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 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">Actual problems in dentistry</journal-id>
   <journal-title-group>
    <journal-title xml:lang="en">Actual problems in dentistry</journal-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Проблемы стоматологии</trans-title>
    </trans-title-group>
   </journal-title-group>
   <issn publication-format="print">2077-7566</issn>
   <issn publication-format="online">2412-9461</issn>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="publisher-id">124578</article-id>
   <article-id pub-id-type="doi">10.18481/2077-7566-2026-22-2-44-54</article-id>
   <article-categories>
    <subj-group subj-group-type="toc-heading" xml:lang="ru">
     <subject>ПАРОДОНТОЛОГИЯ. ОБЗОРЫ ЛИТЕРАТУРЫ</subject>
    </subj-group>
    <subj-group subj-group-type="toc-heading" xml:lang="en">
     <subject>PERIODONTAL DISEASES. REVIEWS</subject>
    </subj-group>
    <subj-group>
     <subject>ПАРОДОНТОЛОГИЯ. ОБЗОРЫ ЛИТЕРАТУРЫ</subject>
    </subj-group>
   </article-categories>
   <title-group>
    <article-title xml:lang="en">BIDIRECTIONAL RELATIONSHIP BETWEEN PERIODONTITIS AND SOMATIC PATHOLOGY: FROM SYSTEMIC INFLAMMATION TO CLINICAL PROGNOSIS</article-title>
    <trans-title-group xml:lang="ru">
     <trans-title>ДВУНАПРАВЛЕННАЯ ВЗАИМОСВЯЗЬ ПАРОДОНТИТА И СОМАТИЧЕСКОЙ ПАТОЛОГИИ: ОТ СИСТЕМНОГО ВОСПАЛЕНИЯ К КЛИНИЧЕСКОМУ ПРОГНОЗУ</trans-title>
    </trans-title-group>
   </title-group>
   <contrib-group content-type="authors">
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Бражникова</surname>
       <given-names>Анна Николаевна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Brazhnikova</surname>
       <given-names>Anna N.</given-names>
      </name>
     </name-alternatives>
     <email>annbrazhnikova@yandex.ru</email>
     <bio xml:lang="ru">
      <p>кандидат медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>candidate of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Долгалев</surname>
       <given-names>Александр Анатольевич</given-names>
      </name>
      <name xml:lang="en">
       <surname>Dolgalev</surname>
       <given-names>Aleksandr Anatol'evich</given-names>
      </name>
     </name-alternatives>
     <email>dolgalev1@mail.ru</email>
     <bio xml:lang="ru">
      <p>доктор медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>doctor of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-2"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Эм</surname>
       <given-names>Александра Викторовна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Em</surname>
       <given-names>Alexandra V.</given-names>
      </name>
     </name-alternatives>
     <email>Alexandra.Em.Work@gmail.com</email>
     <bio xml:lang="ru">
      <p>кандидат медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>candidate of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-3"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Гарус</surname>
       <given-names>Яна Николаевна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Garus</surname>
       <given-names>Yana N.</given-names>
      </name>
     </name-alternatives>
     <email>doctor_garus@mail.ru</email>
     <bio xml:lang="ru">
      <p>доктор медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>doctor of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-4"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Лавриненко</surname>
       <given-names>Екатерина Дмитриевна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Lavrinenko</surname>
       <given-names>Ekaterina D.</given-names>
      </name>
     </name-alternatives>
     <email>lavrinenko.k99@mail.ru</email>
     <xref ref-type="aff" rid="aff-5"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Хейгетян</surname>
       <given-names>Артур Вараздатович</given-names>
      </name>
      <name xml:lang="en">
       <surname>Heigetyan</surname>
       <given-names>Artur Varazdatovich</given-names>
      </name>
     </name-alternatives>
     <email>artur5953@yandex.ru</email>
     <bio xml:lang="ru">
      <p>кандидат медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>candidate of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-6"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Хорев</surname>
       <given-names>Олег Юрьевич</given-names>
      </name>
      <name xml:lang="en">
       <surname>Khorev</surname>
       <given-names>Oleg Yu.</given-names>
      </name>
     </name-alternatives>
     <email>bezrodnova.s@yandex.ru</email>
     <bio xml:lang="ru">
      <p>кандидат медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>candidate of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-7"/>
    </contrib>
   </contrib-group>
   <aff-alternatives id="aff-1">
    <aff>
     <institution xml:lang="ru">Ставропольский государственный медицинский университет</institution>
     <city>Ставрополь</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Stavropol State Medical University</institution>
     <city>Stavropol</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-2">
    <aff>
     <institution xml:lang="ru">Ставропольский государственный медицинский университет</institution>
     <city>Ставрополь</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Stavropol State Medical University</institution>
     <city>Stavropol</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-3">
    <aff>
     <institution xml:lang="ru">Ставропольский государственный медицинский университет</institution>
     <city>Ставрополь</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Stavropol State Medical University</institution>
     <city>Stavropol</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-4">
    <aff>
     <institution xml:lang="ru">Ставропольский государственный медицинский университет</institution>
     <city>Ставрополь</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Stavropol State Medical University</institution>
     <city>Stavropol</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-5">
    <aff>
     <institution xml:lang="ru">Ставропольский государственный медицинский университет</institution>
