<!DOCTYPE article
PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.4 20190208//EN"
       "JATS-journalpublishing1.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.4" xml:lang="en">
 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">Actual problems in dentistry</journal-id>
   <journal-title-group>
    <journal-title xml:lang="en">Actual problems in dentistry</journal-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Проблемы стоматологии</trans-title>
    </trans-title-group>
   </journal-title-group>
   <issn publication-format="print">2077-7566</issn>
   <issn publication-format="online">2412-9461</issn>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="publisher-id">30173</article-id>
   <article-id pub-id-type="doi">10.18481/2077-7566-2019-15-2-114-121</article-id>
   <article-categories>
    <subj-group subj-group-type="toc-heading" xml:lang="ru">
     <subject>ПАРОДОНТОЛОГИЯ</subject>
    </subj-group>
    <subj-group subj-group-type="toc-heading" xml:lang="en">
     <subject>PERIODONTIC DENTISTRY</subject>
    </subj-group>
    <subj-group>
     <subject>ПАРОДОНТОЛОГИЯ</subject>
    </subj-group>
   </article-categories>
   <title-group>
    <article-title xml:lang="en">OPTIMIZATION OF METHODS FOR THE PREVENTION AND TREATMENT                      OF INFLAMMATORY PERIODONTAL DISEASES</article-title>
    <trans-title-group xml:lang="ru">
     <trans-title>ОПТИМИЗАЦИЯ МЕТОДОВ ПРОФИЛАКТИКИ И ЛЕЧЕНИЯ ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЙ ПАРОДОНТА</trans-title>
    </trans-title-group>
   </title-group>
   <contrib-group content-type="authors">
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Мамедов</surname>
       <given-names>Ризван Мохсун оглы</given-names>
      </name>
      <name xml:lang="en">
       <surname>Mamedov</surname>
       <given-names>Rizvan M.</given-names>
      </name>
     </name-alternatives>
     <email>dr.rizvan/mammadov@mail.ru</email>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Садыгова</surname>
       <given-names>Нигяр Нариман кызы</given-names>
      </name>
      <name xml:lang="en">
       <surname>Sadigova</surname>
       <given-names>Nigar N.</given-names>
      </name>
     </name-alternatives>
     <email>nsadigova79@gmail.ru</email>
     <xref ref-type="aff" rid="aff-2"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Ибрагимова</surname>
       <given-names>Лала Кочари кызы</given-names>
      </name>
      <name xml:lang="en">
       <surname>Ibrahimova</surname>
       <given-names>Lala K.</given-names>
      </name>
     </name-alternatives>
     <email>lalaflower2@mail.ru</email>
     <xref ref-type="aff" rid="aff-3"/>
    </contrib>
   </contrib-group>
   <aff-alternatives id="aff-1">
    <aff>
     <institution xml:lang="ru">Азербайджанский медицинский университет</institution>
     <city>Баку</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Azerbaijan Medical University</institution>
     <city>Baku</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-2">
    <aff>
     <institution xml:lang="ru">Азербайджанский медицинский университет</institution>
     <city>Баку</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Azerbaijan Medical University</institution>
     <city>Baku</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-3">
    <aff>
     <institution xml:lang="ru">Азербайджанский медицинский университет</institution>
     <city>Баку</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Azerbaijan Medical University</institution>
     <city>Baku</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <volume>15</volume>
   <issue>2</issue>
   <fpage>114</fpage>
   <lpage>121</lpage>
   <self-uri xlink:href="https://dental-press.ru/en/nauka/article/30173/view">https://dental-press.ru/en/nauka/article/30173/view</self-uri>
   <abstract xml:lang="ru">
    <p>Предмет. Лечебные средства с учетом роли различных микробных ассоциаций в развитии тяжелых генерализованных форм гингивита и пародонтита должны обладать высокой антимикробной активностью, но их применение также может вызывать подавление роста представителей нормальной микрофлоры. &#13;
