Baku, Azerbaijan
Baku, Azerbaijan
Baku, Russian Federation
Baku, Azerbaijan
Baku, Azerbaijan
Baku, Azerbaijan
Subject. The results of a sociological survey and questioning of doctors about prescribed antiseptic drugs and comparative data on their effectiveness are considered. The goal is to justify the feasibility of using various antiseptics in the complex treatment of patients with periodontal diseases. Methodology. Dentists were questioned to identify the most commonly prescribed drugs. 36 patients were divided into 3 experimental groups depending on the composition or concentration of the antiseptic drug used. Results. The values of the GI, SBI and API indices statistically significantly and more pronounced decreased at almost all stages of observation after the use of the traditional antiseptic at a concentration of 0.2 % and rinse aid Curasept. After 2 weeks of the study after completion of treatment, the pH level in the 1st group was 7.33 ± 0.035, in the 2nd and 3rd — 7.02 ± 0.049 and 6.69 ± 0.131, respectively. When analyzing the detection rate of P. gingivalis in the 1st group, it was found that out of 8 patients (72.7 %) after the completion of therapeutic measures, only 2 (18.2 %) had a high level of dissemination (χ2 = 6.60 p = 0.010), when studying the level of inoculation of A. Actinomycetemcomitans, similar results were obtained. Conclusions. Antiseptic 0.2 % chlorhexidine bigluconate solution and mouthwash Curasept ADS 212 (0.12 % chlorhexidine solution) in the treatment of chronic periodontitis lead to a more pronounced destruction of periodontal pathogenic microflora, normalization of acid-base balance and GI, SBI and API indices both at the initial stage of research, and in its most remote dates. After the use of the drug chlorhexidine bigluconate 0.05 %, the microbial contamination rates decrease, but bacteria do not completely eradicate and at all stages of observation, the average index values in the 3rd group are significantly higher compared to other groups.
periodontium, inflammation, treatment, antiseptic, index, microbes
1. Bulgakova, A. I. (2017). Kliniko-mikrobiologicheskoye obosnovaniye kompleksnogo lecheniya bol'nykh parodontitom so sredney i tyazheloy stepeni tyazhesti s uchetom molekulyarno-geneticheskoy kharakteristiki mikrobioty polosti rta [Clinical and microbiological substantiation of the complex treatment of patients with periodontitis with moderate and severe severity, taking into account the molecular genetic characteristics of the microbiota of the oral cavity]. Parodontologiya [Periodontology], 22, 1, 70-73. (In Russ.)
2. Egorova, A. B., Musina, L. T., Urazova, R. Z. (2010). Vliyaniye antiseptikov na sostoyaniye mikroflory polosti rta [The effect of antiseptics on the state of the microflora of the oral cavity]. Kazanskiy meditsinskiy zhurnal [Kazan Medical Journal], 4, 525-528. (In Russ.)
3. Elovikova, T. M., Gaysina, E. F., Prikhodkin, A. S. (2019). Primeneniye antibakterial'nykh preparatov pri agressivnykh formakh parodontita [The use of antibacterial drugs with aggressive forms of periodontitis]. Problemy stomatologii [Problems of Dentistry], 15, 1, 10-15. (In Russ.)
4. Zorina, O. A., Grudyanov, A. I., Kulakov, A. A., Boriskina, O. A., Reberikov, D. V. (2010). Kolichestvennaya otsenka mikrobiotsenozov polosti rta pri zabolevaniyakh parodonta [Quantification of oral microbiocenoses in periodontal diseases]. Parodontologiya [Periodontology], 2 (59), 18-21. (In Russ.)
5. Crihelli, N. I., Popova, A. E. (2013). Izmeneniye mikrobiologicheskikh i biokhimicheskikh pokazateley u patsiyentov s khronicheskim generalizovannym parodontitom sredney stepeni posle vklyucheniya fotodinamicheskoy terapii v plan kompleksnogo lecheniya [Changes in microbiological and biochemical parameters in patients with moderate generalized periodontitis after the inclusion of photodynamic therapy in the comprehensive treatment plan]. Rossiyskaya stomatologiya [Russian Dentistry], 4, 4-11. (In Russ.)
6. Mamedov, R. M., Sadigova, N. N., Ibragimova, L. K. (2019). Optimizatsiya metodov profilaktiki i lecheniya vospalitel'nykh zabolevaniy parodonta [Optimization of methods for the prevention and treatment of inflammatory periodontal diseases]. Problemy stomatologii [Problems of Dentistry], 15, 2, 114-121. (In Russ.)
7. Melekhov, S. V., Kolesnikova, N. V., Ovcharenko, E. S. (2013). Sostoyaniye mestnogo immuniteta i mikrobiotsenoza polosti rta u bol'nykh khronicheskim generalizovannym parodontitom [The state of local immunity and oral microbiocenosis in patients with chronic generalized periodontitis]. Parodontologiya [Periodontology], 17, 1, 3-9. (In Russ.)
8. Mitronin, A. V., Vavilova, T. P., Zhilkina, O. E. (2011). Otsenka effektivnosti lecheniya khronicheskogo parodontita s primeneniyem antimikrobnykh i antioksidantnykh sredstv [Evaluation of the effectiveness of the treatment of chronic periodontitis using antimicrobial and antioxidant agents]. Parodontologiya [Periodontology], 16, 4, 52-56. (In Russ.)
9. Orekhova, L. Yu. (2017). Rezul'taty klinicheskikh issledovaniy po otsenke effektivnosti lechebno-profilakticheskikh programm s zubnymi pastami i stomatologicheskimi gelyami u patsiyentov s zabolevaniyami parodonta [The results of clinical studies evaluating the effectiveness of treatment programs with toothpastes and dental gels in patients with periodontal disease]. Parodontologiya [Periodontology], 22, 1, 27-30. (In Russ.)
