Actual problems in dentistry Actual problems in dentistry Проблемы стоматологии 2077-7566 2412-9461 48764 10.18481/2077-7566-21-17-4-32-38 ЛЕКЦИИ / ЛИТЕРАТУРНЫЕ ОБЗОРЫ LITERATURE REVIEW ЛЕКЦИИ / ЛИТЕРАТУРНЫЕ ОБЗОРЫ EXTRA-INTESTINAL MANIFESTATIONS OF CROHN DISEASE AND CHRONIC ULCERATIVE COLITIS IN THE ORAL CAVITY ВНЕКИШЕЧНЫЕ ПРОЯВЛЕНИЯ БОЛЕЗНИ КРОНА И ХРОНИЧЕСКОГО НЕСПЕЦИФИЧЕСКОГО ЯЗВЕННОГО КОЛИТА В ПОЛОСТИ РТА Юнусова Рита Дамировна Yunusova Rita Damirovna puma-a-1990@ya.ru Усманова Ирина Николаевна Usmanova Irina N. irinausmanova@mail.ru

доктор медицинских наук;

doctor of medical sciences;

 Ишмухаметова Амина Насимовна Ishmukhametova Amina Nasimovna amina.ishmukhametova@mail.ru

кандидат медицинских наук;

candidate of medical sciences;

 Герасимова Лариса Павловна Gerasimova Larisa Pavlovna gerasimovalarisa@rambler.ru

доктор медицинских наук;

doctor of medical sciences;

 Гранот Игаль Granot Yigal igranot@yahoo.com

доктор медицинских наук;

doctor of medical sciences;

 Кагарманова Эльмина Марвановна Kgarmanova Elmina Marvanovna gastro21@yandex.ru Хуснаризанова Рауза Фазыловна Khusnarizanova Rauza F. roza.khusna@mail.ru

кандидат биологических наук;

candidate of sciences in biology;

 Сарвалиева Алина Фагимовна Sarvalieva Alina Fagimovna sarvalieva98@bk.ru Башкирский государственный медицинский университет Уфа Россия Bashkir State Medical Universitey Ufa Russian Federation Башкирский государственный медицинский университет Bashkirian State Medical University Башкирский государственный медицинский университет Уфа Россия Башкирский государственный медицинский университет Уфа Russian Federation Институт максило-фациальной хирургии, оральной медицины и стоматологии, Медицинский факультет университета Бар Илан, Медицинский центр Галилеи Нагария Израиль Institute of Maxilofacial Surgery, Oral Medicine and Dentistry, Bar Ilan University School of Medicine, Galilee Medical Center Nagaria Israel Городская клиническая больница № 21 Уфа Россия City Clinical Hospital No. 21 Ufa Russian Federation Башкирский государственный медицинский университет Уфа Россия Bashkir State Medical Universitey Ufa Russian Federation 28 12 2021 28 12 2021 17 4 32 38 03 12 2021 10 12 2021 https://dental-press.ru/en/nauka/article/48764/view

Предмет. Проведенный обзор позволяет рассматривать вопросы этиопатогенеза, распространенности болезни Крона и неспецифического язвенного колита, а также их проявлений на слизистой оболочке рта. Цель — провести системный анализ современных отечественных и зарубежных литературных источников для определения некоторых особенностей этиопатогенеза, распростаненности и проявлений в полости рта болезни Крона и хронического несспецифического язвенного колита. Методология. Поиск исследовательских работ по этиологии и патогенезу болезни Крона, неспецифического язвенного колита осуществлялся с помощью следующих баз данных: PubMed, Web of Science, elibrary.ru, Scopus в период с 2010 по 2021 год. Также в обзор включены отдельные значимые публикации, касающиеся проявлений в полости рта БК и ХНЯК за период с 2014 по 2021 годы. Были использованы следующие ключевые слова: хронический неспецифический язвенный колит, болезнь Крона, кариес, пародонт, слизисая оболочка рта, афты, дисбиоз. Результаты. Среди основных стоматологических заболеваний чаще всего превалирует патология твердых тканей, воспалительные заболевания тканей пародонта, патология слизистой оболочки рта на фоне выраженного дисбиоза. При комплексном обследовании данных пациентов очень важно анализировать не только особенности проявлений болезни Крона и неспецифического язвенного колита, но и оценивать их проявления на твердых тканях зубов, слизистой оболочке рта и тканях пародонта. Выводы. Анализ полученных данных литературы имеет особую актуальность для выявления некоторых особенностей состояния стоматологического статуса при БК и ХНЯК в республике Башкортостан и может стать основой для разработки алгоритмов диагностических особенностей ведения данной категории лиц.

