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 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">Actual problems in dentistry</journal-id>
   <journal-title-group>
    <journal-title xml:lang="en">Actual problems in dentistry</journal-title>
    <trans-title-group xml:lang="ru">
     <trans-title>Проблемы стоматологии</trans-title>
    </trans-title-group>
   </journal-title-group>
   <issn publication-format="print">2077-7566</issn>
   <issn publication-format="online">2412-9461</issn>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="publisher-id">50213</article-id>
   <article-id pub-id-type="doi">10.18481/2077-7566-22-18-1-78-86</article-id>
   <article-categories>
    <subj-group subj-group-type="toc-heading" xml:lang="ru">
     <subject>ТЕРАПЕВТИЧЕСКАЯ СТОМАТОЛОГИЯ</subject>
    </subj-group>
    <subj-group subj-group-type="toc-heading" xml:lang="en">
     <subject>THERAPEUTIC  DENTISTRY</subject>
    </subj-group>
    <subj-group>
     <subject>ТЕРАПЕВТИЧЕСКАЯ СТОМАТОЛОГИЯ</subject>
    </subj-group>
   </article-categories>
   <title-group>
    <article-title xml:lang="en">PROCESSING OF CBCT DATA WITH ARTIFICIAL INTELLIGENCE IN THE DIAGNOSIS OF CARIES AND ITS COMPLICATIONS</article-title>
    <trans-title-group xml:lang="ru">
     <trans-title>ОБРАБОТКА КЛКТ-ДАННЫХ ИСКУССТВЕННЫМ ИНТЕЛЛЕКТОМ ПРИ ДИАГНОСТИКЕ КАРИЕСА И ЕГО ОСЛОЖНЕНИЙ</trans-title>
    </trans-title-group>
   </title-group>
   <contrib-group content-type="authors">
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Хабадзе</surname>
       <given-names>Зураб Суликоевич</given-names>
      </name>
      <name xml:lang="en">
       <surname>Khabadze</surname>
       <given-names>Zurab Sulikoevich</given-names>
      </name>
     </name-alternatives>
     <email>dr.zura@mail.ru</email>
     <bio xml:lang="ru">
      <p>кандидат медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>candidate of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Макеева</surname>
       <given-names>Ирина Михайловна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Makeeva</surname>
       <given-names>Irina Mikhailovna</given-names>
      </name>
     </name-alternatives>
     <email>makeeva_i_m@staff.sechenov.ru</email>
     <bio xml:lang="ru">
      <p>доктор медицинских наук;</p>
     </bio>
     <bio xml:lang="en">
      <p>doctor of medical sciences;</p>
     </bio>
     <xref ref-type="aff" rid="aff-2"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Морданов</surname>
       <given-names>Олег Сергеевич</given-names>
      </name>
      <name xml:lang="en">
       <surname>Mordanov</surname>
       <given-names>Oleg Sergeevich</given-names>
      </name>
     </name-alternatives>
     <email>mordanov-os@rudn.ru</email>
     <xref ref-type="aff" rid="aff-3"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Назарова</surname>
       <given-names>Дарья Александровна</given-names>
      </name>
      <name xml:lang="en">
       <surname>Nazarova</surname>
       <given-names>Daria A.</given-names>
      </name>
     </name-alternatives>
     <email>1032182486@rudn.ru</email>
     <xref ref-type="aff" rid="aff-4"/>
    </contrib>
   </contrib-group>
   <aff-alternatives id="aff-1">
    <aff>
     <institution xml:lang="ru">Российский университет дружбы народов</institution>
     <city>Москва</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Peoples' Friendship University of Russia</institution>
     <city>Moscow</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-2">
    <aff>
     <institution xml:lang="ru">Первый Московский государственный медицинский университет имени И. М. Сеченова</institution>
     <city>Москва</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">I. M. Sechenov First Moscow State Medical University</institution>
     <city>Moscow</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-3">
    <aff>
     <institution xml:lang="ru">Российский университет дружбы народов</institution>
     <city>Москва</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Peoples' Friendship University of Russia</institution>