10. Protsenko, A. S. (2011). Stomatologicheskoye zdorov'ye v sisteme zhiznennykh tsennostey sovremennoy molodezhi [Dental health in the system of life values of modern youth]. Sbornik materialov 17 mezhdunarodnoy nauchno-prakticheskoy konferentsii «Sistema tsennostey sovremennogo obshchestva» [The collection of materials of the 17th international scientific-practical conference "The system of values of modern society"], Novosibirsk, 150-155. (In Russ.)
11. Risovannaya, O. N., Laliyeva, Z. V. (2019). Izucheniye mikrobnogo peyzazha desnevoy borozdy v zavisimosti ot klinicheskogo sostoyaniya tkaney parodonta i urovnya emotsional'nogo napryazheniya [The study of the microbial landscape of the gingival sulcus depending on the clinical condition of periodontal tissues and the level of emotional stress]. Problemy stomatologii [Problems of Dentistry], 15, 2, 135-140. (In Russ.)
12. Tsepov, L. M. (2017). Vozmozhnosti lecheniya bol'nykh khronicheskim generalizovannym parodontitom v sovremennykh usloviyakh [The possibility of treating patients with chronic generalized periodontitis in modern conditions]. Parodontologiya [Periodontology], 22, 2, 40-46. (In Russ.)
13. Yanushevich, O. O., Grinin, V. M., Pochtarenko, V. A., Runova, G. S. et al. (2010). Zabolevaniya parodonta. Sovremennyy vzglyad na kliniko-diagnosticheskiye i lechebnyye aspekty [Periodontal disease. A modern look at clinical diagnostic and therapeutic aspects]. Moscow : GEOTAR-Media, 160. (In Russ.)
14. Anilkumar, K., Monisha, A. L. (2012). Role of friendly bacteria in oral health - a short review. Oral Health Prev. Dent, 10 (1), 3-8.
15. Becerik, S., Türkoğlu, O., Emingil, G., Vural, C., Ozdemir, G. (2011). Antimicrobial effect of adjunctive use of chlorhexidine mouthrinse in untreated gingivitis: a randomized, placebo-controlled study. APMIS, 19 (6), 364-372.
16. Vanucci, C., de Freitas, S., Galdez, L. P. V., Dias, H. L. M., Cirelli, J. A., Souza1, E. M., da Silva, V. K. (2016). Effect of Subgingival Irrigation with Different Substances in the Treatment of Periodontal Disease. A Histometric Study in Rats. J Int Acad Periodontol, 14, 18 (1), 2-6.
17. Belokonova, N., Elovicova, T., Kiseleva, D., Chervyakovskaya, M., Antropova, O., Olshvang, O. (2019). Clinical and experimental substantiation of the choice of toothpastes on the basis of monitoring the composition of the oral fluid in the inhabitants of industrial areas. Problems of Dentistry, 15, 1, 33-37.
18. Diaz, P. I. (2011). Microbial diversity and interactions in subgingival biofilm communities. Front Oral Biol, 15, 17-40.
19. Dosseva-Panova, V. T., Popova, C. L., Panov, V. E. (2014). Subgingival microbial profile and production of proinflammatory cytokines in chronic periodontitis. Folia Med. (Plovdiv), 56 (3), 152-160.
20. Feres, M., Haffajee, A. D., Allard, K., Som, S., Goodson, J. M., Socransky, S. S. (2002). Antibiotic resistance of subgingival species during and after antibiotic therapy. J Clin Periodontol, 29, 724-735.
21. He, J., Huang, W., Pan, Z., Cui, H., Qi, G., Zhou, X., Chen, H. (2012). Quantitative analysis of microbiota in saliva, supragingival, and subgingival plaque of Chinese adults with chronic periodontitis. Clin Oral Investig, 11, 16-26.
22. Holt, S. C., Ebersole, J. L. (2005). Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: the «red complex», a prototype polybacterial pathogenic consortium in periodontitis. Periodontol 2000, 38, 72-122.
23. Keestra, J. A., Grosjean, I., Coucke, W., Quirynen, M., Teughels, W. (2015). Non-surgical periodontal therapy with systemic antibiotics in patients with untreated aggressive periodontitis: A systematic review and meta-analysis. J. Periodontal Res, 50, 689-706.
24. Lasserre, J. F., Toma, S., Bourgeois, T., El Khatmaoui, H., Marichal, E., Brecx, M. C. (2016). Influence of low direct electric currents and chlorhexidine upon human dental biofilms. Clin. Exp. Dent. Res, 2, 146-154.
25. Heta, S., Robo, I. (2018). The Side Effects of the Most Commonly Used Group of Antibiotics in Periodontal Treatments. Med Sci (Basel), 6 (1), 6-11.
26. Sharva, V., Reddy, V., Bhambal, A., Agrawal, R. (2014). Prevalence of Gingivitis among Children of Urban and Rural Areas of Bhopal District, India. J. Clin. Diagn. Res, 8 (11), 52-54.
27. Vadiakas, G., Oulis, C. J., Tsinidou, K., Mamai-Homata, E., Polychronopoulou, A. (2012). Oral hygiene and periodontal status of 12 and 15-year-old Greek adolescents. A national pathfinder survey. Eur. Arch. Paediatr. Dent, 13 (1), 11-20.
28. Yao, S. G., Fine, J. B. (2014). Probiotics for bacterial disease treatment in the oral environment. Compend. Contin. Educ. Dent, 35 (9), 658-663.