Subject. The review allows us to consider the issues of etiopathogenesis, the prevalence of Crohn disease and ulcerative colitis, as well as their manifestations on the oral mucosa. The aim is to conduct a systematic analysis of modern indigenous and foreign literary sources to determine some features of etiopathogenesis, prevalence and manifestations in the oral cavity of Crohn disease and chronic non-specific ulcerative colitis. Methodology. The search for research works on the etiology and pathogenesis of Crohn disease, ulcerative colitis was carried out using the following databases: PubMed, Web of Science, elibrary.ru , Scopus in the period from 2010 to 2021, as well as the review includes some significant publications concerning the manifestations in the oral cavity of CD and NCUC for the period from 2014 to 2021. The following keywords were used: chronic ulcerative colitis, Crohn disease, caries, periodontal disease, oral mucosa, aphthae, dysbiosis. Results. Among the main dental diseases, pathology of hard tissues, inflammatory diseases of periodontal tissues, pathology of the oral mucosa against the background of pronounced dysbiosis most often prevails. During a comprehensive examination of these patients, it is very important to analyze not only the features of the manifestations of Crohn disease and ulcerative colitis, but also to evaluate their manifestations on the hard tissues of the teeth, the oral mucosa and periodontal tissues. Conclusions. Thus, the analysis of the literature data obtained is of particular relevance for identifying some features of the state of dental status in CD and NCUC in the Republic of Bashkortostan and the basis for the development of algorithms for diagnostic features of the management of this category of persons.

 хронический неспецифический язвенный колит болезнь Крона кариес пародонт слизисая оболочка рта афты кандидоз chronic nonspecific ulcerative colitis Crohn disease caries periodontal disease oral mucosa aphthae candidiasis