     <city>Moscow</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-4">
    <aff>
     <institution xml:lang="ru">Российский университет дружбы народов</institution>
     <city>Москва</city>
     <country>Россия</country>
    </aff>
    <aff>
     <institution xml:lang="en">Peoples' Friendship University of Russia</institution>
     <city>Moscow</city>
     <country>Russian Federation</country>
    </aff>
   </aff-alternatives>
   <pub-date publication-format="print" date-type="pub" iso-8601-date="2022-05-17T21:19:55+03:00">
    <day>17</day>
    <month>05</month>
    <year>2022</year>
   </pub-date>
   <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2022-05-17T21:19:55+03:00">
    <day>17</day>
    <month>05</month>
    <year>2022</year>
   </pub-date>
   <volume>18</volume>
   <issue>1</issue>
   <fpage>78</fpage>
   <lpage>86</lpage>
   <history>
    <date date-type="received" iso-8601-date="2022-05-06T00:00:00+03:00">
     <day>06</day>
     <month>05</month>
     <year>2022</year>
    </date>
   </history>
   <self-uri xlink:href="https://dental-press.ru/en/nauka/article/50213/view">https://dental-press.ru/en/nauka/article/50213/view</self-uri>
   <abstract xml:lang="ru">
    <p>За последние несколько лет технологии искусственного интеллекта (ИИ) стали активно применяться во многих разделах медицины, в том числе в стоматологии. &#13;
Цель исследования — определить диагностическую ценность ИИ в выявлении кариеса и его осложнений по данным конусно-лучевой компьютерной томографии (КЛКТ) в сопоставлении с клиническим обследованием. &#13;
Материалы и методы. КЛКТ-изображения 15 пациентов с кариозными и периодонтальными поражениями были проанализированы опытным врачом-стоматологом, имеющим специализацию в области рентгенологии, и программным обеспечением Diagnocat AI. Также врачом-стоматологом был проведен визуальный осмотр данных пациентов.&#13;
Результаты. Больше всего контактных кариесов было определено с помощью ИИ (n = 20), а окклюзионных кариесов — при клиническом обследовании (n = 10). Наибольшее количество периапикальных изменений было обнаружено при применении ИИ (n = 22). Разница между показателями выявления патологических очагов при оценке ИИ и врачом-рентгенологом была статистически незначимой, что говорит о равнозначности данных методов. Рентгенологическая оценка изображений позволила выявить большее число контактных кариесов по сравнению с клиническим осмотром (14 против 7, p &lt; 0,05), но клинический осмотр оказался эффективнее в отношении выявления окклюзионных кариесов (10 против 2, p &lt; 0,03). Заболевания периодонта были точнее диагностированы рентгенологическим методом (17 против 9, p &lt; 0,05). Среднее время оценки КЛКТ-изображений врачом-рентгенологом составило 21,54 ± 4,4 минуты, а ИИ выполнил отчет за 4,6 ± 4,4 минуты от момента завершения загрузки КЛКТ (p &lt; 0,01). &#13;
Заключение. Применение технологий ИИ при анализе КЛКТ-изображений позволяет повысить точность диагностики кариеса и его осложнений до 98%, а также существенно ускорить время принятия диагностического решения.</p>
   </abstract>
   <trans-abstract xml:lang="en">
    <p>Over the past few years, artificial intelligence (AI) technologies have been actively used in many areas of medicine, including dentistry. &#13;
The aim of the study is to determine the diagnostic value of IS in the detection of caries and its complications according to cone beam computed tomography (CBCT) data in comparison with clinical examination. &#13;
Materials and methods. CBCT images of 15 patients with carious and periodontal lesions were analyzed by an experienced dentist, who also specializes in radiology, and the Diagnocat AI software. The dentist also performed a visual examination of these patients. &#13;
