<!DOCTYPE article
PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.4 20190208//EN"
       "JATS-journalpublishing1.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.4" xml:lang="en">
 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">Actual problems in dentistry</journal-id>
   <journal-title-group>
    <journal-title xml:lang="en">Actual problems in dentistry</journal-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Проблемы стоматологии</trans-title>
    </trans-title-group>
   </journal-title-group>
   <issn publication-format="print">2077-7566</issn>
   <issn publication-format="online">2412-9461</issn>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="publisher-id">64544</article-id>
   <article-id pub-id-type="doi">10.18481/2077-7566-2023-19-1-35-39</article-id>
   <article-categories>
    <subj-group subj-group-type="toc-heading" xml:lang="ru">
     <subject>ТЕРАПЕВТИЧЕСКАЯ СТОМАТОЛОГИЯ</subject>
    </subj-group>
    <subj-group subj-group-type="toc-heading" xml:lang="en">
     <subject>THERAPEUTIC  DENTISTRY</subject>
    </subj-group>
    <subj-group>
     <subject>ТЕРАПЕВТИЧЕСКАЯ СТОМАТОЛОГИЯ</subject>
    </subj-group>
   </article-categories>
   <title-group>
    <article-title xml:lang="en">EVALUATION OF QUALITATIVE, QUANTITATIVE AND ORGANOLEPTIC PROPERTIES OF NEW REMINERALIZING TOOTHPASTE</article-title>
    <trans-title-group xml:lang="ru">
     <trans-title>ОЦЕНКА КАЧЕСТВЕННЫХ, КОЛИЧЕСТВЕННЫХ И ОРГАНОЛЕПТИЧЕСКИХ ПАРАМЕТРОВ НОВОЙ ЗУБНОЙ ПАСТЫ С РЕМИНЕРАЛИЗУЮЩИМ КОМПОНЕНТОМ</trans-title>
    </trans-title-group>
   </title-group>
   <contrib-group content-type="authors">
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Еловикова</surname>
       <given-names>Татьяна Михайловна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Elovicova</surname>
       <given-names>Tat'yana Mihaylovna</given-names>
      </name>
     </name-alternatives>
     <email>ugma-elovik@yandex.ru</email>
     <bio xml:lang="ru">
      <p>доктор медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>doctor of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
    <contrib contrib-type="author">
     <contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1838-3535</contrib-id>
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Саблина</surname>
       <given-names>Светлана Николаевна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Sablina</surname>
       <given-names>Svetlana Nikolaevna</given-names>
      </name>
     </name-alternatives>
     <email>9122541494@mail.ru</email>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Григорьев</surname>
       <given-names>Сергей Сергеевич</given-names>
      </name>
      <name xml:lang="en">
       <surname>Griroriev</surname>
       <given-names>Sergey Sergeevich</given-names>
      </name>
     </name-alternatives>
     <email>sergeygrig28@gmail.com</email>
     <bio xml:lang="ru">
      <p>доктор медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>doctor of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Упорова</surname>
       <given-names>Наталья Андреевна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Uporova</surname>
       <given-names>Natal'ya Andreevna</given-names>
      </name>
     </name-alternatives>
     <bio xml:lang="ru">
      <p>кандидат медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>candidate of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Шимова</surname>
       <given-names>Маргарита Ефимовна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Shimova</surname>
       <given-names>Margarita Efimovna</given-names>
      </name>
     </name-alternatives>
     <email>fake@neicon.ru</email>
     <bio xml:lang="ru">
      <p>кандидат медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>candidate of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Чагай</surname>
       <given-names>Андрей Анатольевич</given-names>
      </name>
      <name xml:lang="en">
       <surname>Chagay</surname>
       <given-names>Andrey Anatol'evich</given-names>
      </name>
     </name-alternatives>
     <email>79226086649@yandex.ru</email>
     <bio xml:lang="ru">
      <p>кандидат медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>candidate of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Иванова</surname>