Авалуева Е.Б., Бакулин И.Г., Ситкин С.И., Воробьев С.Л., Беляков И.А., Трушникова Н.А., Карпеева Ю.С. Болезнь Крона с изолированным поражением желудка как пример редкого фенотипа заболевания: клиническое наблюдение. Альманах клинической медицины. 2019;47(6):592-602. [E.B. Avalueva, I.G. Bakulin, S.I. Sitkin, S.L. Vorobyev, I.. Belyakov, N.A. Trushnikova, Yu.S. Karpeeva. Crohn’s disease with isolated gastric involvement as an example of a rare disease phenotype: a clinical case. Almanac of Clinical Medicine. 2019;47(6):592-602. (In Russ.)]. https://doi.org/10.18786/2072-0505-2019-47-074 Avalueva E.B., Bakulin I.G., Sitkin S.I., Vorob'ev S.L., Belyakov I.A., Trushnikova N.A., Karpeeva Yu.S. Bolezn' Krona s izolirovannym porazheniem zheludka kak primer redkogo fenotipa zabolevaniya: klinicheskoe nablyudenie. Al'manah klinicheskoy mediciny. 2019;47(6):592-602. [E.B. Avalueva, I.G. Bakulin, S.I. Sitkin, S.L. Vorobyev, I.. Belyakov, N.A. Trushnikova, Yu.S. Karpeeva. Crohn’s disease with isolated gastric involvement as an example of a rare disease phenotype: a clinical case. Almanac of Clinical Medicine. 2019;47(6):592-602. (In Russ.)]. https://doi.org/10.18786/2072-0505-2019-47-074 Робакидзе Н.С., Барановский А.Ю. Анализ течения рецидивирующего афтозного стоматита у больных с воспалительными заболеваниями кишечника. Институт стоматологии. 2016;1(70):58-59. [N.S. Robakidze, A.Yu. Baranovsky. The analysis of recurrent aphthous stomatitis of the patients with inflammatory bowel disease. The Dental Institute. 2016;1(70):58-59. (In Russ.)]. https://elibrary.ru/item.asp?id=25844124 Robakidze N.S., Baranovskiy A.Yu. Analiz techeniya recidiviruyuschego aftoznogo stomatita u bol'nyh s vospalitel'nymi zabolevaniyami kishechnika. Institut stomatologii. 2016;1(70):58-59. [N.S. Robakidze, A.Yu. Baranovsky. The analysis of recurrent aphthous stomatitis of the patients with inflammatory bowel disease. The Dental Institute. 2016;1(70):58-59. (In Russ.)]. https://elibrary.ru/item.asp?id=25844124 Андронова Н.А., Мамаева М.И., Митронин А.В. Стоматологический статус пациентов, страдающих язвенным колитом, на фоне биологической терапии селективным иммунодепрессантом (моноклональные антитела к ФНО-α). Российская стоматология. 2014;7(2):39-42. [N.A. Andronova, M.I. Mamaeva, A.V. Mitronin. The dental status of the patients presenting with ulcerative colitis during biological therapy with a selective immunodepressant (monoclonal anti-TNF-α antibodies). Russian Stomatology. 2014;7(2):39-42. (In Russ.)]. https://elibrary.ru/item.asp?id=22364426 Andronova N.A., Mamaeva M.I., Mitronin A.V. Stomatologicheskiy status pacientov, stradayuschih yazvennym kolitom, na fone biologicheskoy terapii selektivnym immunodepressantom (monoklonal'nye antitela k FNO-α). Rossiyskaya stomatologiya. 2014;7(2):39-42. [N.A. Andronova, M.I. Mamaeva, A.V. Mitronin. The dental status of the patients presenting with ulcerative colitis during biological therapy with a selective immunodepressant (monoclonal anti-TNF-α antibodies). Russian Stomatology. 2014;7(2):39-42. (In Russ.)]. https://elibrary.ru/item.asp?id=22364426 Щукина О.Б., Робакидзе Н.С., Насыхова Ю.А. Ассоциация полиморфизма гена nod 2/card 15 с афтозным стоматитом при болезни Крона. Экспериментальная и клиническая гастроэнтерология. 2017;10(146):46-49. [O.B. Shchukina, N.S. Robakidze, J.A. Nasykhova. Association of polymorphism of the nod 2/ card 15 gene with aphthous stomatitis in crohn’s disease. Experimental and clinical gastroenterology journal. 2017;10(146):46-49. (In Russ.)]. https://elibrary.ru/item.asp?id=32405812 Schukina O.B., Robakidze N.S., Nasyhova Yu.A. Associaciya polimorfizma gena nod 2/card 15 s aftoznym stomatitom pri bolezni Krona. Eksperimental'naya i klinicheskaya gastroenterologiya. 2017;10(146):46-49. [O.B. Shchukina, N.S. Robakidze, J.A. Nasykhova. Association of polymorphism of the nod 2/ card 15 gene with aphthous stomatitis in crohn’s disease. Experimental and clinical gastroenterology journal. 2017;10(146):46-49. (In Russ.)]. https://elibrary.ru/item.asp?id=32405812 Ахриева Х.М., Тертычный А.С., Маев И.В., Зайратьянц О.В. Классификация и морфологическая диагностика язвенного колита и болезни Крона. Клиническая и экспериментальная морфология. 