Results. Most of all contact caries were determined using AI (n = 20), and occlusal caries − during clinical examination (n = 10). The greatest number of periapical changes was also detected using IS (n = 22). The difference between the indicators of detection of pathological foci in the assessment of IS and the radiologist was statistically insignificant, which indicates the equivalence of these methods. X-ray image evaluation revealed more contact caries compared to clinical examination (14 vs. 7, p &lt; 0.05), but clinical examination was superior in detecting occlusal caries (10 vs. 2, p &lt; 0.03). Periodontal disease was more accurately diagnosed by X-ray (17 vs. 9, p &lt; 0.05). The average time for evaluation of CBCT images by a radiologist was 21.54 ± 4.4 minutes, and the AI completed the report in 4.6 ± 4.4 minutes from the moment the loading of CBCT was completed (p &lt; 0.01). &#13;
Conclusion. The use of AI technologies in the analysis of CBCT images can improve the accuracy of diagnosing caries and its complications by up to 98%, as well as significantly speed up the time for making a diagnostic decision.</p>
   </trans-abstract>
   <kwd-group xml:lang="ru">
    <kwd>искусственный интеллект</kwd>
    <kwd>кариес</kwd>
    <kwd>диагностика</kwd>
    <kwd>конусно-лучевая компьютерная томография</kwd>
    <kwd>периапикальные изменения</kwd>
   </kwd-group>
   <kwd-group xml:lang="en">
    <kwd>artificial intelligence</kwd>
    <kwd>caries</kwd>
    <kwd>diagnostics</kwd>
    <kwd>cone beam computed tomography</kwd>
    <kwd>periapical changes</kwd>
   </kwd-group>
  </article-meta>
 </front>
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 </body>
 <back>
  <ref-list>
   <ref id="B1">
    <label>1.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Бурда А.Н., Рутковская А.С. Диагностика скрытого кариеса с помощью рентген-диагностики BITEWING. Современная стоматология. 2020;3:86-90. [A.N. Burda, A.S. Rutkovskaya. Diagnosis of latent caries using BITEWING X-ray diagnostics. Modern dentistry. 2020;3:86-90. (In Russ.)]. https://www.elibrary.ru/item.asp?id=44144549</mixed-citation>
     <mixed-citation xml:lang="en">Burda A.N., Rutkovskaya A.S. Diagnostika skrytogo kariesa s pomosch'yu rentgen-diagnostiki BITEWING. Sovremennaya stomatologiya. 2020;3:86-90. [A.N. Burda, A.S. Rutkovskaya. Diagnosis of latent caries using BITEWING X-ray diagnostics. Modern dentistry. 2020;3:86-90. (In Russ.)]. https://www.elibrary.ru/item.asp?id=44144549</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B2">
    <label>2.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Казумян С.В., Дегтев И.А., Борисов В.В., Ершов К.А. Виртуальные технологии в стоматологии. Вестник Авиценны. 2020;22(4):606-612. [S.V. Kazumyan, I.A. Degtev, V.V. Borisov, K.A. Ershov. Virtual technologies in dentistry. Bulletin of Avicenna. 2020;22(4):606-612. (In Russ.)]. doi: 10.25005/2074-0581-2020-22-4-606-612</mixed-citation>
     <mixed-citation xml:lang="en">Kazumyan S.V., Degtev I.A., Borisov V.V., Ershov K.A. Virtual'nye tehnologii v stomatologii. Vestnik Avicenny. 2020;22(4):606-612. [S.V. Kazumyan, I.A. Degtev, V.V. Borisov, K.A. Ershov. Virtual technologies in dentistry. Bulletin of Avicenna. 2020;22(4):606-612. (In Russ.)]. doi: 10.25005/2074-0581-2020-22-4-606-612</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B3">
    <label>3.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Пальмов С.В., Бахмурина А.А. Использование нейронных сетей в стоматологии. Проблемы развития предприятий: теория и практика. 2020;1-2:237-240. [S.V. Palmov, A.A. Bakhmurina. The use of neural networks in dentistry. Problems of enterprise development: theory and practice. 2020;1-2:237-240. (In Russ.)]. https://www.elibrary.ru/item.asp?id=44800679</mixed-citation>
     <mixed-citation xml:lang="en">Pal'mov S.V., Bahmurina A.A. Ispol'zovanie neyronnyh setey v stomatologii. Problemy razvitiya predpriyatiy: teoriya i praktika. 2020;1-2:237-240. [S.V. Palmov, A.A. Bakhmurina. The use of neural networks in dentistry. Problems of enterprise development: theory and practice. 2020;1-2:237-240. (In Russ.)]. https://www.elibrary.ru/item.asp?id=44800679</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B4">
    <label>4.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Abdalla-Aslan R., Yeshua T., Kabla D., Nadler C. An artificial intelligence system using machine-learning for automatic detection and classification of dental restorations in panoramic radiography // Oral Surg Oral Med Oral Pathol Oral Radiol. - 2020;130(5):593-602. https://doi.org/10.1016/j.oooo.2020.05.012</mixed-citation>