Цель  ― оценка эффективности комплексного лечения воспалительных заболеваний пародонта с применением новых профилактических средств.&#13;
Методология. Все пациенты с хроническим генерализованным пародонтитом легкой степени тяжести были разделены на три группы:  контрольную (18 чел.), в которой лечение ограничивалось только гигиеническим обучением и проведением профессиональной гигиены, группу сравнения (20 чел.), лечение в ней включало общепринятую стандартную схему и применение гелеобразной зубной пасты Curasept ADS 712, и основную (20 чел.), в которой применялась стандартная терапия с назначением  зубной пасты Curaprox Enzycal 1450ppm. Проведены микробиологические исследования смешанной ротовой жидкости, определены индекс кровоточивости десневой борозды SBI (Muhlemann, 1971) и гигиенический индекс Silness-Loe (S-L, 1964). Очищающее, противовоспалительное и кровоостанавливающее действия предложенных средств оценивали до лечения и через 1, 3 и 6 месяцев после лечения.&#13;
Результаты. В контрольной группе  частота встречаемости A. actinomycetemcimitans и P. intermedia через 3 месяца после завершения лечебно-профилактических мероприятий составила 5,6±5,4 и 11,1±7,4 %, в группе сравнения, где назначалась зубная паста Curasept ADS 712, показатели по вышеуказанным бактериям снизились до нулевой отметки. Выявленные значения гигиенического индекса через 3 месяца после лечения в основной, контрольной и группе сравнения составили 1,12 ± 0,038; 1,30 ± 0,028 и 1,13 ± 0,041 соответственно. &#13;
Выводы. По полученным данным, применение пасты Curaprox Enzycal с тремя ферментами и фторидом натрия в минимальном для использования количестве выявило ее высокую профилактическую эффективность.</p>
   </abstract>
   <trans-abstract xml:lang="en">
    <p>Relevance. Medicines, taking into account the role of various microbial associations in the development of severe generalized forms of gingivitis and periodontitis, should have high antimicrobial activity, but their use can also cause growth inhibition and representatives of normal microflora.&#13;
The purpose ― to evaluate the effectiveness of complex treatment of inflammatory periodontal diseases using new prophylactic agents.&#13;
Material and research methods. For a comparative clinical and laboratory evaluation of the effectiveness of the therapeutic and prophylactic agents used, the patients were divided into 3 groups. With HGPLS - the control group - 18, in which treatment was limited only to hygienic education and the conduct of professional hygiene. The comparison group (20 people with CHPH) received treatment according to the generally accepted standard regimen and prescribed Curasept ADS 712 gel toothpaste. The main group (20 people with CHPH) received the standard therapy with Curaprox Enzycal toothpaste 1450ppm. Microbiological studies of a mixed oral fluid and clinical indices were performed in the work — the SBI bleeding index of the gingival sulcus (Muhlemann, 1971), Silness-Loe hygienic index (S-L, 1964). Evaluation of the cleansing, anti-inflammatory and hemostatic effects of the proposed medications was carried out before treatment and 1,3.6 months after treatment.&#13;
Research results. The control group, the frequency of occurrence of A.actinomycetemcimitans and P.intermedia three months after the completion of treatment and preventive measures was 5.6 ± 5.4 and 11.1 ± 7.4 %, in the comparison group, where Curasept ADS toothpaste was administered 712, the indicators for the above bacteria dropped to zero. The detected values of the hygienic index three months after treatment in the main, control groups and in the comparison group, respectively, amounted to 1.12 ± 0.038; 1.30 ± 0.028 and 1.13 ± 0.041. In the long-term clinical observations in the main group, the values of the &#13;
Conclusion. According to the data obtained, the use of Curaprox Enzycal paste with 3 enzymes and sodium fluoride in the minimum amount for use revealed its high prophylactic efficacy.</p>
   </trans-abstract>
   <kwd-group xml:lang="ru">
    <kwd>пародонтит</kwd>
    <kwd>микробы</kwd>
    <kwd>воспаление</kwd>
    <kwd>лечение</kwd>
    <kwd>зубные пасты</kwd>
   </kwd-group>
   <kwd-group xml:lang="en">
