Nizhniy Novgorod, Russian Federation
Background. The analysis of the dynamics of biochemical parameters of bone metabolism of the oral fluid in the treatment of rapidly progressive periodontitis with the use of drugs Eplun, Metronidazole, Osteogenon and feel better. The most effective scheme of medical treatment was determined. We propose the use of EPLAN and Osteogenon in the complex treatment of aggressive periodontitis, and the use of Parodontax COMPREHENSIVE PROTECTION and Parodontax Classic mouthwash without alcohol for a rational hygiene of oral cavity. Objectives ― study the dynamics of biochemical parameters of bone metabolism of oral fluid in the treatment of aggressive forms of periodontitis. Methods. 100 patients aged from 26 to 35 years with a diagnosis of moderate CGP were examined. Depending on the prescribed treatment, all patients were divided into 4 groups by stratified randomization of 25 people. In the treatment of patients used medicines that are allowed to use: Eplun, Metronidazole, Osteogenon, homeopathic remedy. The study of biochemical parameters of oral liquid (calcium, phosphorus, alkaline phosphatase) in patients with present study included was carried out on the time frame: before treatment, after 3, 7 days, 1, 3, 6 and 12 months follow-up, patients in the control group – once. Results. The most pronounced changes in the biochemical parameters of the oral fluid, which led to the normalization of calcium, phosphorus and schf levels, were registered in the 4th group, in the complex therapy of which the drugs "EPLAN" and "Osteogenon" were used, and for rational oral hygiene, toothpaste Parodontax COMPLEX PROTECTION and rinse Rarodontax Classic without alcohol were used. Conclusions. The inclusion in the scheme of complex treatment of drugs "EPLAN" and "Osteogenon", and for rational oral hygiene, the use of toothpaste Parodontax COMPLEX PROTECTION and rinse Parodontax Classic alcohol-free was the most effective in the treatment of rapidly progressive periodontitis.
fast-progressing periodontitis, calcium, phosphorus, alkaline phosphatase, biochemical parameters of oral fluid, Parodontax COMPLEX PROTECTION
1. Blashkova, S. L., Vasilevskaya, E. M. (2015). Kliniko-immunnologicheskaya xarakteristika bol`ny`x xronicheskim generalizovanny`m parodontitom na fone ishemicheskoj bolezni serdcza do i posle aortokoronarnogo shuntirovaniya [Clinical and immunological characteristics of patients with chronic generalized periodontitis on the background of coronary heart disease before and after coronary artery bypass surgery]. Parodontologiya [Periodontics], 20, 4 (77), 28-32. (In Russ.)
2. Bulkina, N. V., Vedyaeva, A. P. (2012). K voprosu ob e`tiologii i patogeneze by`stroprogressiruyushhego parodontita [On the question of etiology and pathogenesis of rapidly progressive periodontitis]. Rossijskij stomatologicheskij zhurnal [Russian Dental Journal], 5, 50-52. (In Russ.)
3. Vol`f, G. F., Ratejczxak, E. M., Ratejczxak, K. (2008). Parodontologiya [Periodontics]. Moscow: MEDpress-Inform, 548. (In Russ.)
4. Gazhva, S. I., Voronina, A. I., Kul`kova, D.A. (2013). Medikamentozny`e sxemy` konservativnogo lecheniya xronicheskix form parodontitov [Medical regimens for conservative treatment of chronic forms of periodontitis]. Fundamental`ny`e issledovaniya [Basic research], 5-1, 55-57. (In Russ.)
5. Gileva, O. S., Sadilova, V. A. (2013). Zabolevaniya parodonta u vich-inficirovanny`x bol`ny`x: rasprostranennost` i osobennosti klinicheskix proyavlenij v zavisimosti ot priverzhennosti antiretrovirusnoj terapii [Periodontal disease in HIV-infected patients: prevalence and features of clinical manifestations depending on adherence to antiretroviral therapy]. Permskij medicinskij zhurnal [Perm medical journal], 30, 2, 34-42. (In Russ.)
6. Grigorovich, E`. Sh., Gorodilov, R. V., Arsent`eva, K. I. (2015). Ocenka e`kspressii markerov vrozhdennogo i priobretennogo immuniteta v bioptatax desny` bol`ny`x xronicheskim generalizovanny`m parodontitom na fone lecheniya [Evaluation of the expression of markers of congenital and acquired immunity in the gums biopsies of patients with chronic generalized periodontitis during treatment]. Stomatologiya [Dentistry], 94, 5, 17-20. (In Russ.)
7. Grudyanov, A. I. (2009). Zabolevaniya parodonta [Periodontal diseases]. Moscow : Med. inform agency, 336. (In Russ.)
8. Zhulev, E. N., Aleksandrov, A. A., Shevchenko, E. A., Uspenskaya, O. A. (2017). Patofiziologiya bruksizma [Pathophysiology of bruxism]. Nizhnij Novgorod, 73. (In Russ.)
9. Kazarina, L. N., Bolsunovskij, S. M., Pursanova, A. E. (2016). Vliyanie simvastatina na izmenenie bioximicheskogo statusa u bol`ny`x xronicheskim parodontitom i metabolicheskim sindromom [The effect of simvastatin on the change of the biochemical status in patients with chronic periodontitis and metabolic syndrome]. Parodontologiya [Periodontics], 4 (81), 61-68. (In Russ.)
