Sorption-applicative therapy in purulent-inflammatory diseases of the maxillofacial region is a promising direction that increases the effectiveness of traditional methods in this pathology. The aim is to study the dynamics of clinical and hematological parameters in rats with experimental submandibular phlegmon on the background of sorption-application therapy. Methodology. An experimental study of the effectiveness of sorption-application therapy with plant cellulose sorbent in case of submandibular phlegmon was conducted on 40 male Wistar rats. All the rats were divided into groups. The first group is an intact control group, without pathology modeling. Rats of the second, third and fourth groups underwent induction of submandibular phlegmon. Statistical processing of the digital experimental material was carried out using the Microsoft Excel program; Student's t-test was used to determine the significance of differences. Results. It has been established that in the first days of distress, there are changes in the clinical condition of the animals and a decrease in body weight. In the treatment of induced phlegmon, the best therapeutic effect is achieved with combined local sorption-application therapy compared to antimicrobial monotherapy, which is confirmed by a positive change in the clinical condition and leukocyte response in the animals of these groups. There were no significant differences in biochemical parameters in the animals that received different treatments. Conclusions. An increase in cases of purulent-inflammatory lesions of soft tissues and local infectious complications associated with an increase in the resistance of pathogenic microorganisms to antibacterial drugs and a weakening of the body's immune forces determines the urgency of developing new non-medicinal products for local wound therapy. This includes the creation of a variety of improved sorption materials capable of having a targeted effect on the dynamics of the wound process [6].