     <city>Ставрополь</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Ставропольский государственный медицинский университет</institution>
     <city>Ставрополь</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-6">
    <aff>
     <institution xml:lang="ru">Ростовский государственный медицинский университет</institution>
    </aff>
    <aff>
     <institution xml:lang="en">Rostov State Medical University</institution>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-7">
    <aff>
     <institution xml:lang="ru">Ставропольский государственный медицинский университет</institution>
     <city>Ставрополь</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Stavropol State Medical University</institution>
     <city>Stavropol</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <pub-date publication-format="print" date-type="pub" iso-8601-date="2026-06-29T19:24:06+03:00">
    <day>29</day>
    <month>06</month>
    <year>2026</year>
   </pub-date>
   <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2026-06-29T19:24:06+03:00">
    <day>29</day>
    <month>06</month>
    <year>2026</year>
   </pub-date>
   <volume>22</volume>
   <issue>2</issue>
   <fpage>44</fpage>
   <lpage>54</lpage>
   <history>
    <date date-type="received" iso-8601-date="2026-05-27T00:00:00+03:00">
     <day>27</day>
     <month>05</month>
     <year>2026</year>
    </date>
   </history>
   <self-uri xlink:href="https://dental-press.ru/en/nauka/article/124578/view">https://dental-press.ru/en/nauka/article/124578/view</self-uri>
   <abstract xml:lang="ru">
    <p>Предмет исследования — двунаправленная взаимосвязь пародонтита и соматической патологии, рассматриваемая через призму хронического системного воспаления как общего патофизиологического механизма.&#13;
Цель — систематизация современных представлений о механизмах взаимного влияния пародонтита и соматических заболеваний и оценка их клинического значения для прогнозирования и планирования стоматологического лечения.&#13;
Методология. Работа выполнена в формате обзора литературы с основе анализа 52 отечественных и зарубежных источников, опубликованных в период с 2018 по 2026 годы. Проведена оценка данных о патогенезе пародонтита, системных эффектах хронического воспаления, роли соматической коморбидности и влиянии медикаментозной терапии на ткани пародонта.&#13;
Результаты. Установлено, что пародонтит представляет собой не только локальное воспалительное заболевание, но и источник системной иммуновоспалительной активации. Показано, что хроническое воспаление в тканях пародонта сопровождается поступлением в системный кровоток микробных факторов и медиаторов воспаления, способствуя развитию эндотелиальной дисфункции и метаболических нарушений. Выявлено, что соматическая патология, включая сердечно-сосудистые заболевания, сахарный диабет и метаболические нарушения, усиливает воспалительно-деструктивные процессы в пародонте и ухудшает клинический прогноз. Обосновано формирование замкнутого патогенетического контура, в котором локальные и системные воспалительные реакции взаимно потенцируют друг друга.&#13;
Выводы. Пародонтит следует рассматривать как компонент общей воспалительной патологии организма. Двунаправленный характер его взаимосвязи с соматическими заболеваниями определяет необходимость комплексного подхода к ведению пациентов с учетом системного статуса. Учет соматической коморбидности и воспалительного фона позволяет повысить точность прогноза и эффективность стоматологического лечения.</p>
   </abstract>
   <trans-abstract xml:lang="en">
    <p>Subject. The subject of the study is the bidirectional relationship between periodontitis and somatic pathology, considered through the lens of chronic systemic inflammation as a common pathophysiological mechanism.&#13;
Objectives. To systematize current concepts regarding the mechanisms of mutual influence between periodontitis and somatic diseases and to assess their clinical significance for prognosis and planning of dental treatment.&#13;
Methodology. The work is presented in the form of a literature review, analyzing 52 published sources published between 2018 and 2026. Data on the pathogenesis of periodontitis, systemic effects of chronic inflammation, the role of somatic comorbidity, and the impact of pharmacotherapy on periodontal tissues were evaluated.&#13;
Results. It was established that periodontitis is not only a local inflammatory disease but also a source of systemic immune-inflammatory activation. Chronic inflammation in periodontal tissues is associated with the entry of microbial factors and inflammatory mediators into the systemic circulation, contributing to endothelial dysfunction and metabolic disturbances. Somatic pathology, including cardiovascular diseases, diabetes mellitus, and metabolic disorders, was shown to enhance inflammatory-destructive processes in periodontal tissues and worsen clinical prognosis. The formation of a closed pathogenic loop was substantiated, in which local and systemic inflammatory reactions mutually potentiate each other.&#13;
Conclusion. Periodontitis should be considered as a component of systemic inflammatory pathology. The bidirectional nature of its relationship with somatic diseases determines the need for an integrated approach to patient management, taking into account systemic status. Consideration of somatic comorbidity and inflammatory status allows for improved prognostic accuracy and increased effectiveness of dental treatment.</p>
   </trans-abstract>
   <kwd-group xml:lang="ru">
    <kwd>пародонтит</kwd>
    <kwd>соматическая патология</kwd>
    <kwd>системное воспаление</kwd>
    <kwd>эндотелиальная дисфункция</kwd>
    <kwd>коморбидность</kwd>
    <kwd>клинический прогноз</kwd>
    <kwd>патогенез</kwd>
    <kwd>двунаправленная взаимосвязь</kwd>
   </kwd-group>
   <kwd-group xml:lang="en">
    <kwd>periodontitis</kwd>
    <kwd>somatic pathology</kwd>
    <kwd>systemic inflammation</kwd>
    <kwd>endothelial dysfunction</kwd>
    <kwd>comorbidity</kwd>
    <kwd>clinical prognosis</kwd>
    <kwd>pathogenesis</kwd>
    <kwd>bidirectional relationship</kwd>
   </kwd-group>
  </article-meta>
 </front>
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