Ekaterinburg, Ekaterinburg, Russian Federation
Ekaterinburg, Ekaterinburg, Russian Federation
Ekaterinburg, Russian Federation
from 01.01.1992 until now
Ekaterinburg, Ekaterinburg, Russian Federation
Predmet. V dannoy stat'e privedeny rezul'taty issledovaniya dezaktiviruyuschey sposobnosti razlichnyh adgezivnyh gelevyh osnov po otnosheniyu k metilmetakrilatu, toksichnomu veschestvu, vydelyaemomu iz bazisa s'emnyh zubnyh protezov, kotoroe preimuschestvenno porazhaet nervnuyu i sosudistuyu sistemy i obladaet rezko vyrazhennym kumulyativnym deystviem. V kachestve adgezivnyh gelevyh osnov ispol'zovali: kremniysoderzhaschiy glicerogidrogel' «Silativit», kremniytitanso-derzhaschiy glicerogidrogel', titansoderzhaschiy glicerogidrogel' (tizol'), kremniyhitozansoderzhaschiy glicerogidrogel', a takzhe gel', soderzhaschiy 2% karbopola. Cel'. Ocenka sposobnosti k «neytralizacii» ostatochnogo monomera akrilovyh bazisov s'emnyh zubnyh protezov (MMA) razlichnymi adgezivnymi gelevymi osnovami. Metodologiya. Metodom UF-spektroskopii provedena sravnitel'naya ocenka dezaktiviruyuschey sposobnosti razlichnyh gelevyh osnov po otnosheniyu k MMA. V kachestve adgezivnyh gelevyh osnov ispol'zovali: kremniysoderzhaschiy glicerogidrogel' «Silativit», kremniytitansoderzhaschiy glicerogidrogel', titansoderzhaschiy glicerogidrogel' (tizol'), kremniyhitozansoderzhaschiy glicerogidrogel', a takzhe gel', soderzhaschiy 2% karbopola. Rezul'taty. Ustanovlen ryad dezaktiviruyuschey aktivnosti po otnosheniyu k metilmetakrilatu. Vyyavleno, chto naibolee aktivnym yavlyaetsya kremniyhitozansoderzhaschiy glicerogidrogel'. Titan-, kremniytitan- i kremniysoderzhaschie glicerogidrogeli, a takzhe gidrogel', soderzhaschiy 2% karbopola, v usloviyah eksperimenta suschestvennyh razlichiy ne proyavili. Vyvody. Metodom UF-spektroskopii provedena sravnitel'naya ocenka dezaktiviruyuschey sposobnosti razlichnyh gelevyh osnov po otnosheniyu k MMA. Ustanovlen ryad aktivnosti; pokazano, chto naibol'shey neytralizuyuschey sposobnost'yu obladaet kremniyhitozansoderzhaschiy glicerogidrogel'. Vysokaya dezaktiviruyuschaya aktivnost' kremniyhitozansoderzhaschego glicerogidrogelya po otnosheniyu k MMA otkryvaet perspektivy dlya dal'neyshego ego ispol'zovaniya v sostave adgezivnyh sredstv, sposobnyh predohranyat' pacientov ot vydelyaemogo bazisom akrilovogo s'emnogo proteza ostatochnogo monomera.
metilmetakrilat, dezaktiviruyuschaya sposobnost', mazevye osnovy, element-soderzhaschie glicerogidrogeli, s'emnye zubnye protezy
1. Blinnikova A.D. Povyshenie kachestva akrilovykh stomatologicheskikh plastmass metodom fizicheskogo modifitsirovaniya (Quality improvement of acrylic dental polymers using physical modification), author’s abstract of PhD Thesis, Omsk, 2000, 18 p.
2. Emelyanov A.S., Zholudev S.E., Mirsaev T.D. Fiksiruyuschii sostav dlya cemnykh zebnykh protezov (Fixating composition for removable dentures): Patent of Russian Federation № 2177304. 2001. Bul. № 25.
