graduate student
Ufa, Kazan, Russian Federation
Ufa, Ufa, Russian Federation
employee
Ufa, Ufa, Russian Federation
Ufa, Ufa, Russian Federation
employee
Nagariya, Israel
Ufa, Ufa, Russian Federation
employee
Ufa, Kazan, Russian Federation
Ufa, Ufa, Russian Federation
student
Ufa, Ufa, Russian Federation
student
Ufa, Ufa, Russian Federation
Subject. Some features of the clinical picture, hygienic and microbiological state of the oral cavity, acidity and free-radical oxidation of the oral fluid in patients with recurrent aphthates on the background of acid-dependent diseases of the gastrointestinal tract are considered. The aim is to assess the relationship between clinical and laboratory parameters in patients with recurrent oral aphthae associated with acid-dependent diseases of the gastrointestinal tract. Methodology. A comprehensive clinical and laboratory examination of 58 young people with revealed recurrent aphthae of the oral cavity against the background of acid-dependent diseases of the gastrointestinal tract was carried out. The level of oral hygiene was assessed using the ONI-s index, the state of free-radical oxidation of the oral fluid - the "Chemilumimer-003" device, individual representatives of the normal flora were identified by inoculating the contents from the surface of aphthous elements on special differential diagnostic media of the HiCrome series. The acidity of the oral fluid was determined using a universal indicator litmus paper pH-1-14, short-term intragastric pHmetry was performed directly during fibrogastroduodenoscopy. Results. In 46.4 % of those examined, recurrent aphthae were found on the oral mucosa. In persons with chronic gastritis and duodenitis, the frequency of recurrences once a year was 37.9 %, 2-3 times a year ― 62.0, with the presence of chronic pancreatitis against the background of hyperacid gastric secretion ― 44.8 and 55.2, respectively. In patients with recurrent aphthae, a low level of oral hygiene, a violation of its microbiome, and a change in the acidity of the oral fluid were revealed. Conclusions. The presence of recurrent aphthae complicates individual oral hygiene, because accompanied by severe pain and paresthetic symptoms. This is manifested by an increase in the ONI-S index and a disturbance in the state of the normobiome in the form of an increase in the growth of resident microflora against the background of changes in the acidity of the oral fluid. Chemiluminescence indices correlate with the hygienic state of the oral cavity, qualitative changes in the normobiota and pH of the oral fluid in the studied clinical groups.
recurrent aphthae of the oral cavity, acid-related disease gastrointestinal tract, normaliam, the pH of the oral fluid, free-radical оxidation
1. Axamit, L. A., Tsvetkova, A. A. (2016). Zabolevaniya slizistoy obolochki rta. Svyaz' s obshchey patologiyey. Diagnostika. Lecheniye [Diseases of the oral mucosa. Connection with the general pathology. Diagnostics. Treatment]. Moscow : MEDpress-inform, 288. (In Russ.)
2. Bulkina, N. V., Meleshina, O. V., Lomakina, D. O. (2011). Khronicheskiy retsidiviruyushchiy aftoznyy stomatit: osobennosti klinicheskogo techeniya i kompleksnogo lecheniya [Chronic recurrent aphthous stomatitis: features of the clinical course and complex treatment]. Saratovskiy nauchno-meditsinskiy zhurnal [Saratov Journal of Medical Scientific Research], 7, 1, 281-282. (In Russ.)
3. Karpuk, N. A. (2018). Vliyaniye allergicheskikh zabolevaniy na stomatologicheskiy status patsiyentov [Effect of allergy diseases on the dental status of patients]. Immunopatologiya, allergologiya, infektologiya [Immunopathology, allergology, infectology], 4, 56-61. (In Russ.)
4. Gazhva, S. I., Leskov, A. S., Shkarednaya, O. V. et al. (2012). Osobennosti stomatologicheskogo statusa patsiyentov s gastroduodenal'noy patologiyey [Features of the dental status of patients with gastroduodenal pathology]. Obozreniye [Review], 1 (75), 4950. (In Russ.)
5. Gileva, O. S., Khalilaeva, E. V., Libik, T. V. et al. (2009). Mnogostupenchataya validatsiya mezhdunarodnogo oprosnika kachestva zhizni «Profil' vliyaniya stomatologicheskogo zdorov'ya» OHIP-49-RU [Multistage validation of the international quality of life questionnaire “Dental Health Impact Profile” OHIP-49-RU]. Ural'skiy meditsinskiy zhurnal [Ural Medical Journal], 8, 104-109. (In Russ.)