2017;3:4-15. [Kh.M. Akhrieva, A.S. Tertychniy, I.V. Maev, O.V. Zayratyants. Classification and morphological diagnosis of ulcerative colitis and crohn’s disease. Clinical And Experimental Morphology. 2017;3:4-15. (In Russ.)]. https://elibrary.ru/item.asp?id=29946271 Ahrieva H.M., Tertychnyy A.S., Maev I.V., Zayrat'yanc O.V. Klassifikaciya i morfologicheskaya diagnostika yazvennogo kolita i bolezni Krona. Klinicheskaya i eksperimental'naya morfologiya. 2017;3:4-15. [Kh.M. Akhrieva, A.S. Tertychniy, I.V. Maev, O.V. Zayratyants. Classification and morphological diagnosis of ulcerative colitis and crohn’s disease. Clinical And Experimental Morphology. 2017;3:4-15. (In Russ.)]. https://elibrary.ru/item.asp?id=29946271 Бакулин И.Г., Скалинская М.И., Сказываева Е.В. «Трудные» вопросы при ведении пациентов с воспалительными заболеваниями кишечника. Медико-социальная экспертиза и реабилитация. 2018;21(1-2):94-100. [I.G. Bakulin, M.I. Skalinskaya, E.V. Skazyvaeva. “Difficult” issues of the management of inflammatory bowel diseases patients. Medical and Social Expert Evaluation and Rehabilitation, Russian Journal. 2018;21(1-2):94-100. (In Russ.)]. http://doi.org/10.18821/1560-9537-2018-21-1-94-100 Bakulin I.G., Skalinskaya M.I., Skazyvaeva E.V. «Trudnye» voprosy pri vedenii pacientov s vospalitel'nymi zabolevaniyami kishechnika. Mediko-social'naya ekspertiza i reabilitaciya. 2018;21(1-2):94-100. [I.G. Bakulin, M.I. Skalinskaya, E.V. Skazyvaeva. “Difficult” issues of the management of inflammatory bowel diseases patients. Medical and Social Expert Evaluation and Rehabilitation, Russian Journal. 2018;21(1-2):94-100. (In Russ.)]. http://doi.org/10.18821/1560-9537-2018-21-1-94-100 Белоусова Е.А., Абдулганиева Д.И., Алексеева О.П. и др. Социально-демографическая характеристика, особенности течения и варианты лечения воспалительных заболеваний кишечника в России. Результаты двух многоцентровых исследований. Альманах клинической медицины. 2018;46(5):445-463. [E.A. Belousova, D.I. Abdulganieva, O.P. Alexeeva et al. Social and demographic characteristics, features of disease course and treatment options of inflammatory bowel disease in Russia: results of two multicenter studies. Almanac of Clinical Medicine. 2018;46(5):445-463. (In Russ.)]. https://doi.org/10.18786/2072-0505-2018-46-5-445-463 Belousova E.A., Abdulganieva D.I., Alekseeva O.P. i dr. Social'no-demograficheskaya harakteristika, osobennosti techeniya i varianty lecheniya vospalitel'nyh zabolevaniy kishechnika v Rossii. Rezul'taty dvuh mnogocentrovyh issledovaniy. Al'manah klinicheskoy mediciny. 2018;46(5):445-463. [E.A. Belousova, D.I. Abdulganieva, O.P. Alexeeva et al. Social and demographic characteristics, features of disease course and treatment options of inflammatory bowel disease in Russia: results of two multicenter studies. Almanac of Clinical Medicine. 2018;46(5):445-463. (In Russ.)]. https://doi.org/10.18786/2072-0505-2018-46-5-445-463 Бодрягина Е.С., Абдулганиева Д.И., Щдинцова А.Х. Клинико-эпидемиологические показатели воспалительныхзаболеваний кишечника по Республике Татарстан. Лечащий врач. 2013;7:21-26. [E.S. Bodryagina, D.I. Abdulganieva, A.H. Odintsovo. The Clinico-epidemiological indices of intestine inflammatory diseases in the republic of Tatarstan. Therapist. 2013;7:21-26. (In Russ.)]. https://elibrary.ru/item.asp?id=22474147 Bodryagina E.S., Abdulganieva D.I., Schdincova A.H. Kliniko-epidemiologicheskie pokazateli vospalitel'nyhzabolevaniy kishechnika po Respublike Tatarstan. Lechaschiy vrach. 2013;7:21-26. [E.S. Bodryagina, D.I. Abdulganieva, A.H. Odintsovo. The Clinico-epidemiological indices of intestine inflammatory diseases in the republic of Tatarstan. Therapist. 2013;7:21-26. (In Russ.)]. https://elibrary.ru/item.asp?id=22474147 Гриневич В.Б., Кравчук Ю.А., Педь В.И. и др. Ведение пациентов с заболеваниями органов пищеварения в период пандемии COVID-19. Клинические рекомендации Научного общества гастроэнтерологов России. Экспериментальная и клиническая гастроэнтерология. 2020;7(179):4-51. [V.B. Grinevich, Yu.A. Kravchuk, V.I. Ped. et al. Management of patients with digestive diseases during the covid-19 pandemic: clinical practice guidelines by the gastroenterological scientific society of Russia. Experimental and clinical gastroenterology journal. 