graduate student
Dental clinic "Elite" (Department of Therapeutic Dentistry with the course of ICPEdentist-therapist)
employee
Ufa, Kazan, Russian Federation
Omsk, Omsk, Russian Federation
employee
Ufa, Ufa, Russian Federation
employee
Ufa, Ufa, Russian Federation
Omsk, Ufa, Russian Federation
employee
Nagariya, Israel
student
Nizhniy Novgorod, Nizhny Novgorod, Russian Federation
employee
Kazan', Kazan, Russian Federation
Relevance. Lichen planus is a chronic disease affecting the skin and oral mucosa. There is no exact data on the prevalence of lichen planus, which is due to the late appeal of patients not only to dentists, but also to dermatologists. The aim of this study was to learn some of the features of the clinical manifestations of typical, exudative-hyperemic, erosive-ulcerative and bullous forms of lichen planus on the oral mucosa. Material and methods. In the present study, on the basis of screening examination of patients who applied for dental care in dental clinics and living in the cities of Ufa, Omsk, Nizhny Novgorod, Nahariya, Kazan, we studied some of the clinical features of various forms of lichen planus of the oral mucosa, and the peculiarities of their course. In the course of a comprehensive dental examination, all examined persons were divided into four study groups: 1 clinical group (39.5%) — patients with a typical form, 2 clinical group (25.6%) — patients with exudative-hyperemic form, 3 clinical group (6.9%) — patients with a bullous form, 4 clinical group (27.9%) — with an erosive and ulcerative form of lichen planus. Results. In the course of a comprehensive dental examination, in 39.5% of cases, a typical form of lichen planus was revealed, in 61.3% of cases it was bullous, exudative-hyperemic and erosive-ulcerative forms, with their prevalence in 70.9% of cases in females. The average age of patients diagnosed with a typical form of lichen planus was on average 42.5±3.5 years, exudative-hyperemic form — 48.2±3.8 years, bullous — 49.8±3.6, erosive ulcerative form — 50.6±3.2 years. The duration of development of all studied forms of lichen planus was on average from 4 months to 5 years (the development of the typical form was 1.4±0.4 years, exudative-hyperemic — 2.1±0.8 years, bullous form — 3.9±1.2, and the erosive and ulcerative form — 4.3±1.2 years.
lichen planus, oral mucosa, clinical features, manifestation, typical and complicated forms of lichen planus
1. Anisimova I.V., Simonyan L.A. Chastota sochetaniya krasnogo ploskogo lishaya s somaticheskoy patologiey i mestnymi neblagopriyatnymi faktorami polosti rta. Problemy stomatologii 2019;1(15):16-22. [I. Anisimova, L. Simonyan.The frequency of combination of oral lichen planus with somatic pathology and local unfavorable factors of the oral cavity. Actual problems in dentistry. 2019;1(15):16-22. (In Russ.)]. https://elibrary.ru/item.asp?id= 37602574
2. Lukinyh L.M., Tiunova N.V. Krasnyy ploskiy lishay slizistoy obolochki polosti rta. Uchebnoe posobie. Nizhniy Novgorod : Nizhegorodskaya gosudarstvennaya medicinskaya akademiya. 2014;68. [L.M. Lukinykh, N.V. Tiunova. Lichen planus of the mucous membrane of the oral cavity. Textbook. Nizhny Novgorod : Nizhny Novgorod State Medical Academy. 2014;68. (In Russ.)]. https://elibrary.ru/item.asp?id= 23253691
