graduate student
Kazan, Kazan, Russian Federation
Kazan', Kazan, Russian Federation
Kazan, Kazan, Russian Federation
Kazan, Kazan, Russian Federation
UDC 616.31
Sorption-applicative therapy in purulent-inflammatory diseases of the maxillofacial region is a promising direction that increases the effectiveness of traditional methods in this pathology. The aim is to study the dynamics of clinical and hematological parameters in rats with experimental submandibular phlegmon on the background of sorption-application therapy. Methodology. An experimental study of the effectiveness of sorption-application therapy with plant cellulose sorbent in case of submandibular phlegmon was conducted on 40 male Wistar rats. All the rats were divided into groups. The first group is an intact control group, without pathology modeling. Rats of the second, third and fourth groups underwent induction of submandibular phlegmon. Statistical processing of the digital experimental material was carried out using the Microsoft Excel program; Student's t-test was used to determine the significance of differences. Results. It has been established that in the first days of distress, there are changes in the clinical condition of the animals and a decrease in body weight. In the treatment of induced phlegmon, the best therapeutic effect is achieved with combined local sorption-application therapy compared to antimicrobial monotherapy, which is confirmed by a positive change in the clinical condition and leukocyte response in the animals of these groups. There were no significant differences in biochemical parameters in the animals that received different treatments. Conclusions. An increase in cases of purulent-inflammatory lesions of soft tissues and local infectious complications associated with an increase in the resistance of pathogenic microorganisms to antibacterial drugs and a weakening of the body's immune forces determines the urgency of developing new non-medicinal products for local wound therapy. This includes the creation of a variety of improved sorption materials capable of having a targeted effect on the dynamics of the wound process [6].
acute purulent-inflammatory diseases, phlegmon, sorbent, blood, rats
1. Grachev D.A., Ksembaev S.S., Agatieva E.A., Mubarakova L.N. Rasprostranennost' i harakteristika ostryh gnoyno-vospalitel'nyh zabolevaniy chelyustno-licevoy oblasti. Problemy stomatologii. 2024;20(4):40-45. [Grachev D.A., Ksembaev S.S., Agatieva E.A., Mubarakova L.N. Prevalence and characteristics of acute purulent-inflammatory diseases of the maxillofacial region. Actual problems in dentistry. 2024;20(4):40-45. (In Russ.)]. https://doi.org/10.18481/2077-7566-2024-20-4-40-45
2. Alhamada M., El' Bazzal H.A.R., Smirnova A.V. Odontogennyy osteomielit. Obzor literatury. Pridneprovskiy nauchnyy vestnik. 2024;6(1):100-104. [Alhamada M., El Bazzal H.A.R., Smirnova A.V. Odontogenic osteomyelitis. Literature review. Pridneprovskii nauchnyi vestnik. 2024;6(1):100-104. (In Russ.)].
3. Salieva Z.S., Grigor'yanc A.G., Halilova Z.S., Izmailova Z.A. Rezul'taty mikrobiologicheskogo issledovaniya soderzhimogo gnoynyh ran u bol'nyh s ostrymi gnoyno-vospalitel'nymi zabolevaniyami chelyustno-licevoy oblasti. V: Fundamental'naya i prikladnaya nauka: sostoyanie i tendencii razvitiya: sbornik statey XLVIII Mezhdunarodnoy nauchno-prakticheskoy konferencii; Petrozavodsk; 27 fevralya 2025 goda. Petrozavodsk: Mezhdunarodnyy centr nauchnogo partnerstva «Novaya Nauka» (IP Ivanovskaya I.I.); 2025. S. 63-69. [Salieva Z.S., Grigoryants A.G., Khalilova Z.S.K., Izmailova Z.A. The results of a microbiological research of the contents of purulent wounds in patients with acute pyo-inflammatory diseases of the maxillofacial area. In: Fundamental and applied science: state and development trends: collection of articles from the XLVIII International scientific and practical conference; Petrozavodsk; February 27, 2025. Petrozavodsk: International Center for Scientific Partnership "New Science" (IP Ivanovskaya I.I.); 2025. Pp. 63-69. (In Russ.)]. https://elibrary.ru/item.asp?id=80421618