2020;7(179):4-51. (In Russ.)]. http://dx.doi.org/10.31146/1682-8658-ecg-179-7-4-51. Grinevich V.B., Kravchuk Yu.A., Ped' V.I. i dr. Vedenie pacientov s zabolevaniyami organov pischevareniya v period pandemii COVID-19. Klinicheskie rekomendacii Nauchnogo obschestva gastroenterologov Rossii. Eksperimental'naya i klinicheskaya gastroenterologiya. 2020;7(179):4-51. [V.B. Grinevich, Yu.A. Kravchuk, V.I. Ped. et al. Management of patients with digestive diseases during the covid-19 pandemic: clinical practice guidelines by the gastroenterological scientific society of Russia. Experimental and clinical gastroenterology journal. 2020;7(179):4-51. (In Russ.)]. http://dx.doi.org/10.31146/1682-8658-ecg-179-7-4-51. Кляритская И.Л., Стилиди Е.И., Максимова Е.В., Шахбазиди Г. Внекишечные проявления воспалительных заболеваний кишечника. Крымский Терапевтический Журнал. 2017;1(32):47-51. [I.L. Kliaritskaia, E.I. Stilidi, E.V. Maksimova, G. Shakhbazidi. Extraintestinal manifestations of inflammatory bowel disease. Crimean journal of internal diseases. 2017;1(32):47-51. (In Russ.)]. https://elibrary.ru/item.asp?id=28367558 Klyaritskaya I.L., Stilidi E.I., Maksimova E.V., Shahbazidi G. Vnekishechnye proyavleniya vospalitel'nyh zabolevaniy kishechnika. Krymskiy Terapevticheskiy Zhurnal. 2017;1(32):47-51. [I.L. Kliaritskaia, E.I. Stilidi, E.V. Maksimova, G. Shakhbazidi. Extraintestinal manifestations of inflammatory bowel disease. Crimean journal of internal diseases. 2017;1(32):47-51. (In Russ.)]. https://elibrary.ru/item.asp?id=28367558 Губонина И.В., Гриневич В.Б., Ткаченко Е.И. и др. Клинико-эпидемиологическая характеристика и исходы воспалительных заболеваний кишечника в когорте больных по данным восьмилетнего наблюдения. Экспериментальная и клиническая гастроэнтерология. 2019;172(12):24-33. [I.V. Gubonina, V.B. Grinevich, E.I. Tkachenko et al. Clinical and epidemiological characteristics and outcomes of infl amatory bowel diseases according to 8-year follow-up in a cohort of patients in the North-West region. Experimental and Clinical Gastroenterology. 2019;172(12):24-33. (In Russ.)]. https://doi.org/10.31146/1682-8658-ecg-172-12-24-33 Gubonina I.V., Grinevich V.B., Tkachenko E.I. i dr. Kliniko-epidemiologicheskaya harakteristika i ishody vospalitel'nyh zabolevaniy kishechnika v kogorte bol'nyh po dannym vos'miletnego nablyudeniya. Eksperimental'naya i klinicheskaya gastroenterologiya. 2019;172(12):24-33. [I.V. Gubonina, V.B. Grinevich, E.I. Tkachenko et al. Clinical and epidemiological characteristics and outcomes of infl amatory bowel diseases according to 8-year follow-up in a cohort of patients in the North-West region. Experimental and Clinical Gastroenterology. 2019;172(12):24-33. (In Russ.)]. https://doi.org/10.31146/1682-8658-ecg-172-12-24-33 Долгушина А.И., Хусаинова Г.М., Василенко А.Г., Кононец В.А. Распространенность воспалительных заболеваний кишечника в Челябинской области. Альманах клинической медицины. 2019;47(6):511-517. [A.I. Dolgushina, G.M. Khusainova, A.G. Vasilenko, V.A. Kononets. Prevalence of inflammatory bowel disease in the Chelyabinsk Region. Almanac of Clinical Medicine. 2019;47(6):511-517. (In Russ.)]. https://doi.org/10.18786/2072-0505-2019-47-066 Dolgushina A.I., Husainova G.M., Vasilenko A.G., Kononec V.A. Rasprostranennost' vospalitel'nyh zabolevaniy kishechnika v Chelyabinskoy oblasti. Al'manah klinicheskoy mediciny. 2019;47(6):511-517. [A.I. Dolgushina, G.M. Khusainova, A.G. Vasilenko, V.A. Kononets. Prevalence of inflammatory bowel disease in the Chelyabinsk Region. Almanac of Clinical Medicine. 2019;47(6):511-517. (In Russ.)]. https://doi.org/10.18786/2072-0505-2019-47-066 Робакидзе Н.С. Клинико-морфологические и иммуногистохимические особенности патологии слизистой оболочки полости рта при воспалительных заболеваниях кишечника : автореф. дис. ... доктора медицинских наук. [Сев.-Зап. гос. мед. ун-т.] Санкт-Петербург, 2016:22. [N.S. Robakidze. Clinical, morphological and immunohistochemical features of pathology of the oral mucosa in inflammatory bowel diseases : abstract of the dissertation ... Doctors of Medical sciences. Sev.