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 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">Actual problems in dentistry</journal-id>
   <journal-title-group>
    <journal-title xml:lang="en">Actual problems in dentistry</journal-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Проблемы стоматологии</trans-title>
    </trans-title-group>
   </journal-title-group>
   <issn publication-format="print">2077-7566</issn>
   <issn publication-format="online">2412-9461</issn>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="publisher-id">55051</article-id>
   <article-id pub-id-type="doi">10.18481/2077-7566-2022-18-3-57-64</article-id>
   <article-categories>
    <subj-group subj-group-type="toc-heading" xml:lang="ru">
     <subject>ЛЕКЦИИ / ЛИТЕРАТУРНЫЕ ОБЗОРЫ</subject>
    </subj-group>
    <subj-group subj-group-type="toc-heading" xml:lang="en">
     <subject>LITERATURE REVIEW</subject>
    </subj-group>
    <subj-group>
     <subject>ЛЕКЦИИ / ЛИТЕРАТУРНЫЕ ОБЗОРЫ</subject>
    </subj-group>
   </article-categories>
   <title-group>
    <article-title xml:lang="en">THE FEATURES OF CHRONIC PERIODONTITIS, COMPLICATED BY FURCATION DEFECTS. CAUSES OF DEFECTS. LITERATURE REVIEW</article-title>
    <trans-title-group xml:lang="ru">
     <trans-title>ОСОБЕННОСТИ ХРОНИЧЕСКИХ ПЕРИОДОНТИТОВ, ОСЛОЖНЕННЫХ ФУРКАЦИОННЫМИ ДЕФЕКТАМИ. ОБЗОР ЛИТЕРАТУРЫ</trans-title>
    </trans-title-group>
   </title-group>
   <contrib-group content-type="authors">
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Хабадзе</surname>
       <given-names>Зураб Суликоевич</given-names>
      </name>
      <name xml:lang="en">
       <surname>Khabadze</surname>
       <given-names>Zurab Sulikoevich</given-names>
      </name>
     </name-alternatives>
     <email>dr.zura@mail.ru</email>
     <bio xml:lang="ru">
      <p>кандидат медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>candidate of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Гасбанов</surname>
       <given-names>Магомед-Али Аликович</given-names>
      </name>
      <name xml:lang="en">
       <surname>Gasbanov</surname>
       <given-names>Magomed-Ali A.</given-names>
      </name>
     </name-alternatives>
     <email>Magomed.gazmanov@mail.ru</email>
     <xref ref-type="aff" rid="aff-2"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Болячин</surname>
       <given-names>Алексей Вячеславович</given-names>
      </name>
      <name xml:lang="en">
       <surname>Bolyachin</surname>
       <given-names>Aleksey V.</given-names>
      </name>
     </name-alternatives>
     <email>abc135@mail.ru</email>
     <xref ref-type="aff" rid="aff-3"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Тебердиев</surname>
       <given-names>Тахир Расулович</given-names>
      </name>
      <name xml:lang="en">
       <surname>Taberdiev</surname>
       <given-names>Tahir R.</given-names>
      </name>
     </name-alternatives>
     <email>Taha_teberdiev@mail.ru</email>
     <xref ref-type="aff" rid="aff-4"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Морданов</surname>
       <given-names>Олег Сергеевич</given-names>
      </name>
      <name xml:lang="en">
       <surname>Mordanov</surname>
       <given-names>Oleg Sergeevich</given-names>
      </name>
     </name-alternatives>
     <email>mordanov-os@rudn.ru</email>
     <xref ref-type="aff" rid="aff-5"/>
    </contrib>
   </contrib-group>
   <aff-alternatives id="aff-1">
    <aff>
     <institution xml:lang="ru">Российский университет дружбы народов</institution>
     <city>Москва</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Peoples' Friendship University of Russia</institution>
     <city>Moscow</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-2">
    <aff>
     <institution xml:lang="ru">Центр дентальной травматологии «Айсберг»</institution>
     <city>Москва</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Center for Dental Traumatology &quot;Iceberg&quot;</institution>
     <city>Moscow</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-3">
    <aff>
     <institution xml:lang="ru">Центр дентальной травматологии «Айсберг»</institution>
     <city>Москва</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Center for Dental Traumatology &quot;Iceberg&quot;</institution>
     <city>Moscow</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-4">
    <aff>
     <institution xml:lang="ru">Центр дентальной травматологии «Айсберг»</institution>
     <city>Москва</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Center for Dental Traumatology &quot;Iceberg&quot;</institution>
     <city>Moscow</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-5">
    <aff>
     <institution xml:lang="ru">Российский университет дружбы народов</institution>
     <city>Москва</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Peoples' Friendship University of Russia</institution>
     <city>Moscow</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <pub-date publication-format="print" date-type="pub" iso-8601-date="2022-11-23T21:53:19+03:00">
    <day>23</day>
    <month>11</month>
    <year>2022</year>
   </pub-date>
   <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2022-11-23T21:53:19+03:00">
    <day>23</day>
    <month>11</month>
    <year>2022</year>
   </pub-date>
   <volume>18</volume>
   <issue>3</issue>
   <fpage>57</fpage>
   <lpage>64</lpage>
   <history>
    <date date-type="received" iso-8601-date="2022-11-12T00:00:00+03:00">
     <day>12</day>
     <month>11</month>
     <year>2022</year>
    </date>
   </history>
   <self-uri xlink:href="https://dental-press.ru/en/nauka/article/55051/view">https://dental-press.ru/en/nauka/article/55051/view</self-uri>
   <abstract xml:lang="ru">