       <given-names>Валерия Владимировна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Ivanova</surname>
       <given-names>Valeria V.</given-names>
      </name>
     </name-alternatives>
     <email>9126193222@mail.ru</email>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
   </contrib-group>
   <aff-alternatives id="aff-1">
    <aff>
     <institution xml:lang="ru">Уральский государственный медицинский университет</institution>
    </aff>
    <aff>
     <institution xml:lang="en">Ural State Medical University</institution>
    </aff>
   </aff-alternatives>
   <pub-date publication-format="print" date-type="pub" iso-8601-date="2023-05-22T22:04:31+03:00">
    <day>22</day>
    <month>05</month>
    <year>2023</year>
   </pub-date>
   <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2023-05-22T22:04:31+03:00">
    <day>22</day>
    <month>05</month>
    <year>2023</year>
   </pub-date>
   <volume>19</volume>
   <issue>1</issue>
   <fpage>35</fpage>
   <lpage>39</lpage>
   <history>
    <date date-type="received" iso-8601-date="2023-05-18T00:00:00+03:00">
     <day>18</day>
     <month>05</month>
     <year>2023</year>
    </date>
   </history>
   <self-uri xlink:href="https://dental-press.ru/en/nauka/article/64544/view">https://dental-press.ru/en/nauka/article/64544/view</self-uri>
   <abstract xml:lang="ru">
    <p>Предмет исследования — лечебно-профилактическая зубная паста «DentaSwiss Enamel Repair &amp; Protect».&#13;
Цель исследования — оценка органолептических характеристик новой лечебно-профилактической зубной пасты «DentaSwiss Enamel Repair &amp; Protect», ее влияния на функциональную активность малых слюнных желез и слизистую оболочку полости рта.&#13;
Методология. Исследование проведено на кафедре терапевтической стоматологии и пропедевтики стоматологических заболеваний, на кафедре общей химии ФГБОУВО УГМУ Минздрава России. Обследовано 65 пациентов-добровольцев из числа студентов стоматологического факультета (юношей — 24, девушек — 41; средний возраст пациентов составил 21,25 ± 1,65 лет). Проводили исследование смешанной слюны по следующим параметрам: качественный анализ секрета —  характеристика цвета, прозрачности, определение включений, водородного показателя, функциональной активности малых слюнных желез, микрокристаллизации смешанной слюны. &#13;
Выводы. Высокий результат показали такие параметры зубной пасты «DentaSwiss Enamel Repair &amp; Protect» как вкус, «ощущение чистоты», «сенситивность» — 9,7 ± 0,3 балла. «DentaSwiss Enamel Repair &amp; Protect» обладает хорошими пенообразующими свойствами — 9,25 ± 0,75 балла. Это можно объяснить наличием поверхностно-активных веществ в ее составе. Параметр «отбеливающий эффект» оценен на 8,5 ± 1,5 балла. Результаты исследования применения зубной пасты «DentaSwiss Enamel Repair &amp; Protect» показали достоверное изменение значений водородного показателя, функциональной активности малых слюнных желез и микрокристаллизации смешанной слюны, что способствует увеличению реминерализующих свойств смешанной слюны и восстановлению эмали зубов. Органолептические свойства зубной пасты «DentaSwiss Enamel Repair &amp; Protect» высоко оценены участниками исследования по всем параметрам и составили в среднем 9,95 ± 0,05 балла.</p>
   </abstract>
   <trans-abstract xml:lang="en">
    <p>Subject. The subject of this study is “DentaSwiss Enamel Repair &amp; Protect” treatment-and-prophylactic toothpaste.&#13;
Objective. The purpose of this study is to evaluate organoleptic properties of the new “DentaSwiss Enamel Repair &amp; Protect” treatment-and-prophylactic toothpaste, and its effects on the functional activity of minor salivary glands and oral mucosa.&#13;
Methodology. The study was carried out by the Department of Therapeutic Dentistry and Propedeutics of Dental Disease together with the Department of General Chemistry, Ural State Medical University of the Ministry of Health of the Russian Federation. The study involved 65 volunteer patients recruited from the dental students (24 young male adults, 41 young adult women; the average age of patients was 21.25 ± 1.65 years old). The assessment of mixed saliva was performed for the following parameters: the qualitative analysis of such characteristics of saliva secretions such as color, transparency, presence of inclusions, the hydrogen-ion concentration, the functional activity of minor salivary glands, microcrystallization of mixed saliva.&#13;
