Ufa, Ufa, Russian Federation
Ufa, Ufa, Russian Federation
Ufa, Ufa, Russian Federation
Subject. Such a cytokine as transforming factor β (TFRß) deserves special attention in stress-induced gingivitis, since there are observations indicating its ability to stimulate the differentiation of myofibroblasts, which results in an increase in collagen production, the development of fibrous changes in the gum, which ultimately lead to tooth loss. Goal. The aim is to determine the relationship between the development of signs of depression, the frequency of detection of periodontal pathogenic bacteria and the spectrum of cytokines that play a likely role in the pathogenesis of gingivitis in cadets of the departmental institute under conditions of psychoemotional stress. Methodology. Psychological testing, clinical dental and laboratory examinations of 71 cadets of the departmental institute (41 women, 30 men) aged from 18 to 23 years were conducted. The detection of depression was carried out using the A. Beck scale, reactive and personal anxiety — Ch. Spielberger — Y.L. Khanin. To assess the periodontal condition, traditional hygienic and periodontal indices (OHI-s, RNR, PMA) were used. Identification of the marker DNA of periodontal pathogenic bacteria was carried out using a polymerase chain reaction using a test kit "Multident-5" manufactured by NPF GenLab (Russia). The content of cytokines in saliva was determined by solid-phase enzyme immunoassay. For the detection of IL-1β, IL-4, IL-10, IL-12, IFNu, TNFa, sets of NPO "Vector Best" (Russia) were used, for the cytokine TFRß — from Biosource (Canada). Results. It was found that the development of depression and gingivitis is accompanied by changes in the cytokine status, the main pathogenetic significance is IL-1β and TFRß, and the auxiliary is IL-12 and TNFa. At the same time, the cytokines IL-1β and TNFa are associated with the severity of the course of gingivitis. Conclusions. A correlation was established for the cytokines IL-1β, TNFa and TFRß with the first-order periodontopathogenic species A actinomycetemcomitans and T. forsythia.
depression, psychoemotional stress, polymerase chain reaction, enzyme immunoassay, gingivitis, periodontal pathogenic bacteria, A. actinomycetemcomitans, T. forsythia, correlation
1. Aver'yanov S.V., Gulyaeva O.A., Il'chigulova O.E. i dr. Sravnenie effektivnosti nemedikamentoznyh metodov v komplekse podderzhivayuschey parodontal'noy terapii. Problemy stomatologii. 2017;13(1):51-55. [S.V. Averyanov, O.A. Gulyaeva, O.E. Ilchigulova et al. Comparison of the effectiveness of non-drug methods in the complex of supportive periodontal therapy. Actual problems in dentistry. 2017;13(1):51-55. (In Russ.)]. https://elibrary.ru/item.asp?id=29256722
2. Bazarnyy V.V., Polushina L.G., Maksimova A.Yu., Svetlakova E.N., Mandra Yu.V. Patogeneticheskoe obosnovanie novyh podhodov k ocenke sostoyaniya tkaney polosti rta pri hronicheskom generalizovannom parodontite. Problemy stomatologii. 2018;14(4):14-18. [V.V. Bazarny, L.G. Polushina, A.Yu. Maksimova, E.N. Svetlakova, Yu.V. Mandra. Pathogenetic justification of new approaches to assessing the state of oral tissues in chronic generalized periodontitis. Actual problems in dentistry.2018;14(4):14-18. (In Russ.)]. https://elibrary.ru/item.asp?id=36777701
3. Vasil'eva N.A., Bulgakova A.I., Imel'baeva E.A. i dr. Osobennosti lokal'nogo immuniteta polosti rta pri tradicionnoy terapii vospalitel'nyh zabolevaniy parodonta. Problemy stomatologii. 2018;14(3):11-16. [N.A. Vasilyeva, A.I. Bulgakova, E.A. Imelbaeva et al. Features of local immunity of the oral cavity in traditional therapy of inflammatory periodontal diseases. Actual problems in dentistry. 2018;14(3):11-16. (In Russ.)]. https://www.elibrary.ru/item.asp?id=36458685
4. Gileva O.S. Konservativno-profilakticheskaya stomatologiya: sovremennye trendy razvitiya. Permskiy medicinskiy zhurnal. 2018;35(6):61-72. [O.S. Gileva. Conservative-preventive dentistry: modern development trends. Perm Medical Journal. 2018;35(6):61-72. (In Russ.)]. https://cyberleninka.ru/article/n/konservativno-profilakticheskaya-stomatologiya-sovremennye-trendy-razvitiya/viewer
5. Davtyan G.A., Spiridonova S.A., Uspenskaya O.A., Shevchenko E.A. Izmenenie gormonal'nogo fona u lic s hronicheskim generalizovannym parodontitom. Endodontiya Today. 2019;17(4):16-20. [G.A. Davtyan, S.A. Spiridonova, O.A. Uspenskaya, E.A. Shevchenko. Changes in hormonal levels in persons with chronic generalized periodontitis. Endodontics Today. 2019;17(4):16-20. (In Russ.)]. https://doi.org/10.1234/10.36377/1683-2981-2019-17-4-16-20
6. Red. Uspenskaya O.A., Zhulev E.N. Zabolevaniya slizistoy obolochki polosti rta. Uchebnoe posobie. N. Novgorod : Izdatel'stvo Nizhegorodskoy gosudarstvennoy medicinskoy akademii. 2017:504. [Eds. O.A. Uspenskaya, E.N. Zhulev. Diseases of the oral mucosa. Textbook. N. Novgorod : Publishing house of the Nizhny Novgorod State Medical Academy. 2017:504. (In Russ.)].
