Ufa, Russian Federation
Ufa, Ufa, Russian Federation
Ufa, Ufa, Russian Federation
UDK 61 Медицина. Охрана здоровья
GRNTI 76.29 Клиническая медицина
OKSO 31.08.57 Онкология
BISAC MED062000 Oncology
Subject. At the present stage of society development cancer incidence remains among the most pressing medical and social problems. In the structure of oncopathology a special place is occupied by malignant neoplasms of lymphoid and hematopoietic tissues which include chronic myeloid leukemia (CML). In some patients, the disease can appear with dental symptoms associated with a decrease in local immunity of the oral cavity — the appearance of aphthae, plaque on the oral mucosa, angular cheilosis, bleeding gums, dry mouth. It is diagnostically significant that such oral symptoms may precede general clinical symptoms, that is, they can be considered as early symptoms of CML. In addition, their severity often prompts a patient with CML to see a dentist. Thus, the importance of the professional knowledge of the dentist in general clinical and dental symptomatology of CML, the correct routing of the patient for further clinical and laboratory examination, treatment and observation by a hematologist is undeniably high. The goal is to study and identify the features of the dental status of patients with chronic myeloid leukemia. Methodology. The work carried out a comprehensive assessment of the state of the oral cavity and the need for dental treatment of patients with chronic myeloid leukemia in which patients with preserved systemic status and patients with chronic myeloid leukemia took part. Results. According to the results of a complex dental examination and the calculation of the main dental indices, patients with CML were found to have serious disorders in the state of their oral health. Conclusions. Patients with CML showed a high need for various types of dental care, primarily in conservative oral cavity sanitation, periodontal treatment and rationalization of oral hygiene protocols (professional and individual).
oral mucosa, oral diseases, chronic myeloid leukemia, periodontal disease, dental status
1. Turkina A.G., Novickaya N.V., Golenkov A.K., Shuvaev A.V. i dr. Registr bol'nyh hronicheskim mieloleykozom v Rossiyskoy Federacii: ot nablyudatel'nogo issledovaniya k ocenke effektivnosti terapii v klinicheskoy praktike. Klinicheskaya onkogematologiya. 2017;10(3):390-401. [A.G. Turkina, N.V. Novitskaya, A.K. Golenkov, A.V. Shuvaev et al. Register of patients with chronic myeloid leukemia in the Russian Federation: from an observational study to evaluating the effectiveness of therapy in clinical practice. Clinical Oncohematology. 2017;10(3):390-401. (In Russ.)].
2. Turkina A.G., Zarickiy A.Yu., Shuvaev V.A. Klinicheskie rekomendacii po diagnostike i lecheniyu hronicheskogo mieloleykoza. Klinicheskaya onkogematologiya. 2017:294-316. [A.G. Turkina, A.Yu. Zaritsky, V.A. Shuvaev. Clinical recommendations for the diagnosis and treatment of chronic myeloid leukemia. Clinical Oncohematology. 2017:294-316. (In Russ.)].
3. Sirazetdinova A.R., Kirillova V.P., Trunin D.A. i dr. Harakteristika izmeneniy slizistoy obolochki polosti rta bol'nyh hronicheskim mieloleykozom na fone priema imatiniba. Rossiyskiy stomatologicheskiy zhurnal. 2016;20(1):32-35. [A.R. Sirazetdinova, V.P. Kirillova, D.A. Trunin et al. Characteristics of changes in the oral mucosa of patients with chronic myeloid leukemia while taking imatinib. Russian stomatological journal. 2016;20(1):32-35. (In Russ.)].
4. Kulikov S.V., Vinogradova O.Yu., Chelysheva E.Yu. i dr. Zabolevaemost' hronicheskim mieloleykozom v 6 regionah Rossii po dannym populyacionnogo issledovaniya 2009-2012 gg. Terapevticheskiy arhiv. 2014;86(7):24-30. [S.V. Kulikov, O. Yu. Vinogradova, E.Yu. Chelysheva et al. The incidence of chronic myeloid leukemia in 6 regions of Russia according to the population study 2009-2012. Therapeutic archive. 2014;86(7):24-30. (In Russ.)].
5. Ryabchikova N.R., Safuanova G.Sh., Nikulicheva V.I. Epidemiologiya hronicheskogo mieloleykoza v Respublike Bashkortostan. Onkogematologiya. 2018;11(4):349-353. [N.R. Ryabchikova, G. Sh. Safuanova, V.I. Nikulicheva. Epidemiology of chronic myeloid leukemia in the Republic of Bashkortostan. Oncohematology. 2018;11(4):349-353. (In Russ.)].
6. Buchan J., McKibbin M., Burton T. The prevalence of ocular disease in chronic lymphocytic leukaemia // Eye. - 2003;17(1):3-4.
