Actual problems in dentistry Actual problems in dentistry Проблемы стоматологии 2077-7566 2412-9461 52302 10.18481/2077-7566-2022-18-2-61-67 ТЕРАПЕВТИЧЕСКАЯ СТОМАТОЛОГИЯ THERAPEUTIC DENTISTRY ТЕРАПЕВТИЧЕСКАЯ СТОМАТОЛОГИЯ THE STATE OF HYGIENE AND CLINICAL MANIFESTATIONS OF DISEASES OF THE ORAL MUCOSA IN PATIENTS WITH COVID-19 СОСТОЯНИЕ ГИГИЕНЫ И КЛИНИЧЕСКИЕ ПРОЯВЛЕНИЯ ЗАБОЛЕВАНИЙ СЛИЗИСТОЙ ОБОЛОЧКИ ПОЛОСТИ РТА У ПАЦИЕНТОВ С COVID-19 Демьяненко Светлана Александровна Dem'yanenko Svetlana Aleksandrovna dc.kvalitet@gmail.com

доктор медицинских наук;

doctor of medical sciences;

 Дурягина Лариса Хамидуловна Duryagina Larisa Khamidulovna terstom-ua@mail.ru

доктор медицинских наук;

doctor of medical sciences;

 Дегтярева Людмила Анатольевна Degtyareva Ludmila A. belludic@yandex.ru

кандидат медицинских наук;

candidate of medical sciences;

 Прийма Наталья Владимировна Prijma Natalia V. nat.simferopol@yandex.ru

кандидат медицинских наук;

candidate of medical sciences;

 Дубровина-Парус Татьяна Анатольевна Dubrovina-Parus Tatiana A. casandra.2008@yandex.ru Дорофеева Ольга Владимирова Dorofeeva Olga V. terstom-ua@mail.ru Тофан Юлия Владимировна Tofan Yulia V. julia.tofan@yandex.ru Крымский федеральный университет им. В. И. Вернадского Симферополь Россия Crimea State Medical University named after S.I.Georgievsky Simferopol Russian Federation Крымский федеральный университет им. В. И. Вернадского Симферополь Россия Crimean Federal University. V. I. Vernadsky Simferopol Russian Federation Крымский федеральный университет им. В. И. Вернадского Симферополь Россия Institute «Medical Academy named after S.I. Georgievsky» of V.I. Vernadsky Crimean Federal University Simferopol Russian Federation Крымский федеральный университет им. В. И. Вернадского Симферополь Россия Crimean Federal University Simferopol Russian Federation Крымский федеральный университет им. В. И. Вернадского Симферополь Россия Crimean Federal University. V. I. Vernadsky Simferopol Russian Federation Крымский федеральный университет им. В. И. Вернадского Симферополь Россия Crimean Federal University. V. I. Vernadsky Simferopol Russian Federation Крымский федеральный университет им. В. И. Вернадского Симферополь Россия Crimean Federal University. V. I. Vernadsky Simferopol Russian Federation 18 08 2022 18 08 2022 18 2 61 67 04 08 2022 https://dental-press.ru/en/nauka/article/52302/view

Цель исследования: изучить гигиеническое состояние полости рта и клинические проявления заболеваний СОПР у пациентов с COVID-19 в условиях стационара и обосновать необходимость мотивации раннего проведения гигиенических мероприятий с использованием зубной щетки и зубной пасты у данного контингента больных. Материал и методы. Под нашим наблюдением находились 43 пациента инфекционного отделения ГБУЗ РК КРКГВВ г. Симферополя в возрасте 21–25 лет с COVID-19 легкой и средней степени тяжести. Всем пациентам было проведено комплексное стоматологическое обследование с определением индекса Грина–Вермиллиона, индекса РМА. Особое внимание обращали на используемые средства гигиены и режим проведения гигиенических мероприятий до и во время пребывания в стационаре. Результаты и их обсуждение. Установлено, что 67,44% обследованных чистили зубы с разной кратностью применения зубной щетки и зубной пасты. До поступления в стационар 93,02% пациентов чистили зубы регулярно 2 раза в день. Использовали чистящие тампоны и ополаскиватель 27,91%, не чистили зубы 4,65% обследованных. Выявлено достоверное увеличение индекса гигиены и индекса РМА у пациентов 1-й и 2-й группы, которые не пользуются для ухода за полостью рта зубной щеткой и пастой (p < 0,001). У 27,91% пациентов отмечены изменения губ и СОПР: 4,65% — рецидивирующий лабиальный герпес, 4,65% — десквамативный глоссит, афтозные высыпания — 16,28%, лихеноидные проявления — 2,32% обследованных. Заживление афтозных поражений СОПР у пациентов, которые чистили зубы, было отмечено на 5–10-е сутки, а у пациентов, которые не чистили зубы, — на 15-й день. Выводы. Полученные в нашем исследовании данные свидетельствуют о необходимости активной мотивации пациентов с COVID-19 в условиях стационара к раннему проведению гигиенических мероприятий с обязательным использованием зубной щетки и зубной пасты.

