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 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">Actual problems in dentistry</journal-id>
   <journal-title-group>
    <journal-title xml:lang="en">Actual problems in dentistry</journal-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Проблемы стоматологии</trans-title>
    </trans-title-group>
   </journal-title-group>
   <issn publication-format="print">2077-7566</issn>
   <issn publication-format="online">2412-9461</issn>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="publisher-id">30149</article-id>
   <article-id pub-id-type="doi">10.18481/2077-7566-2019-15-2-4-10</article-id>
   <article-categories>
    <subj-group subj-group-type="toc-heading" xml:lang="ru">
     <subject>ЛЕКЦИИ / ЛИТЕРАТУРНЫЕ ОБЗОРЫ</subject>
    </subj-group>
    <subj-group subj-group-type="toc-heading" xml:lang="en">
     <subject>LITERATURE REVIEW</subject>
    </subj-group>
    <subj-group>
     <subject>ЛЕКЦИИ / ЛИТЕРАТУРНЫЕ ОБЗОРЫ</subject>
    </subj-group>
   </article-categories>
   <title-group>
    <article-title xml:lang="en">ANTIBIOTIC PROPHYLAXIS OF INFECTIVE ENDOCARDITIS IN DENTISTRY</article-title>
    <trans-title-group xml:lang="ru">
     <trans-title>АНТИБИОТИКОПРОФИЛАКТИКА ИНФЕКЦИОННОГО ЭНДОКАРДИТА НА СТОМАТОЛОГИЧЕСКОМ ПРИЕМЕ</trans-title>
    </trans-title-group>
   </title-group>
   <contrib-group content-type="authors">
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Гайсина</surname>
       <given-names>Елена Фахаргалеевна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Gaysina</surname>
       <given-names>Elena F.</given-names>
      </name>
     </name-alternatives>
     <email>egaisina68@mail.ru</email>
     <bio xml:lang="ru">
      <p>кандидат медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>candidate of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Еловикова</surname>
       <given-names>Татьяна Михайловна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Elovicova</surname>
       <given-names>Tat'yana Mihaylovna</given-names>
      </name>
     </name-alternatives>
     <email>ugma-elovik@yandex.ru</email>
     <bio xml:lang="ru">
      <p>доктор медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>doctor of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-2"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Изможерова</surname>
       <given-names>Надежда Владимировна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Izmozherova</surname>
       <given-names>Nadezhda Vladimirovna</given-names>
      </name>
     </name-alternatives>
     <bio xml:lang="ru">
      <p>доктор медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>doctor of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-3"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Мотоусова</surname>
       <given-names>Софья Александровна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Motousova</surname>
       <given-names>Sof'ya Aleksandrovna</given-names>
      </name>
     </name-alternatives>
     <email>missmotousova@mail.ru</email>
     <xref ref-type="aff" rid="aff-4"/>
    </contrib>
   </contrib-group>
   <aff-alternatives id="aff-1">
    <aff>
     <institution xml:lang="ru">ФГБОУ ВО «Уральский государственный медицинский университет» Минздрава России</institution>
     <city>Екатеринбург</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Ural State Medical University</institution>
     <city>Ekaterinburg</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-2">
    <aff>
     <institution xml:lang="ru">Уральский государственный медицинский университет</institution>
    </aff>
    <aff>
     <institution xml:lang="en">Ural State Medical University</institution>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-3">
    <aff>
     <institution xml:lang="ru">ФГБОУ ВО &quot;Уральский государственный медицинский университет&quot; Минздрава России</institution>
     <city>Екатеринбург</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Ural State Medical University</institution>
     <city>Ekaterinburg</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-4">
    <aff>
     <institution xml:lang="ru">ФГБОУ ВО Уральский Государственный Медицинский Университет Минздрава России</institution>
     <city>Екатеринбург</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Federal State Budget Educational Institution of Higher Education &quot;URAL STATE MEDICAL UNIVERSITY&quot; OF THE MINISTRY OF HEALTH OF THE RUSSIAN FEDERATION</institution>
