Actual problems in dentistry Actual problems in dentistry Проблемы стоматологии 2077-7566 2412-9461 97911 10.18481/2077-7566-2025-21-1-142-147 ХИРУРГИЧЕСКАЯ СТОМАТОЛОГИЯ И ИМПЛАНТОЛОГИЯ SURGICAL DENTISTRY AND IMPLANTOLOGY ХИРУРГИЧЕСКАЯ СТОМАТОЛОГИЯ И ИМПЛАНТОЛОГИЯ EFFECT OF BONE MORPHOGENETIC PROTEIN COATING 2 ON THE SURFACE OF A DENTAL IMPLANT ON ITS OSTEOGENESIS ВЛИЯНИЕ ПОКРЫТИЯ КОСТНЫМ МОРФОГЕНЕТИЧЕСКИМ БЕЛКОМ 2 ПОВЕРХНОСТИ ДЕНТАЛЬНОГО ИМПЛАНТАТА НА ЕГО ОСТЕОГЕНЕРАЦИЮ Степанов Александр Геннадьевич Stepanov Alexander G. stepanovmd@list.ru

доктор медицинских наук;

doctor of medical sciences;

 Апресян Самвел Владиславович Apresyan Samvel S. apresyan@rudn.ru

доктор медицинских наук;

doctor of medical sciences;

 Начарьян Эдуард Георгиевич Nacharyan Eduard G. ndg033@me.com Копылов Максим Валерьевич Kopylov Maksim V. kopylov.surg@gmail.ru Маркин Владимир Александрович Markin Maxim A. mavlal@yandex.ru

доктор медицинских наук;

doctor of medical sciences;

 Российского университета дружбы народов имени Патриса Лумумбы Москва Россия Peoples' Friendship University of Russia named after Patrice Lumumba Moscow Russian Federation Российский университет дружбы народов имени Патриса Лумумбы Москва Россия Peoples' Friendship University of Russia named after Patrice Lumumba Moscow Russian Federation Российский университет дружбы народов Москва Россия Peoples’ Friendship University of Russia Moscow Russian Federation Российский университет дружбы народов имени Патриса Лумумбы Москва Россия Peoples’ Friendship University of Russia Moscow Russian Federation Российский университет медицины Москва Россия Peoples' Friendship University of Russia Moscow Russian Federation 01 05 2025 01 05 2025 21 1 142 147 22 04 2025 https://dental-press.ru/en/nauka/article/97911/view

Одной из актуальных задач современной стоматологии является решение проблемы оптимальной остеоинтеграции дентального имплантата – прочной структурно-функциональной связи между поверхностью имплантата и костной тканью, что является решающим фактором для обеспечения позитивных отдаленных результатов ортопедического лечения. Известно, что имплантационное протезирование сопряжено с достаточно широким спектром рисков, включая вероятность отторжения имплантатов. Современным клиническим сообществом предложен достаточно широкий спектр подходов к профилактике и лечению нарушений остеогенерации, как предиктивной меры для достижения оптимальных, в том числе, отдаленных результатов дентальной имплантации: реализация антирезорбтивной и остеоанаболической терапии, локальное использование в качестве модифицирующих компонентов факторов роста и морфогенетических белков костной ткани. Статья посвящена изучению вопроса влияния покрытия костным морфогенетическим белком 2 (ВМР-2) поверхности дентального импланта на его остеогенерацию. Авторами обосновывается актуальность и значимость темы исследования. Рассматриваются современные методы биологической (биохимической) модификации поверхности дентальных имплантов. Проводится обзор литературы и анализ накопленного в международной доклинической и клинической практике опыта в области применения ВМР-2 как компонента остеоиндуктивных материалов. Обобщаются данные о влиянии покрытия ВМР-2 поверхности дентального импланта, в том числе в комбинации с другими биоактивными компонентами, на его остеогенерацию. Делается вывод об актуальности применения ВМР-2 в стоматологии с целью увеличения остеогенного потенциала дентальной имплантации у пациентов «группы риска» с нарушениями костного метаболизма, в том числе, минерального обмена в челюстных костях. Указывается на необходимость дальнейших углубленных исследований для уточнения факторов риска (побочных эффектов), связанных с применением ВМР-2, и разработки оптимальных систем его доставки, позволяющих длительно контролировать и точно высвобождать белок с течением времени.

One of the urgent tasks of modern dentistry is to solve the problem of optimal osseointegration of a dental implant – a strong structural and functional connection between the implant surface and bone tissue, which is a crucial factor for ensuring positive long-term results of orthopedic treatment. It is known that implantation prosthetics is associated with a fairly wide range of risks, including the possibility of implant rejection. The modern clinical community has proposed a fairly wide range of approaches to the prevention and treatment of osteogenesis disorders as a predictive measure to achieve optimal, including long-term results of dental implantation: the implementation of antiresorption and osteoanabolic therapy, the local use of growth factors and morphogenetic bone proteins as modifying components. The article is devoted to the study of the effect of coating with bone morphogenetic protein 2 (BMP2) on the surface of a dental implant on its osteogenesis. The authors substantiate the relevance and significance of the research topic. Modern methods of biological (biochemical) modification of the surface of dental implants are considered. A review of the literature and an analysis of the experience gained in international preclinical and clinical practice in the field of BMP2 application as a component of osteoinductive materials is carried out. The data on the effect of the BMP2 coating on the surface of a dental implant, including in combination with other bioactive components, on its osteogenesis are summarized. It is concluded that the use of VMR-2 in dentistry is relevant in order to increase the osteogenic potential of dental implantation in patients at risk with impaired bone metabolism, including mineral metabolism in the jawbones. It is pointed out that further in-depth research is needed to clarify the risk factors (side effects) associated with the use of BMP-2 and to develop optimal delivery systems for its long-term monitoring and accurate release of protein over time.

 вторичная адентия дентальная имплантация остеоинтеграция остеоиндуктивный материал модификация поверхности дентального имплантата бактериальная адгезия костный морфогенетический белок 2 secondary adentia dental implantation osseointegration osteoinductive material modification of the surface of a dental implant bacterial adhesion bone morphogenetic protein 2

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