The purpose of the research: to study the hygienic condition of the oral cavity and clinical manifestations of diseases of the oral mucosa in patients with COVID-19 in a hospital setting and to justify the need to motivate early hygienic measures using a toothbrush and toothpaste in this contingent of patients. Material and methods. We observed 43 patients of the infectious diseases department of the Simferopol clinic aged 21–25 years with COVID-19 of mild and moderate severity. All patients underwent a comprehensive dental examination with the determination of the Green–Vermillion index, the PMA index. Particular attention was paid to the hygiene products used and the regime of hygienic measures before and during hospital stay. Results and their discussion. It was found that 67.44% of the surveyed brushed their teeth with different frequency of use of a toothbrush and toothpaste. Before admission to the hospital, 93.02% of patients brushed their teeth regularly 2 times a day. 27.91% used cleaning tampons and a mouthwash, 4.65% of the surveyed did not brush their teeth. A significant increase in the hygiene index and the PMA index was revealed in patients of groups 1 and 2 who do not use a toothbrush and paste for oral care (p < 0.001). In 27.91% of patients, changes in the lips and oral mucosa was noted: 4.65% – recurrent labial herpes, 4.65% – desquamative glossitis, aphthous rashes – 16.28%, lichenoid manifestations – 2.32% of the examined. Healing of aphthous lesions of oral mucosa in patients who brushed their teeth was noted on the day 5–10, and in patients who did not brush their teeth – on 15th day. Conclusions. The data obtained in our research indicate the need for active motivation of patients with COVID-19 in a hospital setting for early hygienic measures with the mandatory use of a toothbrush and toothpaste.

 COVID-19 коронавирусная инфекция гигиена полости рта средства гигиены слизистая оболочка полости рта COVID-19 coronavirus infection oral hygiene hygiene products oral mucosa