Conclusions. The research results showed that the use of “DentaSwiss Enamel Repair &amp; Protect” toothpaste reliably changes the pH-value, the functional activity of minor salivary glands and microcrystallization of mixed saliva which consequently enhances remineralizing effects of mixed saliva and the ability of the tooth enamel to restore. On all parameters, organoleptic properties of “DentaSwiss Enamel Repair &amp; Protect” toothpaste were highly ranked by the study participants scoring the average of 9.95 ± 0.05.</p>
   </trans-abstract>
   <kwd-group xml:lang="ru">
    <kwd>водородный показатель</kwd>
    <kwd>зубная паста с реминерализирующим эффектом</kwd>
    <kwd>функциональная активность малых слюнных желез</kwd>
    <kwd>микрокристаллизация слюны</kwd>
    <kwd>смешанная слюна</kwd>
   </kwd-group>
   <kwd-group xml:lang="en">
    <kwd>pH-value</kwd>
    <kwd>remineralizing toothpaste</kwd>
    <kwd>the functional activity of minor salivary glands</kwd>
    <kwd>microcrystallization of saliva</kwd>
    <kwd>mixed saliva</kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <p></p>
 </body>
 <back>
  <ref-list>
   <ref id="B1">
    <label>1.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Bosomykina A.S., Ermishina E.Yu., Elovikova T.M. Comparative study of changes in physical and chemical parameters of young adults’ oral fluid when using toothpastes of two titles // Actual Problems in Modern Dentistry and Health Care: Collection of proceedings of VII International Scientific and Practical Conference of young scientists and students, Yekaterinburg, 17-18 May 2022. Ural State Medical University of the Ministry of Health of the Russian Federation ; Scientific society for young scientists and students. Yekaterinburg : Ural State Medical University of the Ministry of Health of the Russian Federation. - 2022:2432-2438. http://elib.usma.ru/bitstream/usma/10120/1/USMU_Sbornik_statei_2022_486.pdf</mixed-citation>
     <mixed-citation xml:lang="en">Bosomykina A.S., Ermishina E.Yu., Elovikova T.M. Comparative study of changes in physical and chemical parameters of young adults’ oral fluid when using toothpastes of two titles // Actual Problems in Modern Dentistry and Health Care: Collection of proceedings of VII International Scientific and Practical Conference of young scientists and students, Yekaterinburg, 17-18 May 2022. Ural State Medical University of the Ministry of Health of the Russian Federation ; Scientific society for young scientists and students. Yekaterinburg : Ural State Medical University of the Ministry of Health of the Russian Federation. - 2022:2432-2438. http://elib.usma.ru/bitstream/usma/10120/1/USMU_Sbornik_statei_2022_486.pdf</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B2">
    <label>2.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Elovikova T.M., Ermishina E.Yu., Sablina S.N., Grigoriev S.S., Koshcheev A.S. Clinical and laboratorial research in physical-chemical characteristics of a new toothpaste with Hyaluron-Ti forte complex // Actual Problems in Dentistry. - 2020;16(4):46-50. https://www.elibrary.ru/item.asp?id=44667776</mixed-citation>
     <mixed-citation xml:lang="en">Elovikova T.M., Ermishina E.Yu., Sablina S.N., Grigoriev S.S., Koshcheev A.S. Clinical and laboratorial research in physical-chemical characteristics of a new toothpaste with Hyaluron-Ti forte complex // Actual Problems in Dentistry. - 2020;16(4):46-50. https://www.elibrary.ru/item.asp?id=44667776</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B3">
    <label>3.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Elovikova T.M., Sablina S.N., Grigoriev S.S. et al. Qualitative and quantitative characteristics of fluoride toothpaste with antiseptic effect // Proceedings of International Congress “Dentistry of the Great Urals”, 04-06 December 2019. - 2020:46-48. https://riorpub.com/en/nauka/bibcontroller/import/conference_article/4023.enw</mixed-citation>
     <mixed-citation xml:lang="en">Elovikova T.M., Sablina S.N., Grigoriev S.S. et al. Qualitative and quantitative characteristics of fluoride toothpaste with antiseptic effect // Proceedings of International Congress “Dentistry of the Great Urals”, 04-06 December 2019. - 2020:46-48. https://riorpub.com/en/nauka/bibcontroller/import/conference_article/4023.enw</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B4">