    <p>Заболевания тканей периодонта остаются одной из актуальных проблем в современной стоматологии в связи с их высокой распространенностью и количеством осложнений после лечения. Продолжительное бессимптомное течение хронических форм периодонтита вызывает нарастание деструкционных процессов не только в тканях периодонта и альвеолярной кости, но и способствует деминерализации дентина корня и резорбции цемента корня, что зачастую усугубляется и фуркационными дефектами. Вовлечение в патологический процесс области фуркации корней существенно осложняет течение заболевания, диагностику, лечение и прогноз. Сложность диагностики, вариативность методов лечения в зависимости от общей клинической картины и высокий процент потери зубов при вовлечении в патологический процесс области фуркации обуславливают актуальность темы исследования. Цель: изучение особенностей хронических периодонтитов, осложненных фуркационными дефектами, и выявление основных причин указанных дефектов. Материалы и методы: по ключевым словам проведен анализ отечественных и зарубежных публикаций, размещенных в базах данных eLibrary и PubMed. Результаты. Проводится анализ литературных данных об особенностях хронических периодонтитов, осложненных фуркационными дефектами, рассматриваются вопросы этиологии данной патологии. Заключение. Показано, что лечение хронического апикального периодонтита зубов, осложненного фуркационными дефектами, является одной из важных проблем стоматологии, что определяется значительной распространенностью заболевания и частотой возникновения осложнений после проведенного лечения. Наиболее распространенным этиологическим фактором поражения фуркации является микробная инвазия, вызывающая воспалительный процесс, прогрессирование которого приводит к резорбции костной ткани в области фуркационного свода зубов. Также вовлечению фуркации способствуют и этиологические факторы пародонтопатогенного генеза, эндодонтические повреждения, фрактуры, ятрогенные факторы,а также анатомические особенности.</p>
   </abstract>
   <trans-abstract xml:lang="en">
    <p>Periodontal tissue diseases remain one of the urgent problems in modern dentistry due to their high prevalence and the number of complications after treatment. The prolonged asymptomatic course of chronic forms of periodontitis causes an increase in destructive processes not only in periodontal tissues and alveolar bone, but also contributes to the resorption of cementum and root dentin, which causes the formation of bone pockets, called furcation defects. Involvement in the pathological process of the zone of divergence of the roots significantly complicates the course of the disease, diagnosis, treatment and prognosis. The complexity of diagnosis, the variability of treatment methods depending on the overall clinical picture and the high percentage of tooth loss when the furcation area is involved in the pathological process determine the relevance of the research topic. Purpose: to study the features of chronic periodontitis complicated by furcation defects and to identify the main causes of these defects. Materials and Methods: the analysis of domestic and foreign publications placed in the eLibrary and PubMed databases was carried out by keywords. Results. The analysis of literature data on the features of chronic periodontitis complicated by furcation defects is carried out, the issues of the etiology of this pathology are considered. Conclusion. It is shown that the treatment of chronic apical periodontitis complicated by furcation defects is one of the important problems of dentistry, which is determined by the significant prevalence of the disease and the incidence of complications after treatment. The most common etiological factor in furcation lesions is microbial invasion, which causes an inflammatory process, the progression of which leads to bone resorption in the area of the furcation arch of the teeth. Also, the etiological factors of periodontal pathogenic genesis, endodontic lesions, fractures, iatrogenic factors, as well as anatomical features contribute to the involvement of furcation.</p>
   </trans-abstract>
   <kwd-group xml:lang="ru">
    <kwd>дефекты фуркации</kwd>
    <kwd>перфорация фуркации</kwd>
    <kwd>фуркационный периодонтит</kwd>
    <kwd>апикальный периодонтит</kwd>
    <kwd>канал фуркации корней</kwd>
   </kwd-group>
   <kwd-group xml:lang="en">
    <kwd>furcation defects</kwd>
    <kwd>furcation perforation</kwd>
    <kwd>furcation periodontitis</kwd>
    <kwd>apical periodontitis</kwd>
    <kwd>root canal</kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <p></p>
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 <back>
  <ref-list>
   <ref id="B1">
    <label>1.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Hernández S.R., Pérez A.R., Baasch A.C., Brisson-Suárez K., Sellera D.P., Ferrari P.H.P., Alberdi J.C., Carreira C.M., Gomes-Azevedo S., Alves F.R.F, Rôças I.N., Siqueira J.F. Management of teeth with dens invaginatus and apical periodontitis: A case series // J Am Dent Assoc. - 2022;153(5):470-478. doi: 10.1016/j.adaj.2021.10.009.</mixed-citation>
     <mixed-citation xml:lang="en">Hernández S.R., Pérez A.R., Baasch A.C., Brisson-Suárez K., Sellera D.P., Ferrari P.H.P., Alberdi J.C., Carreira C.M., Gomes-Azevedo S., Alves F.R.F, Rôças I.N., Siqueira J.F. Management of teeth with dens invaginatus and apical periodontitis: A case series // J Am Dent Assoc. - 2022;153(5):470-478. doi: 10.1016/j.adaj.2021.10.009.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B2">
    <label>2.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Sabeti M., Tayeed H., Kurtzman G., Mashhadi Abbas F., Talebi Ardakani M. Histopathological Investigation of Dental Pulp Reactions Related to Periodontitis // Eur Endod J. - 2021;6(2):164-169. doi: 10.14744/eej.2021.96268.</mixed-citation>
     <mixed-citation xml:lang="en">Sabeti M., Tayeed H., Kurtzman G., Mashhadi Abbas F., Talebi Ardakani M. Histopathological Investigation of Dental Pulp Reactions Related to Periodontitis // Eur Endod J. - 2021;6(2):164-169. doi: 10.14744/eej.2021.96268.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B3">