4. Chuykin S.V., Hasanov T.A., Shikova Yu.V., Izosimov A.A., Viktorov S.V., Rahmangulov R.R. i dr. Mestnoe lechenie gnoynyh ran pri gnoyno-vospalitel'nyh zabolevaniyah chelyustno-licevoy oblasti u detey. Problemy stomatologii. 2019;15(1):99-103. [Chuykin S.V., Kxasanov T.A., Shikova I.V., Izosimov A.A., Victorov S.V., Rahmangulov R.R. et al. Local treatment of purulent wounds in purulent-inflammatory diseases of the maxillofacial region in children. Actual problems in dentistry. 2019;15(1):99-103. (In Russ.)]. https://doi.org/10.18481/2077-7566-2019-15-1-99-103
5. Imenov D.A., Bakiev B.A., Kasenova N.S., Kuramaeva U.K. Mestnoe medikamentoznoe lechenie gnoynyh ran u bol'nyh s gnoyno - vospalitel'nymi zabolevaniyami chelyustno-licevoy oblasti i shei (obzor literatury). Vestnik Kyrgyzskoy gosudarstvennoy medicinskoy akademii imeni I.K. Ahunbaeva. 2015;(4);88-95. [Imenov D.A., Bakiev B.A., Kasenova N.S., Kuramaeva U.K. Local drug treatment of purulent wounds in patients with purulent-inflammatory diseases of the maxillofacial region and neck (literature review). Vestnik KSMA n.a. I.K. Akhunbaev. 2015;(4);88-95. (In Russ.)]. https://elibrary.ru/item.asp?id=25580214
6. Lepeshkina E.V., Odaryuk V.A. Sozdanie novogo pokoleniya steril'nyh otechestvennyh izdeliy medicinskogo naznacheniya na osnove cellyulozy i ee proizvodnyh dlya povysheniya kachestva obsluzhivaniya naseleniya v period chrezvychaynyh situaciy. Tehnologii grazhdanskoy bezopasnosti. 2013;10(1):64-67. [Lepeshkina E., Odarjuk V. Creation of the new generation sterile domestic products of medical purpose on the basis of cellulose and its derivatives for improvement of service quality for the population in emergency situations. Civil Security Technologies. 2013;10(1):64-67. (In Russ.)]. https://elibrary.ru/item.asp?id=19123397
7. Grachev D.A., Ksembaev S.S., Musin I.N., Galeev R.D., Ivanov O.A., Nesterova E.E. i dr. Perspektivy razrabotki i ispol'zovaniya v klinicheskoy praktike novyh cellyuloznyh sorbentov. V: Zdorov'e cheloveka v XXI veke. Kachestvo zhizni: Sbornik nauchnyh statey; Kazan'; 21–22 marta 2024 goda. Kazan': Izdatel'skiy dom «MeDDoK»; 2024. S. 26-31. [Grachev D.A., Ksembaev S.S., Musin I.N., Galeev R.D., Ivanov O.A., Nesterova E.E. and others. Prospects for the development and use of new cellulose sorbents in clinical practice. In: Human health in the 21st century. Quality of life: Collection of scientific articles; Kazan; March 21-22, 2024. Kazan: Publishing house "Meddock"; 2024. Pp. 26-31. (In Russ.)].
8. Islamov R.R., Agatieva E.A., Gazizov I.M., Ksembaev S.S., Andreeva T.M., Cyplakov D.E. i dr. Sposob modelirovaniya flegmony okolochelyustnoy oblasti u krysy. Geny i Kletki. 2019;14(S):102. [Islamov R.R., Agatieva E.A., Gazizov I.M., Ksembaev S.S., Andreeva T.M., Tsyplakov D.E. et al. A method for modeling the phlegmon of the maxillary region in a rat. Genes & Cells. 2019;14(S):102. (In Russ.)]. https://elibrary.ru/item.asp?id=42333906
9. Yarec Yu.I. Specificheskie belki: prakticheskoe posobie dlya vrachey: v 2 chastyah. Chast' II. Kliniko-diagnosticheskoe znachenie opredeleniya specificheskih belkov. Gomel': GU «RNPC RMiECh»; 2015. 47 s. [Yarets Yu.I. Specific proteins: a practical guide for doctors: in 2 parts. Part II. The clinical and diagnostic significance of the determination of specific proteins. Gomel: State Institution "Republican Scientific and Practical Center of Radiation Medicine and Human Ecology"; 2015. 47 p. (In Russ.)]. https://studfile.net/preview/7603281/
