Abstract and keywords
Abstract (English):
Aphthous stomatitis is an urgent problem of modern medicine dentistry and is an inflammatory disease of the mucous membrane mouth with a long, manifest flow. The aim of the study is to study the structure of somatic pathology in children with aphthous stomatitis. In the course of the study, a single-center clinical examination and treatment was performed at the clinical dental clinic of the Federal state budgetary educational institution of higher education "Bashkir state medical University" of the Ministry of health of the Russian Federation in 37 patients (20 boys and 17 girls) aged 4 to 14 years. The diagnosis of concomitant systemic pathology was recorded based on the results of the conclusions of district pediatricians, ENT doctors, gastroenterologists, immunologists, allergists, and rheumatologists. As a result of the study, it turned out that all the examined patients had comorbidities, namely, chronic diseases of the gastrointestinal tract, diseases of ENT organs, allergic reactions, as well as a violation of the immune status, Behcet's disease. Based on the results of the study, it turned out that patients with aphthous stomatitis, as a rule, have a wide range of health-related problems, which should be taken into account when drawing up a comprehensive treatment plan for patients with this disease. The somatic status of all patients with aphthous stomatitis is burdened with comorbid pathology. The structure of somatic pathology in patients with aphthous stomatitis is dominated by diseases of the gastrointestinal tract (chronic gastritis in 17 people, gastric and duodenal ulcer in 1 person, biliary dyskinesia in 5 people, chronic cholecystitis in 3 patients, Crohn's disease in 1 patient).

aphthous stomatitis, oral mucosa, aphthae, somatic pathology, children, chronic inflammatory disease, Behcet's Disease, Crohn's disease, relapses, diseases of the gastrointestinal tract

1. Preeti, L., Magesh, K., Rajkumar, K., Karthik, R. (2011). Recurrent aphthous stomatitis. J Oral Maxillofac Pathol, 15, 252-256.

2. Kosuga, S. U., Klenina, V. U. (2014). Sovremennye aspekty etiopathogenesa recydyviryushego aftosnogo stomatita [Modern aspects of the etiopathogenesis of recurrent aphthous stomatitis]. Sovremennye problem nauki i obrazovaniya [Modern problems of science and education], 6, 1112-1117. (In Russ.)

3. Jenerowicz, D., Silny, W., Dańczak-Pazdrowska, A. et al. (2012). Environmental factors and allergic diseases. Ann Agric Environ Med, 19, 475-481.

4. Namrata, M., Abilasha, R. (2018). Recurrent aphthous stomatitis. International journal of orofacial biology, 1 (2), 43-47.

5. Beguerie, J., Sabas, M. (2015). Reccurent aphtous stomatitis: An update on etiopathogenia and treatment. Journal og the Dermatology Nurses Association, 7 (1), 13-14.

6. Queros, S., Silva, M., Medeiros, A., Oliveira, P., Gurgel, B., Silveira, E. (2018) Recurrent aphthous ulceration: an epidemiological study of etiological factors, treatment and differential diagnosis. Anais Brasileiros de Dermatologia journal, 93 (3), 341-346.

7. Robakidze, N. S., Baranovskij, A. Yu. (2016). Analiz techeniya recidiviruyushhego aftoznogo stomatita u bol`ny`x s vospalitel`ny`mi zabolevaniyami kishechnika [Analysis of the course of recurrent aphthous stomatitis in patients with inflammatory bowel diseases]. Institut stomatlogii [Institute of dentistry], 1 (70), 58-59. (In Russ.)

8. Dudar’, L. V., Kolesnik, K. A., Romanenko, I. G., Dudar’, D. V. (2014). Celiaciya i hronocheskiyi aftosniyi stomatit: chto obshego? [Celiac disease and chronic recurrent aphthous stomatitis: what do they have in common?]. Sovremennaya gastroentarologiya [Modern gastroenterology], 3 (77), 37-42. (In Russ.)

9. Shakeri, R., Zamani, F., Sotoudehmanesh, R. (2009). Gluten sensitivity enteropathy in patients with recurrent aphthous stomatitis. BMC Gastroenterol, 17 (9), 44-45.

10. Scully, C., Porter, S. (2008). Oral mucosal disease: recurrent aphthous stomatitis. Br J Oral Maxillofac Surg., 46, 198-206.

11. Jenerowicz, D., Silny, W., Dańczak-Pazdrowska, A. et al. (2012). Environmental factors and allergic diseases. Ann Agric Environ Med, 475-481.