    <label>3.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Baochun T., Jianping X., Fuhua Y., Hong H. Clinical comparative study on the efficacy of periodontal endodontic therapy and periodontal treatment alone for advanced periodontitis // Hua Xi Kou Qiang Yi Xue Za Zhi. - 2016;34(6):600-605. doi: 10.7518/hxkq.2016.06.010.</mixed-citation>
     <mixed-citation xml:lang="en">Baochun T., Jianping X., Fuhua Y., Hong H. Clinical comparative study on the efficacy of periodontal endodontic therapy and periodontal treatment alone for advanced periodontitis // Hua Xi Kou Qiang Yi Xue Za Zhi. - 2016;34(6):600-605. doi: 10.7518/hxkq.2016.06.010.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B4">
    <label>4.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Куратов И.А., Нагаева М.О., Корнеева М.В., Сурков М.А. Анализ причин неудач эндодонтического лечения и удаления зубов с диагнозом «хронический апикальный периодонтит». Проблемы стоматологии. 2019;15(1):28-32. [I.A. Kuratov, M.O. Nagaeva, M.V. Korneeva, M.A. Surkov. Analysis of the causes of failure of endodontic treatment and extraction of teeth diagnosed with chronic apical periodontitis. Actual problems in dentistry. 2019;15(1):28-32. (In Russ.)]. https://www.elibrary.ru/item.asp?id=37602576</mixed-citation>
     <mixed-citation xml:lang="en">Kuratov I.A., Nagaeva M.O., Korneeva M.V., Surkov M.A. Analiz prichin neudach endodonticheskogo lecheniya i udaleniya zubov s diagnozom «hronicheskiy apikal'nyy periodontit». Problemy stomatologii. 2019;15(1):28-32. [I.A. Kuratov, M.O. Nagaeva, M.V. Korneeva, M.A. Surkov. Analysis of the causes of failure of endodontic treatment and extraction of teeth diagnosed with chronic apical periodontitis. Actual problems in dentistry. 2019;15(1):28-32. (In Russ.)]. https://www.elibrary.ru/item.asp?id=37602576</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B5">
    <label>5.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Юровская И.А., Педорец А.П., Пиляев А.Г., Терпигорьева Л.П. Патогистологические проявления в зубах с различным течением хронического периодонтита. Actual Questions and Innovations in Science 2. Conference Proceedings (in English, Russian, Turkish, Kazakh languages). Editor-in-Chief Abdullah Soykan. 2019:143-145. [I.A. Yurovskaya, A.P. Pedorec, A.G. Pilyaev, L.P. Terpigor'eva. Pathohistological manifestations in teeth with different course of chronic periodontitis. Actual Questions and Innovations in Science 2. Conference Proceedings (in English, Russian, Turkish, Kazakh languages). Editor-in-Chief Abdullah Soykan. 2019:143-145. (In Russ.)]. https://www.elibrary.ru/item.asp?id=41347432</mixed-citation>
     <mixed-citation xml:lang="en">Yurovskaya I.A., Pedorec A.P., Pilyaev A.G., Terpigor'eva L.P. Patogistologicheskie proyavleniya v zubah s razlichnym techeniem hronicheskogo periodontita. Actual Questions and Innovations in Science 2. Conference Proceedings (in English, Russian, Turkish, Kazakh languages). Editor-in-Chief Abdullah Soykan. 2019:143-145. [I.A. Yurovskaya, A.P. Pedorec, A.G. Pilyaev, L.P. Terpigor'eva. Pathohistological manifestations in teeth with different course of chronic periodontitis. Actual Questions and Innovations in Science 2. Conference Proceedings (in English, Russian, Turkish, Kazakh languages). Editor-in-Chief Abdullah Soykan. 2019:143-145. (In Russ.)]. https://www.elibrary.ru/item.asp?id=41347432</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B6">
    <label>6.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Widbiller M., Knüttel H., Meschi N., Durán-Sindreu Terol F. Effectiveness of endodontic tissue engineering in treatment of apical periodontitis: A systematic review. Int Endod J. 2022 Jun 14. doi: 10.1111/iej.13784.</mixed-citation>
     <mixed-citation xml:lang="en">Widbiller M., Knüttel H., Meschi N., Durán-Sindreu Terol F. Effectiveness of endodontic tissue engineering in treatment of apical periodontitis: A systematic review. Int Endod J. 2022 Jun 14. doi: 10.1111/iej.13784.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B7">
    <label>7.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Amaranath B.J., Das N., Gupta I., Gupta R., John B., Devi M.P. Types of bone destruction and its severity in chronic periodontitis patients with tobacco smoking habit using periapical radiographs and transgingival probing: A cross-sectional study // J Indian Soc Periodontol. - 2020;24(1):20-25. doi: 10.4103/jisp.jisp_212_19.</mixed-citation>
     <mixed-citation xml:lang="en">Amaranath B.J., Das N., Gupta I., Gupta R., John B., Devi M.P. Types of bone destruction and its severity in chronic periodontitis patients with tobacco smoking habit using periapical radiographs and transgingival probing: A cross-sectional study // J Indian Soc Periodontol. - 2020;24(1):20-25. doi: 10.4103/jisp.jisp_212_19.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B8">
    <label>8.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Yang H., Zhang M.L., Chen Y., Ding Y. Surface-enhanced raman scattering-based technique for detecting periodontal disease // Journal of Applied Spectroscopy. - 2021;88(6):920-925.  doi:10.1007/s10812-022-01298-5</mixed-citation>
     <mixed-citation xml:lang="en">Yang H., Zhang M.L., Chen Y., Ding Y. Surface-enhanced raman scattering-based technique for detecting periodontal disease // Journal of Applied Spectroscopy. - 2021;88(6):920-925.  doi:10.1007/s10812-022-01298-5</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B9">
    <label>9.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Tan B., Sun Q., Xiao J., Zhang L., Yan F. Pulp status of teeth in patients with chronic advanced periodontitis // Int J Clin Exp Pathol. - 2020;13(4):635-641. PMID: 32355511.</mixed-citation>
     <mixed-citation xml:lang="en">Tan B., Sun Q., Xiao J., Zhang L., Yan F. Pulp status of teeth in patients with chronic advanced periodontitis // Int J Clin Exp Pathol. - 2020;13(4):635-641. PMID: 32355511.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B10">
