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Home / Journals / Actual problems in dentistry / Volume 13 Issue 2 / THE PROSPECTS AND POSSIBILITIES OF USE OF THE WARNERIN NIZKOMOLKULYARNY CATIONIC PEPTIDE IN PRACTICAL ACTIVITIES OF THE DENTIST (EXPERIMENTAL CLINICAL TRIAL)
THE PROSPECTS AND POSSIBILITIES OF USE OF THE WARNERIN NIZKOMOLKULYARNY CATIONIC PEPTIDE IN PRACTICAL ACTIVITIES OF THE DENTIST (EXPERIMENTAL CLINICAL TRIAL)
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THE PROSPECTS AND POSSIBILITIES OF USE OF THE WARNERIN NIZKOMOLKULYARNY CATIONIC PEPTIDE IN PRACTICAL ACTIVITIES OF THE DENTIST (EXPERIMENTAL CLINICAL TRIAL)
GRNTI 76.29 Клиническая медицина
Shulyatnikova Oksana 1
Rogozhnikov Gennadiy 2
Rogozhnikov Aleksey 3
Authors:
1.  Perm State Medical University named after Academician E. A. Vagner (department of orthopedic stomatology, Professor of the Department)
from 01.01.2004 to 01.01.2018
Perm', Perm, Russian Federation
2.  Perm State Medical University named after Academician E. A. Vagner (Orthopedic Dentistry Department, Professor of the Department)

Perm, Perm, Russian Federation
3.  Perm State Medical University named after academician E.A. Wagner (Department of Prosthetic Dentistry, docent of the department)

Perm', Perm, Russian Federation
Type:
Article
DOI:
https://doi.org/10.18481/2077-7566-2017-13-2-74-79
Pages:
from 74 to 79
Status:
Published
Received:
25.05.2017
Accepted:
25.05.2017
Published:
25.05.2017
Subject area:
GRNTI 76.29 Клиническая медицина
Language:
Russian
Keywords:
chelyustno-licevaya oblast', defekty, mikrobnaya plenka, ingibirovanie, peptid varnerin.
Abstract and keywords
Abstract (English):
Predmet. Uvelichenie urovnya travmatizma i novoobrazovaniy chelyustno-licevoy oblasti opredelyaet aktual'nost' lecheniya dannyh pacientov. Poterya anatomicheskoy celostnosti chelyustnyh kostey vliyaet na izmenenie mikrobiocenoza polosti rta i privodit k hronizacii vospalitel'nyh processov. V stat'e rassmatrivaetsya vozmozhnost' ispol'zovaniya v prakticheskoy deyatel'nosti vracha-stomatologa nizkomolekulyarnogo kationnogo peptida varnerina dlya ingibirovaniya obrazovaniya mikrobnoy plenki na pervichnom etape bakterial'nogo prikrepleniya. Cel'. Eksperimental'no-klinicheskoe issledovanie vozmozhnosti ingibirovaniya plenkoobrazuyuschih svoystv mikro‑ organizmov. Metodologiya. Predvaritel'no provedeny issledovaniya rosta bioplenok na obrazcah dioksida titana s nanostrukturirovannoy poverhnost'yu i pri ego ispol'zovanii s peptidom varnerinom. Ocenivali obschuyu biomassu plenok i kolichestva zhiznesposobnyh kletok. Klinicheskoe izuchenie provodili na etape ortopedicheskogo lecheniya. Izuchali mikrobiologicheskiy status polosti rta bol'nyh do nachala eksperimental'noy chasti i posle putem issledovaniya smeshannoy stimulirovannoy slyuny i naleta. V kachestve primera konkretnogo vypolneniya priveden klinicheskiy sluchay. Rezul'taty. Nanostrukturirovannoe pokrytie dioksida titana v tri raza snizhaet kolichestvo zhivyh kletok i v dva raza snizhaet biomassu Staphylococcus epidermidis 33 v bioplenkah. Deystvie peptida varnerina effektivno na obrazcah s nanostrukturirovannym pokrytiem i bez nego. Klinicheskoe issledovanie mestnogo ispol'zovaniya peptida varnerina pokazalo snizhenie kolichestva Str. mutans i Lactobacillus v smeshannoy stimulirovannoy slyune i nalete. Vyvody. Rezul'taty nauchnogo issledovaniya sposobny uluchshit' kachestvo lecheniya bol'nyh s priobretennymi defektami i deformaciyami chelyustno-licevoy oblasti putem sokrascheniya ego srokov i material'nyh zatrat. Nizkomolekulyarnyy kationnyy peptid varnerin pozvolyaet snizit' risk razvitiya nozokomial'nyh infekciy, sposobstvuet resheniyu problem profilaktiki i lecheniya vospalitel'nyh oslozhneniy myagkotkannogo parodonta i slizistoy obolochki na etapah slozhno-chelyustnogo protezirovaniya

Keywords:
chelyustno-licevaya oblast', defekty, mikrobnaya plenka, ingibirovanie, peptid varnerin.
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References

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