    <kwd>periodontitis</kwd>
    <kwd>inflammation</kwd>
    <kwd>microb</kwd>
    <kwd>treatment</kwd>
    <kwd>toothpaste</kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <p></p>
 </body>
 <back>
  <ref-list>
   <ref id="B1">
    <label>1.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Гажва, С. И. Распространенность и интенсивность воспалительных заболеваний пародонта (обзор литературы) / С. И. Гажва, Р. С. Гулуев // Обозрение. Стоматология. - 2012. - № 1. - С. 13-14.</mixed-citation>
     <mixed-citation xml:lang="en">Gazhva, S. I., Guluyev, R. S. (2012). Rasprostranennost' i intensivnost' vospalitel'nykh zabolevaniy parodonta (obzor literatury) [Prevalence and intensity of inflammatory periodontal diseases (literature review)]. Obozreniye. Stomatologiya [Obozrenie. Dentistry], 1, 13-14. (In Russ.)</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B2">
    <label>2.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Гилева, О. С. Заболевания пародонта у вич-инфицированных больных: распространенность и особенности клинических проявлений в зависимости от приверженности антиретровирусной терапии / О. С. Гилева, А. В. Садилова // Пермский медицинский журнал. - 2013. - Т. 30, № 2. - С. 34-42.</mixed-citation>
     <mixed-citation xml:lang="en">Gileva, O. S., Sadilova, A. V. (2013). Zabolevaniya parodonta u vich-infitsirovannykh bol'nykh: rasprostranennost' i osobennosti klinicheskikh proyavleniy v zavisimosti ot priverzhennosti antiretrovirusnoy terapii [Periodontal diseases in HIV-infected patients: prevalence and features of clinical manifestations depending on adherence to antiretroviral therapy]. Permskiy meditsinskiy zhurnal [Perm Medical Journal], 30, 2, 34-42. (In Russ.)</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B3">
    <label>3.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Гончарова, Е. И. Препараты лекарственных растений в лечении заболеваний слизистой оболочки рта / Е. И. Гончарова // Российский стоматологический журнал. - 2015. - Т. 19, № 4. - С. 55-57.</mixed-citation>
     <mixed-citation xml:lang="en">Goncharova, Ye. I. (2015). Preparaty lekarstvennykh rasteniy v lechenii zabolevaniy slizistoy obolochki rta [Preparations of medicinal plants in the treatment of diseases of the oral mucosa]. Rossiyskiy stomatologicheskiy zhurnal [Russian dental journal], 19, 4, 55-57. (In Russ.)</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B4">
    <label>4.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Еловикова, Т. М. Клиническая характеристика отечественной лечебно-профилактической зубной пасты на основе растительных экстрактов / Т. М. Еловикова, Е. Ю. Ермишина, Н. А. Белоконова // Пародонтология. - 2014. - № 2 (71). - С. 68-71.</mixed-citation>
     <mixed-citation xml:lang="en">Yelovikova, T. M., Yermishina, Ye. YU., Belokonova, N. A. (2014). Klinicheskaya kharakteristika otechestvennoy lechebno-profilakticheskoy zubnoy pasty na osnove rastitel'nykh ekstraktov [Clinical characteristics of domestic therapeutic and prophylactic toothpaste based on plant extracts]. Parodontologiya [Periodontology], 2 (71), 68-71. (In Russ.)</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B5">
    <label>5.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Зорина, О. А. Микробиоценоз полости рта в норме и при воспалительных заболеваниях пародонта / О. А. Зорина, А. А. Кулаков, А. И. Грудянов // Стоматология. - 2011. - № 1. - С. 73-78.</mixed-citation>
     <mixed-citation xml:lang="en">Zorina, O. A., Kulakov, A. A., Grudyanov, A. I. (2011). Mikrobiotsenoz polosti rta v norme i pri vospalitel'nykh zabolevaniyakh parodonta [Microbiocenosis of the oral cavity in normal and inflammatory periodontal diseases]. Stomatologiya [Dentistry], 1, 73-78. (In Russ.)</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B6">
    <label>6.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Кузьмина, И. Н. Опыт применения комплекса лечебно-профилактических средств для профилактики стоматологических заболеваний / И. Н. Кузьмина, А. В. Лапатина // Dental Forum. - 2009. - № 2. - С. 33-39.</mixed-citation>