     <city>Yekaterinburg</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <volume>15</volume>
   <issue>2</issue>
   <fpage>4</fpage>
   <lpage>10</lpage>
   <self-uri xlink:href="https://dental-press.ru/en/nauka/article/30149/view">https://dental-press.ru/en/nauka/article/30149/view</self-uri>
   <abstract xml:lang="ru">
    <p>Предмет. Инфекционный эндокардит является заболеванием с тяжелым течением и имеющим риск инвалидизации и высокой смертности. Он может стать грозным осложнением как после общехирургических, так и стоматологических инвазивных процедур. Проблема инфекционного эндокардита актуальна в большинстве стран мира, что обуславливает необходимость адресного проведения его профилактики при стоматологических вмешательствах. Важнейшим патогенетическим компонентом этого заболевания является транзиторная бактериемия, развивающаяся при повреждении кожи и слизистой оболочки полости рта под влиянием различных травмирующих агентов. Предупредить и снизить риск возникновения инфекционного эндокардита помогает антибиотикопрофилактика. &#13;
Цель ― выявление и анализ наиболее эффективных методов антибиотикопрофилактики инфекционного эндокардита на стоматологическом приеме.&#13;
Методология. Проведен обзор публикаций отечественных и зарубежных исследований с использованием научных поисковых библиотечных баз данных: PubMed, Medline, Cochrane, Elibrary. Всего найдено 38 публикаций из России, США, Германии, Иордании, Саудовской Аравии, Сингапура, Японии и других стран.&#13;
Результаты. В обзоре рассмотрены исследования-анкетирования людей, клинические исследования с «двойным ослеплением», публикации патентов, раскрывающие отношение к антибиотикопрофилактике инфекционного эндокардита на стоматологическом приеме в мире, а также проанализированы выбор препаратов и схемы их использования. &#13;
Выводы. Наиболее предпочтительным вариантом является проведение антибиотикопрофилактики заболевания у лиц с высоким фактором риска: с протезами клапанов сердца, врожденными пороками сердца и инфекционным эндокардитом в анамнезе. Современные исследования свидетельствуют о большей эффективности применения амоксициллина в комбинации с клавулановой кислотой, чем незащищенного амоксициллина.</p>
   </abstract>
   <trans-abstract xml:lang="en">
    <p>Background. Infective endocarditis is a serious disease and has the risk of disability and high mortality. This disease can be a terrible complication of both general surgical and dental invasive procedures. The problem of infective endocarditis is relevant in most countries of the world, which determine the need for targeted prevention of dental interventions. The most important pathogenetic component of this disease is transient bacteremia, which develops when the skin and mucous membrane of the oral cavity are damaged under the influence of various traumatic agents. Antibiotic prophylaxis prevents of infective endocarditis and helps to reduce the risk.&#13;
Objectives ― to identify and analyze the most effective methods of antibiotic prophylaxis of IE at the dental admission.&#13;
Methodology. A review of literature - publications of domestic and foreign studies using the scientific search library databases PubMed, Medline, Cochrane, Elibrary. Total found 38 publications from Russia, USA, Germany, Jordan, Saudi Arabia, Singapore, Japan and other countries.&#13;
Results. The review examines studies - questioning people, clinical studies with &quot;double glare&quot;, publication of patents, revealing the attitude to antibiotic prophylaxis of infective endocarditis at a dental reception in the world, and also analyzed the choice of drugs and their use.&#13;
Conclusions. The most preferred option is to carry out antibiotic prophylaxis of the disease in people with a high risk factor, which include patients with prosthetic heart valves, congenital heart defects and patients with a history of infectious endocarditis. The drug of choice among antibacterial agents is the use of amoxicillin / clavulanic acid combination.</p>
   </trans-abstract>
   <kwd-group xml:lang="ru">
    <kwd>инфекционный эндокардит</kwd>
    <kwd>осложнение</kwd>
    <kwd>антибиотики</kwd>
    <kwd>профилактика</kwd>
    <kwd>стоматологическое вмешательство</kwd>
   </kwd-group>
   <kwd-group xml:lang="en">
    <kwd>infectious endocarditis</kwd>
    <kwd>complication</kwd>
    <kwd>antibiotics</kwd>
    <kwd>prevention</kwd>
    <kwd>dental intervention</kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <p></p>
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