employee
Ekaterinburg, Ekaterinburg, Russian Federation
Ekaterinburg, Ekaterinburg, Russian Federation
student
Ekaterinburg, Russian Federation
Subject. Periodontal disease, according to WHO, is an urgent problem in modern society. The main cause of this group of diseases is poor oral hygiene. Despite the huge number of anti-inflammatory toothpastes, the dynamics of reducing periodontal disease in society is not observed. In the absence of an effective solution to this problem, various complications can arise: pathological mobility, tooth loss, halitosis, the addition of pathogenic microflora with the further development of the inflammatory process. Good hygiene and new effective toothpastes with anti-inflammatory activity will reduce the risk of periodontal disease and improve the condition of the oral mucosa. The goal is to identify and analyze new toothpastes with anti-inflammatory activity. Methodology. A review of 25 publications from the USA, Great Britain, Germany, Spain, Croatia, China, India, Jordan, Saudi Arabia, the United Arab Emirates and other countries using scientific search library databases: PubMed, Medline, Cochrane, Elibrary. Results. The data of questioning people, clinical trials with "double blinding", which are based on the development and analysis of new toothpastes with anti-inflammatory activity against periodontal tissues, are examined. Conclusions. The most effective toothpastes with anti-inflammatory activity are new developments based on plant materials. However, modern studies indicate a good efficiency in the use of toothpastes with enzymatic activity against periodontal diseases. Also, new toothpastes with quite interesting compositions are currently appearing on the world market: with probiotic, active oxygen, environmentally friendly toothpastes without sodium lauryl sulfate.
periodontium, periodontitis, gingivitis, prophylaxis, toothpastes, anti-inflammatory toothpastes
1. Zubkova, A. A., Felker, E. V., Guiter, O. S., Mitin, N. E., Oleinikov, A. A., Tishkina L. N. (2019). Otsenka rasprostranennosti osnovnykh stomatologicheskikh zabolevaniy u patsiyentov s serdechno-sosudistymi zabolevaniyami [Assessment of the prevalence of major dental diseases in patients with cardiovascular diseases]. Problemy stomatologii [Actual problems in dentistry], 15 (3), 34-40. (In Russ.)
2. Sarkisov, A. K., Zelensky, V. A., Polunina, E. A., Sarkisov, K. A. (2019). Otsenka urovnya markera apoptoza anneksina A5 i znacheniy stomatologicheskikh indeksov pri khronicheskom generalizovannom parodontite razlichnoy stepeni tyazhesti bez obshchesomaticheskoy patologii i na fone bronkhoektaticheskoy bolezni [Assessment of the level of annexin A5 apoptosis marker and the values of dental indices for chronic generalized periodontitis of varying severity without somatic pathology and against the background of bronchiectatic disease]. Problemy stomatologii [Actual problems in dentistry], 15 (3), 56-61. (In Russ.)
3. Ugilkhon Orzijon Kiza Navruzova (2019). Sovremennyye aspekty etiopatogeneza generalizovannogo parodontita [Modern aspects of the etiopathogenesis of generalized periodontitis]. Biologiya i integrativnaya meditsina [Biology and integrative medicine], 30 (2), 62-89. (In Russ.)
4. Leonel Martins, M., Souza Nunes Monteiro, A., Campos Ferreira-Filho, J., Isidro Vieira, T., Bárbara de Carvalho, M., Guimarães, T., Farah, A., Villela Romanos, M., Maia, L., Wanderley Cavalcanti, Y., Fonseca-Gonçalves, A. (2019). Antibacterial and Cytotoxic Potential of a Brazilian Red Propolis. Pesqui. Bras. Odontopediatria Clín. Integr, 19 (1), 1-9.
5. Parčina Amižić, I., Cigić, L., Gavić, L., Radić, M., Lukenda, D. B., Barišić, I. G. (2017). Antimicrobial efficacy of probiotic-containing toothpastes: an invitro evaluation. Medicinski Glasnik, 1 (14), 139-144.
