Subject. The subject of this research is Sjogren's syndrome. Objective. The objective of this research is to report a clinical case of Sjogren's syndrome associated with osteoporosis under hospital outpatient care provided by a dental therapist. Methodology. The research design includes description of one clinical case. The study is conducted by the Department of Preventive Dentistry and Propedeutics of Dental Disease, and the Department of Intermediate Level Therapy and Geriatrics of Ural State Medical University. This paper presents clinical observations of the patient developing main symptoms of Sjogren's syndrome, as well it explores somatic/dental status and describes the framework for supervision during dynamic observation. Conclusion. The case study allows to explore one of the multiple cases leading to development of chronic Sjogren's syndrome. The patient experiences a worsening of symptoms associated with menopausal transition and with new signs brought on by osteoporosis shows specific symptoms. Clinical manifestations of Sjogren's disease are highly variable, complicating the diagnostic process. This creates a risk of delayed treatment and provokes the development of severe complications, especially against the background of osteoporosis. Rational selection of appropriate modern medical treatment (active general drug therapy) and dynamic observation of a reumatologyst are specially important. However, being an interdisciplinary problem Sjogren's syndrome requires involvement of dental professionals, training in professional oral hygiene procedure which is the initial step of comprehensive maintenance treatment (based on clinical recommendations) and dynamic observation of patients; based on systemic manifestations, other specialists such as a reumatologyst, a gastroenterologist, an endocrinologist, an ophthalmologist may be involved.