    <label>4.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Elovikova T.M., Ermishina E.Yu., Sablina S.N. et al. Personal hygiene innovations: clinical laboratory characteristics of a new calcium hydroxylapatite toothpaste // Ural State Medical University Bulletin. - 2021;3(54):50-54. https://usma.ru/wp-content/uploads/2021/09/Vest3_2021_all.pdf</mixed-citation>
     <mixed-citation xml:lang="en">Elovikova T.M., Ermishina E.Yu., Sablina S.N. et al. Personal hygiene innovations: clinical laboratory characteristics of a new calcium hydroxylapatite toothpaste // Ural State Medical University Bulletin. - 2021;3(54):50-54. https://usma.ru/wp-content/uploads/2021/09/Vest3_2021_all.pdf</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B5">
    <label>5.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Elovikova T.M., Ermishina E.Yu., Sablina S.N., Koshcheev A.S. A new therapeutic and prophylactic mouthwash of domestic production. Analysis of organoleptic properties // Vyatka Medical Bulletin. - 2022;3(75):38-41. DOI 10.24412/2220-7880-2022-3-38-41.</mixed-citation>
     <mixed-citation xml:lang="en">Elovikova T.M., Ermishina E.Yu., Sablina S.N., Koshcheev A.S. A new therapeutic and prophylactic mouthwash of domestic production. Analysis of organoleptic properties // Vyatka Medical Bulletin. - 2022;3(75):38-41. DOI 10.24412/2220-7880-2022-3-38-41.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B6">
    <label>6.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Elovikova T.M., Sablina S.N., Ermishina E.Yu., Koshcheev A.S. Study on effects of therapeutic and prophylactic toothpaste with NovaMin on oral cavity in young tobacco users // Stomatology. - 2021;100(3):35-39. DOI 10.17116/stomat202110003135.</mixed-citation>
     <mixed-citation xml:lang="en">Elovikova T.M., Sablina S.N., Ermishina E.Yu., Koshcheev A.S. Study on effects of therapeutic and prophylactic toothpaste with NovaMin on oral cavity in young tobacco users // Stomatology. - 2021;100(3):35-39. DOI 10.17116/stomat202110003135.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B7">
    <label>7.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Ermishina E.Yu., Elovikova T.M., Sablina S.N. et al. Investigation of changes in physicochemical properties of mixed saliva in young people subjected to liquid oral hygiene products // Actual Problems in Dentistry. - 2021;17(4):50-55. DOI 10.18481/2077-7566-21-17-4-50-55.</mixed-citation>
     <mixed-citation xml:lang="en">Ermishina E.Yu., Elovikova T.M., Sablina S.N. et al. Investigation of changes in physicochemical properties of mixed saliva in young people subjected to liquid oral hygiene products // Actual Problems in Dentistry. - 2021;17(4):50-55. DOI 10.18481/2077-7566-21-17-4-50-55.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B8">
    <label>8.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Orekhova L.Yu., Kudryavtseva T.V., Musaeva R.S. et al. Review of extended-release drug delivery systems for non-surgical treatment of inflammatory periodontal diseases // Parodontologiya. - 2022;27(4):298-307. DOI 10.33925/1683-3759-2022-27-4-298-307.</mixed-citation>
     <mixed-citation xml:lang="en">Orekhova L.Yu., Kudryavtseva T.V., Musaeva R.S. et al. Review of extended-release drug delivery systems for non-surgical treatment of inflammatory periodontal diseases // Parodontologiya. - 2022;27(4):298-307. DOI 10.33925/1683-3759-2022-27-4-298-307.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B9">
    <label>9.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Frolova D.V. Study of the physicochemical properties of dispersed aqueous toothpaste systems with sodium chloride and calcium glycerophosphate // Actual Problems in Modern Dentistry and Health Care. Proceedings of V International Scientific and Practical Conference of young scientists and students devoted to the 75th anniversary of the WWII victory, the 90th anniversary of Ural State Medical University, and the 100th anniversary of medical education in the Urals. - 2020:343-347. http://elib.usma.ru/handle/usma/3384</mixed-citation>