6. Tadikonda, A., Pentapati, K. C., Urala, A. S., Acharya, S. (2017). Anti-plaque and anti-gingivitis effect of Papain, Bromelain, Miswak and Neem containing dentifrice: a randomized controlled trial. J Clin Exp Dent, 9, 1-6.
7. Adams, S. E., Arnold, D., Murphy, B., Carroll, P., Green, A. K., Smith, A. M. et al. (2017). A randomized clinical study to determine the effect of a toothpaste containing enzymes and proteins on plaque oral microbiome ecology. Sci. Rep, 7.
8. Daly, S., Seong, J., Newcombe, R. et al. (2019). A randomized clinical trial to determine the effect of a toothpaste containing enzymes and proteins on gum health over 3 months. Journal of Dentistry, 80, 26-32.
9. Marcela, A., Ingrid, A., Guedes, C., Silva, T., Alcino, L., Monteiro, G., Jair, C., Arnaldo, F., Caldas, Jr. (2019). Clinical Assessment of Rosemary - based Toothpaste (Rosmarinus officinalis Linn.): A Randomized Controlled Double - blind Study. Dent. J, 30 (2).
10. Kraivaphan, P., Amornchat, C. (2017). Comparative clinical efficacy of three toothpastes in the control of supragingival calculus formation. European Journal of Dentistry, 11 (1), 94-98.
11. Warley, D., Shun-Iti, E., Isaac, D., Mendes, C., Prates Vilas, H., Silva, E. (2017). Comparison of two commercial dentifrices in the reduction of gingivitis and plaque: A pilot study. Braz Dent Sci, 20 (4), 71-77.
12. Mehta, V., Hegde Shetiya, S., Kakodkar, P., Janakiram, C., Rizwan, S. A. (2018). Efficacy of herbal dentifrice on the prevention of plaque and gingivitis as compared to conventional dentifrice: A systematic review and meta - analysis. Journal of Indian Society of Periodontology, 22 (5), 379-389.
13. Chakravarthy, K., Meena, P., Kukkamallab, A., Siddiqa, H., Sabnisc, N. Effectiveness of novel herbal dentifrice in control of plaque, gingivitis, and halitosis - Randomized controlled trial. Journal of Traditional and Complementary Medicine, 25, 1-5.
14. Hosadurga, R., Boloor, V. A., Rao, S. N., MeghRani, N. (2018). Effectiveness of two different herbal toothpaste formulations in the reduction of plaque and gingival inflammation in patients with established gingivitis - a randomized controlled trial. J Tradit Complement Med, 8, 113-119.
15. Saliasi, I., Llodra, J. C., Bravo, M., Tramini, P., Dussart, C., Viennot, S., Carrouel, F. (2018). Effect of a Toothpaste/Mouthwash Containing Carica papaya Leaf Extract on Interdental Gingival Bleeding: A Randomized Controlled Trial. Int. J. Environ. Res. Public Health, 15, 1-16.
16. Cunha, E. J., Auersvald, C. M., Deliberador, T. M., Gonzaga, C. C., Florez, F. L. E., Correr, G. M., Storrer, C. M. (2019). Effects of Active Oxygen Toothpaste in Supragingival Biofilm Reduction: A Randomized Controlled Clinical Trial. International Journal of Dentistry, 1-7.
17. Stewart, B., Awad, J., Mauricio, S., Luciene, A., Figueiredo, C., Panagakos, F., Matarazzo, F., Mairink, R., Onuma, T., Faveri, M., Retamal-Valdes, B., Feres, M. (2019). Effects of a toothpaste containing 0.3% triclosan on periodontal parameters of subjects enrolled in a regular maintenance program: A secondary analysis of a 2-year randomized clinical trial. Journal of Periodontology, 9 (3), 1-10.
18. Peychevaa, S., Apostolovab, E., Gardjevac, P., Peychevd, Z., Kokova, V., Angelove, A., Slavovf, A., Murdjevac, M. (2019). Effect of Bulgarian propolis on the oral microflora in adolescents with plaque-induced gingivitis. Revista Brasileira de Farmacognosia, 29 (3), 271-277.
