SOMATIC DISEASES IN CHILDREN WITH CONGENITAL LIP AND PALATE IN A REGION WITH INDUSTRIAL PETROCHEMICAL ECOTOXICANTS
Abstract and keywords
Abstract (English):
Monitoring of congenital malformations and concomitant somatic diseases in children is one of the important indicators of the causal influence of environmental factors on the health of the population. From the moment of birth, a child with congenital cleft lip and palate differs significantly from healthy peers not only externally, but also morpho-functional features of the structure of the primary section of the digestive and respiratory systems and often has a greater number of previous diseases in the history. Purpose: To determine the structure and frequency of somatic morbidity in children with congenital cleft lip and palate in regions with petrochemical ecotoxicants. Materials and methods: During the study, 3463 children from birth to 16 years old with congenital cleft lip were treated and monitored at the Department of Maxillofacial Surgery at the Republican Children's Clinical Hospital, Ufa for the period from January 1, 1985 to December 31, 2019 and / or sky. The diagnosis of concomitant systemic pathology was recorded based on the findings of the district pediatricians, ENT doctor, gastroenterologist, immunologist, allergist, rheumatologist from outpatient and inpatient records of the examined patients. Conclusion. In the course of our study, a direct relationship was noted between the level of environmental pollution by ecotoxicants and the frequency of concomitant somatic diseases in children with congenital cleft lip and palate. This must be taken into account in the pre- and postoperative algorithm for the rehabilitation of children with congenital cleft lip and palate with the involvement of pediatricians to improve the general somatic state of children when planning reconstructive surgery.

Keywords:
congenital cleft lip and palate, industrial ecotoxicants, concomitant somatic diseases, preoperative preparation
References

1. Zdravoohranenie v Rossii : sbornik statey. Moskva : Rosstat. 2019:170. [Healthcare in Russia: a collection of articles. Moscow: Rosstat. 2019:170. (In Russ.)]. https://rosstat.gov.ru/folder/210/document/13218

2. Chuykin S.V., Davletshin N.A., Chuykin O.S., Kuchuk K.N., Dzhumartov N.N., Grin' E.A., Gil'manov M.V., Muratov A.M. Algoritm reabilitacii detey s vrozhdennoy rasschelinoy guby i neba v regione s ekotoksikantami. Problemy stomatologii. 2019;15(2):89-96. [S.V. Chuikin, N.A. Davletshin, O.S. Chuikin, K.N. Kuchuk, N.N. Dzhumartov, E.A. Grin, M.V. Gilmanov, A.M. Muratov. Algorithm for the rehabilitation of children with congenital cleft lip and palate in the region with ecotoxicants. Actual problems in dentistry. 2019;15(2):89-96. (In Russ.)]. https://www.elibrary.ru/item.asp?id=39165968

3. Chuykin S.V., Davletshin N.A., Kuchuk K.N., Chuykin O.S., Grin' E.A., Muratov A.M. Analiz rezul'tatov i oslozhneniy uranoplastiki u detey s vrozhdennoy rasschelinoy guby i neba. Problemy stomatologii. 2020;16(1):133-138. [S.V. Chuikin, N.A. Davletshin, K.N. Kuchuk, O.S. Chuikin, E.A. Grin, A.M. Muratov. Analysis of the results and complications of uranoplasty in children with congenital cleft lip and palate. Actual problems in dentistry. 2020;16(1):133-138. (In Russ.)]. https://www.elibrary.ru/item.asp?id=42817262

4. Chuykin S.V., Snetkova T.V., Chuykin O.S., Kuchuk K.N., Murzina A.N., Bilak A.G., Chuykin G.L. Posleoperacionnaya reabilitaciya detey s vrozhdennoy rasschelinoy neba. Ural'skiy medicinskiy zhurnal. 2020;9(192):123-127. [S.V. Chuikin, T.V. Snetkova, O.S. Chuikin, K.N. Kuchuk, A.N. Murzina, A.G. Bilak, G.L. Chuikin. Postoperative rehabilitation of children with congenital cleft palate. Ural Medical Journal. 2020;9(192):123-127. (In Russ.)].

