The serum calcium-phosphorus balance and bone metabolism markers estimation in 72 patients with severe chronic generalized periodontitis and 20 patients of control healthy group at the age of 25 to 55 was performed. A comprehensive laboratory mineral balance study plays an important role in modern diagnostics of periodontal diseases and allows not only to determine the process of bone destruction activity, but also to control the periodontal treatment ef ciency. The rst examination revealed that 19,4% patients with severe periodontitis had low level of serum ionized calcium, its level being 1,05 mmol/l and less. The Drug-induced management of such patients included prescribing osteogenon in their preoperative period which resulted in 12,61% calcium levels increase within 2 months of osteogenon taking. Thus, adding osteogenon to severe periodontitis combination therapy leads to ionized calcium low level recovery in patients’ serum, bene ts bone regeneration and clinical stabilization of periodontal tissues process due to this medicine active components: hydroxyl apatite and ossein, represented by different growth factors, having a direct impact on bone tissue.
periodontitis, osteogenon, calcium-phosphorus balance, ossein, bone tissue destruction
