Yekaterinburg, Ekaterinburg, Russian Federation
Ufa, Russian Federation
UDC 616.31
The subject of the study. This study aims to evaluate humoral immunity in patients with a thin gum phenotype 6 months after dental implantation using various types of grafts. Aim. The main purpose of the work was to determine the effect of auto- and allografts on immunological and reparative processes in the oral fluid (OF). The hypothesis of the study suggested that the levels of cytokines (IL-2, IL-4) and transforming growth factor alpha (TFR-α) in the oral fluid reflect the dynamics of inflammatory reactions and tissue regeneration. Research methods. The concentration of cytokines and transforming growth factor alpha was measured, and a morphological assessment of gum tissue was performed. Results. The data obtained demonstrated that the use of autografts taken from the bone tissue of the upper jaw led to a noticeable increase in IL-2 and IL-4, which indicated a pronounced inflammatory reaction. At the same time, allografts (testicular membrane, pericardium, wide fascia of the thigh) showed bioinertness and did not cause an immune response. The highest level of TFR-α was observed when using the ovarian membrane (140 times higher), which indicates an active renewal of connective tissue. At the same time, this indicator had no connection with the formation of a "thin" or "thick" gum type. Conclusions. The study highlights the importance of choosing the right graft to reduce immune responses and improve regeneration processes. The most promising materials were allografts (ovarian membrane, pericardium, wide fascia of the thigh) and autografts obtained from the palatal mucosa.
dental implantation, humoral immunity, oral fluid, cytokines, transforming growth factor, allografts, autografts, thin gingival phenotype, immunological reaction, tissue regeneration
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