5. Dudnik O.V., Mamedov A.A., Volkov Yu.O., Odzhaggulieva G.E.K., Ahmethanov S.M.A., Gorlova N.V., Ma G., Bille D.S., Chertihina A.S., Beznosik A.R. Analiz metodov diagnostiki i lecheniya detey s dvustoronney rasschelinoy guby i neba v period novorozhdennosti. Voprosy prakticheskoy pediatrii. 2020;15;3:65-70. [O.V. Dudnik, A.A. Mamedov, Yu.O. Volkov, G.E.K. Ojaggulieva, S.M. Akhmetkhanov, N.V. Gorlova, G. Ma, D.S. Bille, A.S. Chertikhina, A.R. Beznosik. Analysis of methods of diagnosis and treatment of children with bilateral cleft lip and palate during the neonatal period. Practical issues of pediatrics. 2020;15;3:65-70. (In Russ.)]. https://www.elibrary.ru/item.asp?id=43808716

6. Mamedov A.A., Stebeleva Yu.V., Maklennan A.B., Volkov Yu.O., Ahmethanov S.M.S.A. Okazanie hirurgicheskoy pomoschi detyam s rasschelinoy neba v periode grudnogo vozrasta. Voprosy prakticheskoy pediatrii. 2019;14;6:89-93. [A.A. Mamedov, Yu.V. Stebeleva, A.B. McLennan, Yu.O. Volkov, S.M.S.A. Akhmetkhanov. Providing surgical care to children with a cleft palate during infancy. Practical issues of pediatrics. 2019;14;6:89-93. (In Russ.)]. https://www.elibrary.ru/item.asp?id=42514114

7. Sodikov B.R., Inoyatov A.Sh., Norova A.N. Funkcional'nye narusheniya u detey s vrozhdennoy rasschelinoy guby i neba (na primere sobstvennyh issledovaniy). Vestnik Soveta molodyh uchenyh i specialistov Chelyabinskoy oblasti. 2016;1;2(13):24-28. [B.R. Sodikov, A.Sh. Inoyatov, A.N. Norova. Functional disorders in children with congenital cleft lip and palate (on the example of our own research). Bulletin of the Council of Young Scientists and Specialists of the Chelyabinsk Region. 2016;1;2(13):24-28. (In Russ.)].

8. Nesterova I.V., Mitropanova M.N., Chudilova G.A., Kovaleva S.V., Matushkina V.A. Defekty funkcionirovaniya immunnoy sistemy pri recidiviruyuschih respiratornyh infekciyah u immunokomprometirovannyh detey s vrozhdennoy rasschelinoy guby i neba. Immunologiya. 2020;41;1:64-73. [I.V. Nesterova, M.N. Mitropanova, G.A. Chudilova, S.V. Kovaleva, V.A. Matushkina. Defects in the functioning of the immune system in recurrent respiratory infections in immunocompromised children with congenital cleft lip and palate. Immunology. 2020;41;1:64-73. (In Russ.)]. https://www.elibrary.ru/item.asp?id=42799618

9. Mitropanova M.N. Osobennosti funkcionirovaniya immunnoy sistemy u detey s vrozhdennymi rasschelinami guby i neba na etapah hirurgicheskogo lecheniya. Stomatologiya detskogo vozrasta i profilaktika. 2017;16;2(61):79-83. [M.N. Mitropanova. Features of the functioning of the immune system in children with congenital clefts of the lip and palate at the stages of surgical treatment. Pediatric dentistry and prevention. 2017;16;2(61):79-83. (In Russ.)]. https://www.elibrary.ru/item.asp?id=29206060

10. Mitropanova M.N. Lokal'naya interferonoterapiya u detey s vrozhdennymi rasschelinami guby i neba na raznyh etapah hirurgicheskogo lecheniya. Lechaschiy vrach. 2018;1:6. [M.N. Mitropanova. Local interferon therapy in children with congenital cleft lip and palate at different stages of surgical treatment. Attending doctor. 2018;1:6. (In Russ.)]. https://www.elibrary.ru/item.asp?id=32333007

11. Dusmuhamedov M.Z., Hodzhimetov A.A., Dusmuhamedova A.F., Shamsiev R.A. Vliyanie hronicheskih ochagov infekcii v nosoglotke i legkih na funkcional'noe sostoyanie trombocitov u detey s vrozhdennoy rasschelinoy neba. Stomatologiya. 20174:54-55. [M.Z. Dusmukhamedov, A.A. Khodzhimetov, A.F. Dusmukhamedova, R.A. Shamsiev. Influence of chronic foci of infection in the nasopharynx and lungs on the functional state of platelets in children with congenital cleft palate. Dentistry. 20174:54-55. (In Russ.)]. https://www.elibrary.ru/item.asp?id=37055948