Гилева О.С., Либик Т.В., Гибадуллина Н.В., Сивак Е.Ю., Гавриленко М.С., Белева Н.С., Задорина И.И. Ключевые стоматологические проблемы периода пандемии COVID-19: мониторинг состояния стоматологического здоровья у пациентов с хроническими заболеваниями слизистой оболочки полости рта. Стоматология. 2021;100(6-2):8-15. [O.S. Gileva, T.V. Libik, N.V. Gibadullina, E.Ju. Sivak, M.S. Gavrilenko, N.S. Beleva, I.I. Zadorina. Key dental challenges during COVID-19 pandemic: oral health monitoring in patients with chronic oral mucosal diseases. Dentistry. 2021;100(6-2):8-15. (In Russ.)]. https://doi.org/10.17116/stomat20211000628 Gileva O.S., Libik T.V., Gibadullina N.V., Sivak E.Yu., Gavrilenko M.S., Beleva N.S., Zadorina I.I. Klyuchevye stomatologicheskie problemy perioda pandemii COVID-19: monitoring sostoyaniya stomatologicheskogo zdorov'ya u pacientov s hronicheskimi zabolevaniyami slizistoy obolochki polosti rta. Stomatologiya. 2021;100(6-2):8-15. [O.S. Gileva, T.V. Libik, N.V. Gibadullina, E.Ju. Sivak, M.S. Gavrilenko, N.S. Beleva, I.I. Zadorina. Key dental challenges during COVID-19 pandemic: oral health monitoring in patients with chronic oral mucosal diseases. Dentistry. 2021;100(6-2):8-15. (In Russ.)]. https://doi.org/10.17116/stomat20211000628 Гилева О.С., Фелюдблюм И.В., Либик Т.В., Байдаров А.А., Сметанин Д.Г., Чупракова Е.В., Сивак Е.Ю., Сюткина Е.С. Ключевые стоматологические проблемы периода пандемии COVID-19: междисциплинарная платформа. Стоматология детского возраста и профилактика. 2021;21(1(77)):61-65. [O.S. Gileva, I.V. Feljudbljum, T.V. Libik, A.A. Bajdarov, D.G. Smetanin, E.V. Chuprakova, E.Ju. Sivak, E.S. Sjutkina. Key dental problems of the COVID-19 pandemic period: an interdisciplinary platform. Pediatric dentistry and prevention. 2021;21(1(77)):61-65. (In Russ.)]. https://doi.org/10.33925/1683-3031-2021-21-1-61-65 Gileva O.S., Felyudblyum I.V., Libik T.V., Baydarov A.A., Smetanin D.G., Chuprakova E.V., Sivak E.Yu., Syutkina E.S. Klyuchevye stomatologicheskie problemy perioda pandemii COVID-19: mezhdisciplinarnaya platforma. Stomatologiya detskogo vozrasta i profilaktika. 2021;21(1(77)):61-65. [O.S. Gileva, I.V. Feljudbljum, T.V. Libik, A.A. Bajdarov, D.G. Smetanin, E.V. Chuprakova, E.Ju. Sivak, E.S. Sjutkina. Key dental problems of the COVID-19 pandemic period: an interdisciplinary platform. Pediatric dentistry and prevention. 2021;21(1(77)):61-65. (In Russ.)]. https://doi.org/10.33925/1683-3031-2021-21-1-61-65 Модина Т.Н., Циннекер Д.Т., Харитонова М.А., Махди Мохаймен Махмуд Махди, Мамаева Е.В., Усманова И.Н. SARS-COV-2 в полости рта и обострение хронической пародонтальной патологии у пациентов с новой коронавирусной инфекцией (COVID-19). Проблемы стоматологии. 2021;1:70-75. [T.N. Modina, D.T. Cinneker, M.A. Haritonova, Mahdi Mohajmen Mahmud Mahdi, E.V. Mamaeva, I.N. Usmanova. SARS-COV-2 in the oral cavity and exacerbation of chronic periodontal pathology in patients with a new coronavirus infection (COVID-19). Actual problems in dentistry. 2021;1:70-75. (In Russ.)]. https://doi.org/10.18481/2077-7566-20-17-1-70-75 Modina T.N., Cinneker D.T., Haritonova M.A., Mahdi Mohaymen Mahmud Mahdi, Mamaeva E.V., Usmanova I.N. SARS-COV-2 v polosti rta i obostrenie hronicheskoy parodontal'noy patologii u pacientov s novoy koronavirusnoy infekciey (COVID-19). Problemy stomatologii. 2021;1:70-75. [T.N. Modina, D.T. Cinneker, M.A. Haritonova, Mahdi Mohajmen Mahmud Mahdi, E.V. Mamaeva, I.N. Usmanova. SARS-COV-2 in the oral cavity and exacerbation of chronic periodontal pathology in patients with a new coronavirus infection (COVID-19). Actual problems in dentistry. 2021;1:70-75. (In Russ.)]. https://doi.org/10.18481/2077-7566-20-17-1-70-75 Насибуллина А.