    <label>10.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Jepsen S., Gennai S., Hirschfeld J., Kalemaj Z., Buti J., Graziani F. Regenerative surgical treatment of furcation defects: A systematic review and Bayesian network meta-analysis of randomized clinical trials // J Clin Periodontol. - 2020;47;22:352-374. doi: 10.1111/jcpe.13238.</mixed-citation>
     <mixed-citation xml:lang="en">Jepsen S., Gennai S., Hirschfeld J., Kalemaj Z., Buti J., Graziani F. Regenerative surgical treatment of furcation defects: A systematic review and Bayesian network meta-analysis of randomized clinical trials // J Clin Periodontol. - 2020;47;22:352-374. doi: 10.1111/jcpe.13238.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B11">
    <label>11.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Alsakr A.M., Creanga A.G., Alqahtani A.S., Gufran K. Accuracy and Reliability of CBCT Compared to Clinical Probing in Detection of Trifurcation Defects: An In Vivo Study // Biomed Res Int. - 2022;2022:5805776. doi: 10.1155/2022/5805776.</mixed-citation>
     <mixed-citation xml:lang="en">Alsakr A.M., Creanga A.G., Alqahtani A.S., Gufran K. Accuracy and Reliability of CBCT Compared to Clinical Probing in Detection of Trifurcation Defects: An In Vivo Study // Biomed Res Int. - 2022;2022:5805776. doi: 10.1155/2022/5805776.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B12">
    <label>12.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Акимова М.Ю., Туркина А.Ю., Шелеметьева Г.Н Опыт лечения различных форм периодонтита в одно посещение. серия клинических случаев. Эндодонтия Today. 2018;2:32-36. [M.Yu. Akimova, A.Yu. Turkina, G.N. Shelemet'eva. Experience in the treatment of various forms of periodontitis in one visit. a series of clinical cases. Endodontiya Today. 2018;2:32-36. (In Russ.)]. doi:10.25636/PMP.2.2018.2.7.</mixed-citation>
     <mixed-citation xml:lang="en">Akimova M.Yu., Turkina A.Yu., Shelemet'eva G.N Opyt lecheniya razlichnyh form periodontita v odno poseschenie. seriya klinicheskih sluchaev. Endodontiya Today. 2018;2:32-36. [M.Yu. Akimova, A.Yu. Turkina, G.N. Shelemet'eva. Experience in the treatment of various forms of periodontitis in one visit. a series of clinical cases. Endodontiya Today. 2018;2:32-36. (In Russ.)]. doi:10.25636/PMP.2.2018.2.7.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B13">
    <label>13.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Silva R.A.B., Borges A.T.N., Hernandéz-Gatón P., de Queiroz A.M., Arzate H., Romualdo P.C., Nelson-Filho P., Silva L.A.B. Histopathological, histoenzymological, immunohistochemical and immunofluorescence analysis of tissue response to sealing materials after furcation perforation // Int Endod J. - 2019;52(10):1489-1500. doi: 10.1111/iej.13145.</mixed-citation>
     <mixed-citation xml:lang="en">Silva R.A.B., Borges A.T.N., Hernandéz-Gatón P., de Queiroz A.M., Arzate H., Romualdo P.C., Nelson-Filho P., Silva L.A.B. Histopathological, histoenzymological, immunohistochemical and immunofluorescence analysis of tissue response to sealing materials after furcation perforation // Int Endod J. - 2019;52(10):1489-1500. doi: 10.1111/iej.13145.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B14">
    <label>14.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Lin J., Huang D., Xu H., Zhan F., Tan X. Macrophages: A communication network linking Porphyromonas gingivalis infection and associated systemic diseases // Front Immunol. - 2022;13:952040. doi: 10.3389/fimmu.2022.952040.</mixed-citation>
     <mixed-citation xml:lang="en">Lin J., Huang D., Xu H., Zhan F., Tan X. Macrophages: A communication network linking Porphyromonas gingivalis infection and associated systemic diseases // Front Immunol. - 2022;13:952040. doi: 10.3389/fimmu.2022.952040.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B15">
    <label>15.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Huang H.L., Ma Y.H., Tu C.C., Chang P.C. Radiographic Evaluation of Regeneration Strategies for the Treatment of Advanced Mandibular Furcation Defects: A Retrospective Study // Membranes (Basel). - 2022;12(2):219. doi: 10.3390/membranes12020219.</mixed-citation>
     <mixed-citation xml:lang="en">Huang H.L., Ma Y.H., Tu C.C., Chang P.C. Radiographic Evaluation of Regeneration Strategies for the Treatment of Advanced Mandibular Furcation Defects: A Retrospective Study // Membranes (Basel). - 2022;12(2):219. doi: 10.3390/membranes12020219.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B16">
    <label>16.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Корнетова И.В., Митронин А.В., Рабинович И.М. Современные возможности первичного эндодонтического лечения хронического апикального периодонтита эндопародонтального происхождения. Эндодонтия Today. 2021;19(4):338-342. [I.V. Kornetova, A.V. Mitronin, I.M. Rabinovich. Modern possibilities of primary endodontic treatment of chronic apical periodontitis of endoperiodontal origin. Endodontiya Today. 2021;19(4):338-342. (In Russ.)]. doi:36377/1683-2981-2021-19-4-338-342</mixed-citation>
     <mixed-citation xml:lang="en">Kornetova I.V., Mitronin A.V., Rabinovich I.M. Sovremennye vozmozhnosti pervichnogo endodonticheskogo lecheniya hronicheskogo apikal'nogo periodontita endoparodontal'nogo proishozhdeniya. Endodontiya Today. 2021;19(4):338-342. [I.V. Kornetova, A.V. Mitronin, I.M. Rabinovich. Modern possibilities of primary endodontic treatment of chronic apical periodontitis of endoperiodontal origin. Endodontiya Today. 2021;19(4):338-342. (In Russ.)]. doi:36377/1683-2981-2021-19-4-338-342</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B17">
    <label>17.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Niazi S.A., Bakhsh A. Association between Endodontic Infection, Its Treatment and Systemic Health: A Narrative Review // Medicina (Kaunas). - 2022;58(7):931. doi: 10.3390/medicina58070931.</mixed-citation>