3. Emelyanova I.V., Lopatina G.P. Sposob polucheniya tizolya - kompleksa tetrakoptan gidroksotetrakis(oksi-3,4-digidroksipropil)titanas dekan-1,2,3-trigidroksipropanom, obladayuschego transkutannoy provodimostyu medicamentoznykh dobavok (The way of retrieving tisol - a complex of tetracoptan hydroxytetraoxys(oxy-3,4-dihydroxypropyl)titanium with dekan-1,2,3 - trihydroxypropane, providing transcutaneous drug delivery: Patent of Russian Federation № 1838318. 1993. Bul. № 32.
4. Zhovtyak P.B., Grigoriev S.S., Shadrina E.V. Sredstvo dlya mestnogo lecheniya krasnogo ploskogo lishaya slizistoy obolochki polosti rta i sposob lecheniya krasnogo ploskogo lishaya lishaya slizistoy obolochki polosti rta (A remedy for local treatment of lichen planus of oral mucosa and a treatment technique for lichen planus of oral mucosa): Patent of Russian Federation № 2583945. 2016. Bul. № 13.
5. Zholudev S.E. Adgezivnye sredstva v ortopedicheskoy stomatologii (Adhesive agents in orthopedic dentistry), Moscow, Medical Literature, 2007, pp. 84-89.
6. Zholudev S.E., Mirsaev T.D., Khonina T.G. Uralskiy stomatological journal - Ural Dentistry Journal, 2002, no. 2, pp. 52.
7. Klemin V.A., Vorozhko A.A. Dalnevostochnyi meditsinsky zhurnal - Far East Medical Journal, 2015, no. 1, pp. 42.
8. Mirsaev T.D. Kliniko-laboratornoe obosnovanie uluchsheniya adaptatsii k semnym plastinochnym protezam pri ispolzovanii adgezivnykh sredstv (Clinical-laboratory substantiation of adaptive improvement of removable laminar dentures using adhesives), author’s abstract of PhD Thesis, Ekaterinburg, 2004. 22 p.
9. Mirsaev T.D., Zholudev S.E., Khonina T.G. Sredstvo dlya fiksatsii semnykh zubnykh protezov (Fixing agent for removable dentures): Patent of Russian Federation № 2287323. 2006. Bul. № 32.
10. Mirsaev T.D., Zholudev S.E., Khonina T.G. Sredstvo dlya fiksatsii semnykh zubnykh protezov (Fixing agent for removable dentures): Patent of Russian Federation №2338513. 2007. Bul. № 32.
11. Mirsaev T.D., Zholudev S.E., Chupakhin O.N. Sredstvo dlya fiksatsii semnykh zubnykh protezov (Fixing agent for removable dentures): Patent of Russian Federation №2558934. 2015. Bul. № 22.
12. Kharenko E.A., Larionova N.I., Demina N.B. Khimiko-farmatsevticheskiy zhurnal - Pharmaceutical Chemistry Journal, 2009, Vol. 43, no. 4, pp.21-29.
13. Khonina T.G., Larionov L.P., Rusinov G.L. Glitseraty kremniya, obladayuschie transkutannoy provodimostyu medicamentoznykh sredstv, i glitserogidrogeli na ikh osnove (Silicon glycerates providing transcutaneous drug delivery, and glycerol hydrogels on their base): Patent of Russian Federation № 2255939. 2005, Bul. № 19.
14. Khonina T.G., Chupakhin O.N., Larionov L.P. Khimiko-farmatsevticheskiy zhurnal - Pharmaceutical Chemistry Journal, 2008, Vol. 42, no. 11, pp. C. 5-9.
15. Khonina T.G., Chupakhin O.N., Larionov L.P. Solvatokompleksy glitseratov kremniya i titana obladayuschie transkutannoy aktivnostyu, i gidrogeli na ikh osnove (Solvate complexes of silicon and titanium glycerates having transcutaneous activity, and hydrogels on their base): Patent of Russian Federation № 23224 48. 2008. Bul. №17.
16. Khonina T.G., Chupakhin O.N., Larionov L.P. Khimiko-farmatsevticheskiy zhurnal - Pharmaceutical Chemistry Journal, 2009, vol. 43, no. 2, pp. 26-32.
17. Chizhov Yu.V., Maskadynov L.E., Maskadynov E.N. Sibirskoe meditsinskoe obozrenie - Siberian Medical Review, 2015, no.6, p. 69.
