Actual problems in dentistry Actual problems in dentistry Проблемы стоматологии 2077-7566 2412-9461 97566 10.18481/2077-7566-2025-21-1-37-47 ЛЕКЦИИ / ЛИТЕРАТУРНЫЕ ОБЗОРЫ LITERATURE REVIEW ЛЕКЦИИ / ЛИТЕРАТУРНЫЕ ОБЗОРЫ APPLICATION OF BIOREGENERATIVE MATERIALS IN THE TREATMENT OF PERIODONTITIS AND PERIIMPLANTITIS: A SYSTEMATIC REVIEW ПРИМЕНЕНИЕ БИОРЕГЕНЕРАТИВНЫХ МАТЕРИАЛОВ В ЛЕЧЕНИИ ПАРОДОНТИТА И ПЕРИИМПЛАНТИТА: СИСТЕМАТИЧЕСКИЙ ОБЗОР Рисованная Ольга Николаевна Risovannaya Olga N. dentrosa@mail.ru

доктор медицинских наук;

doctor of medical sciences;

 Андреасян Татев Шотаевна Andreasyan Tatev Sh. andreasyan1983@mail.ru Кубанский государственный медицинский университет Краснодар Россия Kuban State Medical University Krasnodar Russian Federation Стоматологическая клиника «Корона» Туапсе Россия «Corona» Dental Clinic Tuapse Russian Federation 01 05 2025 01 05 2025 21 1 37 47 15 04 2025 https://dental-press.ru/en/nauka/article/97566/view

Воспалительные заболевания ротовой полости, такие как пародонтит и периимплантит, остаются одной из ведущих причин потери зубов и снижения качества жизни пациентов. Стандартные методы лечения направлены на устранение инфекции и воспаления, однако не всегда обеспечивают достаточное восстановление поражённых тканей. В этой связи биорегенеративные материалы, обладающие противовоспалительными и регенеративными свойствами, привлекают всё большее внимание как перспективный инструмент в комплексной терапии. Данный обзор актуален в свете растущего числа исследований, посвящённых эффективности различных биоматериалов и необходимости их систематизированного анализа. Цель исследования – систематизация существующих данных о биорегенеративных материалах, определение их регенеративного потенциала и анализ преимуществ в терапии пародонтита и периимплантита. Методология. Обзор выполнен в соответствии с рекомендациями PRISMA. Литературный поиск проводился в базах данных PubMed, Cochrane Library и eLibrary. В анализ включены рандомизированные контролируемые исследования и метаанализы, соответствующие критериям включения. Для оценки качества исследований использовался инструмент Cochrane Risk of Bias. Результаты. Из 404 идентифицированных публикаций в итоговый анализ было включено 24 исследования. Основными биорегенеративными материалами стали тромбоцитарно-обогащённый фибрин (PRF), гидрогели, биоактивные стекла и стволовые клетки. PRF показал высокую эффективность в заживлении мягких тканей и регенерации костных дефектов, а гидрогели – в снижении воспалительных процессов. Оценка клинической эффективности продемонстрировала значительное улучшение показателей глубины пародонтальных карманов и уровня клинического прикрепления. Выводы. Биорегенеративные материалы обладают высоким потенциалом в комплексной терапии воспалительных заболеваний ротовой полости, обеспечивая противовоспалительный и регенеративный эффект. Однако для их широкого внедрения необходимы дополнительные исследования с большими выборками и долгосрочным наблюдением.

Inflammatory diseases of the oral cavity, such as periodontitis and peri-implantitis, remain one of the leading causes of tooth loss and decreased quality of life for patients. Standard treatment methods focus on eliminating infection and inflammation; however, they do not always provide adequate restoration of the affected tissues. In this context, bioregenerative materials with anti-inflammatory and regenerative properties are gaining increasing attention as a promising tool in comprehensive therapy. This review is relevant in light of the growing number of studies devoted to the effectiveness of various biomaterials and the need for their systematic analysis. Objective. The aim of this study is to systematize existing data on bioregenerative materials, determine their regenerative potential, and analyze their advantages in the treatment of periodontitis and peri-implantitis. Methodology. The review was conducted in accordance with PRISMA guidelines. Literature searches were carried out in the PubMed, Cochrane Library, and Elibrary databases. The analysis included randomized controlled trials and meta-analyses that met the inclusion criteria. The Cochrane Risk of Bias tool was used to assess the quality of the studies. Results. Of the 404 publications identified, 24 studies were included in the final analysis. The main bioregenerative materials included were platelet-rich fibrin (PRF), hydrogels, bioactive glasses, and stem cells. PRF demonstrated high effectiveness in soft tissue healing and bone defect regeneration, while hydrogels were effective in reducing inflammatory processes. Clinical efficacy assessment showed significant improvements in probing depth and clinical attachment level. Conclusion. Bioregenerative materials have high potential in the comprehensive treatment of inflammatory oral diseases, providing anti-inflammatory and regenerative effects. However, further studies with larger sample sizes and long-term follow-up are necessary for their widespread implementation.

 биорегенеративные материалы тромбоцитарно-обогащённый фибрин гидрогели биоактивные стекла стволовые клетки воспалительные заболевания ротовой полости пародонтит периимплантит регенерация тканей систематический обзор bioregenerative materials platelet-rich fibrin (PRF) hydrogels bioactive glass stem cells inflammatory oral diseases periodontitis peri-implantitis tissue regeneration systematic review

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