     <mixed-citation xml:lang="en">Niazi S.A., Bakhsh A. Association between Endodontic Infection, Its Treatment and Systemic Health: A Narrative Review // Medicina (Kaunas). - 2022;58(7):931. doi: 10.3390/medicina58070931.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B18">
    <label>18.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Perminio D.J., Rodrigues D.M., Vianna K.C., Machado A., Lopes R., Barboza E.P. Micro-tomographic analysis of the root trunk and pre-furcation area of the first mandibular molars // Odontology. - 2022;110(1):120-126. doi: 10.1007/s10266-021-00645-w.</mixed-citation>
     <mixed-citation xml:lang="en">Perminio D.J., Rodrigues D.M., Vianna K.C., Machado A., Lopes R., Barboza E.P. Micro-tomographic analysis of the root trunk and pre-furcation area of the first mandibular molars // Odontology. - 2022;110(1):120-126. doi: 10.1007/s10266-021-00645-w.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B19">
    <label>19.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Singh O., Sinha D.J., Tyagi S.P., Tyagi N. Root resorption: challenge to the endodontist // International Jornal of Dental Research and Oral Sciences. - 2017;2(1):31-41. https://www.researchgate.net/profile/Dakshita-Sinha/publication/317678428_Root_Resorption_Challenge_to_the_Endodontist/links/5948b77c0f7e9b1d9b2341a5/Root-Resorption-Challenge-to-the-Endodontist.pdf</mixed-citation>
     <mixed-citation xml:lang="en">Singh O., Sinha D.J., Tyagi S.P., Tyagi N. Root resorption: challenge to the endodontist // International Jornal of Dental Research and Oral Sciences. - 2017;2(1):31-41. https://www.researchgate.net/profile/Dakshita-Sinha/publication/317678428_Root_Resorption_Challenge_to_the_Endodontist/links/5948b77c0f7e9b1d9b2341a5/Root-Resorption-Challenge-to-the-Endodontist.pdf</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B20">
    <label>20.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Гизатуллина Э.Р., Маршинская А.А. Исход хронического апикального периодонтита зуба 27. Клинический случай. Эндодонтия Today. 2019;17(4):63-66. [E.R. Gizatullina, A.A. Marshinskaya. Outcome of chronic apical periodontitis of tooth 27. Clinical case. Endodontiya Today. 2019;17(4):63-66. (In Russ.)]. doi: 10.36377/1683-2981-2019-17-4-63-66</mixed-citation>
     <mixed-citation xml:lang="en">Gizatullina E.R., Marshinskaya A.A. Ishod hronicheskogo apikal'nogo periodontita zuba 27. Klinicheskiy sluchay. Endodontiya Today. 2019;17(4):63-66. [E.R. Gizatullina, A.A. Marshinskaya. Outcome of chronic apical periodontitis of tooth 27. Clinical case. Endodontiya Today. 2019;17(4):63-66. (In Russ.)]. doi: 10.36377/1683-2981-2019-17-4-63-66</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B21">
    <label>21.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Li X., Liu Y., Yang X., Li C., Song Z. The Oral Microbiota: Community Composition, Influencing Factors, Pathogenesis, and Interventions // Front Microbiol. - 2022;13:895537. doi: 10.3389/fmicb.2022.895537.</mixed-citation>
     <mixed-citation xml:lang="en">Li X., Liu Y., Yang X., Li C., Song Z. The Oral Microbiota: Community Composition, Influencing Factors, Pathogenesis, and Interventions // Front Microbiol. - 2022;13:895537. doi: 10.3389/fmicb.2022.895537.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B22">
    <label>22.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Tonetti M.S., Greenwell H., Kornman K.S. Staging and grading periodontitis: Framework and proposal new classification and case // J Periodontol. - 2018;89;1:S159-S172. doi: 10.1002/JPER.18-0006.</mixed-citation>
     <mixed-citation xml:lang="en">Tonetti M.S., Greenwell H., Kornman K.S. Staging and grading periodontitis: Framework and proposal new classification and case // J Periodontol. - 2018;89;1:S159-S172. doi: 10.1002/JPER.18-0006.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B23">
    <label>23.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Nazir M.A. Prevalence of periodontal disease, its association with systemic diseases and prevention // Int J Health Sci (Qassim). - 2017;11(2):72-80. PMID: 28539867.</mixed-citation>
     <mixed-citation xml:lang="en">Nazir M.A. Prevalence of periodontal disease, its association with systemic diseases and prevention // Int J Health Sci (Qassim). - 2017;11(2):72-80. PMID: 28539867.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B24">
    <label>24.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Silva B.S., Bueno M.R., Yamamoto-Silva F.P., Gomez R.S., Peters O.A., Estrela C. Differential diagnosis and clinical management of periapical radiopaque/hyperdense jaw lesions // Braz Oral Res. - 2017;31:e52. doi: 10.1590/1807-3107BOR-2017.vol31.0052.</mixed-citation>
     <mixed-citation xml:lang="en">Silva B.S., Bueno M.R., Yamamoto-Silva F.P., Gomez R.S., Peters O.A., Estrela C. Differential diagnosis and clinical management of periapical radiopaque/hyperdense jaw lesions // Braz Oral Res. - 2017;31:e52. doi: 10.1590/1807-3107BOR-2017.vol31.0052.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B25">
    <label>25.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Connert T., Truckenmüller M., ElAyouti A., Eggmann F., Krastl G., Löst C., Weiger R. Changes in periapical status, quality of root fillings and estimated endodontic treatment need in a similar urban German population 20 years later // Clin Oral Investig. - 2019;23(3):1373-1382. doi: 10.1007/s00784-018-2566-z.</mixed-citation>
     <mixed-citation xml:lang="en">Connert T., Truckenmüller M., ElAyouti A., Eggmann F., Krastl G., Löst C., Weiger R. Changes in periapical status, quality of root fillings and estimated endodontic treatment need in a similar urban German population 20 years later // Clin Oral Investig. - 2019;23(3):1373-1382. doi: 10.1007/s00784-018-2566-z.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B26">