     <mixed-citation xml:lang="en">Kuz'mina, I. N., Lapatina, A. V. (2009). Opyt primeneniya kompleksa lechebno-profilakticheskikh sredstv dlya profilaktiki stomatologicheskikh zabolevaniy [Experience in the use of complex therapeutic and prophylactic agents for the prevention of dental diseases]. Dental Forum [Dental Forum], 2, 33-39. (In Russ.)</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B7">
    <label>7.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Кунин, А. А. Эффективность включения в схему комплексного подбора средств гигиены при начальных формах воспалительных заболеваний пародонта ферментосодержащих зубных паст / А. А. Кунин, А. Н. Коровкина, О. И. Олейник // Институт Стоматологии. - 2012. - № 1. - С. 62-64.</mixed-citation>
     <mixed-citation xml:lang="en">Kunin, A. A., Korovkina, A. N., Oleynik, O. I. (2012). Effektivnost' vklyucheniya v skhemu kompleksnogo podbora sredstv gigiyeny pri nachal'nykh formakh vospalitel'nykh zabolevaniy parodonta fermentosoderzhashchikh zubnykh past [The effectiveness of the inclusion in the scheme of a comprehensive selection of hygiene products in the initial forms of inflammatory periodontal diseases of enzyme-containing toothpastes]. Institut Stomatologii [Institute of Dentistry], 1, 62-64. (In Russ.)</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B8">
    <label>8.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Леус, П. А. Микробный биофильм на зубах. Физиологическая роль и патогенное значение / П. А. Леус // Стоматологический журнал. - 2007. - № 2. - С. 100-111.</mixed-citation>
     <mixed-citation xml:lang="en">Leus, P. A. (2007). Mikrobnyy biofil'm na zubakh. Fiziologicheskaya rol' i patogennoye znacheniye [Microbial biofilm on the teeth. Physiological role and pathogenic value]. Stomatologicheskiy zhurnal [Dental Journal], 2, 100-111. (In Russ.)</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B9">
    <label>9.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Павлович, С. А. Микробиология с вирусологией и иммунологией : учеб. пособие / С. А. Павлович. - 3-е изд., испр. - Минск : Вышэйшая школа, 2013. - 799 с.</mixed-citation>
     <mixed-citation xml:lang="en">Pavlovich, S. A. (2013). Mikrobiologiya s virusologiyey i immunologiyey : ucheb. posobiye [Microbiology with virology and immunology : studies. manual]. Minsk : Higher School, 3, 799. (In Russ.)</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B10">
    <label>10.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Тарико, О. С. Влияние гигиенических средств на микробный состав полости рта у пациентов с пародонтитом средней или тяжелой степени, пользующихся комби нированными шинирующими конструкциями / О. С. Тарико, С. Е. Жолудев // Проблемы стоматологии. - 2010. - № 2. - С. 48-52.</mixed-citation>
     <mixed-citation xml:lang="en">Tariko, O. S., Zholudev, S. Ye. (2010). Vliyaniye gigiyenicheskikh sredstv na mikrobnyy sostav polosti rta u patsiyentov s parodontitom sredney ili tyazheloy stepeni, pol'zuyushchikhsya kombi nirovannymi shiniruyushchimi konstruktsiyami [The effect of hygiene products on the microbial composition of the oral cavity in patients with moderate to severe periodontitis using a combination splinting structure]. Problemy stomatologii [Dentistry problems], 2, 48-52. (In Russ.)</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B11">
    <label>11.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Теблоева, Л. М. Факторы риска развития хронического генерализованного пародонтита / Л. М. Теблоева, К. Г. Гуревич // Институт стоматологии. - 2014. - № 2. - С. 54-56.</mixed-citation>
     <mixed-citation xml:lang="en">Tebloyeva, L. M., Gurevich, K. G. (2014). Faktory riska razvitiya khronicheskogo generalizovannogo parodontita [Risk factors for the development of chronic generalized periodontitis]. Institut stomatologii [Institute of Dentistry], 2, 54-56. (In Russ.)</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B12">
    <label>12.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Yaseen, A. A. Limited Evidence Suggests High Risk of Implant Failure Rates Among People With Generalized Aggressive Periodontitis / A. A. Yaseen, R. S. Algabri // Journal of Evidence Based Dental Practice. - 2015. - Vol. 15, № 4. - P. 187-189.</mixed-citation>