7. Kuznecova N.S., Kabirova M.F., Gerasimova L.P., Haybullina R.R., Kogina E.N., Miftahova Z.K. Pokazateli gemodinamiki tkaney parodonta u lic molodogo vozrasta v sostoyanii psihoemocional'nogo napryazheniya. Problemy stomatologii. 2018;14(1):37-42. [N.S. Kuznetsova, M.F. Kabirova, L.P. Gerasimova, R.R. khaybullina, E.N. Kogina, Z.K. Miftakhova. Indicators of hemodynamics of periodontal tissues in young people in a state of psychoemotional stress. Actual problems in dentistry. 2018;14(1):37-42. (In Russ.)]. https://elibrary.ru/item.asp?id=32840687
8. Kraynov S.V., Mihal'chenko V.F., Yakovlev A.T. i dr. «Glubina parodontal'nogo karmana» ili «velichina poteri prikrepleniya», kakoy parametr vybrat' v gerontostomatologii. Problemy stomatologii. 2017;13(4):9-14. [S.V. Krainov, V.F. Mikhalchenko, A.T. Yakovlev et al. "The Depth of the periodontal pocket" or "value of loss of attachment" which option to choose gerontechnology? Actual problems in dentistry. 2017;13(4):9-14. (In Russ.)]. https://elibrary.ru/item.asp?id=30638213
9. Lyubomirskiy G.B. Analiz funkcional'nyh pokazateley sostoyaniya parodonta u pacientov s hronicheskim generalizovannym parodontitom v dinamike lazeroterapii. Aspirantskiy vestnik Povolzh'ya. 2018;5-6:152-161. [G.B. Lyubomirsky. Analysis of functional indicators of periodontal condition in patients with chronic generalized periodontitis in the dynamics of laser therapy. Postgraduate Bulletin of the Volga region. 2018;5-6:152-161. (In Russ.)]. https://doi.org/10.17816/2072-2354.2018.18.3.152-161
10. Mamedov R.M., Sadygova N.N., Ibragimova L.K. Optimizaciya metodov profilaktiki i lecheniya vospalitel'nyh zabolevaniy parodonta. Problemy stomatologii. 2019;15(2):114-121. [R.M. Mamedov, N.N. Sadigova, L.K. Ibragimova. Optimization of methods of prevention and treatment of inflammatory periodontal diseases. Actual problems in dentistry. 2019;15(2):114-121. (In Russ.)]. https://elibrary.ru/item.asp?id=39165973
11. Mangold A.R., Torgerson R.R., Rogers R.S. Diseases of the tongue // Clinics in Dermatology. − 2016;34;4:458-469. doi.org/10.1016/j. Clindermatol. 2016.02.018
12. Niimi N., Mori N. Papillary atrophy of the tongue // Clin Case Rep. − 2018;6(11):2283-2284. doihttps://doi.org/10.1002/ccr3.1808
13. Reren E.V., Toma E.I., Sharifov A.A. Kachestvo zhizni stomatologicheskogo pacienta posle provedennogo ortopedicheskogo lecheniya. Rossiyskaya stomatologiya. 2017;10;2:62-65. [E.V. Reren, E.I. Toma, A.A. Sharifov. Quality of life of a dental patient after orthopedic treatment. Russian dentistry. 2017;10;2:62-65. (In Russ.)]. DOI:https://doi.org/10.17116/rosstomat201710262-65
14. Ryabcun O.I., Edeleev D.A., Nagornev S.N. i dr. Zavisimost' indeksnyh pokazateley stomatologicheskogo statusa i ih korrekciya v ocenke kachestva zhizni naseleniya. Russian Journal of Rehabilitation Medicine. 2019;1:16-27. [O.I. Ryabtsun, D.A. Edeleev, S.N. Nagornev et al. Dependence of index indicators of dental status and their correction in assessing the quality of life of the population. Russian Journal of Rehabilitation Medicine. 2019;1:16-27. (In Russ.)]. https://www.elibrary.ru/item.asp?id=37417468
