Chelyabinsk, Chelyabinsk, Russian Federation
from 01.01.2017 to 01.01.2020
Chelyabinsk, Chelyabinsk, Russian Federation
Chelyabinsk, Chelyabinsk, Russian Federation
Chelyabinsk, Chelyabinsk, Russian Federation
Chelyabinsk, Chelyabinsk, Russian Federation
UDK 61 Медицина. Охрана здоровья
GRNTI 76.29 Клиническая медицина
OKSO 31.08.74 Стоматология хирургическая
BBK 566 Стоматология
BISAC MED016080 Dentistry / Dental Implants
BISAC MED016050 Dentistry / Oral Surgery
Subject. The risks of an unfavorable outcome of simultaneous implantation in most cases are associated with the installation of an implant in the tooth wells with chronic foci of odontogenic infection. The goal is to study the effector indicators of phagocytes and the level of cytokines of the local focus of inflammation in patients with various forms of chronic periodontitis. Methodology. The study involved 65 dental patients with a diagnosis of "K 04.5―K 04.9" (ICD-10, 1997), a comprehensive examination using laboratory immunological methods which included the study of the functional activity of neutrophils (phagocytic activity and intensity on a model of latex particle absorption; lysosomal activity and index of the total luminescence of lysosomes; HCT-reducing activity and intensity according to spontaneous and induced tests) and the concentration of IL-1-RA IL-1β, IL-2, IL-8, IFN–α, IFN-γ (PCG/ml) wound detachable wells of the extracted tooth. Results. A study of the immunological parameters of the local foci of periapical inflammation in patients with various forms of chronic periodontitis revealed some features of the cytokine profile and the functional activity of neutrophils in the wound detachable hole of the extracted tooth. The data obtained in patients with chronic fibrous periodontitis allowed us to determine the signs of activity of chronic inflammation. In subjects who had their teeth removed due to chronic granulating periodontitis, immunological predictors of a prolonged course of inflammatory and reparative processes were revealed. In patients with chronic granulomatous lesions of the periapical zone, evidence of prolonged contamination of the periapical zone was obtained, which may lead to changes in effector parameters against the background of the preserved bactericidal potential of neutrophilic granulocytes. Findings. Immunological predictors of the development of infectious and inflammatory complications were identified in the context of the planned simultaneous dental implantation when implants are inserted into the wells of the teeth with chronic periodontal foci.
chronic periodontitis, HCT test, local immunity, simultaneous implantation, cytokines
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