3. Slesarenko N.A., Utc S.R., Bakulev A.L., Eremina M.G., Sherstneva V.N. Klinicheskiy polimorfizm krasnogo ploskogo lishaya. Saratovskiy nauchno-medicinskiy zhurnal. 2017;3(13):652-661. [N.A. Slesarenko, S.R. Utz, A.L. Bakulev, M.G. Eremina, V.N. Sherstneva. Clinical polymorphism of lichen ruber planus. Saratov Journal Of Medical Scientific Research. 2017;3(13):652-661. (In Russ.)]. https://elibrary.ru/item.asp?id= 32484262
4. Kubanova A.A., Kubanov A.A., Olisova O.Yu., Chikin V.V., Mineeva A.A. Federal'nye klinicheskie rekomendacii. Dermatovenerologiya. Bolezni kozhi. Infekcii, peredavaemye polovym putem. Moskva. 2016:768. [A.A. Kubanova, A.A. Kubanov, O.Yu. Olisova, V.V. Chikin, A.A. Mineeva. Federal clinical recommendations. Dermatovenerology. Diseases of the skin. Sexually transmitted infections. Moscow. 2016:768. (In Russ.)]. https://elibrary.ru/item.asp?id= 43829144
5. Melkumyan S.S., Ragimova A.N., Tarasova V.V. Krasnyy ploskiy lishay v praktike vracha-stomatologa (literaturnyy obzor). Studencheskiy vestnik. 2019;2-1:45-48. [S.S. Melkumyan, A.N. Ragimova, V.V. Tarasova. Lichen planus in the practice of a dentist (literature review). Student bulletin. 2019;2-1:45-48. (In Russ.)]. https://elibrary.ru/item.asp?id=36825543
6. Leont'eva E.S. Stomatologicheskie proyavleniya krasnogo ploskogo lishaya i prognosticheskaya znachimost' faktorov, vliyayuschih na ego techenie : diss. … kand. med. nauk. 14.01.14 [Mesto zaschity: Kazanskiy gosudarstvennyy medicinskiy universitet]. Kazan', 2014:169. [E.S. Leontieva. Dental manifestations of lichen planus erythematosus and prognostic significance of factors affecting its course : diss. … Cand. Med. Sciences. 14.01.14 [Place of defense: Kazan State Medical University]. Kazan, 2014:169]. http://www.dslib.net/stomatologia/ stomatologicheskie-projavlenija-krasnogo-ploskogo-lishaja-i-prognosticheskaja-znachimost.html
7. Molochkov V.A., Prokof'ev A.A., Bobrov M.A., Pereverzeva O.E. Klinicheskie osobennosti razlichnyh form krasnogo ploskogo lishaya. Rossiyskiy zhurnal kozhnyh i venerologicheskih bolezney. 2011;1:30-36. [V.A. Molochkov, A.A. Prokofiev, O.E. Pereverseva, M.A. Bobrov. Clinical features of different forms of lichen planus. Russian Journal Of Skin And Venereal Diseases. 2011;1:30-36. (In Russ.)]. https://elibrary.ru/item.asp?id= 16335481
8. Makedonova Yu.A. Optimizaciya patogeneticheskoy terapii bol'nyh krasnym ploskim lishaem slizistoy obolochki polosti rta : diss. … dokt. med. nauk. 14.01.14 [Mesto zaschity: Volgogradskiy Gosudarstvennyy medicinskiy universitet]. Volgograd, 2018:338. [Y.A. Makedonova. Optimization of pathogenetic therapy of patients with lichen planus of the oral mucosa : diss. ... doc. med. sciences. 14.01.14 [Place of defense: Volgograd State Medical University]. Volgograd, 2018:338. (In Russ.)]. https://search.rsl.ru/ru/record/01009837697
9. Gileva O.L., Libik T.V., Pozdnyakova A.A., Satyukova L.Ya. Predrakovye zabolevaniya v strukture patologii slizistoy obolochki polosti rta. Problemy stomatologii. 2013;2:3-8. [O.S. Gileva, T.V. Libik, A.A. Pozdnyakova, L.Y. Satyukova. Precancerous lesions in structure of oral mucosa diseases. Actual problems in dentistry. 2013;2:3-8. (In Russ.)]. https://elibrary.ru/item.asp?id=18976565
10. Blashkova S.L., Fazylova Yu.V. Osobennosti gigienicheskogo uhoda u pacientov s proyavleniyami dermatozov na slizistoy obolochke rta. Parodontologiya. 2018;2(87):53-57. [I. Anisimova, L. Simonyan. The frequency of combination of oral lichen planus with somatic pathology and local unfavorable factors of the oral cavity. Actual problems in dentistry. Periodontics. 2018;2(87):53-57. (In Russ.)]. https://elibrary.ru/item.asp?id= 35786798