     <mixed-citation xml:lang="en">Abdalla-Aslan R., Yeshua T., Kabla D., Nadler C. An artificial intelligence system using machine-learning for automatic detection and classification of dental restorations in panoramic radiography // Oral Surg Oral Med Oral Pathol Oral Radiol. - 2020;130(5):593-602. https://doi.org/10.1016/j.oooo.2020.05.012</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B5">
    <label>5.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Anwar S.M., Majid M., Qayyum A., Awais M., Alnowami M., Khan K. Medical Image Analysis using Convolutional Neural Networks: A Review // J Med Syst. - 2018;42;11:226. https://doi.org/10.1007/s10916-018-1088-1</mixed-citation>
     <mixed-citation xml:lang="en">Anwar S.M., Majid M., Qayyum A., Awais M., Alnowami M., Khan K. Medical Image Analysis using Convolutional Neural Networks: A Review // J Med Syst. - 2018;42;11:226. https://doi.org/10.1007/s10916-018-1088-1</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B6">
    <label>6.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Balyen L., Peto T. Promising Artificial Intelligence-Machine Learning-Deep Learning Algorithms in Ophthalmology // Asia Pac J Ophthalmol (Phila). - 2019;8(3):264-272. doi: 10.22608/APO.2018479</mixed-citation>
     <mixed-citation xml:lang="en">Balyen L., Peto T. Promising Artificial Intelligence-Machine Learning-Deep Learning Algorithms in Ophthalmology // Asia Pac J Ophthalmol (Phila). - 2019;8(3):264-272. doi: 10.22608/APO.2018479</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B7">
    <label>7.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Bayrakdar S.K., Orhan K., Bayrakdar I.S., Bilgir E., Ezhov M., Gusarev M., Shumilov E. A deep learning approach for dental implant planning in cone-beam computed tomography images // BMC Med Imaging. - 2021;21(1):86. https://doi.org/10.1186/s12880-021-00618-z</mixed-citation>
     <mixed-citation xml:lang="en">Bayrakdar S.K., Orhan K., Bayrakdar I.S., Bilgir E., Ezhov M., Gusarev M., Shumilov E. A deep learning approach for dental implant planning in cone-beam computed tomography images // BMC Med Imaging. - 2021;21(1):86. https://doi.org/10.1186/s12880-021-00618-z</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B8">
    <label>8.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Casalegno F., Newton T., Daher R., Abdelaziz M., Lodi-Rizzini A., Schürmann F., Krejci I., Markram H. Caries Detection with Near-Infrared Transillumination Using Deep Learning // J Dent Res. - 2019;98;11:1227-1233. https://doi.org/10.1177/0022034519871884</mixed-citation>
     <mixed-citation xml:lang="en">Casalegno F., Newton T., Daher R., Abdelaziz M., Lodi-Rizzini A., Schürmann F., Krejci I., Markram H. Caries Detection with Near-Infrared Transillumination Using Deep Learning // J Dent Res. - 2019;98;11:1227-1233. https://doi.org/10.1177/0022034519871884</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B9">
    <label>9.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Chen Y.-W., Stanley K., Att W. Artificial intelligence in dentistry: current applications and future perspectives // Quintessence Int. - 2020;1(3):248-257. DOI: 10.3290/j.qi.a44465</mixed-citation>
     <mixed-citation xml:lang="en">Chen Y.-W., Stanley K., Att W. Artificial intelligence in dentistry: current applications and future perspectives // Quintessence Int. - 2020;1(3):248-257. DOI: 10.3290/j.qi.a44465</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B10">
    <label>10.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Choi H.I., Jung S.-K., Baek S.-H., Lim W.H., Ahn S.-J., Yang I.-H., Kim T.-W. Artificial Intelligent Model With Neural Network Machine Learning for the Diagnosis of Orthognathic Surgery  // J Craniofac Surg. - 2019;30;7:1986-1989. doi: 10.1097/SCS.0000000000005650</mixed-citation>