-Zap. gos. med. un-T. Saint Petersburg, 2016:22. (In Russ.)]. ]https://elibrary.ru/item.asp?id=30445655 Robakidze N.S. Kliniko-morfologicheskie i immunogistohimicheskie osobennosti patologii slizistoy obolochki polosti rta pri vospalitel'nyh zabolevaniyah kishechnika : avtoref. dis. ... doktora medicinskih nauk. [Sev.-Zap. gos. med. un-t.] Sankt-Peterburg, 2016:22. [N.S. Robakidze. Clinical, morphological and immunohistochemical features of pathology of the oral mucosa in inflammatory bowel diseases : abstract of the dissertation ... Doctors of Medical sciences. Sev.-Zap. gos. med. un-T. Saint Petersburg, 2016:22. (In Russ.)]. ]https://elibrary.ru/item.asp?id=30445655 Робакидзе Н.С., Цимбалистов А.В., Барановский А.Ю. Клинико-морфологические и иммуногистохимические особенности слизистой оболочки рта при болезни Крона и язвенном колите. Голова и шея. 2017;3:40-45. [N.S. Robakidze, A.V. Tzimbalistov, A.Yu. Baranovsky. Clinical, morphological and immunohistochemical specifics of oral cavity mucosa in patients with crohn’s disease and ulcerous colitis. Head and neck. 2017;3:40-45. (In Russ.)]. https://elibrary.ru/item.asp?id=335058551 Robakidze N.S., Cimbalistov A.V., Baranovskiy A.Yu. Kliniko-morfologicheskie i immunogistohimicheskie osobennosti slizistoy obolochki rta pri bolezni Krona i yazvennom kolite. Golova i sheya. 2017;3:40-45. [N.S. Robakidze, A.V. Tzimbalistov, A.Yu. Baranovsky. Clinical, morphological and immunohistochemical specifics of oral cavity mucosa in patients with crohn’s disease and ulcerous colitis. Head and neck. 2017;3:40-45. (In Russ.)]. https://elibrary.ru/item.asp?id=335058551 Клинические рекомендации по диагностике и лечению болезни крона у взрослых (проект). Колопроктология. 2020;19(2):8-38. [Crohn's disease. Clinical recommendations (preliminary version). Koloproktologia. 2020;19(2):8-38. (In Russ.)]. https://doi.org/10.33878/2073-7556-2020-19-2-8-38 Klinicheskie rekomendacii po diagnostike i lecheniyu bolezni krona u vzroslyh (proekt). Koloproktologiya. 2020;19(2):8-38. [Crohn's disease. Clinical recommendations (preliminary version). Koloproktologia. 2020;19(2):8-38. (In Russ.)]. https://doi.org/10.33878/2073-7556-2020-19-2-8-38 Митронин А.В., Андронова Н.А. Клиническое исследование частоты встречаемости воспалительных заболеваний пародонта у пациентов, страдающих язвенным колитом. Dental Forum. 2017;4:60. [A.V. Mitronin, N.A. Andronova. Clinical investigation of prevalence of inflammatory periodontal diseases in patients with ulcerative colitis. Dental Forum. 2017;4:60. (In Russ.)]. https://elibrary.ru/item.asp?id=30504306 Mitronin A.V., Andronova N.A. Klinicheskoe issledovanie chastoty vstrechaemosti vospalitel'nyh zabolevaniy parodonta u pacientov, stradayuschih yazvennym kolitom. Dental Forum. 2017;4:60. [A.V. Mitronin, N.A. Andronova. Clinical investigation of prevalence of inflammatory periodontal diseases in patients with ulcerative colitis. Dental Forum. 2017;4:60. (In Russ.)]. https://elibrary.ru/item.asp?id=30504306 Коломиец С.В., Удальцова К.А., Шинкевич В.И. Дебют болезни Крона в полости рта. Клинический случай. Стоматология. 2017;96(5):28-30. [S.V. Kolomiets, K.A. Udaltsova, V.I. Shinkevich. Crohn's disease debut in the oral cavity. Case report Dentistry. 2017;96(5):28-30. (In Russ.)]. https://doi.org/10.17116/stomat201796528-30 Kolomiec S.V., Udal'cova K.A., Shinkevich V.I. Debyut bolezni Krona v polosti rta. Klinicheskiy sluchay. Stomatologiya. 2017;96(5):28-30. [S.V. Kolomiets, K.A. Udaltsova, V.I. Shinkevich. Crohn's disease debut in the oral cavity. Case report Dentistry. 2017;96(5):28-30. (In Russ.)]. https://doi.org/10.17116/stomat201796528-30 Тытюк С.Ю., Пихур О.Л., Тишков Д.С., Иорданишвили А.К. Морфофункциональные особенности слизистой оболочки полости рта лиц, страдающих хроническими воспалительными заболеваниями кишечника. Курский научно-практический вестник «Человек и его здоровье». 2016;3:49-55. [S.Yu. Tityuk, O.L. Pikhur, D.S. Tishkov, A.K. Iordanishvili. Morphological and functional features of oral mucosa in persons with chronic inflammatory bowel diseases. Kursk scientific and practical bulletin "Man and his health". 