6. Drobotko, L. N., Strakhova, S. Yu. (2006). Khronicheskiy retsidiviruyushchiy aftoznyy stomatit [Chronic recurrent aphthous stomatitis]. Rossiyskiy Meditsinskiy Zhurnal [Russian Medical Journal], 29, 2096-2098. (In Russ.)
7. Denisova, T. P., Shuldyakov, V. A., Tultyaeva, L. A., Chernenkov, Yu. V., Alipova, L. N., Sadzhaya, L. A. (2011). Monitoring rasprostranennosti zabolevaniy vnutrennikh organov na primere patologii pishchevaritel'noy sistemy [Monitoring the prevalence of diseases of internal organs on the example of the pathology of the digestive system]. Saratovskiy nauchno-meditsinskiy zhurnal [Saratov Journal of Medical Scientific Research], 7, 4, 772-776. (In Russ.)
8. Ionov, V. V. (2008). Sostoyaniye mestnogo immuniteta, svobodnoradikal'nykh protsessov i antioksidantnoy zashchity v slyune pri khronicheskom retsidiviruyushchem aftoznom stomatite : diss. ... kand. med. nauk [State of local immunity, free radical processes and antioxidant protection in saliva in chronic recurrent aphthous stomatitis : diss. ... cand. med. sciences]. Moscow. (In Russ.)
9. Galimova, I. A., Usmanova, I. N., Gerasimova, L. P. et al. (2019). Diagnosticheskaya znachimost' nekotorykh predstaviteley normobioma polosti rta v razvitii retsidiviruyushchikh aft polosti rta u patsiyentov s kislotozavisimymi zabolevaniyami zheludochno-kishechnogo trakta [Diagnostic significance of some representatives of normal microbiome of the oral cavity in the development of recoverable acts of the oral cavity in patients with acid-dependent gastrointestinal diseases]. Problemy stomatologii [Actual problems in dentistry], 15, 4, 31-37. (In Russ.)
10. Karakov, K. G., Vlasova, T. N., Sirak, S. V., Porfiriadis, M. P., Lavrinenko, V. I., Oganyan, A. V., Khachaturian, E. E., Sarkisov, A. A., Khubaev, S-S. Z., Mordasov, N. A. (2016). Retsidiviruyushchiye i rubtsuyushchiyesya afty pri zabolevaniyakh zheludochno-kishechnogo trakta [Recurrent and scarring aphthae in diseases of the gastrointestinal tract]. Nauchnoye obozreniye. Referativnyy zhurnal [Scientific Review. Abstract journal], 5, 19-20. (In Russ.)
11. Gileva, O. S., Yashina, J. S., Libik, T. V., Pozdnyakova, A. A., Gorodilova. E. A. (2013). Kompleksnaya stomatologicheskaya reabilitatsiya bol'nykh s zabolevaniyami slizistoy obolochki polosti rta: ratsional'nyye podkhody k proteticheskomu lecheniyu [Complex dental rehabilitation of patients with oral mucosal diseases: rational approaches to prosthetic treatment]. Stomatologiya dlya vsekh [International Dental Review], 4, 9-14. (In Russ.)
12. Lukina, G. I. (2011). Morfofunktsional'nyye osobennosti slizistoy obolochki polosti rta u bol'nykh s zabolevaniyami organov pishchevareniya : dis. ... d-ra. med. nauk [Morphological and functional features of the oral mucosa in patients with diseases of the digestive system : diss. ... doc. med. sciences]. Moscow. (In Russ.)
13. Latysheva, S. (2004). Klinicheskaya otsenka sostoyaniya slizistoy obolochki polosti rta [Clinical evaluation of the condition of the mucous membrane of the oral cavity]. Stomatolog [Dentist], 4, 46-49. (In Russ.)
14. Karakov, K. G., Vlasova, T. N., Oganyan, A. V., Khachaturian, A. E., Karakova, S. N., Harutyunyan, M. L., Amirova, S. D. (2019). Nozogennyye depressii u patsiyentov s patologiyey slizistoy polosti rta [Nosogenic depression in patients with pathology of the oral mucosa]. Problemy stomatologii [Problems of dentistry], 15, 4, 50-54. (In Russ.)