     <mixed-citation xml:lang="en">Choi H.I., Jung S.-K., Baek S.-H., Lim W.H., Ahn S.-J., Yang I.-H., Kim T.-W. Artificial Intelligent Model With Neural Network Machine Learning for the Diagnosis of Orthognathic Surgery  // J Craniofac Surg. - 2019;30;7:1986-1989. doi: 10.1097/SCS.0000000000005650</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B11">
    <label>11.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Devito K.L., de Souza Barbosa F., Felippe Filho W.N. An artificial multilayer perceptron neural network for diagnosis of proximal dental caries // Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. - 2008;106(6):879-884. https://doi.org/10.1016/j.tripleo.2008.03.002</mixed-citation>
     <mixed-citation xml:lang="en">Devito K.L., de Souza Barbosa F., Felippe Filho W.N. An artificial multilayer perceptron neural network for diagnosis of proximal dental caries // Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. - 2008;106(6):879-884. https://doi.org/10.1016/j.tripleo.2008.03.002</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B12">
    <label>12.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Esteva A., Kuprel B., Novoa R.A., Ko J., Swetter S.M., Blau H.M., Thrun S. Dermatologist-level classification of skin cancer with deep neural networks // Nature. - 2017;542;7639:115-118. https://doi.org/10.1038/nature21056</mixed-citation>
     <mixed-citation xml:lang="en">Esteva A., Kuprel B., Novoa R.A., Ko J., Swetter S.M., Blau H.M., Thrun S. Dermatologist-level classification of skin cancer with deep neural networks // Nature. - 2017;542;7639:115-118. https://doi.org/10.1038/nature21056</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B13">
    <label>13.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Estrela C., Bueno M.R.,  De Alencar A.H.G., Mattar R., Neto J.V., Azevedo B.C., De Araújo Estrela C.R. Method to evaluate inflammatory root resorption by using cone beam computed tomography // J Endod. - 2009;35;11:1491-1497. https://doi.org/10.1016/j.joen.2009.08.009</mixed-citation>
     <mixed-citation xml:lang="en">Estrela C., Bueno M.R.,  De Alencar A.H.G., Mattar R., Neto J.V., Azevedo B.C., De Araújo Estrela C.R. Method to evaluate inflammatory root resorption by using cone beam computed tomography // J Endod. - 2009;35;11:1491-1497. https://doi.org/10.1016/j.joen.2009.08.009</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B14">
    <label>14.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Ezhov M., Gusarev M., Golitsyna M., Yates J.M., Kushnerev E., Tamimi D., Aksoy S., Shumilov E., Sanders A., Orhan K. Clinically applicable artificial intelligence system for dental diagnosis with CBCT // Scientific reports. - 2021;11(1):1-16. https://doi.org/10.1038/s41598-021-94093-9</mixed-citation>
     <mixed-citation xml:lang="en">Ezhov M., Gusarev M., Golitsyna M., Yates J.M., Kushnerev E., Tamimi D., Aksoy S., Shumilov E., Sanders A., Orhan K. Clinically applicable artificial intelligence system for dental diagnosis with CBCT // Scientific reports. - 2021;11(1):1-16. https://doi.org/10.1038/s41598-021-94093-9</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B15">
    <label>15.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Fazal M.I., Patel M.E., Tye J., Gupta Y. The past, present and future role of artificial intelligence in imaging // Eur J Radiol. - 2018;5:246-250. https://doi.org/10.1016/j.ejrad.2018.06.020</mixed-citation>
     <mixed-citation xml:lang="en">Fazal M.I., Patel M.E., Tye J., Gupta Y. The past, present and future role of artificial intelligence in imaging // Eur J Radiol. - 2018;5:246-250. https://doi.org/10.1016/j.ejrad.2018.06.020</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B16">
    <label>16.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Ferizi U., Besser H., Hysi P., Jacobs J., Rajapakse C.S., Chen C., Saha P.K., Honig S., Chang G. Artificial Intelligence Applied to Osteoporosis: A Performance Comparison of Machine Learning Algorithms in Predicting Fragility Fractures From MRI Data // J Magn Reson Imaging. - 2019;49(4):1029-1038. https://doi.org/10.1002/jmri.26280</mixed-citation>