12. Shashy, R. G., Ridley, M. B. (2000). Aphthous ulcers: a difficult clinical entity. Am J Otolaryngol, 21, 389-393.

13. Aydemir, S., Solak Tekin, N., Aktunç, E. et al. (2004). Celiac disease in patients having recurrent aphthous stomatitis. Turk J Gastroenterol, 15, 192-195.

14. Miziara, I. D., Filho, B. C., Weber, R. (2005). AIDS and recurrent aphthous stomatitis. Rev Bras Otorrinolaringol, 71, 517-520.

15. Gomes, C. C., Gomez, R. S., Zina, L. G., Amaral, F. R. (2016). Recurrent aphthous stomatitis and Helicobacter pylori. Med Oral Patol Oral Cir Bucal, 21 (2), 187-191.

16. Najafi, S., Yousefi, H., Mohammadzadeh, M. et al. (2015). Association study of interleukin-1 family and interleukin-6 gene single nucleotide polymorphisms in recurrent aphthous stomatitis. Int J Immunogenet, 42 (6), 428-431.

17. Uspenskaya, O. A., Shevchenko, E. A., Ivanchenko, E. U., Potemina, T. E., Novodgilova, O. A., Morozova, T. A., Skotareva, M. A. (2019). Osobennosti stomatologicheskogo statusa polymorbydnyh pacientov s kardiometabolicheskim fenotypom [Features of the dental status of polymorbid patients with cardiometabolic phenotype]. Problemy stomatologii [Actual problems in dentistry], 15 (4), 66-70. (In Russ.)

18. Karakov, K. G., Vlasova, T. N., Oganyan, A. V., Xachaturyan, A. E., Karakova, S. N., Aratyunyan, M. L., Amirova, S. D. (2019). Nozogenny`e depressii u pacientov s patologiej slizistoj polosti rta [Nosogenic depression in patients with pathology of the oral mucosa]. Problemy stomatologii [Actual problems in dentistry], 15 (4), 50-54. (In Russ.)

19. Tokmakova, S. I., Lunicyna, Yu. V. (2013). Korrekciya mestnogo immuniteta u pacientov s vospalitel`no-destruktivny`mi zabolevaniyami polosti rta [Correction of local immunity in patients with inflammatory and destructive diseases of the oral cavity]. Problemy stomatlogii [Actual problems in dentistry], 9 (4), 27-30. (In Russ.)

20. Gül, A., Inanç, M., Ocal, L., Aral, O., Koniçe, M. (2000). Familial aggregation of Behçet’s disease in turkey. Ann Rheum Dis, 59 (8), 622-625.

21. Remmers, E. F., Cosan, F., Kirino, Y., Ombrello, M. J., Abaci, N., Satorius, C. et al. (2010). Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet’s disease. Nat Genet, 42 (8), 698-702.

22. Saadoun, D., Wechsler, B., Terrada, C., Hajage, D., Le Thi Huong, D., Resche-Rigon, M. et al. (2010). Azathioprine in severe uveitis of Behçet’s disease. Arthritis Care Res (Hoboken), 62 (12), 1733-1738.

23. Takeuchi, M., Kastner, D. L., Remmers, E. F. (2015). The immunogenetics of Behçet’s disease: a comprehensive review. J Autoimmun, 64, 137-148.

24. Altenburg, A., El-Haj, N., Micheli, C., Puttkammer, M., Abdel-Naser, M. B., Zouboulis, C. C. (2014). The treatment of chronic reccurent oral aphtous ulcers. Deutsches Arzteblatt International journal, 111 (40), 665-673.

25. Bas, Y., Seckin, H., Kalkan, G., Takci, Z., Onder, Y., Citil, R., Demir, S., Sahin, S.(2016). Investigation of Behcet’s disease and recurrent aphthous stomatitis frequency: the highest prevalence in Turkey. Balkan medical journal, 33 (4), 390-395.

26. Thakrar, P., Chaudhry, S. I. (2016). Oral ulceration: an overview of diagnosis and management. Prim Dent J, 5, 30-33.

27. Liu, H.-L., Chiu, S.-C. (2015). The effectiveness of vitamin B12 for relieving pain in Aphthous ulcers: a randomized, double-blind, Placebo-controlled Trial. Pain Manag Nurs, 16, 182-187.

28. Wallace, A., Rogers, H. J., Hughes, S. C. et al. (2015). Management of recurrent aphthous stomatitis in children. Oral Medicine, 42 (6), 564-572.

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