Perm, Russian Federation
Perm', Russian Federation
Chelyabinsk, Russian Federation
Predmet. Poisk ob'ektivnyh skrinigovyh metodov diagnostiki oslozhneniy dental'noy implantacii, obladayuschih vysokoy chuvstvitel'nost'yu i specifichnost'yu, a takzhe sluzhaschih indikatorom doklinicheskoy stadii razvitiya periimplantita i prognozirovaniya effektivnosti osteointegracii. Cel' issledovaniya. Izuchenie dinamiki izmeneniy urovnya okislitel'noy modifikacii belkov v slyune dlya razrabotki metoda ranney diagnostiki oslozhneniy pri dental'noy implantacii. Metodologiya. V issledovanii prinyali uchastie 84 pacienta, kotorym byla proizvedena operaciya dental'noy implantacii s primeneniem razlichnyh implantacionnyh sistem. Osnovnuyu gruppu sostavili 53 pacienta s diagnostirovannymi oslozhneniyami, razvivshimisya posle implantacii; gruppa sravneniya sformirovana iz 31 pacienta s blagopoluchnym ishodom lecheniya; v gruppu kontrolya voshli 13 prakticheski zdorovyh lic, kotorym operaciya dental'noy implantacii ne provodilas'. Diagnostika periimplantita osuschestvlyalas' v hode klinicheskogo, rentgenologicheskogo i laboratornogo issledovaniy pri povtornom obsledovanii pacientov. V slyune, poluchennoy na etape podgotovki k dental'noy implantacii, opredelyali uroven' okislitel'noy modifikacii belkov. Povtornyy zabor slyuny osuschestvlyalsya cherez chetyre mesyaca posle dental'noy implantacii (pri ee blagopoluchnom ishode) ili v sluchae verifikacii periimplantita. Rezul'taty. Ustanovleno, chto razvitie oslozhneniy dental'noy implantacii soprovozhdaetsya okislitel'nym stressom i nakopleniem produktov okislitel'noy modifikacii belkov v slyune. Povyshenie salivarnogo urovnya okislitel'noy modifikacii belkov pri dental'noy implantacii nablyudaetsya zadolgo do formirovaniya klinicheski znachimyh izmeneniy v tkanyah implantacionnogo kanala i sopryazheno s vysokim riskom razvitiya vospalitel'nyh oslozhneniy dental'noy implantacii. Vyvody. Vysokiy ishodnyy uroven' okislitel'noy modifikacii belkov slyuny mozhet yavlyat'sya nadezhnym prognosticheskim priznakom periimplantita.
dental'naya implantaciya, periimplantit, slyuna, okislitel'naya modifikaciya belkov
1. Li S., Yang Y., Yu C., Yao Y., Wu Y., Qian L., Cheung C. W. Dexmedetomidine Analgesia Effects in Patients Undergoing Dental Implant Surgery and Its Impact on Postoperative Inflammatory and Oxidative Stress. Oxid. Med. Cell Longev, 2015, vol. 2015, pp. 1-11.
2. Salvi G. E., Cosgarea R., Sculean A. Prevalence and mechanisms of peri-implant diseases. Journal of dental research, 2017, vol. 96, no. 1, pp. 31-37.
3. Guo M., Lin L., Zhang J., Liu M. Role of Reactive Oxygen Species (ROS) and Advanced Glycation End Products (AGE) in the Malfunctioning of Dental Implants. West Indian Medical Journal, 2015, no. 7.
4. Halliwell B., Gutteridge J. M. C. Free Radicals in Biology and Medicine. Oxford University Press, 2015.
5. Pietropaoli D., Ortu E., Severino M., Ciarrocchi I., Gatto R., Monaco A. Glycation and oxidative stress in the failure of dental implants: a case series. BMC Research Notes. Springer Nature, 2013, vol. 6, no. 1, pp. 296.
6. Osobennosti svobodnoradikal'nogo okisleniya lipidov i belkov plazmy krovi pri dental'noy implantacii i periimplantite / D. V. Plyuhin, V. E Ceylikman, O. B. Ceylikman, A. I. Sinickiy // Kazanskiy medicinskiy zhurnal. - 2015. - T. 96, № 5. - S. 756-759.
7. Fedorova M., Bollineni R. C., Hoffmann R. Protein carbonylation as a major hallmark of oxidative damage: update of analytical strategies. Mass spectrometry reviews, 2014, vol. 33, no. 2, pp. 79-97.
8. Zhang C.-Z., Cheng X.-Q., Li J.-Y., Zhang P., Yi P., Xu X. [et al.] Saliva in the diagnosis of diseases. International Journal of Oral Science. Springer Nature, 2016, vol. 8, no. 3, pp. 33-137.
9. Fomina, M. A. Sposob kompleksnoy ocenki soderzhaniya produktov okislitel'noy modifikacii belkov v tkanyah i biologicheskih zhidkostyah: metodicheskie rekomendacii / M. A. Fomina, Yu. V. Abalenihina. - Ryazan': RIORyazGMU, 2014.
10. Aktivnost' glutationzavisimyh fermentov rotovoy zhidkosti pri vtorichnoy adentii do i posle zubnogo protezirovaniya / A. V. Mitina, A. A. Ladut'ko, N. I. Bykova, V. V. Erichev // Kubanskiy nauchnyy medicinskiy vestnik. - 2011. - № 3. - S. 121-125.
11. Grimsrud P. A., Xie H., Griffin T. J., Bernlohr D. A. Oxidative stress and covalent modification of protein with bioactive aldehydes. J. Biol. Chem, 2008, vol. 283, no. 32, pp. 21837-21841.
