Chelyabinsk, Chelyabinsk, Russian Federation
Chelyabinsk, Russian Federation
Chelyabinsk, Chelyabinsk, Russian Federation
Chelyabinsk, Chelyabinsk, Russian Federation
Predmet. Primenenie topicheskoy immunomoduliruyuschey terapii pri provedenii metodiki zakrytogo sinus-liftinga s odnomomentnoy dental'noy implantaciey. Cel' — izuchit' vliyanie lokal'nogo deystviya ronkoleykina (rekombinantnogo IL-2) u pacientov, poluchivshih implantologicheskoe lechenie. Metodologiya. Metodom prostoy randomizacii bylo sformirovano dve sopostavimyh po gendernym i vozrastnym priznakam gruppy: osnovnaya, n=35 (pri provedenii hirurgicheskogo vmeshatel'stva osuschestvlyalas' topicheskaya citokinoterapiya ronkoleykinom) i sravneniya, n = 35 (ustanovleny implantaty s manipulyaciey zakrytogo sinus-liftinga po standartnoy metodike). Gruppu kontrolya (n=10) sostavili klinicheski zdorovye dobrovol'cy, sopostavimye po polu i vozrastu s pacientami issleduemyh grupp. Ocenka klinicheskogo sostoyaniya i zabor biologicheskogo materiala osuschestvlyalis' na 3-i, 6-e, 12-i i 24-e sutki posleoperacionnogo perioda. Rezul'taty issledovaniya. Provedennyy sravnitel'nyy analiz klinicheskih pokazateley rannego posleoperacionnogo perioda i salivatornogo urovnya pro- i protivovospalitel'nyh citokinov u pacientov pri provedenii zakrytogo sinus-liftinga s odnomomentnoy dental'noy implantaciey svidetel'stvoval o neoslozhnennom techenii rannego posleoperacionnogo perioda i kupirovanii v rannie sroki vospalitel'nogo komponenta v gruppe bol'nyh, poluchavshih mestnoe lechenie ronkoleykinom. Vyvody. Izuchenie salivatornogo urovnya citokinov u pacientov, poluchavshih topicheskuyu citokinoterapiyu, vyyavilo, chto ronkoleykin privel k znachitel'nomu povysheniyu vyrabotki endogennogo IL-2, kotoryy usilival sekreciyu IFN-γ. Kak izvestno, eti citokiny aktiviziruyut tkanevye makrofagi i uchastvuyut v otvetnoy reakcii na patogennoe vozdeystvie infekcionnogo agenta, formiruya effektornye immunologicheskie mehanizmy zaschitnogo kletochnogo immuniteta, chto, veroyatno, sposobstvovalo blagopriyatnomu ishodu lecheniya.
dental'naya implantaciya, zakrytyy sinus-lifting, ronkoleykin
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