Х., Кабирова М.Ф., Кабиров И.Р., Валишин Д.А. Особенности стоматологического статуса пациентов с SARS-COV-2. Проблемы стоматологии. 2021;17(3):29-34. [A.H. Nasibullina, M.F. Kabirova, I.R. Kabirov, D.A. Valishin. Features of the dental status of patients with SARS-COV-2. Actual problems in dentistry. 2021;17(3):29-34. (In Russ.)].https://doi.org/10.18481/2077-7566-21-17-3-29-34 Nasibullina A.H., Kabirova M.F., Kabirov I.R., Valishin D.A. Osobennosti stomatologicheskogo statusa pacientov s SARS-COV-2. Problemy stomatologii. 2021;17(3):29-34. [A.H. Nasibullina, M.F. Kabirova, I.R. Kabirov, D.A. Valishin. Features of the dental status of patients with SARS-COV-2. Actual problems in dentistry. 2021;17(3):29-34. (In Russ.)].https://doi.org/10.18481/2077-7566-21-17-3-29-34 Розов Р.А., Чебуранова Н.Н., Северова О.М., Первухина Н.А., Сопрун Л.А. Организация неотложной стоматологической помощи взрослым и детям с новой коронавирусной инфекцией, вызванной SARS-CoV-2, на базе городской стоматологической поликлиники мегаполиса. Стоматология. 2021;100(4):88-97. [R.A. Rozov, N.N. Cheburanova, O.M. Severova, N.A. Pervukhina, L.A. Soprun. Emergency dental care for adults and children with a new coronavirus infection caused by SARS-Cov-2 at an out-patients dental clinic in a megapolis. Dentistry. 2021;100(4):88-97. (In Russ.)]. https://doi.org/10.17116/stomat202110004188 Rozov R.A., Cheburanova N.N., Severova O.M., Pervuhina N.A., Soprun L.A. Organizaciya neotlozhnoy stomatologicheskoy pomoschi vzroslym i detyam s novoy koronavirusnoy infekciey, vyzvannoy SARS-CoV-2, na baze gorodskoy stomatologicheskoy polikliniki megapolisa. Stomatologiya. 2021;100(4):88-97. [R.A. Rozov, N.N. Cheburanova, O.M. Severova, N.A. Pervukhina, L.A. Soprun. Emergency dental care for adults and children with a new coronavirus infection caused by SARS-Cov-2 at an out-patients dental clinic in a megapolis. Dentistry. 2021;100(4):88-97. (In Russ.)]. https://doi.org/10.17116/stomat202110004188 Amorim Dos Santos J., Normando A.G.C., Carvalho da Silva R.L. et al. Oral Manifestations in Patients with COVID-19: A Living Systematic Review // J Dent Res. - 2021;100(2):141-154. https://doi.org/10.1177/0022034520957289 Amorim Dos Santos J., Normando A.G.C., Carvalho da Silva R.L. et al. Oral Manifestations in Patients with COVID-19: A Living Systematic Review // J Dent Res. - 2021;100(2):141-154. https://doi.org/10.1177/0022034520957289 Baig A.M., Khaleeq A., Ali U., Syeda H. Evidence of the COVID-19 virus targeting the CNS: Tissue distribution, host-virus interaction, and proposed neurotropic mechanisms // ACS Chemical Neuroscience. - 2020;11(7):995-998. https://doi.org/10.1021/acschemneuro.0c00122 Baig A.M., Khaleeq A., Ali U., Syeda H. Evidence of the COVID-19 virus targeting the CNS: Tissue distribution, host-virus interaction, and proposed neurotropic mechanisms // ACS Chemical Neuroscience. - 2020;11(7):995-998. https://doi.org/10.1021/acschemneuro.0c00122 Bhujel N., Zaheer K., Singh R.P. Oral mucosal lesions in patients with COVID-19: a systematic review // Br J Oral Maxillofac Surg. - 2021;S0266-4356(21)00243-6. https://doi.org/10.1016/j.bjoms.2021.06.011 Bhujel N., Zaheer K., Singh R.P. Oral mucosal lesions in patients with COVID-19: a systematic review // Br J Oral Maxillofac Surg. - 2021;S0266-4356(21)00243-6. https://doi.org/10.1016/j.bjoms.2021.06.011 Bradley M., Black P., Noble S., Thompson R., Lamey P.J. Application of teledentistry in oral medicine in a community dental service, N. Ireland // British Dental Journal. - 2010;209(8):399- 404.https://doi.org/10.1038/sj.bdj.2010.928 Bradley M., Black P., Noble S., Thompson R., Lamey P.J. Application of teledentistry in oral medicine