2016;3:49-55. (In Russ.)]. https://doi.org/10.21626/vestnik/2016-3/08 Tytyuk S.Yu., Pihur O.L., Tishkov D.S., Iordanishvili A.K. Morfofunkcional'nye osobennosti slizistoy obolochki polosti rta lic, stradayuschih hronicheskimi vospalitel'nymi zabolevaniyami kishechnika. Kurskiy nauchno-prakticheskiy vestnik «Chelovek i ego zdorov'e». 2016;3:49-55. [S.Yu. Tityuk, O.L. Pikhur, D.S. Tishkov, A.K. Iordanishvili. Morphological and functional features of oral mucosa in persons with chronic inflammatory bowel diseases. Kursk scientific and practical bulletin "Man and his health". 2016;3:49-55. (In Russ.)]. https://doi.org/10.21626/vestnik/2016-3/08 Назирбекова М.М., Абасова А.С. Структура заболеваемости воспалительными заболеваниями кишечника в Дагестане за последние 5 лет. Кардиоваскулярная терапия и профилактика. 2021;20(1S):61. [M.M. Nazirbekova, A.S. Abasova. The structure of the incidence of inflammatory bowel diseases in Dagestan over the past 5 years. Cardiovascular therapy and prevention. 2021;20(1S):61. (In Russ.)]. https://doi.org/10.15829/1728-8800-2021-1S Nazirbekova M.M., Abasova A.S. Struktura zabolevaemosti vospalitel'nymi zabolevaniyami kishechnika v Dagestane za poslednie 5 let. Kardiovaskulyarnaya terapiya i profilaktika. 2021;20(1S):61. [M.M. Nazirbekova, A.S. Abasova. The structure of the incidence of inflammatory bowel diseases in Dagestan over the past 5 years. Cardiovascular therapy and prevention. 2021;20(1S):61. (In Russ.)]. https://doi.org/10.15829/1728-8800-2021-1S Тытюк С.Ю., Иорданишвили А.К., Романенко И.Г. Особенности морфологического строения и химического состава твердых тканей зубов при болезни Крона и хроническом неспецифическом язвенном колите. Вестник медицинского института «РЕАВИЗ»: Реабилитация, Врач И Здоровье. 2019;1(37):88-92. [S.Yu. Tytyuk, A.K. Iordanishvili, I.G. Romanenko. Morphological structure and chemical composition of hard dental tissues in patients with crohn's disease and chronic ulcerative colitis. Bulletin of the medical Institute "REAVIZ": Rehabilitation, Doctor And Health. 2019;1(37):88-92. (In Russ.)]. https://elibrary.ru/item.asp?id=37634606 Tytyuk S.Yu., Iordanishvili A.K., Romanenko I.G. Osobennosti morfologicheskogo stroeniya i himicheskogo sostava tverdyh tkaney zubov pri bolezni Krona i hronicheskom nespecificheskom yazvennom kolite. Vestnik medicinskogo instituta «REAVIZ»: Reabilitaciya, Vrach I Zdorov'e. 2019;1(37):88-92. [S.Yu. Tytyuk, A.K. Iordanishvili, I.G. Romanenko. Morphological structure and chemical composition of hard dental tissues in patients with crohn's disease and chronic ulcerative colitis. Bulletin of the medical Institute "REAVIZ": Rehabilitation, Doctor And Health. 2019;1(37):88-92. (In Russ.)]. https://elibrary.ru/item.asp?id=37634606 Тытюк С.Ю., Пихур О.Л., Шулутко Б.И., Иорданишвили А.К., Карев Ф.А., Васильев А.В. Поражения органов и тканей полости рта при хронических воспалительных заболеваниях кишечника у взрослого человека. Курский научно-практический вестник Человек и его здоровье. 2015;3:49-55. [S.Yu. Tytyuk, O.L. Pikhur, B.I. Shulutko, A.K. Iordanishvili, F.A. Karev, A.V. Vasiliev. Lesions of organs and tissues of oral cavity in chronic inflammatory bowel diseases in adults. Kursk scientific and practical bulletin man and his health. 2015;3:49-55. (In Russ.)]. https://elibrary.ru/item.asp?id=24394965 Tytyuk S.Yu., Pihur O.L., Shulutko B.I., Iordanishvili A.K., Karev F.A., Vasil'ev A.V. Porazheniya organov i tkaney polosti rta pri hronicheskih vospalitel'nyh zabolevaniyah kishechnika u vzroslogo cheloveka. Kurskiy nauchno-prakticheskiy vestnik Chelovek i ego zdorov'e. 2015;3:49-55. [S.Yu. Tytyuk, O.L. Pikhur, B.I. Shulutko, A.K. Iordanishvili, F.A. Karev, A.V. Vasiliev. Lesions of organs and tissues of oral cavity in chronic inflammatory bowel diseases in adults. Kursk scientific and practical bulletin man and his health. 2015;3:49-55. (In Russ.)]. https://elibrary.ru/item.asp?id=24394965 Робакидзе Н.С. Профилактика рецидивирующего стоматита при болезни крона. Профилактика в стоматологии : материалы международной научно-практической конференции. Северо-Западный государственный медицинский университет имени И.