7. Basistaya A.S., Prodanchuk A.I. Stomatologicheskiy status pacientov s onkogematologicheskimi zabolevaniyami i rekomendacii po gigienicheskomu uhodu. Molodoy uchenyy. 2017;17(151):111-114. [A.S. Basistaya, A.I. Prodanchuk. Dental status of patients with oncohematological diseases and recommendations for hygienic care. Young scientist. 2017;17(151):111-114. (In Russ.)].
8. Rahymbekov K.K. Vospalitel'nye zabolevaniya polosti rta: sovremennye podhody k profilaktike i lecheniyu. Vestnik hirurgii. 2012;2(30):121-122. [K.K. Rakhymbekov. Inflammatory diseases of the oral cavity: modern approaches to prevention and treatment. Bulletin of surgery. 2012;2(30):121-122. (In Russ.)].
9. Sokolova O.A. Etiologicheskoe i patogeneticheskoe obosnovanie znachimosti gigienicheskih meropriyatiy u bol'nyh s patologiey sistemy krovi. Zdorov'e i obrazovanie v XXI veke. 2012;3:261-262. [O.A. Sokolova. Etiological and pathogenetic substantiation of the importance of hygiene measures in patients with blood system pathology. Health and education in the XXI century. 2012;3:261-262. (In Russ.)]. https://www.elibrary.ru/item.asp?id=21686677
10. Uspenskaya O.A., Fadeeva I.I. Osobennosti stomatologicheskogo statusa pacientov s onkologicheskimi zabolevaniyami. Problemy stomatologii. 2019;15(1):63-67. [O.A. Uspenskaya, I.I. Fadeeva. Features of the dental status of patients with cancer. Actual problems in dentistry. 2019;15(1):63-67. (In Russ.)]. https://www.elibrary.ru/item.asp?id=37602582
11. Vasil'eva N.A., Bulgakova A.I., Imel'baeva E.A. i dr. Osobennosti lokal'nogo immuniteta polosti rta pri tradicionnoy terapii vospalitel'nyh zabolevaniy parodonta. Problemy stomatologii. 2018;14(3):11-16. [N.A. Vasilyeva, A.I. Bulgakova, E.A. Imelbaeva et al. Features of local immunity of the oral cavity in traditional therapy of inflammatory periodontal diseases. Actual problems in dentistry. 2018;14(3):11-16. (In Russ.)]. https://www.elibrary.ru/item.asp?id=36458685
12. Shinkevich D.S. Kliniko-morfologicheskie proyavleniya gemoblastozov v chelyustno - licevoy oblasti. Taktika hirurgicheskoy pomoschi bol'nym gemoblastozami. Rossiyskaya stomatologiya. 2015;(2):19-28. [D.S. Shinkevich. Clinical and morphological manifestations of hemoblastosis in the maxillofacial region. Tactics of surgical care for patients with hemoblastosis. Russian dentistry. 2015;(2):19-28. (In Russ.)]. https://www.elibrary.ru/item.asp?id=24273406
13. Selezneva I.A., Gil'miyarova F.N., Domenyuk D.A. i dr. Kliniko-molekulyarnye osobennosti stomatitov u pacientov s ostrymi i hronicheskimi leykozami. Medicinskiy al'manah. 2018;5(56):230-231. [I.A. Selezneva, F.N. Gilmiyarova, D.A. Domenyuk et al. Clinical and molecular features of stomatitis in patients with acute and chronic leukemia. Medical almanac. 2018;5(56):230-231. (In Russ.)]. https://www.elibrary.ru/item.asp?id=36455628
14. Voycehovskiy V.V., Goborov N.D. Splenomegaliya v klinicheskoy praktike. Amurskiy medicinskiy zhurnal. 2019;2(26):61-63. [V.V. Voitsekhovsky, N.D. Goborov. Splenomegaly in clinical practice. Amur medical journal. 2019;2(26):61-63. (In Russ.)].