in a community dental service, N. Ireland // British Dental Journal. - 2010;209(8):399- 404.https://doi.org/10.1038/sj.bdj.2010.928 Brandão T.B., Gueiros L.A., Melo T.S. et al. Oral lesions in patients with SARS-CoV-2 infection: could the oral cavity be a target organ? // Oral Surg Oral Med Oral Pathol Oral Radiol. - 2021;131(2):45-51. https://doi.org/10.1016/j.oooo.2020.07.014 Brandão T.B., Gueiros L.A., Melo T.S. et al. Oral lesions in patients with SARS-CoV-2 infection: could the oral cavity be a target organ? // Oral Surg Oral Med Oral Pathol Oral Radiol. - 2021;131(2):45-51. https://doi.org/10.1016/j.oooo.2020.07.014 Chan J.-W., Yuan S., Kok K.-H., To K.-W., Chu H., Yang J., Yuen K.-Y. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster // Lancet. - 2020;395(10223):514-523. https://doi.org/10.1016/S0140-6736(20)30154-9 Chan J.-W., Yuan S., Kok K.-H., To K.-W., Chu H., Yang J., Yuen K.-Y. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster // Lancet. - 2020;395(10223):514-523. https://doi.org/10.1016/S0140-6736(20)30154-9 Chaux-Bodard A.-G., Deneuve S., Desoutter A. Oral manifestation of Covid-19 as an inaugural symptom? // Journal of Oral Medicine and Oral Surgery. - 2020;26;2:18. https://doi.org/10.1051/MBCB/2020011 Chaux-Bodard A.-G., Deneuve S., Desoutter A. Oral manifestation of Covid-19 as an inaugural symptom? // Journal of Oral Medicine and Oral Surgery. - 2020;26;2:18. https://doi.org/10.1051/MBCB/2020011 Coulthard P. Dentistry and coronavirus (COVID-19) - moral decision-making // British Dental Journal. - 2020;228:503-505. https://doi.org/10.1038/s41415-020-1482-1 Coulthard P. Dentistry and coronavirus (COVID-19) - moral decision-making // British Dental Journal. - 2020;228:503-505. https://doi.org/10.1038/s41415-020-1482-1 Elmas Ö.F., Dembas A., Özyurt K., Atasoy M., Türsen Ü. Cutaneous manifestations of COVID-19: A review of the published literature // DermatolTher. - 2020;33(4):13696. https://doi.org/10.1111/dth.13696 Elmas Ö.F., Dembas A., Özyurt K., Atasoy M., Türsen Ü. Cutaneous manifestations of COVID-19: A review of the published literature // DermatolTher. - 2020;33(4):13696. https://doi.org/10.1111/dth.13696 Guo Y., Yuan C., Wei C. Emergency measures for acute oral mucosa diseases during the outbreak of COVID-19 // Oral Dis. - 2021;27(3):737-739. https://doi.org/10.1111/odi.13350 Guo Y., Yuan C., Wei C. Emergency measures for acute oral mucosa diseases during the outbreak of COVID-19 // Oral Dis. - 2021;27(3):737-739. https://doi.org/10.1111/odi.13350 Iranmanesh B., Khalili M., Amiri R., Zartab H., Aflatoonian M. Oral manifestations of COVID-19 disease: A review article // DermatolTher. - 2021;34(1):e14578. https://doi.org/10.1111/dth.14578 Iranmanesh B., Khalili M., Amiri R., Zartab H., Aflatoonian M. Oral manifestations of COVID-19 disease: A review article // DermatolTher. - 2021;34(1):e14578. https://doi.org/10.1111/dth.14578 Kumar K.S., Venkitachalam R., Varma B., Nair P.K., Shanmugham A.M., Jose R. Oral medicine practice during COVID-19: A scoping review // J Indian Acad Oral Med Radiol. - 2021;33:215-221. https://doi.org/10.4103/jiaomr.jiaomr_4_21 Kumar K.S., Venkitachalam R., Varma B., Nair P.K., Shanmugham A.M., Jose R. Oral medicine practice during COVID-19: A scoping review // J Indian Acad Oral Med Radiol. - 2021;33:215-221. https://doi.org/10.4103/jiaomr.jiaomr_4_21 Lv N., Sun M., Polonowita A., Mei L., Guan G. Management of oral medicine emergencies during COVID-19: A study to develop practise guidelines // J Dent Sci. - 2021;16(1):493-500. https://doi.org/10.1016/j.jds.2020.07.016 Lv N., Sun M., Polonowita A., Mei L., Guan G. Management of oral medicine emergencies during COVID-19: A study to develop