11. Grigor'ev S.S., Zhovtyak P.B. Ocenka somaticheskoy patologii u pacientov s krasnym ploskim lishaem slizistoy obolochki polosti rta. Problemy stomatologii. 2014;5:15-17. [S.S. Grigorev, P.B. Zhovtyak. Analysis of general desease in patients with oral lichen planus. Actual problems in dentistry. 2014;5:15-17. (In Russ.)]. https://elibrary.ru/item.asp?id= 22509621
12. Shkarednaya O.V., Goryacheva T.P., Chunihin A.A., Bazikyan E.A., Gazhva S.I. Optimizaciya ranney diagnostiki patologicheskih sostoyaniy slizistoy obolochki rta. Sovremennye tehnologii v medicine. 2017;3(9):119-125. [O.V. Shkarednaya, T.P. Goryacheva, A.A. Chunikhin, E.A. Bazikyan, S.I. Gazhva. Optimizing The Early Diagnosis Of Oral Mucosal Pathologies. Modern Technologies in Medicine. 2017;3(9):119-125. (In Russ.)]. https://elibrary.ru/item.asp?id=29947577
13. Ron' G.I., Epishova A.A. Vliyanie haraktera pitaniya na techenie krasnogo ploskogo lishaya slizistoy polosti rta. Problemy stomatologii. 2015;1:19-23. [G.I. Ron, A.A. Epishova. The impact of nutrition on the course of lichen planus. Actual problems in dentistry. 2015;1:19-23. (In Russ.)]. https://elibrary.ru/item.asp?id= 23731231
14. Silin D.S., Konoplya A.I., Tishkov D.S., Pis'mennaya E.V. Osobennosti sostoyaniya slizistoy obolochki polosti rta u bol'nyh krasnym ploskim lishaem. Nauchnye vedomosti Belgorodskogo gosudarstvennogo universiteta. Seriya: medicina. Farmaciya. 2012;22-1(141):103-107. [D.S. Silin, A.I. Conoplya, D.S. Tishkov, E.V. Pismennaya. Condition of oral mucosa in patients with lichen ruber planus. Scientific bulletin of Belgorod State University. Series: medicine. Pharmacy. 2012;22-1(141):103-107. (In Russ.)]. https://elibrary.ru/item.asp?id= 20782067
15. Titarenko M.A., Stolyarova V.A., Sysolyatin P.G., Baydik O.D. Rol' gastrointestinal'noy patologii v razvitii i tyazhesti techeniya krasnogo ploskogo lishaya slizistoy obolochki polosti rta. Byulleten' sibirskoy mediciny. 2018;17(3):151-156. [M.A. Titarenko, V.A. Stolyarova, P.G. Sysolyatin, O.D. Baydik. The role of gastrointestinal pathology in the development and severity of oral lichen planus. Bulletin of siberian medicine. 2018;17(3):151-156. (In Russ.)]. https://doi.org:https://doi.org/10.20538/1682-0363-2018-3-151-156
16. Tiunova N.V., Yanova N.A. Kliniko-epidemiologicheskaya ocenka predrakovyh zabolevaniy slizistoy obolochki polosti rta i krasnoy kaymy gub v krupnom promyshlennom gorode na primere Nizhnego Novgoroda. Klinicheskaya stomatologiya. 2009;3:32-34. [N.V. Tiunova, N.A. Yanova. CLINICAL-epidemiological evaluation of precancerous diseases of oral mucosa and red border in the industrial city by the example of Nizhni Novgorod. Clinical Dentistry. 2019;1(15):16-22. (In Russ.)]. https://elibrary.ru/item.asp?id= 22758065
17. Firsova I.V., Mihal'chenko V.F., Mihal'chenko D.V. Vrachebnaya taktika pri diagnostike predrakovyh zabolevaniy slizistoy obolochki polosti rta i krasnoy kaymy gub. Vestnik Volgogradskogo gosudarstvennogo medicinskogo universiteta. 2013;1(45):3-6. [I.V. Firsova, V.F. Mikhalchenko, Mikhalchenko D. V. Medical tactics in the diagnosis of precancerous diseases of the oral mucosa and the red border of the lips. Bulletin of Volgograd state medical University. 2013;1 (45):3-6. (In Russ.)]. https://elibrary.ru/item.asp?id=18944984