     <mixed-citation xml:lang="en">Yaseen, A., Algabri, R. S. (2015). Limited Evidence Suggests High Risk of Implant Failure Rates Among People With Generalized Aggressive Periodontitis. Journal of Evidence Based Dental Practice, 15, 4, 187-189.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B13">
    <label>13.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Dorri, M. Modelling the factors influencing general and oral hygiene behaviours in adolescents / M. Dorri, A. Sheiham, R. G. Watt // International Journal of Paediatric Dentistry. - 2010. - Vol. 20 (4). - P. 261-269.</mixed-citation>
     <mixed-citation xml:lang="en">Dorri, M., Sheiham, A., Watt, R. G. (2010). Modelling the factors influencing general and oral hygiene behaviours in adolescents. International Journal of Paediatric Dentistry, 20 (4), 261-269.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B14">
    <label>14.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Eke, P. I. Periodontal Disease Surveillance workgroup. James Beck (University of North Carolina, Chapel Hill, USA), Gordon Douglass (Past President, American Academy of Periodontology), Roy Page (University of Washington). Prevalence of periodontitis in adults in the United States: 2009 and 2010 / P. I., B. A. Dye, L. Wei // J Dent Res. - 2012. - P. 914-920.</mixed-citation>
     <mixed-citation xml:lang="en">Eke, P. I., Dye, B. A., Wei, L. (2012). Periodontal Disease Surveillance workgroup. James Beck (University of North Carolina, Chapel Hill, USA), Gordon Douglass (Past President, American Academy of Periodontology), Roy Page (University of Washington). Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Dent Res, 914-920.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B15">
    <label>15.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Hampton-Marcell, J. T. The Human Microbiome: An Emerging Tool in Forensics / J. T. Hampton-Marcell, J. V. Lopez,  J. A. Gilbert // Microbial Biotechnology. - 2017. - Vol. 10, № 2. - P. 228-230.</mixed-citation>
     <mixed-citation xml:lang="en">Hampton-Marcell, J. T., Lopez, J. V., Gilbert, J. A. (2017). The Human Microbiome: An Emerging Tool in Forensics. Microbial Biotechnology, 10, 2, 228-230.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B16">
    <label>16.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Non-surgical periodontal therapy with systemic antibiotics in patients with untreated aggressive periodontitis: A systematic review and meta-analysis / J. A. Keestra, I. Grosjean, W. Coucke, M.  Quirynen, W. Teughels // J. Periodontal Res.  - 2015. - Vol. 50. - P. 689-706.</mixed-citation>
     <mixed-citation xml:lang="en">Keestra, J. A., Grosjean, I., Coucke, W., Quirynen, M., Teughels, W. (2015). Non-surgical periodontal therapy with systemic antibiotics in patients with untreated aggressive periodontitis: A systematic review and meta-analysis. J. Periodontal Res, 50, 689-706.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B17">
    <label>17.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Influence of low direct electric currents and chlorhexidine upon human dental biofilms / J. F. Lasserre, S. Toma, T. Bourgeois, H.  El Khatmaoui, E. Marichal, M. C. Brecx // Clin. Exp. Dent. Res.  - 2016. - № 2. - P. 146-154.</mixed-citation>
     <mixed-citation xml:lang="en">Lasserre, J. F., Toma, S., Bourgeois, T., El Khatmaoui, H., Marichal, E., Brecx, M. C. (2016). Influence of low direct electric currents and chlorhexidine upon human dental biofilms. Clin. Exp. Dent. Res, 2, 146-154.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B18">
    <label>18.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Kinane, D. F. Periodontal diseases / D. F. Kinane, P. G. Stathopoulou , P. N. Papapanou // Nature Reviews Disease Primers. - 2017. - Vol. 22 (3). - P. 225-237.</mixed-citation>
     <mixed-citation xml:lang="en">Kinane, D. F., Stathopoulou, P. G., Papapanou, P. N. (2017). Periodontal diseases. Nature Reviews Disease Primers, 22 (3), 225-237.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B19">