10. Kazarina, L. N., Bolsunovskij, S. M., Gushhina, O. O. (2017). Kliniko-laboratorny`e paralleli izmenenij bioximicheskogo statusa parodonta u bol`ny`x xronicheskim parodontitom i metabolicheskim sindromom na fone terapii statinami [Clinical and laboratory parallels of changes in the biochemical status of periodontal in patients with chronic periodontitis and metabolic syndrome during the treatment with statins]. Zdorov`e i obrazovanie v XXI veke [Health and Education in the XXI century], 19, 9, 52-55. (In Russ.)
11. Kachesova, E. S., Shevchenko, E. A., Uspenskaya, O. A. (2017). Novaya sxema kompleksnogo lecheniya agressivny`x form parodontita [New scheme of complex treatment of aggressive forms of periodontitis]. Sovremenny`e texnologii v medicine [Modern technologies in medicine], 9, 4, 209-216. (In Russ.)
12. Kuzneczov, S. V., ed. Kulakov, A. A. (2013). Klinicheskaya gerontostomatologiya [Clinical gerontostomatology]. Moscow : Med. inform. Agency, 240. (In Russ.)
13. Iordanishvili, A. K. et al. (2011). Lechenie parodontita v pozhilom i starcheskom vozraste [Treatment of periodontitis in the elderly and senile age]. St. Petersburg : MANEB-Nordmedizdat 128. (In Russ.)
14. Ed. Dmitrieva, L. A. (2014). Parodontologiya : nacional`noe rukovodstvo [Periodontology]. Moscow : GEOTAR-Media, 704. (In Russ.)
15. Pinegin, B. V., Nekrasov, A. V., Xaitov, R. M. (2004). Immunomodulyator Polioksidonij: mexanizmy` dejstviya i aspekty` klinicheskogo primeneniya [Polyoxidonium immunomodulator: mechanisms of action and aspects of clinical use]. Citokiny` i vospalenie [Cytokines and inflammation], 3, 3, 41-47. (In Russ.)
16. Cybikov, N. N. et al. (2012). Svojstva desnevoj zhidkosti pri ostrom gingivite i xronicheskom parodontite [Properties of gingival fluid in acute gingivitis and chronic periodontitis]. Ros. stomat. zhurnal [Ros. stomatology magazine], 1, 40-42. (In Russ.)
17. Iordanishvili, A. K. et al. (2010). Stomatologicheskij status lyudej pozhilogo i starcheskogo vozrasta [Dental status of people of elderly and senile age]. Uspexi gerontologii [Successes of gerontology], 23, 4, 644-651. (In Russ.)
18. Uspenskaya, O. A., Kachesova, E. S. (2017). Izmeneniya bioximicheskix pokazatelej krovi pri lechenii by`stroprogressiruyushhego parodontita [Changes in blood biochemical parameters in the treatment of rapidly progressive periodontitis]. Problemy` stomatologii [Problems of Dentistry], 13, 2, 33-38. (In Russ.)
19. Uspenskaya, O. A., Shevchenko, E. A. (2015). Issledovanie vliyaniya ryada lekarstvenny`x preparatov na techenie mestny`x vospalitel`ny`x processov rotovoj polosti i urogenital`nogo trakta u beremenny`x s xpn [Investigation of the effect of a number of drugs on the course of local inflammatory processes of the oral cavity and urogenital tract in pregnant women with chronic respiratory infections]. Fundamental`ny`e issledovaniya [Basic research], 1, 4, 837-839. (In Russ.)
20. Uspenskaya, O. A., Shevchenko, E. A. (2004). Ob``em desnevoj zhidkosti kak kriterij ocenki e`ffektivnosti lecheniya verxushechnogo periodontita [Volume of gingival fluid as a criterion for evaluating the effectiveness of treatment of apical periodontitis]. Fundamental`ny`e issledovaniya [Basic research], 2, 160. (In Russ.)
21. Uspenskaya, O. A., Shevchenko, E. A., Plishkina, A. A., Charaeva, N. D., Chuvashev, N. I. (2018). Primenenie piobakteriofaga v mestnom lechenii parodontita [Application of pyobacteriophage in the local treatment of periodontitis]. Dental Forum [Dental Forum], 3, 55-57. (In Russ.)
22. Cepov, L. M. (2006). Zabolevaniya parodonta: vzglyad na problemu [Periodontal disease: a look at the problem]. Moscow : MEDpress-Inform, 192. (In Russ.)
23. Shevchenko, E. A., Uspenskaya, O. A., Zagrebin, E. A. (2016). Izmenenie urovnya sekretornogo immunoglobulina A v rotovoj zhidkosti pri lechenii xronicheskogo recidiviruyushhego aftoznogo stomatita na fone urogenital`noj infekcii u zhenshhin razny`x vozrastny`x grupp [Changes in the level of secretory immunoglobulin A in the oral fluid in the treatment of chronic recurrent aphthous stomatitis on the background of urogenital infection in women of different age groups]. Sovremenny`e problemy` nauki i obrazovaniya [Modern problems of science and education], 5, 141. (In Russ.)
24. Cristofaro, P., Opal, S. M. (2006). Role of toll-like receptors in infection and immunity: clinical implication. Drugs, 66, 1, 15-29.
25. Gibert, P., Tramini, P., Sieso, V. (2003). Alkaline phosphatase isozyme activity in serum from patients with chronic periodontitis. J. Periodontal Res, 38, 4, 362-365.
26. Fagiolo, U. et al. (1993). Humoral and cellular immune response to influenza virus vaccination in aged humans. Aging (Milano), 5, 451-458.