    <label>26.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Meirinhos J., Martins J., Pereira B., Baruwa A., Ginjeira A. Prevalence of Lateral Radiolucency, Apical Root Resorption and Periapical Lesions in Portuguese Patients: A CBCT Cross-Sectional Study with a Worldwide Overview // Eur Endod J. - 2021;6(1):56-71. doi: 10.14744/eej.2021.29981.</mixed-citation>
     <mixed-citation xml:lang="en">Meirinhos J., Martins J., Pereira B., Baruwa A., Ginjeira A. Prevalence of Lateral Radiolucency, Apical Root Resorption and Periapical Lesions in Portuguese Patients: A CBCT Cross-Sectional Study with a Worldwide Overview // Eur Endod J. - 2021;6(1):56-71. doi: 10.14744/eej.2021.29981.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B27">
    <label>27.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Митронин А.В., Рабинович И.М., Корнетова И.В. Лечение пациента с хроническим апикальным периодонтитом зуба 2.1 при наличии перфорации корня зуба 2.2. Клинический случай. Эндодонтия Today. 2018;2:72-77. [A.V. Mitronin, I.M. Rabinovich, I.V. Kornetova. Treatment of a patient with chronic apical periodontitis of tooth 2.1 in the presence of perforation of the root of tooth 2.2. Clinical case. Endodontiya Today. 2018;2:72-77. (In Russ.)]. doi: 10.25636/PMP.2.2018.2.14</mixed-citation>
     <mixed-citation xml:lang="en">Mitronin A.V., Rabinovich I.M., Kornetova I.V. Lechenie pacienta s hronicheskim apikal'nym periodontitom zuba 2.1 pri nalichii perforacii kornya zuba 2.2. Klinicheskiy sluchay. Endodontiya Today. 2018;2:72-77. [A.V. Mitronin, I.M. Rabinovich, I.V. Kornetova. Treatment of a patient with chronic apical periodontitis of tooth 2.1 in the presence of perforation of the root of tooth 2.2. Clinical case. Endodontiya Today. 2018;2:72-77. (In Russ.)]. doi: 10.25636/PMP.2.2018.2.14</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B28">
    <label>28.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Казеко Л.А., Бенеш Ю.Д. Оценка резорбции костной ткани при различных формах течения периодонтита. Актуальные вопросы стоматологии. Сборник III Всероссийской научно-практической конференции с международным участием. Под редакцией Л.М. Железнова. 2019:110-112. [L.A. Kazeko, Yu.D. Benesh. Evaluation of bone tissue resorption in various forms of periodontitis. Topical issues of dentistry. Collection of the III All-Russian scientific-practical conference with international participation. Edited by L.M. Zheleznov. 2019:110-112. (In Russ.)]. https://www.elibrary.ru/item.asp?id=41205123</mixed-citation>
     <mixed-citation xml:lang="en">Kazeko L.A., Benesh Yu.D. Ocenka rezorbcii kostnoy tkani pri razlichnyh formah techeniya periodontita. Aktual'nye voprosy stomatologii. Sbornik III Vserossiyskoy nauchno-prakticheskoy konferencii s mezhdunarodnym uchastiem. Pod redakciey L.M. Zheleznova. 2019:110-112. [L.A. Kazeko, Yu.D. Benesh. Evaluation of bone tissue resorption in various forms of periodontitis. Topical issues of dentistry. Collection of the III All-Russian scientific-practical conference with international participation. Edited by L.M. Zheleznov. 2019:110-112. (In Russ.)]. https://www.elibrary.ru/item.asp?id=41205123</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B29">
    <label>29.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Huamán S.D., Brito Aragão M.G., Dias Moreno A.P., Mussolino de Queiroz A., Bezerra da Silva R.A., Garcia de Paula-Silva F.W., Bezerra da Silva L.A. Accuracy of Conventional Periapical Radiography in Diagnosing Furcation Repair after Perforation Treatment // J Endod. - 2020;46(6):827-831. doi: 10.1016/j.joen.2020.03.004.</mixed-citation>
     <mixed-citation xml:lang="en">Huamán S.D., Brito Aragão M.G., Dias Moreno A.P., Mussolino de Queiroz A., Bezerra da Silva R.A., Garcia de Paula-Silva F.W., Bezerra da Silva L.A. Accuracy of Conventional Periapical Radiography in Diagnosing Furcation Repair after Perforation Treatment // J Endod. - 2020;46(6):827-831. doi: 10.1016/j.joen.2020.03.004.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B30">
    <label>30.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Zhang W., Foss K., Wang B.Y. A retrospective study on molar furcation assessment via clinical detection, intraoral radiography and cone beam computed tomography // BMC Oral Health. - 2018;18(1):75. doi: 10.1186/s12903-018-0544-0.</mixed-citation>
     <mixed-citation xml:lang="en">Zhang W., Foss K., Wang B.Y. A retrospective study on molar furcation assessment via clinical detection, intraoral radiography and cone beam computed tomography // BMC Oral Health. - 2018;18(1):75. doi: 10.1186/s12903-018-0544-0.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B31">
    <label>31.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Bolyachin A., Khabadze Z., Mordanov O., Gasbanov M., Teberdiev T. Symptomatic Apical Periodontitis of the Mandibular First Molar with the Accessory Canal in the Furcation Area Mimicking Furcation Perforation // Case Rep Dent. - 2022;2022:6324447. doi: 10.1155/2022/6324447.</mixed-citation>
     <mixed-citation xml:lang="en">Bolyachin A., Khabadze Z., Mordanov O., Gasbanov M., Teberdiev T. Symptomatic Apical Periodontitis of the Mandibular First Molar with the Accessory Canal in the Furcation Area Mimicking Furcation Perforation // Case Rep Dent. - 2022;2022:6324447. doi: 10.1155/2022/6324447.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B32">
    <label>32.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Gautam S., Galgali S.R., Sheethal H.S., Priya N.S. Pulpal changes associated with advanced periodontal disease: A histopathological study // J Oral Maxillofac Pathol. - 2017;21(1):58-63. doi: 10.4103/0973-029X.203795.</mixed-citation>
     <mixed-citation xml:lang="en">Gautam S., Galgali S.R., Sheethal H.S., Priya N.S. Pulpal changes associated with advanced periodontal disease: A histopathological study // J Oral Maxillofac Pathol. - 2017;21(1):58-63. doi: 10.4103/0973-029X.203795.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B33">
