Stavropol', Stavropol, Russian Federation
Stavropol', Stavropol, Russian Federation
Stavropol', Stavropol, Russian Federation
Volgograd, Volgograd, Russian Federation
Stavropol', Stavropol, Russian Federation
Stavropol', Stavropol, Russian Federation
Stavropol', Stavropol, Russian Federation
Subject. The article presents data from a comparative analysis of the inclusion of an oral probiotic in the traditional treatment regimen for oral candidiasis. The goal is to increase the effectiveness of the traditional treatment regimen by introducing a probiotic for the oral mucosa containing the Streptococcus salivarius K12 strain. Methodology. The study involved 30 patients with a diagnosis of "oral dysbiosis" aged 20 to 60 years, who were divided into 2 groups: control (15 people) and main (15 people). In the control group, conventional medical treatment was carried out with the inclusion of probiotic and antifungal drugs in the general therapy (according to the scheme), the probiotic Bactoblis was introduced into the main drug plan. Results. The proposed treatment regimen using the latest generation probiotic for the oral mucosa containing the Streptococcus salivarius K12 strain, in combination with the traditional treatment regimen for oral dysbiosis, was more effective than conventional complex therapy. Analysis of the clinical data of therapeutic measures in patients of the main group showed stabilization of the process on the 5th day from the start of therapy compared with the control, in which the improvement was diagnosed on the 10th day. Findings. The results indicate a greater effectiveness of therapy compared to the generally accepted method for the treatment of oral dysbiosis when a probiotic containing the Streptococcus salivarius K12 strain is included in the traditional regimen, which can serve as a guideline for practitioners in choosing a treatment plan for oral dysbiosis.
oral dysbiosis, probiotic, oral mucosa, pain, oral microflora
1. Afanasyev, E. V., Kuryaev, I. I., Chernetsov, I. A., Kostrigina, E. D., ed. Tkachev, E. P. (2017). Perspektiva ispol'zovaniya osteoplasticheskikh materialov v khirurgicheskoy stomatologii (parodontologii) [The prospect of using osteoplastic materials in surgical dentistry (periodontics)]. Sbornik nauchnykh trudov po materialam Mezhdunarodnoy nauchno-prakticheskoy konferentsii. V 2 chasti [Collection of scientific papers based on the materials of the International Scientific and Practical Conference. In 2 parts], 115-118. (In Russ.)
2. Akisheva, A. R., Imamieva, R. D., Mamaeva, E. V. (2020). Retsessiya desen u detey i metody yeye lecheniya (obzor literatury) [Recession of the gums in children and methods of its treatment (literature review)]. Aktual'nyye voprosy detskoy stomatologii 3 Vserossiyskaya nauchno-prakticheskaya konferentsiya : sbornik nauchnykh statey [Actual issues of pediatric dentistry 3 All-Russian scientific-practical conference : collection of scientific articles], 28-33. (In Russ.)
3. Elovikova, T. M. Primenenie antibakterial'nyh preparatov pri agressivnyh formah parodontita / T. M. Elovikova, E. F. Gaysina, A. S. Prihod'kin // Problemy stomatologii. - 2019. - T. 15, № 1. - S. 10-15.
4. Garage, S. N., Amkhadova, M. A., Grishilova, E. N., Khubaev, Z. S. S., Rakhaeva, D. Yu., Khachaturov, S. S., Muzayev, Z. R. (2018). Izmeneniya gemodinamiki v kompleksnom lechenii zabolevaniy parodonta i chastichnoy poteri zubov [Hemodynamic changes in the complex treatment of periodontal disease and partial tooth loss]. Russkiy stomatologicheskiy zhurnal [Russian Dental Journal], 22, 6, 288-291. (In Russ.)
5. Grudyanov, A. I., Frolova, O. A., Isadzhanyan, K. E., Popova, V. M. (2017). Kliniko-laboratornoye issledovaniye effektivnosti ispol'zovaniya bakteriofagov v periodontologii [Clinical and laboratory study of the effectiveness of the use of bacteriophages in periodontology]. Stomatologiya dlya vsekh [Dentistry for all], 3, 34-39. (In Russ.)
6. Mamedov, R. M., Sadigova, N. N., Ibragimova, L. K. (2019). Optimizatsiya metodov profilaktiki i lecheniya vospalitel'nykh zabolevaniy parodonta [Optimization of methods for the prevention and treatment of inflammatory periodontal diseases]. Problemy stomatologii [Actual problems in Dentistry], 15, 2, 114-121. (In Russ.)