     <mixed-citation xml:lang="en">Ferizi U., Besser H., Hysi P., Jacobs J., Rajapakse C.S., Chen C., Saha P.K., Honig S., Chang G. Artificial Intelligence Applied to Osteoporosis: A Performance Comparison of Machine Learning Algorithms in Predicting Fragility Fractures From MRI Data // J Magn Reson Imaging. - 2019;49(4):1029-1038. https://doi.org/10.1002/jmri.26280</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B17">
    <label>17.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Geetha V., Aprameya K.S., Hinduja D.M. Dental caries diagnosis in digital radiographs using back-propagation neural network // Health Information Science and Systems. - 2020;8(1):1-14. https://doi.org/10.1007/s13755-019-0096-y</mixed-citation>
     <mixed-citation xml:lang="en">Geetha V., Aprameya K.S., Hinduja D.M. Dental caries diagnosis in digital radiographs using back-propagation neural network // Health Information Science and Systems. - 2020;8(1):1-14. https://doi.org/10.1007/s13755-019-0096-y</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B18">
    <label>18.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Girard M.J.A., Schmetterer L. Artificial intelligence and deep learning in glaucoma: Current state and future prospects // Prog Brain Res. - 2020;257:37-64. https://doi.org/10.1016/bs.pbr.2020.07.002</mixed-citation>
     <mixed-citation xml:lang="en">Girard M.J.A., Schmetterer L. Artificial intelligence and deep learning in glaucoma: Current state and future prospects // Prog Brain Res. - 2020;257:37-64. https://doi.org/10.1016/bs.pbr.2020.07.002</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B19">
    <label>19.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Grischke J., Johannsmeier  L., Eich L., Griga L., Haddadin S. Dentronics: Towards robotics and artificial intelligence in dentistry // Dent Mater. - 2020;36(6):765-778. https://doi.org/10.1016/j.dental.2020.03.021</mixed-citation>
     <mixed-citation xml:lang="en">Grischke J., Johannsmeier  L., Eich L., Griga L., Haddadin S. Dentronics: Towards robotics and artificial intelligence in dentistry // Dent Mater. - 2020;36(6):765-778. https://doi.org/10.1016/j.dental.2020.03.021</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B20">
    <label>20.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Hung K., Yeung  A.W.K., Tanaka R., Bornstein M.M. Current Applications, Opportunities, and Limitations of AI for 3D Imaging in Dental Research and Practice // Int J Environ Res Public Health. - 2020;17(12):4424. https://doi.org/10.3390/ijerph17124424</mixed-citation>
     <mixed-citation xml:lang="en">Hung K., Yeung  A.W.K., Tanaka R., Bornstein M.M. Current Applications, Opportunities, and Limitations of AI for 3D Imaging in Dental Research and Practice // Int J Environ Res Public Health. - 2020;17(12):4424. https://doi.org/10.3390/ijerph17124424</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B21">
    <label>21.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Javed S., Zakirulla M., Baig R.U., Asif S.M., Meer A.B. Development of artificial neural network model for prediction of post-streptococcus mutans in dental caries // Comput Methods Programs Biomed. - 2020;186:105198. https://doi.org/10.1016/j.cmpb.2019.105198</mixed-citation>
     <mixed-citation xml:lang="en">Javed S., Zakirulla M., Baig R.U., Asif S.M., Meer A.B. Development of artificial neural network model for prediction of post-streptococcus mutans in dental caries // Comput Methods Programs Biomed. - 2020;186:105198. https://doi.org/10.1016/j.cmpb.2019.105198</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B22">
    <label>22.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Khanagar S.B., Al-ehaideb A., Maganur P.C., Vishwanathaiah S., Patil S., Baeshen H.A.,  Sarode S.C., Bhandi S. Developments, application, and performance of artificial intelligence in dentistry - A systematic review // Journal of dental sciences. - 2021;16(1):508-522. https://doi.org/10.1016/j.jds.2020.06.019</mixed-citation>
     <mixed-citation xml:lang="en">Khanagar S.B., Al-ehaideb A., Maganur P.C., Vishwanathaiah S., Patil S., Baeshen H.A.,  Sarode S.C., Bhandi S. Developments, application, and performance of artificial intelligence in dentistry - A systematic review // Journal of dental sciences. - 2021;16(1):508-522. https://doi.org/10.1016/j.jds.2020.06.019</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B23">
