Subject of study. Dental status, indicators of oral homeostasis in persons, diet and oral hygiene in persons observing the fast of Ramadan. Purpose of the study. To study the dental status, indicators of homeostasis of the oral cavity and the nature of nutrition in persons observing the fast of Ramadan. Methodology. The study involved 37 male volunteers, aged 25 to 35 years, belonging to the second health group, who did not undergo SARS-CoV-2, with an orthognathic bite, a satisfactory level of hygiene, a PMA equal to zero, and a KPU index below 1.5. In previous years, the studied persons strictly observed the fast of Ramadan and this year, too, were firmly determined to observe it. Before the start, on the 15th day and after the end of the fast, the study studied the hygienic state of the oral cavity, the state of the teeth, the state of periodontal tissues, the functional activity of the salivary glands, the viscosity and pH of saliva, the level of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) and the activity of antioxidant enzymes – superoxide dismutase (SOD), oral fluid catalase. After completing the fast, they filled out questionnaires that included questions about oral care and diet during fasting. Results. In persons observing the fast of Ramadan, the reaction of saliva is shifted to the acid side, the functional activity of saliva decreases, and the viscosity of saliva increases. This leads to a deterioration in the hygienic state of the oral cavity, the formation of soft and hard deposits on the teeth and the development of gum disease. There is also an imbalance in the lipid peroxidation-antioxidants system, an increase in the concentration of pro-inflammatory cytokines IL-1β, IL-6, TNF-α, both on the 15th day of fasting and after its completion. Conclusions. The results of the study allow dentists and nutritionists to purposefully develop recommendations on diet and prevention of dental diseases for people who observe the fast of Ramadan.