15. Galimova, I. A., Usmanova, I. N., Gerasimova, L. P., Petrova, K. A., Ermolaev, A. V., Eshtukova, Yu. V. (2019). Otsenka sostoyaniya slizistoy obolochki rta u lits s patologiyey zheludochnokishechnogo trakta [Assessment of oral mucosa in persons with pathology of the gastrointestinal tract]. Ural'skiy meditsinskiy zhurnal [Ural medical journal], 9 (177), 15-19. (In Russ.)
16. Uspenskaya, O. A., Tiunova, N. V. (2015). Osobennosti biokhimicheskikh pokazateley krovi u bol'nykh retsidiviruyushchim aftoznym stomatitom i urogenital'noy infektsiyey [Biochemical parameters of blood in patients with recurrent aphthous stomatitis and genital infection]. Dental Forum [Dental Forum], 4, 89. (In Russ.)
17. Tsimbalislov, A. V., Robakidze, N. S. (2005). Patofiziologicheskiye aspekty razvitiya sochetannoy patologii polosti rta i zheludochno-kishechnogo trakta [Pathophysiological aspects of the development of combined pathology of the oral cavity and gastrointestinal tract]. Stomatologiya dlya vsekh [International Dental Review], 1, 28-34. (In Russ.)
18. Rabinovich, I. M., Rabinovich, O. F., Panfilova, E. L., Vakhrushina, E. V. (2010). Retsidiviruyushchiy aftoznyy stomatit - etiologiya, patogenez (chast' I) [Recurrent aphthous stomatitis - etiology, pathogenesis (part I)]. Stomatologiya [Dentistry], 1, 71-74. (In Russ.)
19. Rabinovich, I. M., Rabinovich, O. F., Vakhrushina, E. V. (2010). Retsidiviruyushchiy aftoznyy stomatit - klassifikatsii, klinicheskiye formy i lecheniye (chast' II) [Recurrent aphthous stomatitis - classifications, clinical forms and treatment (part II)]. Stomatologiya [Dentistry], 3, 76-80. (In Russ.)
20. Karakov, K. G., Vlasova, T. N., Sirak, S. V., Porfiriadis, M. P., Lavrinenko, V. I., Oganyan, A. V., Khachaturian, E. E., Sarkisov, A. A., Khubaev, S. Z., Mordasov, N. A. (2014). Retsidiviruyushchiye i rubtsuyushchiyesya afty pri zabolevaniyakh zheludochno-kishechnogo trakta : uchebnoye posobiye [Recurrent and scarring aphthae in diseases of the gastrointestinal tract : textbook]. Stavropol : StGMU, 112. (In Russ.)
21. Usmanova, I. N. (2016). Optimizatsiya diagnostiki, lecheniya i profilaktiki vospalitel'nykh zabolevaniy parodonta i slizistoy obolochki rta u lits molodogo vozrasta : dis. ... d-ra. med. nauk [Optimization of diagnostics, treatment and prevention of inflammatory diseases of the periodontal and oral mucosa in young people : diss. ... doc. med. sciences]. Ufa. (In Russ.)
22. Uspenskaya, O. A., Lukinykh, L. M., Shevchenko, E. A., Tiunova, N. V. (2015). Khronicheskiy retsidiviruyushchiy aftoznyy stomatit : uchebnoye posobiye [Chronic recurrent aphthous stomatitis : textbook]. Nizhny Novgorod, 72. (In Russ.)
23. Kabirova, M. F., Gerasimova, L. P., Karimova, S. R., Bashirova, T. V., Chemikosova, T. S. (2019). Effektivnost' kompleksa lechebnykh meropriyatiy khronicheskogo gingivita u patsiyentov s khronicheskim gastroduodenitom [The effectiveness of the complex of therapeutic measures of chronic gingivitis in patients with chronic gastroduodenitis]. Problemy stomatologii [Actual problems in dentistry], 14, 2, 25-29. (In Russ.)
24. Toche, P. P., Salinas, L. J., Guzman, M. M. A., Afani, S. A. (2007). Recurrent oral ulcer: clinical characteristic and differential diagnosis. Rev. ChilenaInfectol, 3, 215-219.
25. Scully, C., Porter, S. (2008). Oral mucosal disease: recurrent aphthous stomatitis. Br. J. Oral Maxillofac. Surg, 46, 198-206.
26. Patil, C. S., Kirkwood, K. L. (2007). MAPK signaling in oral-related diseases. J Dent. Res, 9, 812-825.
27. Titsinides, S., Daskalopoulos, A., Nikitakis, N. (2018). Oral aphthous-like ulcers associated with a selective PI3K inhibitor. Abstracts of EAOM-meeting.
