FEATURES OF DENTAL STATUS OF PATIENTS WITH SARS-COV-2
Abstract and keywords
Abstract (English):
At the end of 2019, an outbreak of a new coronavirus infection occurred in the People's Republic of China with an epicenter in the city of Wuhan [26]. The causative agent was given the temporary name 2019-nCoV. The World Health Organization officially named the infection-COVID-19 on February 11, 2020. The official name of the causative agent of infection SARS-CoV-2, was assigned by the international committee on the taxonomy of viruses [22]. A number of authors have established that the main role is played by receptors of angiotensin converting enzyme 2 (ACE2) in the penetration of the virus into target cells [19]. It is known that the transmission of SARS-CoV-2 occurs more often by airborne droplets during close contact with infected patients [15], as well as through direct contact with infected people and infected objects [17, 18, 20]. For healthcare professionals, SARS-CoV-2 has set tasks related to the rapid diagnosis and provision of medical care to patients. Currently, information on the clinical features, epidemiology, prevention and treatment of this disease is limited [13, 14]. To date, there is a limited amount of literature describing the dental status in patients diagnosed with SARS-CoV-2. Thus, the purpose of this study was to study the state of oral mucosa and substantiate its changes in patients with a laboratory-confirmed diagnosis of SARS-CoV-2 of mild to moderate severity, with or without concomitant oral coinfection. On the other hand, knowledge of the peculiarities of the dental status of Sars-CoV-2 patients and timely rational treatment of diseases of the oral cavity should constitute an important stage in the algorithm for their specialized therapy [2]. The work carried out a comprehensive assessment of the state of the oral cavity and the need for dental treatment in patients with Sars-CoV-2. The conclusions are based on the results of a simple observational clinical study, in which a comparative assessment of dental status indicators was carried out in 40 patients with Sars-CoV-2 and 20 somatically healthy individuals of the same sex and age.

Keywords:
oral mucosa, oral diseases, Sars-CoV-2, periodontal diseases, dental status
References

1. Al' Kofish M., Usmanova I.N., Husnarizanova R.F., Kuznecova L.I., Gumerova M.I., Usmanov I.R., Sarvalieva A.F. Ocenka markerov razvitiya zabolevaniy parodonta na osnovanii izucheniya mikrobnogo sostava razlichnyh biotopov polosti rta. Problemy stomatologii. 2021;4:40-45. [M. Al Kofish, I.N. Usmanova, R.F. Khusnarizanova, L.I. Kuznetsova, M.I. Gumerova, I.R. Usmanov, A.F. Sarvalieva. Assessment of markers of development of periodontal diseases on the basis of studying composition of various biotopes of the oral cavity. Actual problems in dentistry. 2021;4:40-45. (In Russ.)]. https://doi.org/10.18481/2077-7566-20-16-4-40-45

2. Vasil'eva N.A., Bulgakova A.I., Soldatova E.S. Harakteristika stomatologicheskogo statusa pacientov s vospalitel'nymi zabolevaniyami parodonta. Kazanskiy medicinskiy zhurnal. 2017;98(2):204-209. [N.A. Vasilyeva, A.I. Bulgakova, E.S. Soldatova. Characteristics of the dental status of patients with inflammatory periodontal diseases. Kazan Medical Journal. 2017;98(2):204-209. (In Russ.)]. https://doi.org/10.17750/KMJ2017-204

3. Gripp. Informacionnyy byulleten' Vsemirnoy organizacii zdravoohraneniya. Elektronnyy resurs. [Flu. Newsletter of the World Health Organization. Electronic resource. (In Russ.)]. https://www.who.int/ru/news-room/fact-sheets/detail/influenza-(seasonal)

4. Gubina O.F., Sitdikova O.F., Kabirova M.F. Opredelenie vzaimosvyazi osobennostey techeniya hronicheskogo generalizovannogo kataral'nogo gingivita i izmeneniy sostava bioplenki zubnoy blyashki u kursantov ufimskogo yuridicheskogo instituta ministerstva vnutrennih del rossiyskoy federacii v usloviyah psihoemocional'nogo stressa. Problemy stomatologii. 2020;3:38-45. [O.F. Gubin, O.F. Sitdikova, M.F. Kabirov. Determine the relationship features of the current chronic generalized catarrhal gingivitis and changes in the composition of dental plaque biofilm to the students of Ufa Law Institute of the Ministry of Internal Affairs of the Russian Federation in the conditions emotional stress. Actual problems in dentistry. 2020;3:38-45. (In Russ.)]. https://doi.org/10.18481/2077-7566-2020-16-3-38-45

5. Sitdikova O.F., Kabirova M.F., Gubina O.F. Immunnaya regulyaciya sistemy gemostaza pri vospalitel'nyh zabolevaniyah parodonta u kursantov ufimskogo yuridicheskogo instituta ministerstva vnutrennih del rossiyskoy federacii. Problemy stomatologii. 2021;4:84-89. [O.F. Sitdikova, M.F. Kabirova, O.F. Gubina. Immune regulation of the hemostasis system in inflammatory periodontal diseases in cursants of the ufa legal institute of the ministry of internal affairs of the russian dentistry. Actual problems in dentistry. 2021;4:84-89. (In Russ.)]. https://doi.org/10.18481/2077-7566-20-16-4-84-89

6. Trofimova T.N., Lukina O.V., Speranskaya A.A. i dr. Koronavirusnaya infekciya COVID-19. Chast' 5. Luchevye metody issledovaniya pri COVID-19 i virusnyh pnevmoniyah. Elektronnyy resurs. 2020. [T.N. Trofimova, O.V. Lukina, A.A. Speranskaya A.A. et al. Coronavirus infection COVID-19. Part 5. Radiation research methods for COVID-19 and viral pneumonia. Electronic resource. 2020. (In Russ.)]. https://www.1spbgmu.ru/images/home/covid19