19. Suriamah, N., Lessang, R., Kemal, Y. (2019). Effectiveness of toothpaste containing propolis, tea tree oil, and sodium monofluorophosphate against plaque and gingivitis. Int J App Pharm, 11 (1), 114-115.
20. Pedersen, D., Lynge, A. M., Marija, D., Nicholson, J., Edwards, M. I., Gupta, A. K., Belstrøm, D. (2019). Gingival health status in individuals using different types of toothpaste. Journal of Dentistry, 80 (1), 13-18.
21. Lang, N. P., Schatzle, M. A., Löe, H. (2009). Gingivitis as a risk factor in periodontal disease. Journal of Clinical Periodontology, 36, 3-8.
22. Eid Abdelmagydab, H. A., Shettyc, Dr S., Musa, Dr M., Al-Ahmarid, M. (2019). Herbal medicine as adjunct in periodontal therapies - A review of clinical trials in past decade. Journal of Oral Biology and Craniofacial Research, 9 (3), 212-217.
23. Wang, B., Timilsena, Y. P., Blanch, E., Adhikari, B (2019). Lactoferrin: structure, function, denaturation and digestion. Critical Reviews in Food Science and Nutrition, 59 (4), 580-596.
24. Safiaghdam, H., Oveissi, V., Bahramsoltani, R., Hosein, M. (2018). Medicinal plants for gingivitis: a review of clinical trials. Iran J Basic Med Sci, 21 (10), 1-6.
25. Hagenfeld, D., Prior, K., Harks, I., Jockel- Schneider, Y., Theodor, W., Harmsen, D., Schlagenhauf, U., Ehmke, B. (2019). No differences in microbiome changes between anti - adhesive and antibacterial ingredients in toothpastes during periodontal therapy. J Periodont Res, 54, 435-443.
26. Ashraf Nazir, M. (2017). Prevalence of periodontal disease, its association with systemic diseases and prevention. International Journal of Health Sciences, 1 (2), 72-80.
27. Kottgen, Chr., Ernst, Cl.-P., Willishausen, B. (2001). So Wirken Zahnfullungsmaterialen auf das Zahnfleisch. Zahnarztliche. Mitteilungen, 7, 34-40.
28. He, J., Deng, Y., Zhu, F., Zhong, T., Luo, N., Lei, L., Cheng, L., Hu, T. (2019). The Efficacy and Safety of a Herbal Toothpaste in Reducing Gingivitis: A Double-Blind, Randomized, Placebo-Controlled, Parallel Allocation Clinical Trial. Evidence-Based Complementary and Alternative Medicine, 1-10.
29. Sälzer, S., Rosema, N., Hennequin-Hoenderdos, N. L., Slot, D. E., Timmer, C., Dörfer, C. E. et al. (2017). The effectiveness of a dentifrice without sodium lauryl sulphate on dental plaque and gingivitis - a randomized controlled clinical trial. Int J Dent Hyg, 15 (3), 203-210.
30. Green, A. K., Crichard, S., Ling-Mountford, N., Milward, M., Hubber, N., Platten, S., Gupta, A. K., Scott, A., Barfoot, R. (2019). The effect of SLS - free toothpaste containing enzymes and proteins on oral mucosa sloughing. J. Dent, 80, 33-39.
31. Al Habashneh, R., Farasin, R., Khader, Y. (2017). The effect of triclosan/copolymer/fluoride tooth paste on plaque formation, gingivitis, and dentin hypersensitivity: a single-blinded randomized clinical study. Quintessence International, 48 (2), 123-130.
32. Elovikova, T., Karaseva, V., Ermishina, E., Shimova, M., Scurihina, Y. (2019). The experience resulting from the performance of professions oral cavity hygiene in patient with a chronic periodontitis in combination with a medication-associated osteonecrosis of the jaw. Actual problems in dentistry, 15 (3), 28-33. (In Russ.)
33. Imamura, T. (2003). The role of gingipains in the pathogenesis of periodontal disease. J. Periodontol, 74 (1), 111-118.