12. Rogova L.N., Fomenko I.V., Timoshenko A.N. Immunologicheskaya i mikrobiologicheskaya harakteristika slizistoy obolochki polosti rta u detey s vrozhdennoy rasschelinoy verhney guby i neba (obzor literatury). Volgogradskiy nauchno-medicinskiy zhurnal. 2016;3(51):19-22. [L.N. Rogova, I.V. Fomenko, A.N. Timoshenko. Immunological and microbiological characteristics of the oral mucosa in children with congenital cleft of the upper lip and palate (literature review). Volgograd Medical Scientific Journal. 2016;3(51):19-22. (In Russ.)].

13. Gosudarstvennyy doklad o sostoyanii prirodnyh resursov i okruzhayuschey sredy Respubliki Bashkortostan. 2019. [State report on the state of natural resources and the environment of the Republic of Bashkortostan. 2019. (In Russ.)]. https://ecology.bashkortostan.ru/upload/uf/297/Gosdoklad-_-2019-god-17.06.2020-na-utverzhdenie.pdf

14. Galonskiy V.G., Radkevich A.A., Shushakova A.A., Makarchuk M.Yu., Tarasova N.V., Grubcova K.A., Kalimullina M.D., Fomichev D.S. Rasprostranennost' vrozhdennyh rasschelin verhney guby, al'veolyarnogo otrostka verhney chelyusti, tverdogo i myagkogo neba v Krasnoyarskom krae. Stomatologiya detskogo vozrasta i profilaktika. 2012;11;3(42):28-34. [V.G. Galonskiy, A.A. Radkevich, A.A. Shushakova, M.Yu. Makarchuk, N.V. Tarasova, K.A. Grubtsova, M.D. Kalimullina, D.S. Fomichev. Prevalence of congenital clefts of the upper lip, alveolar ridge of the upper jaw, hard and soft palate in the Krasnoyarsk Territory. Pediatric dentistry and prevention. 2012;11;3(42):28-34. (In Russ.)]. https://www.elibrary.ru/item.asp?id=18336530

15. Vasil'ev Yu.A., Red'ko A.N., Gulenko O.V., Udina I.G. Vyyavlenie vrozhdennyh rasschelin guby i neba v hode prenatal'nogo UZI-issledovaniya v Krasnodarskom krae. Rossiyskiy stomatologicheskiy zhurnal. 2017;21;4:190-193. [Yu.A. Vasiliev, A.N. Redko, O.V. Gulenko, I.G. Udina. Identification of congenital clefts of the lip and palate during prenatal ultrasound examination in the Krasnodar Territory. Russian dental journal. 2017;21;4:190-193. (In Russ.)].

16. Ershova O.Yu., Blinov V.S., Kartashov M.V., Blohina S.I. Konusno-luchevaya komp'yuternaya tomografiya v ocenke rezul'tatov lecheniya vrozhdennyh rasschelin al'veolyarnogo otrostka. Problemy stomatologii. 2018;14;1:76-82. [O.Yu. Ershova, V.S. Blinov, M.V. Kartashov, S.I. Blokhina. Cone-beam computed tomography in assessing the results of treatment of congenital clefts of the alveolar process. Actual problems in dentistry. 2018;14;1:76-82. (In Russ.)]. https://www.elibrary.ru/item.asp?id=32840695

17. Chuykin S.V., Akat'eva G.G., Makusheva N.V., Chuykin O.S., Egorova E.G., Kuchuk K.N., Bayburina E.K. Osobennosti stomatologicheskogo statusa detey s vrozhdennoy rasschelinoy guby i neba v regione s neftehimicheskimi ekotoksikantami. Problemy stomatologii. 2020;16;4:147-154. [S.V. Chuikin, G.G. Akatieva, N.V. Makusheva, O.S. Chuikin, E.G. Egorova, K.N. Kuchuk, E.K. Baiburina. Features of the dental status of children with congenital cleft lip and palate in the region with petrochemical ecotoxicants. Actual problems in dentistry. 2020;16;4:147-154. (In Russ.)]. https://www.elibrary.ru/item.asp?id=44667791