15. Saleev R.A., Fedorova N.S., Saleeva G.T. Osobennosti opredeleniya kachestva zhizni u pacientov pozhilogo i starcheskogo vozrasta. Problemy stomatologii. 2017;13(1):84-87. [R.A. Saleev, N.S. Fedorova, G.T. Saleeva. Features of determining the quality of life in elderly and senile patients. Actual problems in dentistry. 2017;13(1):84-87. (In Russ.)]. https://www.elibrary.ru/item.asp?id=29256729
16. Stepanova A.I., Nagaeva M.O., Dzyuba E.V. Dinamika kachestva zhizni bol'nyh hronicheskim generalizovannym parodontitom sredney stepeni tyazhesti na fone tradicionnogo lecheniya. Problemy stomatologii. 2019;15(2):32-36. [A.I. Stepanova, M.O. Nagaeva, E.V. Dzyuba. Dynamics of quality of life of patients with chronic generalized periodontitis of moderate severity against the background of traditional treatment. Actual problems in dentistry. 2019;15(2):32-36. (In Russ.)]. https://www.elibrary.ru/item.asp?id=39165959
17. Sahin V.T., Kryukov E.V., Rukavicy O.A. Anemiya hronicheskih zabolevaniy - osobennosti patogeneza i popytka klassifikacii. Tihookeanskiy medicinskiy zhurnal. 2019;1:33-37. [V.T. Sakhin, E.V. Kryukov, O.A. Mittens. Anemia of chronic diseases − features of pathogenesis and an attempt to classify. Pacific Medical Journal. 2019;1:33-37. (In Russ.)]. doi:https://doi.org/10.17238/PmJ1609-1175.2019.1.33-37
18. Spiridonova S.A., Ruzina K.A., Uspenskaya O.A. Izuchenie psihoemocional'nogo statusa i gigienicheskogo sostoyaniya polosti rta studentov, nahodyaschihsya na distancionnom obuchenii na fone covid-19. Dental Forum. 2020;4(79):59-60. [S.A. Spiridonova, K.A. Ruzina, O.A. Uspenskaya. Study of the psychoemotional status and hygienic state of the oral cavity of distance learning students against the background of covid-19. Dental Forum. 2020;4(79):59-60. (In Russ.)]. https://www.elibrary.ru/item.asp?id=44082057
19. Uspenskaya O.A. Issledovanie biohimicheskih pokazateley kostnogo metabolizma rotovoy zhidkosti pri lechenii agressivnyh form parodontita. Problemy stomatologii. 2019;15(1):68-73. [O.A. Uspenskaya. Investigation of biochemical parameters of bone metabolism of the oral fluid in the treatment of aggressive forms of periodontitis. Actual problems in dentistry. 2019;15(1):68-73. (In Russ.)]. https://www.elibrary.ru/item.asp?id=37602583
20. Zaror C., Pardo Y., Espinoza-Espinoza G., Pont À., Muñoz-Millán P., Martínez-Zapata M.J., Vilagut G., Forero C.G., Garin O., Alonso J., Ferrer M. Assessing oral healthrelated quality of life in children and adolescents: a systematic review and standardized comparison of available instruments // Clin Oral Investig. - 2019;23(1):65-79. doihttps://doi.org/10.1007/s00784 018 2406 1
21. Yuschuk M.V., Suhova T.V., Arutyunov S.D., Carev V.N. Kompleksnyy podhod k ocenke zabolevaniy parodonta kak oposredovannyh proyavleniy akademicheskogo stressa u studentov medicinskogo vuza. Medicinskiy alfavit. 2016;1;2:44-46. [M.V. Yushchuk, T.V. Sukhova, S.D. Arutyunov, V.N. Tsarev. An integrated approach to the assessment of periodontal diseases as mediated manifestations of academic stress in medical university students. Medical alphabet. 2016;1;2:44-46. (In Russ.)]. doihttps://doi.org/10.17238/PmJ1609-1175.2016.1.44-46