    <label>23.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Kulkarni S., Seneviratne N., Baig M.S., Khan A.H.A. Artificial Intelligence in Medicine: Where Are We Now? // Acad Radiol. - 2020;27(1):62-70. https://doi.org/10.1016/j.acra.2019.10.001</mixed-citation>
     <mixed-citation xml:lang="en">Kulkarni S., Seneviratne N., Baig M.S., Khan A.H.A. Artificial Intelligence in Medicine: Where Are We Now? // Acad Radiol. - 2020;27(1):62-70. https://doi.org/10.1016/j.acra.2019.10.001</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B24">
    <label>24.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Lee J.H., Kim D.-H., Jeong S.-N., Choi S.-H. Detection and diagnosis of dental caries using a deep learning-based convolutional neural network algorithm // J Dent. - 2018;77:106-111. https://doi.org/10.1016/j.jdent.2018.07.015</mixed-citation>
     <mixed-citation xml:lang="en">Lee J.H., Kim D.-H., Jeong S.-N., Choi S.-H. Detection and diagnosis of dental caries using a deep learning-based convolutional neural network algorithm // J Dent. - 2018;77:106-111. https://doi.org/10.1016/j.jdent.2018.07.015</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B25">
    <label>25.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Leite A.F., de Faria Vasconcelos K., Willems  H., Jacobs R. Radiomics and Machine Learning in Oral Healthcare // Proteomics Clin Appl. - 2020;14(3):e1900040. https://doi.org/10.1002/prca.201900040</mixed-citation>
     <mixed-citation xml:lang="en">Leite A.F., de Faria Vasconcelos K., Willems  H., Jacobs R. Radiomics and Machine Learning in Oral Healthcare // Proteomics Clin Appl. - 2020;14(3):e1900040. https://doi.org/10.1002/prca.201900040</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B26">
    <label>26.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Leonardi D.K., Dutra K.L., Haas L., Porporatti A.L., Flores-Mir C., Santos J.N., Mezzomo L.A., Corrêa M., De Luca Canto G. Diagnostic Accuracy of Cone-beam Computed Tomography and Conventional Radiography on Apical Periodontitis: A Systematic Review and Meta-analysis // J Endod. - 2016;42(3):356-364. https://doi.org/10.1016/j.joen.2015.12.015</mixed-citation>
     <mixed-citation xml:lang="en">Leonardi D.K., Dutra K.L., Haas L., Porporatti A.L., Flores-Mir C., Santos J.N., Mezzomo L.A., Corrêa M., De Luca Canto G. Diagnostic Accuracy of Cone-beam Computed Tomography and Conventional Radiography on Apical Periodontitis: A Systematic Review and Meta-analysis // J Endod. - 2016;42(3):356-364. https://doi.org/10.1016/j.joen.2015.12.015</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B27">
    <label>27.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Orhan K., Bilgir E., Bayrakdar I.S., Ezhov M., Gusarev M., Shumilov E. Evaluation of artificial intelligence for detecting impacted third molars on cone-beam computed tomography scans // J Stomatol Oral Maxillofac Surg. - 2021;122(4):333-337. https://doi.org/10.1016/j.jormas.2020.12.006</mixed-citation>
     <mixed-citation xml:lang="en">Orhan K., Bilgir E., Bayrakdar I.S., Ezhov M., Gusarev M., Shumilov E. Evaluation of artificial intelligence for detecting impacted third molars on cone-beam computed tomography scans // J Stomatol Oral Maxillofac Surg. - 2021;122(4):333-337. https://doi.org/10.1016/j.jormas.2020.12.006</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B28">
    <label>28.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Orhan K., Bayrakdar I.S., Ezhov M., Kravtsov A., Özyürek T. Evaluation of artificial intelligence for detecting periapical pathosis on cone-beam computed tomography scans // Int Endod J. - 2020;53(5):680-689. https://doi.org/10.1111/iej.13265</mixed-citation>
     <mixed-citation xml:lang="en">Orhan K., Bayrakdar I.S., Ezhov M., Kravtsov A., Özyürek T. Evaluation of artificial intelligence for detecting periapical pathosis on cone-beam computed tomography scans // Int Endod J. - 2020;53(5):680-689. https://doi.org/10.1111/iej.13265</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B29">