7. Grechikhin, S. S. (2020). Vliyaniye kariyesa zubov na vospalitel'nyy status parodonta [The influence of dental caries on the inflammatory status of the periodontium]. Regional'nyy vestnik [Regional Bulletin], 4 (43), 16-17. (In Russ.)
8. Egorova, A. B., Musina, L. T., Urazova, R. Z. (2010). Vliyaniye antiseptikov na sostoyaniye mikroflory polosti rta [Influence of antiseptics on the state of the microflora of the oral cavity]. Kazanskiy meditsinskiy zhurnal [Kazan Medical Journal], 4, 525-528. (In Russ.)
9. Bazarny, V. V., Polushina, L. G., Maksimova, A. Yu., Svetlakova, E. N., Mandra, Yu. V. (2018). Patogeneticheskoye obosnovaniye novykh podkhodov k otsenke sostoyaniya tkaney polosti rta pri khronicheskom generalizovannom parodontite [Pathogenetic substantiation of new approaches to assessing the state of oral tissues in chronic generalized periodontitis]. Problemy stomatologii [Actual problems in Dentistry], 14, 3, 14-18. (In Russ.)
10. Karakov, K. G., Khachaturian, E. E., Vlasova, T. N., Ohanyan, A. V., Khachaturian, A. E. (2016). K voprosu o lechenii khronicheskikh retsidiviruyushchikh treshchin na gubakh i ikh sochetanii s eksfoliativnym kheylitom [To the question of the treatment of chronic recurrent lip cracks and their combination with exfoliative cheilitis]. Vestnik Meditsinskogo stomatologicheskogo instituta [Bulletin of the Medical Dental Institute], 1, 23-25. (In Russ.)
11. Karakov, K. G., Khachaturian, E. E., Vlasova, T. N., Ohanyan, A. V., Khachaturian, A. E., Saveliev, R. A. (2016). Rol' korrektsii individual'noy gigiyeny polosti rta v profilaktike patologii parodonta [The role of the correction of individual oral hygiene in the prevention of periodontal pathology]. Allergologiya i immunologiya [Allergology and Immunology], 17, 1, 62-63. (In Russ.)
12. Karakov, K. G., Vlasova, T. N., Khachaturian, E. E., Khachaturian, A. E. (2015). Prioritetnyy podkhod v parodontal'noy terapii [Priority approach in periodontal therapy]. Nauchnyy al'manakh [Scientific almanac], 10-3 (12), 329-333. (In Russ.)
13. Karakov, K. G., Khachaturian, E. E., Vlasova, T. N., Khachaturian, A. E., Savelyev, P. A. (2016). Rol' korrektsii individual'noy gigiyeny polosti rta v profilaktike patologii parodonta [The role of correction of individual oral hygiene in the prevention of periodontal pathology]. Allergologiya i immunologiya [Allergology and Immunology], 17, 1, 62-63. (In Russ.)
14. Karakov, K. G., Karakova, S. N., Vlasova, T. N., Khachaturian, E. E., Khachaturian, A. E., Porfiriadis, M. P., Sarkisov, A. A. (2017). Opyt klinicheskogo lecheniya boli pri nalichii khronicheskoy travmy slizistoy obolochki polosti rta [The experience of clinical treatment of pain in the presence of chronic trauma to the oral mucosa]. Meditsinskiy alfavit [Medical Alphabet], 11, 308, 42-44. (In Russ.)
15. Lalieva, Z. V. (2019). Osnovnyye aspekty ispol'zovaniya fotodinamicheskoy terapii v periodontologii [The main aspects of the use of photodynamic therapy in periodontology]. Vestnik Severnogo gosudarstvennogo meditsinskogo universiteta [Bulletin of the Northern State Medical University], 1 (42), 16-17. (In Russ.)
16. Belokonova, N., Elovikova, T., Kiseleva, D., Chervyakovskaya, M., Antropova, O., Olshvang, O. (2019). Kliniko-eksperimental'noye obosnovaniye vybora zubnykh past na osnove monitoringa sostava rotovoy zhidkosti u zhiteley promyshlennykh zon [Clinical and experimental justification of the choice of toothpastes based on monitoring the composition of the oral fluid in residents of industrial zones]. Problemy stomatologii [Actual problems in Dentistry], 15, 1, 33-37. (In Russ.)