18. Chkadua T.Z., Romanova E.M., Gileva K.S., Mohirev M.A., Kudryavcev A.V., Arutyunov G.R., Davydenko P.I. Kompleksnaya reabilitaciya pacienta s odnostoronney vrozhdennoy rasschelinoy guby, neba i al'veolyarnogo otrostka (klinicheskoe nablyudenie). Rossiyskiy stomatologicheskiy zhurnal. 2018;22;5:249-254. [T.Z. Chkadua, E.M. Romanova, K.S. Gileva, M.A. Mokhirev, A.V. Kudryavtsev, G.R. Arutyunov, P.I. Davydenko. Comprehensive rehabilitation of a patient with unilateral congenital cleft lip, palate and alveolar bone (clinical observation). Russian dental journal. 2018;22;5:249-254. (In Russ.)]. https://www.elibrary.ru/item.asp?id=37055785

19. Postnikov M.A., Vorozheykina N.A., Karpov A.N., Seregin A.S. Problemy reabilitacii pacientov s vrozhdennoy rasschelinoy verhney guby i neba v Samarskoy oblasti. Stomatologiya detskogo vozrasta i profilaktika. 2019;19;1(69):15-20. [M.A. Postnikov, N.A. Vorozheikina, A.N. Karpov, A.S. Seregin. Problems of rehabilitation of patients with congenital cleft of the upper lip and palate in the Samara region. Pediatric dentistry and prevention. 2019;19;1(69):15-20. (In Russ.)]. https://www.elibrary.ru/item.asp?id=37786892

20. Gvozdeva L.M., Danilova M.A., Aleksandrova L.I. Ocenka prognosticheskih faktorov, vliyayuschih na kachestvo zhizni detey s vrozhdennoy rasschelinoy guby i neba. Stomatologiya. 2020;99;3:57-59. [L.M. Gvozdeva, M.A. Danilova, L.I. Alexandrova. Assessment of prognostic factors affecting the quality of life of children with congenital cleft lip and palate. Dentistry. 2020;99;3:57-59. (In Russ.)].

21. Mamedov Ad.A., Dudnik O.V., Chertihina A.S., Bille D.S., Beznosik A.R. Analiz metodov lecheniya detey s dvustoronney rasschelinoy guby i neba v period smennogo prikusa. Stomatologiya detskogo vozrasta i profilaktika. 2020;20;3(75):184-189. [Ad.A. Mamedov, O.V. Dudnik, A.S. Chertikhina, D.S. Bille, A.R. Beznosik. Analysis of treatment methods for children with bilateral cleft lip and palate during the mixed bite. Pediatric dentistry and prevention. 2020;20;3(75):184-189. (In Russ.)].

22. Dudnik O.V., Mamedov Ad.A., Volkov Yu.O., Parshikova S.A., Mazurina L.A., Ahmethanov S.M.A., Gorlova N.V., Gopey Ma. Mul'tidisciplinarnaya koncepciya diagnostiki i lecheniya detey s rasschelinoy guby i neba v razlichnye vozrastnye periody. Stomatologiya dlya vseh. 2021;1(94):16-23. [O.V. Dudnik, A.A. Mamedov, Yu.O. Volkov, S.A. Parshikova, L.A. Mazurina, S.M. Akhmetkhanov, N.V. Gorlova, Ma. Gopei. A multidisciplinary concept for the diagnosis and treatment of children with cleft lip and palate at different ages. Dentistry for everyone. 2021;1(94):16-23. (In Russ.)]. https://www.elibrary.ru/item.asp?id=44910893

23. Annemieke B., Charlotte R. Oral health-related quality of life in Dutch children with cleft lip and palate // Angle Orthodontist. — 2015;81:865-871.

24. Jose M.B., Daniel L.G., Rodrigo M.C., Silverio T.Z. A new classification approach: Center of integral care of cleft lip palate “SUMA” center // Journal of Cleft Lip Palate and Craniofacial Anomalies. — 2017;4:20-24.

25. Knight J., Cassell C.H., Meyer R.E., Strauss R.P. Academic outcomes of children with isolated orofacial clefts compared with children without a major birth defect // Cleft Palate Craniofac J. — 2015;52(3):259-268.