    <label>33.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Weinberg E.M., Pereda A.E., Khurana S., Lotlikar P.P., Falcon C., Hirschberg C. Incidence of Middle Mesial Canals Based on Distance between Mesial Canal Orifices in Mandibular Molars: A Clinical and Cone-beam Computed Tomographic Analysis // J Endod. - 2020;46(1):40-43. doi: 10.1016/j.joen.2019.10.017.</mixed-citation>
     <mixed-citation xml:lang="en">Weinberg E.M., Pereda A.E., Khurana S., Lotlikar P.P., Falcon C., Hirschberg C. Incidence of Middle Mesial Canals Based on Distance between Mesial Canal Orifices in Mandibular Molars: A Clinical and Cone-beam Computed Tomographic Analysis // J Endod. - 2020;46(1):40-43. doi: 10.1016/j.joen.2019.10.017.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B34">
    <label>34.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Chiu M.Y., Lin C.Y., Kuo P.Y. The predictive performance of surgical treatment in upper molars with combined bony defect and furcation involvement: a retrospective cohort study // BMC Oral Health. - 2022;22(1):156. doi: 10.1186/s12903-022-02196-0.</mixed-citation>
     <mixed-citation xml:lang="en">Chiu M.Y., Lin C.Y., Kuo P.Y. The predictive performance of surgical treatment in upper molars with combined bony defect and furcation involvement: a retrospective cohort study // BMC Oral Health. - 2022;22(1):156. doi: 10.1186/s12903-022-02196-0.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B35">
    <label>35.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Suzuki S., Yamada S. Epigenetics in susceptibility, progression, and diagnosis of periodontitis // Jpn Dent Sci Rev. - 2022;58:183-192. doi: 10.1016/j.jdsr.2022.06.001.</mixed-citation>
     <mixed-citation xml:lang="en">Suzuki S., Yamada S. Epigenetics in susceptibility, progression, and diagnosis of periodontitis // Jpn Dent Sci Rev. - 2022;58:183-192. doi: 10.1016/j.jdsr.2022.06.001.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B36">
    <label>36.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Sun X., Yang Z., Nie Y., Hou B. Microbial Communities in the Extraradicular and Intraradicular Infections Associated With Persistent Apical Periodontitis // Front Cell Infect Microbiol. - 2022;11:798367. doi: 10.3389/fcimb.2021.798367.</mixed-citation>
     <mixed-citation xml:lang="en">Sun X., Yang Z., Nie Y., Hou B. Microbial Communities in the Extraradicular and Intraradicular Infections Associated With Persistent Apical Periodontitis // Front Cell Infect Microbiol. - 2022;11:798367. doi: 10.3389/fcimb.2021.798367.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B37">
    <label>37.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Usui M., Onizuka S., Sato T., Kokabu S., Ariyoshi W., Nakashima K. Mechanism of alveolar bone destruction in periodontitis - Periodontal bacteria and inflammation // Jpn Dent Sci Rev. - 2021;57:201-208. doi: 10.1016/j.jdsr.2021.09.005.</mixed-citation>
     <mixed-citation xml:lang="en">Usui M., Onizuka S., Sato T., Kokabu S., Ariyoshi W., Nakashima K. Mechanism of alveolar bone destruction in periodontitis - Periodontal bacteria and inflammation // Jpn Dent Sci Rev. - 2021;57:201-208. doi: 10.1016/j.jdsr.2021.09.005.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B38">
    <label>38.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Sun P., Guo Z., Guo D., Wang J., Wu T., Li T., Liu J., Liu X. The Microbiota Profile Analysis of Combined Periodontal-Endodontic Lesions Using 16S rRNA Next-Generation Sequencing // J Immunol Res. - 2021;2021:2490064. doi: 10.1155/2021/2490064.</mixed-citation>
     <mixed-citation xml:lang="en">Sun P., Guo Z., Guo D., Wang J., Wu T., Li T., Liu J., Liu X. The Microbiota Profile Analysis of Combined Periodontal-Endodontic Lesions Using 16S rRNA Next-Generation Sequencing // J Immunol Res. - 2021;2021:2490064. doi: 10.1155/2021/2490064.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B39">
    <label>39.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Nibali L., Krajewski A., Donos N., Völzke H., Pink C., Kocher T., Holtfreter B. The effect of furcation involvement on tooth loss in a population without regular periodontal therapy // J Clin Periodontol. - 2017;44(8):813-821. doi: 10.1111/jcpe.12756.</mixed-citation>
     <mixed-citation xml:lang="en">Nibali L., Krajewski A., Donos N., Völzke H., Pink C., Kocher T., Holtfreter B. The effect of furcation involvement on tooth loss in a population without regular periodontal therapy // J Clin Periodontol. - 2017;44(8):813-821. doi: 10.1111/jcpe.12756.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B40">
    <label>40.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Gonçalves B.C., Costa A.L.F, Correa R., Andere N.M.R.B., Ogawa C.M., Santamaria M.P., de Castro Lopes S.L.P.. Analysis of geometrical tomographic parameters of furcation lesions in periodontitis patients // Heliyon. - 2021;7(1):e06119. doi: 10.1016/j.heliyon.2021.e06119.</mixed-citation>
     <mixed-citation xml:lang="en">Gonçalves B.C., Costa A.L.F, Correa R., Andere N.M.R.B., Ogawa C.M., Santamaria M.P., de Castro Lopes S.L.P.. Analysis of geometrical tomographic parameters of furcation lesions in periodontitis patients // Heliyon. - 2021;7(1):e06119. doi: 10.1016/j.heliyon.2021.e06119.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B41">
    <label>41.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Rôças I.N., Siqueira J.F. Frequency and levels of candidate endodontic pathogens in acute apical abscesses as compared to asymptomatic apical periodontitis // PLoS One. - 2018;13(1):e0190469. doi: 10.1371/journal.pone.0190469.</mixed-citation>
     <mixed-citation xml:lang="en">Rôças I.N., Siqueira J.F. Frequency and levels of candidate endodontic pathogens in acute apical abscesses as compared to asymptomatic apical periodontitis // PLoS One. - 2018;13(1):e0190469. doi: 10.1371/journal.pone.0190469.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B42">
