i lecheniya vospalitel'nyh zabolevaniy parodonta. Problemy stomatologii. 2019;15;2:114-121. [R.M. Mamedov, N.N. Sadigova, L.K. Ibragimova. Optimization of methods of prevention and treatment of inflammatory periodontal diseases. Actual problems in dentistry. 2019;15;2:114-121. (In Russ.)]. https://elibrary.ru/item.asp?id = 39165973
11. Mangold A.R., Torgerson R.R., Rogers R.S. Diseases of the tongue // Clinics in Dermatology. − 2016;34(4):458-469. doi.org/10.1016/j. clindermatol. 2016.02.018.
12. Niimi N., Mori N. Papillary atrophy of the tongue // Clin Case Rep. − 2018;6(11):2283-2284. doi:https://doi.org/10.1002/ccr3.1808
13. Reren E.V., Toma E.I., Sharifov A.A. Kachestvo zhizni stomatologicheskogo pacienta posle provedennogo ortopedicheskogo lecheniya. Rossiyskaya stomatologiya. 2017;10(2):62-65. [E.V. Reren, E.I. Toma, A.A. Sharifov. Quality of life of a dental patient after orthopedic treatment. Russian dentistry. 2017;10(2):62-65. (In Russ.)]. https://www.elibrary.ru/item.asp?id = 29764304
14. Ryabcun O.I., Edeleev D.A., Nagornev S.N. i dr. Zavisimost' indeksnyh pokazateley stomatologicheskogo statusa i ih korrekciya v ocenke kachestva zhizni naseleniya. Russian Journal of Rehabilitation Medicine. 2019;1:16-27. [O.I. Ryabtsun, D.A. Edeleev, S.N. Nagornev et al. Dependence of index indicators of dental status and their correction in assessing the quality of life of the population. Russian Journal of Rehabilitation Medicine. 2019;1:16-27. (In Russ.)]. https://www.elibrary.ru/item.asp?id = 37417468
15. Saleev R.A., Fedorova N.S., Saleeva G.T. Osobennosti opredeleniya kachestva zhizni u pacientov pozhilogo i starcheskogo vozrasta. Problemy stomatologii. 2017;1;84-87. [R.A. Saleev, N.S. Fedorova, G.T. Saleeva. Features of determining the quality of life in elderly and senile patients. Actual problems in dentistry. 2017;1;84-87. (In Russ.)]. https://www.elibrary.ru/item.asp?id = 29256729
16. Stepanova A.I., Nagaeva M.O., Dzyuba E.V. Dinamika kachestva zhizni bol'nyh hronicheskim generalizovannym parodontitom sredney stepeni tyazhesti na fone tradicionnogo lecheniya. Problemy stomatologii. 2019;2:32-36. [A.I. Stepanova, M.O. Nagaeva, E.V. Dzyuba. Dynamics of quality of life of patients with chronic generalized periodontitis of moderate severity against the background of traditional treatment. Actual problems in dentistry. 2019;2:32-36. (In Russ.)]. https://www.elibrary.ru/item.asp?id = 39165959
17. Sahin V.T., Kryukov E.V., Rukavicy O.A. Anemiya hronicheskih zabolevaniy - osobennosti patogeneza i popytka klassifikacii. Tihookeanskiy medicinskiy zhurnal. 2019;1:33-37. [V.T. Sakhin, E.V. Kryukov, O.A. Mittens. Anemia of chronic diseases − features of pathogenesis and an attempt to classify. Pacific Medical Journal. 2019;1:33-37. (In Russ.)]. doi:https://doi.org/10.17238/PmJ1609-1175.2019.1.33 37
18. Spiridonova S.A., Ruzina K.A., Uspenskaya O.A. Izuchenie psihoemocional'nogo statusa i gigienicheskogo sostoyaniya polosti rta studentov, nahodyaschihsya na distancionnom obuchenii na fone covid-19. Dental Forum. 2020;4(79):59-60. [S.A. Spiridonova, K.A. Ruzina, O.A. Uspenskaya. Study of the psychoemotional status and hygienic state of the oral cavity of distance learning students against the background of covid-19. Dental Forum. 2020;4(79):59-60. (In Russ.)]. https://www.elibrary.ru/item.asp?id = 44082057
19. Sitdikova O.F., Kabirova M.F., Kudashkina N.V.,Gubina O.F. Patent RF 2390775 C1. Stomatologicheskiy gel' dlya lecheniya vospalitel'nyh zabolevaniy parodonta i slizistoy obolochki polosti rta, voznikshih na fone psihoemocional'nogo stressa. № 2021100184/04(000318). 2021. [O.F. Sitdikova, M.F. Kabirova, N.V. Kudashkina, O.F. Gubina. Patent RF 2390775 C1. Dental gel for the treatment of inflammatory diseases of the periodontal and oral mucosa that have arisen against the background of psychoemotional stress. No. 2021100184/04 (000318). 2021. (In Russ.)]. https://www.elibrary.ru/item.asp?id = 46605739
20. Uspenskaya O.A. Issledovanie biohimicheskih pokazateley kostnogo metabolizma rotovoy zhidkosti pri lechenii agressivnyh form parodontita. Problemy stomatologii. 2019;1(15):68-73. [O.A. Uspenskaya. Investigation of biochemical parameters of bone metabolism of the oral fluid in the treatment of aggressive forms of periodontitis. Actual problems in dentistry. 2019;1(15):68-73. (In Russ.)]. https://www.elibrary.ru/item.asp?id = 37602583
21. Zaror C., Pardo Y., Espinoza-Espinoza G., Pont À., Muñoz-Millán P., Martínez-Zapata M.J., Vilagut G., Forero C.G., Garin O., Alonso J., Ferrer M. Assessing oral healthrelated quality of life in children and adolescents: a systematic review and standardized comparison of available instruments // Clin Oral Investig. - 2019;23(1):65-79. doihttps://doi.org/10.1007/s00784 018 2406 1
22. Liliane-Poconé Dantas, Artur de Oliveira-Ribeiro, Liane-Maciel de Almeida-Souza, Francisco-Carlos Groppo. Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction // Journal section: Oral Surgery. - 2017;22(3):24-29. doihttps://doi.org/10.4317/medoral.21140.
