Actual problems in dentistry Actual problems in dentistry Проблемы стоматологии 2077-7566 2412-9461 89353 10.18481/2077-7566-2024-20-4-55-59 ЛЕКЦИИ / ЛИТЕРАТУРНЫЕ ОБЗОРЫ LITERATURE REVIEW ЛЕКЦИИ / ЛИТЕРАТУРНЫЕ ОБЗОРЫ ADVANTAGES OF USING EXTRACELLULAR MATRIX GEL AND HYALURONIC ACID GEL IN THE CONTEXT OF PERIODONTITIS TREATMENT. LITERATURE REVIEW ПРЕИМУЩЕСТВА ИСПОЛЬЗОВАНИЯ ГЕЛЯ НА ОСНОВЕ ВНЕКЛЕТОЧНОГО МАТРИКСА И ГЕЛЯ НА ОСНОВЕ ГИАЛУРОНОВОЙ КИСЛОТЫ В КОНТЕКСТЕ ЛЕЧЕНИЯ ПАРОДОНТИТА. ОБЗОР ЛИТЕРАТУРЫ Рисованная Ольга Николаевна Risovannaya Olga N. dentrosa@mail.ru

доктор медицинских наук;

doctor of medical sciences;

 Андреасян Татев Шотаевна Andreasyan Tatev Sh. andreasyan1983@mail.ru Кубанский государственный медицинский университет Краснодар Россия Kuban State Medical University Krasnodar Russian Federation Стоматологическая клиника «Корона» Туапсе Россия «Corona» Dental Clinic Tuapse Russian Federation 28 12 2024 28 12 2024 20 4 55 59 10 12 2024 https://dental-press.ru/en/nauka/article/89353/view

Воспалительное заболевание пародонта — это заболевание, распространенное по всему миру, имеющее преимущественно бактериальную этиологию и характеризующееся дисрегуляцией воспалительного ответа хозяина. В настоящее время для лечения пародонтита используются гели на основе гиалуроновой кислоты (ГК), а также инновационный гель на основе внеклеточного матрикса. Он представляет собой многообещающий материал, используемый в регенеративной медицине, тканевой инженерии и других областях биомедицинских исследований. Внеклеточный матрикс является естественным компонентом тканей, обеспечивающим структурную поддержку клеткам и играющим ключевую роль в клеточной адгезии, пролиферации и дифференцировке. Использование гелей на основе внеклеточного матрикса (ВКМ) позволяет создать подходящее микроокружение для клеток, что способствует их функциональной активности и регенерации тканей. Цель статьи: изучение преимуществ гелей на основе внеклеточного матрикса (ВКМ) и геля на основе гиалуроновой кислоты (ГК) в контексте лечения воспалительного заболевания пародонта, а также исследование литературы. Материалы и методы. Для сравнительного анализа гидрогелей был проведен детальный анализ 35 источников литературы в электронных базах данных PubMed, eLibrary за последние 10 лет. Поиск не ограничен статьями, опубликованными на английском языке, использование ключевых слов «гиалуроновая кислота», «пародонтит» способствовало успешному поиску. В обзор были включены исследования, оценивающие эффективность и безопасность использования гидрогелей при лечении различных стоматологических заболеваний. Вывод. Гели на основе внеклеточного матрикса и гиалуроновой кислоты как инновационные технологии имеют значительный потенциал для улучшения исходов лечения различных заболеваний, ускоряя процесс восстановления пациентов.

Inflammatory periodontal disease is a worldwide disease of predominantly bacterial etiology characterized by dysregulation of the host inflammatory response. Currently, hyaluronic acid (HA)-based gels are used to treat periodontitis, as well as an innovative gel based on the extracellular matrix, which is a promising material used in regenerative medicine, tissue engineering and other areas of biomedical research. The extracellular matrix is a natural component of tissues that provides structural support to cells and plays a key role in cellular adhesion, proliferation and differentiation. The use of extracellular matrix (ECM)-based gels allows you to create a suitable microenvironment for cells, which promotes their functional activity and tissue regeneration. The purpose of the article. To study the benefits of extracellular matrix (ECM)-based gels and hyaluronic acid (HA)-based gels in the context of treating inflammatory periodontal disease, and to review the literature. Materials and methods: For comparative analysis of hydrogels, a detailed analysis of 35 literature sources in the electronic database PubMed, dLibrary for the last 10 years was carried out. The search is not limited to articles published in English, the use of keywords “hyaluronic acid”, “periodontitis” contributed to a successful search. The review included studies assessing the effectiveness and safety of using hydrogels in the treatment of various dental diseases. Conclusion: Gels based on extracellular matrix and hyaluronic acid as innovative technologies have significant potential for improving the treatment outcomes of various diseases, accelerating the recovery process of patients.

 гели на основе внеклеточного матрикса гиалуроновая кислота стоматология биосовместимый гель пародонтит биомиметики extracellular matrix-based gels hyaluronic acid dentistry biocompatible gel periodontitis biomimetics

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