Subject. Study of the results and complications of uranoplasty in children with congenital cleft lip and /or palate in the first year after surgical treatment. The goal is to determine the frequency of surgical and speech complications after uranoplasty in children with congenital cleft lip and/or palate in regions with a petrochemical industry and without industrial ecotoxicants. Methodology. After the uranoplasty, 80 children with various forms of cleft palate were examined at the Republican Children's Clinical Hospital. Comprehensive examination included the use of clinical (examination, palpation, percussion ― assessment of surgical status) and functional (electromyography, rheography, magnetic resonance imaging, nasopharyngoendoscopy, speech therapy speech assessment using a sound identification system) research methods. Results. Children with congenital cleft lip and/or palate born and living in regions with petrochemical ecotoxicants more often (37.5 %) have complications after uranoplasty than children from regions without petrochemical ecotoxicants (18.8 %). They have a higher prevalence of palatopharyngeal insufficiency, the frequency of fistulas of the soft and hard palate, and the need for secondary surgical intervention, more often they experience difficulties in restoring speech functions. Conclusions. Due to the presence of somatic diseases and disorders in blood counts at the preoperative stage, more pronounced postoperative complications are noted in the group of children with congenital cleft lip and/or palate from regions with the petrochemical industry, which indicates a violation of their reparative regeneration after uranoplasty. This is the rationale for the development and application of a method for the prevention of postoperative complications, which will be included in the rehabilitation algorithm to improve the physiological and speech functions of children after uranoplasty in a region with a petrochemical industry.