    <label>29.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Pauwels R., Araki K., Siewerdsen J.H., Thongvigitmanee S.S. Technical aspects of dental CBCT: state of the art // Dentomaxillofac Radiol. - 2015;44(1):20140224. https://doi.org/10.1259/dmfr.20140224</mixed-citation>
     <mixed-citation xml:lang="en">Pauwels R., Araki K., Siewerdsen J.H., Thongvigitmanee S.S. Technical aspects of dental CBCT: state of the art // Dentomaxillofac Radiol. - 2015;44(1):20140224. https://doi.org/10.1259/dmfr.20140224</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B30">
    <label>30.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Schuhbaeck A., Otaki Y., Achenbach S., Schneider C., Slomka P., Berman D.S., Dey D. Coronary calcium scoring from contrast coronary CT angiography using a semiautomated standardized method // J Cardiovasc Comput Tomogr. - 2015;9(5):446-453.  https://doi.org/10.1016/j.jcct.2015.06.001</mixed-citation>
     <mixed-citation xml:lang="en">Schuhbaeck A., Otaki Y., Achenbach S., Schneider C., Slomka P., Berman D.S., Dey D. Coronary calcium scoring from contrast coronary CT angiography using a semiautomated standardized method // J Cardiovasc Comput Tomogr. - 2015;9(5):446-453.  https://doi.org/10.1016/j.jcct.2015.06.001</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B31">
    <label>31.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Schwendicke F., Samek W., Krois J. Artificial Intelligence in Dentistry: Chances and Challenges // J Dent Res. - 2020;99(7):769-774. https://doi.org/10.1177/0022034520915714</mixed-citation>
     <mixed-citation xml:lang="en">Schwendicke F., Samek W., Krois J. Artificial Intelligence in Dentistry: Chances and Challenges // J Dent Res. - 2020;99(7):769-774. https://doi.org/10.1177/0022034520915714</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B32">
    <label>32.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Setzer F.C., Shi K.J., Zhang Z., Yan H., Yoon H., Mupparapu M., Li J. Artificial Intelligence for the Computer-aided Detection of Periapical Lesions in Cone-beam Computed Tomographic Images // J Endod. - 2020;46(7):987-993. https://doi.org/10.1016/j.joen.2020.03.025</mixed-citation>
     <mixed-citation xml:lang="en">Setzer F.C., Shi K.J., Zhang Z., Yan H., Yoon H., Mupparapu M., Li J. Artificial Intelligence for the Computer-aided Detection of Periapical Lesions in Cone-beam Computed Tomographic Images // J Endod. - 2020;46(7):987-993. https://doi.org/10.1016/j.joen.2020.03.025</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B33">
    <label>33.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Xiang., Zhao L., Liu Z., Wu X., Chen J., Long E., Lin D., Zhu Y., Chen C., Lin Z., Lin H. Implementation of artificial intelligence in medicine: Status analysis and development suggestions // Artif Intell Med. - 2020;102:101780. https://doi.org/10.1016/j.artmed.2019.101780</mixed-citation>
     <mixed-citation xml:lang="en">Xiang., Zhao L., Liu Z., Wu X., Chen J., Long E., Lin D., Zhu Y., Chen C., Lin Z., Lin H. Implementation of artificial intelligence in medicine: Status analysis and development suggestions // Artif Intell Med. - 2020;102:101780. https://doi.org/10.1016/j.artmed.2019.101780</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B34">
    <label>34.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Zadrożny Ł., Regulski P., Brus-Sawczuk K., Czajkowska M., Parkanyi L., Ganz S., Mijiritsky E. Artificial Intelligence Application in Assessment of Panoramic Radiographs // Diagnostics. - 2022;12(1):224. https://doi.org/10.3390/diagnostics12010224</mixed-citation>
     <mixed-citation xml:lang="en">Zadrożny Ł., Regulski P., Brus-Sawczuk K., Czajkowska M., Parkanyi L., Ganz S., Mijiritsky E. Artificial Intelligence Application in Assessment of Panoramic Radiographs // Diagnostics. - 2022;12(1):224. https://doi.org/10.3390/diagnostics12010224</mixed-citation>
    </citation-alternatives>
   </ref>
  </ref-list>
 </back>
</article>