18. Hayretdinova K.F. Nauchnoe obosnovanie patogeneticheskoy terapii bol'nyh krasnym ploskim lishaem s uchetom klinicheskogo techeniya : diss. ... kand. med. nauk. 14.01.10 [Mesto zaschity: Pervyy Moskovskiy gosudarstvennyy medicinskiy universitet im. I.M. Sechenova]. Moskva, 2020:178. [K.F. Khayretdinova. Scientific substantiation of pathogenetic therapy of patients with lichen planus taking into account the clinical course : diss. … cand. of med. sciences. 14.01.10 [Place of defense: I. M. Sechenov First Moscow State Medical University]. Moscow, 2020:178. (In Russ.)]. https://elibrary.ru/item.asp?id=44216189
19. Hayretdinova K.F., Yusupova L.A. Sovremennyy vzglyad na problemu krasnogo ploskogo lishaya. Lechaschiy vrach. 2015;7:61-65. [K.F. Khairetdinova, L.A. Yusupova. Modern view of the problem of lichen planus. Lechaschi Vrach. 2015;7:61-65. (In Russ.)]. https://elibrary.ru/item.asp?id= 23906236
20. Firsova I.V., Mihal'chenko V.F., Mihal'chenko D.V. Vrachebnaya taktika pri diagnostike predrakovyh zabolevaniy slizistoy obolochki polosti rta i krasnoy kaymy gub. Vestnik Volgogradskogo gosudarstvennogo medicinskogo universiteta. 2013;1(45):3-6. [I.V. Firsova, V.F. Mikhalchenko, D.V. Mikhalchenko. Medical tactics in the diagnosis of precancerous diseases of the oral mucosa and the red border of the lips. Bulletin of Volgograd state medical University. 2013;1(45):3-6. (In Russ.)]. https://elibrary.ru/item.asp?id= 18944984
21. Boorghni M., Gholizadeh N., Zenoyz A., Vatankhak M. Oral lichen planus: clinical features, etiology, treatment and management. A review of literature // J. Dental Res. Dental Clin., Dental Prospects. - 2010;4(1):3-9. https://doi.org/10.5681/joddd.2010.002
22. Bardellini E., Amadori F., Flocchini P., Bonadeo S., Majorana A. Clinicopathological features and malignant transformation of oral lichen planus: A 12-years retrospective study // Acta Odontol Scand. - 2013;71(3-4):834-840. http://dx.doi.org/https://doi.org/10.3109/00016357.2012.734407
23. Farzam Gorouhi. Cutaneous and Mucosal Lichen Planus: A Comprehensive Review of Clinical Subtypes, Risk Factors, Diagnosis, and Prognosis. Farzam Gorouhi, Parastoo Davari, Nasim Fazel // The Scientific World Journal. - 2014;7:21-43. https://doi.org/10.1155/ 2014/742826
24. Lodi G., Pellicano R., Carrozzo M. Hepatitis. C virus infection and lichen planus: a systematic review with meta-analysis // Oral Dis. - 2010;16:601-612. http://dx.doi.org/https://doi.org/10.1111/j.1601-0825.2010.01670.
25. Tovaru S., Parlatescu I.M., Nicolae C.L., Tovaru M. Oral llchen planus and malignancy // Abstracts of EAOM-meeting. - 2018. https://doi.org/https://doi.org/10.1155/2018/1959506
26. Tar I., Márton I. The oral lichen planus: doubts and evidence // Fogorvosi Szemle. - 2009;3(102):103-109. PMID:19618778
27. Torrente-Castells E. Clinical features of oral lichen planus. A retrospective study of 65 cases // Medicina Oral, Patología Oral Y Cirugía Bucal. - 2010;5(15):685-690. PMID: 20383118 http://dx.doi.org/https://doi.org/10.4317/medoral.15.e685
28. Usatine R.P., Tinitigan M. Diagnosis and treatment of lichen planus // American Family Physician. - 2011;1(84):53-60. PMID: 21766756
29. Zaraa I., Mahfoudh A., Sellami M.K. et al. Lichen planus pemphigoides: four new cases and a review of the literature // Int J of Dermatol. - 2013;52:406-412. http://dx.doi.org/10.1111/ j.1365-4632.2012.05693.x.