15. Holmogorova O.A., Gulyaeva L.I., Astashina N.B. Stomatologicheskiy status pacientov s hronicheskim mieloleykozom. Mezhdunarodnyy studencheskiy medicinskiy vestnik. 2017. [O.A. Kholmogorova, L.I. Gulyaeva, N.B. Astashina. Dental status of patients with chronic myeloid leukemia. International student medical Bulletin. 2017. (In Russ.)]. http://eduherald.ru/ru/article/view?id=17693
16. Saydullaeva M.G. Klinicheskaya harakteristika hronicheskogo mieloleykoza i hronicheskogo limfoleykoza i tipy lichnostnogo reagirovaniya pacientov na dannye zabolevaniya. International scientific review of the problems and prospects of modern science and education collection of scientific articles. lxiv international correspondence scientific and practical conference. 2019:90-94. [M.G. Saydullayeva. Clinical characteristics of chronic myeloid leukemia and chronic lymphocytic leukemia and types of personal response of patients to these diseases. International scientific review of the problems and prospects of modern science and education collection of scientific articles. lxiv international correspondence scientific and practical conference. 2019:90-94.]. https://www.elibrary.ru/item.asp?id=41384408
17. Lazareva O.V., Turkina A.G., Chelysheva E.Yu. i dr. Klinicheskaya i gematologicheskaya harakteristika bol'nyh hronicheskim mieloleykozom v sovremennyh usloviyah: rezul'taty rossiyskoy chasti mezhdunarodnogo mnogocentrovogo perspektivnogo populyacionnogo issledovaniya EUTOS Population-based CML Study. Klinicheskaya onkogematologiya. 2017;10(1):65-74. [O.V. Lazareva, A.G. Turkina, E.Yu. Chelysheva et al. Clinical and hematological characteristics of patients with chronic myeloid leukemia in modern conditions: results of the Russian part of the international multicenter prospective population study EUTOS Population-based CML Study. Clinical Oncohematology. 2017;10(1):65-74. (In Russ.)].
18. Grishina E.E., Mamontova A.O. Oftal'mologicheskie proyavleniya leykoza. Al'manah klinicheskoy mediciny. 2016;44(5):587-591. [E.E. Grishina, A.O. Mamontova. Ophthalmological manifestations of leukemia. Almanac of clinical medicine. 2016;44(5):587-591. (In Russ.)].
19. Sycheva Yu.A., Lavrinenko S.Yu., Efimenko D.N., Aksenova I.S., Dubrovina T.A., Zyryanov K.D., Umzar P.A. Tyazhelyy yazvennyy stomatit s vyrazhennoy krovotochivost'yu kak proyavlenie ostrogo gemoblastoza. Zdorov'e i obrazovanie v XXI veke. 2019;21(4):78-81. [Yu.A. Sycheva, S.Yu. Lavrinenko, D.N. Efimenko, I.S. Aksenova, T.A. Dubrovina, K.D. Zyryanov, P.A. Umzar. Severe ulcerative stomatitis with severe bleeding as a manifestation of acute hemoblastosis. Health and education in the 21st century. 2019;21(4):78-81. (In Russ.)]. https://www.elibrary.ru/item.asp?id=38478216
20. Shuvaev V.A., Abdulkadyrov K.M., Martynkevich V.I. i dr. Hronicheskiy mieloleykoz: mnogoletniy opyt targetnoy terapii. Onkogematologiya. 2016;9(1):54-60. [V.A. Shuvaev, K.M. Abdulkadyrov, V.I. Martynkevich et al. Chronic myeloid leukemia: many years of experience in targeted therapy. Oncohematology. 2016;9(1):54-60. (In Russ.)].
21. Vasil'eva N.A., Bulgakova A.I., Soldatova E.S. Harakteristika stomatologicheskogo statusa pacientov s vospalitel'nymi zabolevaniyami parodonta. Kazanskiy medicinskiy zhurnal. 2017;98(2):204-209. [N.A. Vasilieva, A.I. Bulgakova, E.S. Soldatova. Characteristics of the dental status of patients with inflammatory periodontal diseases. Kazan medical journal. 2017;98(2):204-209. (In Russ.)].
22. Svechnikova M.V. Kliniko-molekulyarnaya harakteristika porazheniy slizistoy obolochki polosti rta u pacientov s leykozami: avtoref. dis. … k.m.n. 14.01.14. - Krasnodar, 2017. [M.V. Svechnikova. Clinical and molecular characteristics of oral mucosal lesions in patients with leukemia: author. dis. … cand.med.sciense 14.01.14. - Krasnodar, 2017. (In Russ.)]. https://www.elibrary.ru/item.asp?id=32450409
23. Chistyakova N.V. Oftal'mologicheskie proyavleniya leykozov. Oftal'mologicheskie vedomosti. 2016;9(2):83-96. [N.V. Chistyakova. Ophthalmological manifestations of leukemia. Ophthalmological statements. 2016;9(2):83-96. (In Russ.)].
24. Nurieva N.S., Guz' A.O., Zaharov A.S., Garev A.V. Obzor sovremennogo sostoyaniya problemy pervichnoy vyyavlyaemosti zlokachestvennyh novoobrazovaniy organov polosti rta. Problemy stomatologii. 2019;15(2):52-54. [N.S. Nurieva, A.O. Guz, A.S. Zakharov, A.V. Gorev. Review of the current state of the problem of primary detection of malignant neoplasms of the oral cavity. Actual problems in dentistry. 2019;15(2):52-54. (In Russ.)]. https://www.elibrary.ru/item.asp?id=39165962