17. Rumyantsev, V. A., Shimansky, Sh. L., Budashova, E. I., Yusupova, Yu. I., Afonenkova, V. S., Moiseev, D. A. (2018). Sovremennaya kontseptsiya polyarizatsii makrofagov i yeye znacheniye dlya parodontologii (obzor literatury) [The modern concept of macrophage polarization and its significance for periodontology (literature review)]. Parodontologiya [Periodontology], 23, 3 (88), 64-69. (In Russ.)
18. Rozhko, N. M., Gerelyuk, V. I., Matviykiv, T. I., Pavelko, N. M., Ilkiv, M. M. (2019). Izmeneniya v sostoyanii tkaney parodonta opornykh zubov pod vliyaniyem kompleksnogo lecheniya [Changes in the state of periodontal tissues of supporting teeth under the influence of complex treatment]. Stomatologiya. Estetika. Innovatsiya [Dentistry. Aesthetics. Innovation], 3, 2, 174-180. (In Russ.)
19. Aivazova, R. A., Aksamit, L. A., Akulenko, L. V., Aleksandrovskaya, I. Yu. et al. (2018). Parodontologiya : natsional'noye rukovodstvo [Periodontology : national leadership]. Moscow. (In Russ.)
20. Primenenie preparatov prolongirovannogo deystviya dlya mestnoy protivovospalitel'noy terapii vospalitel'nyh zabolevaniy parodonta / O. A. Solov'eva, E. E. Hachaturyan, A. M. Habyrtova, M. A. Tatarkanova, R. Yu. Temrezov // Problemy mediciny v sovremennyh usloviyah : sbornik nauchnyh trudov. - 2014. - S. 292-294.
21. Sirak, S. V., Karakov, K. G., Kasimova, G. V., Elbekyan, K. S., Babayan, E. G., Khachaturian, E. E. (2014). Sposob lecheniya khronicheskogo generalizovannogo parodontita : patent 2550957 Rossiyskaya Federatsiya [A method for the treatment of chronic generalized periodontitis: patent 2550957 Russian Federation]. 05.30.2014. (In Russ.)
22. Soloviev, O. A., Khachaturian, E. E., Khabyrtova, A. M., Tatarkanova, M. A., Temrezov, R. Yu. (2014). Primeneniye preparatov prolongirovannogo deystviya dlya mestnoy protivovospalitel'noy terapii vospalitel'nykh zabolevaniy parodonta [The use of long-acting drugs for local anti-inflammatory therapy of inflammatory periodontal diseases]. Problemy meditsiny v sovremennykh usloviyakh : sbornik nauchnykh trudov [Problems of medicine in modern conditions : collection of scientific papers], 292-294. (In Russ.)
23. AlMoharib, H. S., AlMubarak, A., Geevarghese, A., Preethanath, R. S., Anil, S. (2014). Oral fluid based biomarkers in periodontal disease: part 1. Saliva. J Int Oral Health, 6 (4), 95-103.
24. Costantinides, F., Parisi, S., Tonni, I., Bodin, C., Vettori, E., Perinetti, G., Di Lenarda, R. (2018). Reliability of kinesiography vs magnetic resonance in internal derangement of TMJ diagnosis: A systematic review of the literature. CRANIO, 1-8. doi: 10.1080 / 08869634.2018.1455433.
25. Botos, A. M., Mesaros, A. S., Zimbran, A. I. (2016). The contribution of computerized axiography to the functional evaluation of the temporomandibular joint: a case report. Clujul Medical, 89 (3), 438. doi: 10.15386 / cjmed-618
26. Elovikova, T. M., Gaysina, E. F., Prikhodkin, A. S. (2019). Primeneniye antibakterial'nykh preparatov pri agressivnykh formakh parodontita [The use of antibacterial drugs for aggressive forms of periodontitis]. Problemy stomatologii [Actual problems in Dentistry], 15, 1, 10-15. (In Russ.)
27. Soloviev, O. A., Khachaturian, E. E., Khabyrtova, A. M., Tatarkanova, M. A., Temrezov, R. Yu. (2014). Primeneniye preparatov prolongirovannogo deystviya dlya mestnoy protivovospalitel'noy terapii vospalitel'nykh zabolevaniy parodonta [The use of prolonged action drugs for local anti-inflammatory therapy of inflammatory periodontal diseases]. Problemy meditsiny v sovremennykh usloviyakh : sbornik nauchnykh trudov [Problems of medicine in modern conditions : collection of scientific papers], 292-294. (In Russ.)