7. Madzhidov T.I., Kurakin G.F. Komp'yuternye tehnologii protiv koronavirusa: pervye rezul'taty. Priroda. 2020;3:3-15. [T.I. Madzhidov, G.F. Kurakin. Computer technologies against coronavirus: first results. Nature. 2020;3:3-15. (In Russ.)]. https://doi.org/10.7868/S0032874X20030011

8. Nikiforov V.V., Suranova T.G., Mironov A.Yu., Zabozlaev F.G. Novaya koronavirusnaya infekciya (COVID-19): etiologiya, epidemiologiya, klinika, diagnostika, lechenie i profilaktika. Moskva. 2020:48. [V.V. Nikiforov, T.G. Suranova, A.Yu. Mironov, F.G. Zabozlaev. New coronavirus infection (COVID-19): etiology, epidemiology, clinical presentation, diagnosis, treatment and prevention. Moscow. 2020:48. (In Russ.)]. https://doi.org/10.20514/2226-6704-2020-10-2-87-93

9. Onlayn-karta rasprostraneniya koronavirusa. Elektronnyy resurs. [Online map of the spread of coronavirus. Electronic resource. (In Russ.)]. https://coronavirus-monitor.ru

10. Callaway E., Cyranoski D. Why snakes probably aren’t spreading the new China virus : One genetic analysis suggests reptilian reservoir – but researchers doubt that the coronavirus could have originated in animals other than birds or mammals // Nature. – 2020. DOI:10.1038/d41586-020-00180-8

11. Cyranoski D. Mystery deepens over animal source of coronavirus // Nature. – 2020:18-19. DOI:10.1038/d41586-020-00548-ch

12. Fox N.F., Xiao C., Sood A.J. et al. Hyperbaric oxygen therapy for the treatment of radiation-induced xerostomia: a systematic review // Oral Surg Oral Med Oral Pathol Oral Radiol. – 2015;120(1):22-28. PMID: 26093680.

13. Liu Y., Yang Y., Zhang C., Huang F., Wang F., Yuan J., Wang Z., Li J., Li J., Feng C., Zhang Z., Wang L., Peng L., Chen L., Qin Y., Zhao D., Tan S., Yin L., Xu J., Zhou C., Jiang L.C. Science China; Life sciences. Liu, Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. 2020. https://doi.org/10.1007/s11427-020-1643-8.

14. Meo S.A., Alhowikan A.M., Al-Khlaiwi T. et al. Novel coronavirus 2019-nCoV: prevalence, biological and clinical characteristics comparison with SARS-CoV and MERS-CoV // Eur Rev Med Pharmacol Sci. – 2020;24(4):2012-2019. PMID: 32141570 DOI:10.26355/eurrev_202002_20379

15. Makarenkov V. et al. Horizontal gene transfer and recombination analysis of SARS-CoV-2 genes helps discover its close relatives and shed light on its origin // BMC Ecology and Evolution. – 2021;21. PMCID: PMC7817968. DOI:10.1186/s12862-020-01732-2

16. She J., Jiang J., Ye L. et al. 2019 novel coronavirus of pneumonia in Wuhan, China: emerging attack and management strategies // Clin Transl Med. – 2020;20;9:19. PMCID: PMC7033263. DOI: 10.1186/s40169-020-00271-z

17. Tang N., Li D., Wang X., Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia // JThromb Haemost JTH. – 2020;18(4):844-847. PMCID: PMC7166509. DOI: 10.1111/jth.14768

18. Van der Hoek L., Pyrc K., Jebbink M.F. et al. Identification of a new human coronavirus // Nat Med. – 2004;10:368-373. PMCID: PMC7095789. DOI: 10.1038/nm1024

19. Walls A.C., Park Y.J., Tortorici M.A. et al. Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein // Cell. – 2020;181(2):281-292.e6. PMCID: PMC7102599

20. World Health Organization. Origin of SARS-CoV-2. Electronic resource. 2020. https://www.who.int/health-topics/coronavirus/who-recommendations-to-reduce-risk-of-transmission-of-emerging-pathogens-from-animals-to-humans-in-live-animal-markets

21. Wu Z., McGoogan J.M. Characteristics of and important lessons from the Coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention // JAMA. – 2020;24. PMID: 32091533. DOI:10.1001/jama.2020.2648

22. Wu C., Chen X., Cai Y. et al. Risk Factors Associated With Acute Respiratory Distress Syn-drome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China // JAMA Intern Med. – 2020;13. PMCID: PMC7070509. DOI: 10.1001/jamainternmed.2020.0994

23. Wu J., Li W., Shi X. et al. Early antiviral treatment contributes to alleviate the severity and improve the prognosis of patients with novel coronavirus disease (COVID-19) // J Intern Med. – 2020. DOI:10.1111/joim.1306.

24. Yang Y., Lu Q., Liu M., Wang Y., Zhang A., Jalali N. Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China // med Rxiv. – 2020;2020. doi: https://doi.org/10.1101/2020.02.10.20021675

25. Zhou P., Yang X-L., Wang X-G. Et al. Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin. 2020:18. https://doi.org/10.1101/2020.01.22.914952

26. Zhou F., Yu T., Du R. et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study // Lancet. – 2020;395(10229):1054-1062. PMCID: PMC7270627. DOI: 10.1016/S0140-6736(20)30566-3