ВЛИЯНИЕ ИММУНОМОДУЛИРУЮЩЕЙ ТЕРАПИИ НА КЛЕТОЧНЫЙ СОСТАВ ДЕСНЕВОЙ ЖИДКОСТИ ЛИЦ ПОЖИЛОГО ВОЗРАСТА, СТРАДАЮЩИХ ПАРОДОНТИТОМ
Аннотация и ключевые слова
Аннотация (русский):
Background. The article shows the problem of clinical laboratory diagnostics optimization in gerontodentistry as well as urgency of immunomodulation in periodontology. Gingival fluid, having a lot of cell constituents, was used to evaluate the immune status of elderly patients. The laboratory parameter “E:N:L” is associated with a degree of inflammation manifestation in parodontium, that can be used for treatment efficacy estimating. Authors suggested Polyoxidonium for immunomodulation, promoting faster immune and clinical recovery compared to conventional treatment modules. Objectives. Estimation of “E:N:L” changes in gingival fluid, depending on immunomodulation, added to the treatment regimen of elderly patients with periodontitis. Methods. 2 patient cohorts of 64 elderly persons with chronic generalized periodontitis were examined. All patients were administered the conventional treatment. But the patients in the second cohort, along with other medications, recieved Polyoxidonium. The examination included gingival fluid sampling (according to Chukaeva N.A.), estimation of “E:N:L” changes in the course of treatment. Results. The study revealed the “E:N:L” disbalance in gingival fluid. The recovery trend was noticed in both cohorts, with a more marked dynamics in the second group. Mean values of “E:N:L” in this clinical group were statistically valid compared to similar measures in the first one. By the 21th day mean values of “E:N:L” nearly reached the normal values and continued to stabilize up to the 30th day. But in the first cohort normal mean values of “E:N:L” were discovered only after 1 month. Hereafter (by the 3th month) the percentage of neutrophils and lymphocytes increased and the fraction of epithelial cells decreased. This trend was more statistically reliable in the second clinical group. Conclusions. The implementation of immunomodulating drug Polyoxidonium into the periodontitis conventional treatment protocol promotes the effectiveness of therapeutic intervention, upregulating prompt and stable “E:N:L” immune recovery, compared to conventional treatment protocols.

Ключевые слова:
periodontitis, gingival fluid, E:N:L, Polyoxidonium, immunomodulation
Список литературы

1. Bykov V.L. Gistologija i jembrional’noe razvitie organov polosti rta cheloveka [Histology and embryogenesis of the human oral cavity]. Moscow, GJeOTARMedia, 2014, 624 p.

2. Krajnov S.V., Mihal’chenko V.F., Jakovlev A.T., Popova A.N., Alehanova I.F. [Depth of the periodontal pockets or «attachment loss», which parameter to select in gerontostomatology?]. Problemy stomatologii = The Problema of Dentistry, 2017, vol. 13, no. 4, pp. 9–14. (In Russ.)

3. Iordanishvili A.K. et al. Lechenie parodontita v pozhilom i starcheskom vozraste [Treating periodontitis in elderly patients]. SPb, MANJeB-Nordmedizdat, 2011, 128 p.

4. Masternak Ju.A., Luss L.V. [The influence of polyoxdonium on parameters of immunity in elderly patients]. Immunologija = The Immunology, 2002, vol. 23, no. 6, pp. 343–346. (In Russ.)

5. Dmitrieva L.A. Parodontologija: nacional’noe rukovodstvo [Periodontology: The National guidebook]. Moscow, GJeOTAR-Media, 2014, 704 p.

6. Pinegin B.V., Nekrasov A.V., Haitov R.M. [Immunomodulator polyoxidonium: mechanisms of action and aspects of clinical application]. Citokiny i vospalenie = Cytokines & inflammation, 2004, vol. 3, no. 3, pp. 41–47. (In Russ.)

7. Cybikov N.N. et al. [The properties of the gingival fluid from the patients presenting with acute gingivitis and chronic periodontitis]. Ros. stomat. Zhurnal = Russian Journal of Dentistry, 2012, no. 1, pp. 40–42. (In Russ.)

8. Iordanishvili A.K. et al. [The stomatologic status of people of elderly and senile age]. Uspehi gerontologii = Advances in Gerontology, 2010, vol. 23, no. 4, pp. 644–651. (In Russ.)

9. Cepov L.M. Zabolevanija parodonta: vzgljad na problem [Periodontal diseases: look at an issue]. Moscow, MEDpress-inform, 2006, 192 p.

10. United Nations. Problems of the elderly and the agrd. Draft programme andarrangements for the World Assembly on the Elderly: report of the Secretary General. New York, 2011, 72 p.


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