     <mixed-citation xml:lang="en">Frolova D.V. Study of the physicochemical properties of dispersed aqueous toothpaste systems with sodium chloride and calcium glycerophosphate // Actual Problems in Modern Dentistry and Health Care. Proceedings of V International Scientific and Practical Conference of young scientists and students devoted to the 75th anniversary of the WWII victory, the 90th anniversary of Ural State Medical University, and the 100th anniversary of medical education in the Urals. - 2020:343-347. http://elib.usma.ru/handle/usma/3384</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B10">
    <label>10.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Arnold W.H., Prange M., Naumova E.A. Effectiveness of various toothpastes on dentine tubule occlusion // Journal of Dentistry. - 2015;43(4):440-449. doi: 10.1016/j.jdent.2015.01.014.</mixed-citation>
     <mixed-citation xml:lang="en">Arnold W.H., Prange M., Naumova E.A. Effectiveness of various toothpastes on dentine tubule occlusion // Journal of Dentistry. - 2015;43(4):440-449. doi: 10.1016/j.jdent.2015.01.014.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B11">
    <label>11.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Mkrtchyan E.S., Neskoromnaya E.A., Burakova I.V. et al. Comparative Analysis of the Adsorption Kinetics of the Methylene Blue Dye on Graphene Aerogel and Activated Coconut Carbon // Advanced Materials and Technologies. - 2020;4(20):21-28. DOI 10.17277/amt.2020.04.pp.021-028.</mixed-citation>
     <mixed-citation xml:lang="en">Mkrtchyan E.S., Neskoromnaya E.A., Burakova I.V. et al. Comparative Analysis of the Adsorption Kinetics of the Methylene Blue Dye on Graphene Aerogel and Activated Coconut Carbon // Advanced Materials and Technologies. - 2020;4(20):21-28. DOI 10.17277/amt.2020.04.pp.021-028.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B12">
    <label>12.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Gorshkova N., Brovko O., Palamarchuk I., Bogolitsyn K., Bogdanovich N., Ivakhnov A., Chukhchin D., Arkhilin M. Formation of supramolecular structure in alginate/chitosan aerogel materials during sol-gel synthesis // Journal of sol-gel science technology - 2020;95:101-108. https://www.elibrary.ru/item.asp?id=43299559</mixed-citation>
     <mixed-citation xml:lang="en">Gorshkova N., Brovko O., Palamarchuk I., Bogolitsyn K., Bogdanovich N., Ivakhnov A., Chukhchin D., Arkhilin M. Formation of supramolecular structure in alginate/chitosan aerogel materials during sol-gel synthesis // Journal of sol-gel science technology - 2020;95:101-108. https://www.elibrary.ru/item.asp?id=43299559</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B13">
    <label>13.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Herman M., Golasik M., Piekoszewski W., Walas S., Napierala M., Wyganowska-Swiatkowska M., Kurhanska-Flisykowska A. et al. Essential and Toxic Metals in Oral Fluid-a Potential Role in the Diagnosis of Periodontal Diseases // Biological Trace Element Research. - 2016;116(2):275-282. doi: 10.1007/s12011-016-0660-0</mixed-citation>
     <mixed-citation xml:lang="en">Herman M., Golasik M., Piekoszewski W., Walas S., Napierala M., Wyganowska-Swiatkowska M., Kurhanska-Flisykowska A. et al. Essential and Toxic Metals in Oral Fluid-a Potential Role in the Diagnosis of Periodontal Diseases // Biological Trace Element Research. - 2016;116(2):275-282. doi: 10.1007/s12011-016-0660-0</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B14">
    <label>14.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Yaprak E., Yolcubal I., Sinanoğlu A., Doğrul-Demiray A., Guzeldemir-Akcakanat E., Marakoğlu I. High levels of heavy metal accumulation in dental calculus of smokers: a pilot inductively coupled plasma mass spectrometry study // Journal of Periodontal Research. - 2016;52(2):83-88. doi: 10.1111/jre.12371.</mixed-citation>
     <mixed-citation xml:lang="en">Yaprak E., Yolcubal I., Sinanoğlu A., Doğrul-Demiray A., Guzeldemir-Akcakanat E., Marakoğlu I. High levels of heavy metal accumulation in dental calculus of smokers: a pilot inductively coupled plasma mass spectrometry study // Journal of Periodontal Research. - 2016;52(2):83-88. doi: 10.1111/jre.12371.</mixed-citation>
    </citation-alternatives>
   </ref>
  </ref-list>
 </back>
</article>