    <label>42.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Глинкин В.В., Клемин В.А., Кондратюк Р.Б. Наличие и локализация микрофлоры в зубах с деструктивными формами периодонтитов. Университетская клиника. 2020;3(36):52-56. [V.V. Glinkin, V.A. Klemin, R.B. Kondratyuk. The presence and localization of microflora in teeth with destructive forms of periodontitis. University clinic. 2020;3(36):52-56. (In Russ.)]. doi: 10.26435/UC.V0I3(36).526</mixed-citation>
     <mixed-citation xml:lang="en">Glinkin V.V., Klemin V.A., Kondratyuk R.B. Nalichie i lokalizaciya mikroflory v zubah s destruktivnymi formami periodontitov. Universitetskaya klinika. 2020;3(36):52-56. [V.V. Glinkin, V.A. Klemin, R.B. Kondratyuk. The presence and localization of microflora in teeth with destructive forms of periodontitis. University clinic. 2020;3(36):52-56. (In Russ.)]. doi: 10.26435/UC.V0I3(36).526</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B43">
    <label>43.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Khijmatgar S., Panda S., Das M., Arbildo-Vega H., Del Fabbro M. Recombinant factors for periodontal intrabony defects: A systematic review and network meta-analysis of preclinical studies // J Tissue Eng Regen Med. - 2021;15(12):1069-1081. doi: 10.1002/term.3250.</mixed-citation>
     <mixed-citation xml:lang="en">Khijmatgar S., Panda S., Das M., Arbildo-Vega H., Del Fabbro M. Recombinant factors for periodontal intrabony defects: A systematic review and network meta-analysis of preclinical studies // J Tissue Eng Regen Med. - 2021;15(12):1069-1081. doi: 10.1002/term.3250.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B44">
    <label>44.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Caselli E., Fabbri C., D'Accolti M., Soffritti I., Bassi C., Mazzacane S., Franchi M. Defining the oral microbiome by whole-genome sequencing and resistome analysis: the complexity of the healthy picture // BMC Microbiol. - 2020;20(1):120. doi: 10.1186/s12866-020-01801-y.</mixed-citation>
     <mixed-citation xml:lang="en">Caselli E., Fabbri C., D'Accolti M., Soffritti I., Bassi C., Mazzacane S., Franchi M. Defining the oral microbiome by whole-genome sequencing and resistome analysis: the complexity of the healthy picture // BMC Microbiol. - 2020;20(1):120. doi: 10.1186/s12866-020-01801-y.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B45">
    <label>45.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Alsakr A.M., Creanga A.G., Alqahtani A.S., Gufran K. Accuracy and Reliability of CBCT Compared to Clinical Probing in Detection of Trifurcation Defects: An In Vivo Study // Biomed Res Int. - 2022;14;2022:5805776. doi: 10.1155/2022/ 5805776.</mixed-citation>
     <mixed-citation xml:lang="en">Alsakr A.M., Creanga A.G., Alqahtani A.S., Gufran K. Accuracy and Reliability of CBCT Compared to Clinical Probing in Detection of Trifurcation Defects: An In Vivo Study // Biomed Res Int. - 2022;14;2022:5805776. doi: 10.1155/2022/ 5805776.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B46">
    <label>46.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Sun X., Yang Z., Nie Y., Hou B. Microbial Communities in the Extraradicular and Intraradicular Infections Associated With Persistent Apical Periodontitis // Front Cell Infect Microbiol. - 2022;12;11:798367. doi: 10.3389/fcimb.2021.798367.</mixed-citation>
     <mixed-citation xml:lang="en">Sun X., Yang Z., Nie Y., Hou B. Microbial Communities in the Extraradicular and Intraradicular Infections Associated With Persistent Apical Periodontitis // Front Cell Infect Microbiol. - 2022;12;11:798367. doi: 10.3389/fcimb.2021.798367.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B47">
    <label>47.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Dubey S., Saha S.G., Rajkumar B., Dhole T.K. Comparative antimicrobial efficacy of selected root canal irrigants on commonly isolated microorganisms in endodontic infection // Eur J Dent. - 2017;11(1):12-16. doi: 10.4103/ejd.ejd_141_16.</mixed-citation>
     <mixed-citation xml:lang="en">Dubey S., Saha S.G., Rajkumar B., Dhole T.K. Comparative antimicrobial efficacy of selected root canal irrigants on commonly isolated microorganisms in endodontic infection // Eur J Dent. - 2017;11(1):12-16. doi: 10.4103/ejd.ejd_141_16.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B48">
    <label>48.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Laugisch O., Cosgarea R., Nikou G., Nikolidakis D., Donos N., Salvi G.E., Stavropoulos A., Jepsen S., Sculean A. Histologic evidence of periodontal regeneration in furcation defects: a systematic review // Clin Oral Investig. - 2019;23(7):2861-2906. doi: 10.1007/s00784-019-02964-3.</mixed-citation>
     <mixed-citation xml:lang="en">Laugisch O., Cosgarea R., Nikou G., Nikolidakis D., Donos N., Salvi G.E., Stavropoulos A., Jepsen S., Sculean A. Histologic evidence of periodontal regeneration in furcation defects: a systematic review // Clin Oral Investig. - 2019;23(7):2861-2906. doi: 10.1007/s00784-019-02964-3.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B49">
    <label>49.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Queiroz L.A., Casarian R.C.V., Daddoub S.M., Tatakis D.N., Enilson A.S., Kumar P.S. Furcation Therapy with Enamel Matrix Derivative: Effects on the Subgingival Microbiome // J Periodontol. - 2017;88(7):617-625. doi: 10.1902 / jop.2017.160542.</mixed-citation>
     <mixed-citation xml:lang="en">Queiroz L.A., Casarian R.C.V., Daddoub S.M., Tatakis D.N., Enilson A.S., Kumar P.S. Furcation Therapy with Enamel Matrix Derivative: Effects on the Subgingival Microbiome // J Periodontol. - 2017;88(7):617-625. doi: 10.1902 / jop.2017.160542.</mixed-citation>
    </citation-alternatives>
   </ref>
  </ref-list>
 </back>
</article>
