THE USE OF GENETIC MARKERS IN PREDICTING OF ORAL LICHEN PLANUS DEVELOPMENT AND RECURRENCE
Rubrics: ORTHOPEDIC DENTISTRY
Authors:
1.
South Ural State Medical university
(Department of therapeutic dentistry propedeutics of dental diseases, Professor of the Department)
Ekaterinburg, Ekaterinburg, Russian Federation
Ekaterinburg, Ekaterinburg, Russian Federation
2.
Ural State Medical University
(Department of Therapeutic Dentistry, Docent)
Ekaterinburg, Ekaterinburg, Russian Federation
Ekaterinburg, Ekaterinburg, Russian Federation
3.
Institute of biochemistry and genetics of the Ufa science center, Russian Academy of Science
4.
Institute of biochemistry and genetics of the Ufa science center, Russian Academy of Science
5.
EBG UNC Russian Science Academy;
Bashkir State University
6.
Bashkir state medical University
7.
Bashkir state medical University, Ufa
Type:
Article
Pages:
from 62
to 69
Status:
Published
Received:
27.03.2016
Accepted:
27.03.2016
Published:
27.03.2016
Language:
Russian
Keywords:
oral lichen planus (OLP), association, allele, genotype, chemokines, susceptibility markers, disease recurrence
Abstract (English):
To reveal the association of the interleukin 8 (IL-8) gene with the development and progression of oral lichen planus (OLP) we performed RT-PCR analysis of rs4073 polymorphism in the IL-8 gene in 92 oral lichen planus patients and 163 healthy individuals of Russian ethnic origin from the Volga-Ural region of Russia. The investigation showed the importance of polymorphism rs4073 of IL-8 gene for oral lichen planus development. The disease was associated with genotype rs4073*T / T which was found to be the genetic marker of high risk for oral lichen planus development, and rs4073*A / T genotype — the genetic marker of low risk for erosive-ulcerous oral lichen planus form development (p=0.016, OR=0.40) and the disease recurrence (p=0.02, OR=0.33). The results obtained in the investigation make a significant contribution to understanding the structure of hereditary predisposition to oral lichen planus development.
To reveal the association of the interleukin 8 (IL-8) gene with the development and progression of oral lichen planus (OLP) we performed RT-PCR analysis of rs4073 polymorphism in the IL-8 gene in 92 oral lichen planus patients and 163 healthy individuals of Russian ethnic origin from the Volga-Ural region of Russia. The investigation showed the importance of polymorphism rs4073 of IL-8 gene for oral lichen planus development. The disease was associated with genotype rs4073*T / T which was found to be the genetic marker of high risk for oral lichen planus development, and rs4073*A / T genotype — the genetic marker of low risk for erosive-ulcerous oral lichen planus form development (p=0.016, OR=0.40) and the disease recurrence (p=0.02, OR=0.33). The results obtained in the investigation make a significant contribution to understanding the structure of hereditary predisposition to oral lichen planus development.
Keywords:
oral lichen planus (OLP), association, allele, genotype, chemokines, susceptibility markers, disease recurrence
oral lichen planus (OLP), association, allele, genotype, chemokines, susceptibility markers, disease recurrence