practise guidelines // J Dent Sci. - 2021;16(1):493-500. https://doi.org/10.1016/j.jds.2020.07.016 Meng L., Hua F., Bian Z. Coronavirus Disease 2019 (COVID-19): Emerging and future challenges for dental and oral medicine // Journal of Dental Research. - 2020;99(5):481-487. https://doi.org/10.1177/0022034520914246 Meng L., Hua F., Bian Z. Coronavirus Disease 2019 (COVID-19): Emerging and future challenges for dental and oral medicine // Journal of Dental Research. - 2020;99(5):481-487. https://doi.org/10.1177/0022034520914246 Nörz D., Fischer N., Schultze A., Kluge S., Mayer-Runge U., Aepfelbacher M., Lütgehetmann M. Clinical evaluation of a SARS-CoV-2 RT-PCR assay on a fully automated system for rapid on-demand testing in the hospital setting // Journal of Clinical Virology. - 2020;128:104390. https://doi.org/10.1016/j.jcv.2020.104390 Nörz D., Fischer N., Schultze A., Kluge S., Mayer-Runge U., Aepfelbacher M., Lütgehetmann M. Clinical evaluation of a SARS-CoV-2 RT-PCR assay on a fully automated system for rapid on-demand testing in the hospital setting // Journal of Clinical Virology. - 2020;128:104390. https://doi.org/10.1016/j.jcv.2020.104390 Peng X., Xu X., Li Y., Cheng L., Zhou X., Ren B. Transmission routes of 2019-nCoV and controls in dental practice // International Journal of Oral Science. - 2020;12(1):9. https://doi.org/10.1038/s41368-020-0075-9 Peng X., Xu X., Li Y., Cheng L., Zhou X., Ren B. Transmission routes of 2019-nCoV and controls in dental practice // International Journal of Oral Science. - 2020;12(1):9. https://doi.org/10.1038/s41368-020-0075-9 Society of Oral Mucosal Diseases, Chinese Stomatological Association. Expert recommendations for prevention, treatment and care of oral ulcers and other mucosal diseases during the outbreak of COVID-19 // Clinical Journal of Dental Research. - 2020;3;23. http://cjdr.cndent.com/uploads/media/200304/13-200304091500.pdf Society of Oral Mucosal Diseases, Chinese Stomatological Association. Expert recommendations for prevention, treatment and care of oral ulcers and other mucosal diseases during the outbreak of COVID-19 // Clinical Journal of Dental Research. - 2020;3;23. http://cjdr.cndent.com/uploads/media/200304/13-200304091500.pdf Stomatological Healthcare Service Branch of Chinese Stomatological Association. The guidelines on prevention and disease control in dental practice during the outbreak of corona virus disease 2019 // Clinical Journal of Dental Research. - 2020;4;23. http://cjdr.cndent.com/uploads/media/200304/13-200304092U5.pdf Stomatological Healthcare Service Branch of Chinese Stomatological Association. The guidelines on prevention and disease control in dental practice during the outbreak of corona virus disease 2019 // Clinical Journal of Dental Research. - 2020;4;23. http://cjdr.cndent.com/uploads/media/200304/13-200304092U5.pdf Xu H., Zhong L., Deng J., Peng J., Dan H., Zeng X., Chen Q. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa // International Journal of Oral Science. - 2020;12(1):8. https://doi.org/10.1038/s41368-020-0074-x Xu H., Zhong L., Deng J., Peng J., Dan H., Zeng X., Chen Q. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa // International Journal of Oral Science. - 2020;12(1):8. https://doi.org/10.1038/s41368-020-0074-x Xu R., Cui B., Duan X., Zhang P., Zhou X., Yuan Q. Saliva: Potential diagnostic value and transmission of 2019-nCoV // International Journal of Oral Science. - 2020;12(1):11. https://doi.org/10.1038/s41368-020-0080-z Xu R., Cui B., Duan X., Zhang P., Zhou X., Yuan Q. Saliva: Potential diagnostic value and transmission of 2019-nCoV // International Journal of Oral Science. - 2020;12(1):11. https://doi.org/10.1038/s41368-020-0080-z