    <label>19.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Marsh, P. D. Contemporary perspective on plaque control / P. D. Marsh // British Dental Journal. - 2012. - Vol. 212. - P. 601-606.</mixed-citation>
     <mixed-citation xml:lang="en">Marsh, P. D. (2012). Contemporary perspective on plaque control. British Dental Journal,  212, 601-606.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B20">
    <label>20.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Generalized Aggressive Periodontitis as a Risk Factor for Dental Implant Failure: A Systematic Review and Meta-Analysis / A. Monje, G. Alcoforado, M. Padial-Molina, F. Suarez, G.-H. Lin, H.-L. Wang // Journal of Periodontology. - 2014. - Vol. 85, № 10. - P. 1398-1407.</mixed-citation>
     <mixed-citation xml:lang="en">Monje, A., Alcoforado, G., Padial-Molina, M., Suarez, F., Lin, G.-H., Wang, H.-L. (2014). Generalized Aggressive Periodontitis as a Risk Factor for Dental Implant Failure: A Systematic Review and Meta-Analysis. Journal of Periodontology, 85, 10, 1398-1407.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B21">
    <label>21.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Inflammatory bowel disease and oral health: systematic review and a meta-analysis / S. N. Papageorgiou, M. Hagner, A. V. B. Nogueira, A. Franke, A. Jäger, J. Deschner // Journal of Clinical Periodontology. - 2017. - Vol. 44 (4). - P. 382-393.</mixed-citation>
     <mixed-citation xml:lang="en">Papageorgiou, S. N., Hagner, M., Nogueira, A. V. B., Franke, A., Jäger, A., Deschner, J. (2017). Inflammatory bowel disease and oral health: systematic review and a meta-analysis. Journal of Clinical Periodontology, 44 (4), 382-393.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B22">
    <label>22.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Schonfeld, S. E. Strategies for managing periodontal inflammation / S. E. Schonheld  // J.Calif. Dent. Assoc. - 2010. - Vol. 38 (4). - P. 272-283.</mixed-citation>
     <mixed-citation xml:lang="en">Schonfeld, S. E. (2010). Strategies for managing periodontal inflammation. J.Calif. Dent. Assoc, 38 (4), 272-283.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B23">
    <label>23.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">A chlorhexidine-loaded biodegradable cellulosic device for periodontal pockets treatment / N. Tabary, F. Chai, N. Blanchemain, C. Neut, L. Pauchet, S. Bertini, E. Delcourt-Debruyne, H. F. Hildebrand, B. Martel // Acta Biomater. - 2014. - № 10 (1). - P. 318-129.</mixed-citation>
     <mixed-citation xml:lang="en">Tabary, N., Chai, F., Blanchemain, N., Neut, C., Pauchet, L., Bertini, S., Delcourt-Debruyne, E., Hildebrand, H. F., Martel, B. (2014). A chlorhexidine-loaded biodegradable cellulosic device for periodontal pockets treatment. Acta Biomater, 10 (1), 318-329.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B24">
    <label>24.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Alcohol consumption and risk of periodontitis: a meta-analysis / J. Wang, W. Wang [et al.] // Journal of Clinical Periodontology. - 2016. - Vol. 43 (7). - P. 572-583.</mixed-citation>
     <mixed-citation xml:lang="en">Wang, J., Wang, W., Jiang, X. et al. (2016). Alcohol consumption and risk of periodontitis: a meta-analysis. Journal of Clinical Periodontology, 43 (7), 572-583.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B25">
    <label>25.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Racial and Ethnic Differences in Self-Reported Periodontal Disease in the Multi-Ethnic Study of Atherosclerosis (MESA) / D. J. Weatherspoon, L. N., Borrell, C. W. Johnson, S. Mahasin, H. W. Neighbors, S. D. Adar // Oral Health &amp; Preventive Dentistry. - 2016. - Vol. 14, № 3. - P. 249.</mixed-citation>
     <mixed-citation xml:lang="en">Weatherspoon, D. J., Borrell, L. N., Johnson, C. W., Mahasin, S. M,, Neighbors, H. W., Adar, S. D. (2016). Racial and Ethnic Differences in Self-Reported Periodontal Disease in the Multi-Ethnic Study of Atherosclerosis (MESA). Oral Health &amp; Preventive Dentistry, 14, 3, 249.</mixed-citation>
    </citation-alternatives>
   </ref>
  </ref-list>
 </back>
</article>