И. Мечникова ; Научное медицинское общество стоматологов Санкт-Петербурга. 2019:70-73. [N.S. Robakidze. Prevention of recurrent stomatitis in Crohn's disease. Prevention in dentistry. Materials of the international scientific and practical conference. North-Western State Medical University named after I.I. Mechnikov ; Scientific Medical Society of Dentists of St. Petersburg. 2019:70-73. (In Russ.)]. https://elibrary.ru/item.asp?id=37273519 Robakidze N.S. Profilaktika recidiviruyuschego stomatita pri bolezni krona. Profilaktika v stomatologii : materialy mezhdunarodnoy nauchno-prakticheskoy konferencii. Severo-Zapadnyy gosudarstvennyy medicinskiy universitet imeni I.I. Mechnikova ; Nauchnoe medicinskoe obschestvo stomatologov Sankt-Peterburga. 2019:70-73. [N.S. Robakidze. Prevention of recurrent stomatitis in Crohn's disease. Prevention in dentistry. Materials of the international scientific and practical conference. North-Western State Medical University named after I.I. Mechnikov ; Scientific Medical Society of Dentists of St. Petersburg. 2019:70-73. (In Russ.)]. https://elibrary.ru/item.asp?id=37273519 Робакидзе Н.С., Барановский А.Ю., Щукина О.Б., Киселева Е.Б. Дифференциально-диагностические критерии болезни Крона и язвенного колита по состоянию слизистой оболочки рта. Институт стоматологии. 2014;3(64):58-59. [N.S. Robakidze, A.Yu. Baranovsky, O.B. Shchukina, E.B. Kiseleva. Diff erential-diagnostic criteria crohn’s disease and ulcerative colitis based on the status of the oral mucosa. The Dental Institute. 2014;3(64):58-59. (In Russ.)]. https://elibrary.ru/item.asp?id=22988384 Robakidze N.S., Baranovskiy A.Yu., Schukina O.B., Kiseleva E.B. Differencial'no-diagnosticheskie kriterii bolezni Krona i yazvennogo kolita po sostoyaniyu slizistoy obolochki rta. Institut stomatologii. 2014;3(64):58-59. [N.S. Robakidze, A.Yu. Baranovsky, O.B. Shchukina, E.B. Kiseleva. Diff erential-diagnostic criteria crohn’s disease and ulcerative colitis based on the status of the oral mucosa. The Dental Institute. 2014;3(64):58-59. (In Russ.)]. https://elibrary.ru/item.asp?id=22988384 Робакидзе Н.С. Оптимизация дифференциальной диагностики воспалительных заболеваний кишечника на основании комплексной оценки стоматологического статуса. Современные технологии в медицине. 2015;7(1):81-88. [N.S. Robakidze. Optimization of Differential Diagnosis of Inflammatory Bowel Diseases Based on an Integrated Assessment of Oral Mucosa Status. Modern Technologies In Medicine. 2015;7(1):81-88. (In Russ.)]. https://dx.doi.org/10.17691/stm2015.7.1.11 Robakidze N.S. Optimizaciya differencial'noy diagnostiki vospalitel'nyh zabolevaniy kishechnika na osnovanii kompleksnoy ocenki stomatologicheskogo statusa. Sovremennye tehnologii v medicine. 2015;7(1):81-88. [N.S. Robakidze. Optimization of Differential Diagnosis of Inflammatory Bowel Diseases Based on an Integrated Assessment of Oral Mucosa Status. Modern Technologies In Medicine. 2015;7(1):81-88. (In Russ.)]. https://dx.doi.org/10.17691/stm2015.7.1.11 Робакидзе Н.С., Щукина О.Б. Патогенетические аспекты поражения полости рта при воспалительных заболеваниях кишечника. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2019;29(4):15-21. [N.S. Robakidze, O.B. Shchukina. Pathogenetic Aspects of Oral Cavity Lesions in Inflammatory Gastrointestinal Tract Diseases. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2019;29(4):15-21. (In Russ.)]. https://doi.org/10.22416/1382-4376-2019-29-4-15-21 Robakidze N.S., Schukina O.B. Patogeneticheskie aspekty porazheniya polosti rta pri vospalitel'nyh zabolevaniyah kishechnika. Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii. 2019;29(4):15-21. [N.S. Robakidze, O.B. Shchukina. Pathogenetic Aspects of Oral Cavity Lesions in Inflammatory Gastrointestinal Tract Diseases. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2019;29(4):15-21. (In Russ.)]. https://doi.org/10.22416/1382-4376-2019-29-4-15-21 Сваткова О.А., Шептулин А.А. Причины ошибок в диагностике хронических воспалительных заболеваний кишечника в общей врачебной практике. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2020;30(5):26-29. [O.A. Svatkova, A.A. Sheptulin. Sources of Bias in Common Diagnosis of Chronic Inflammatory Bowel Diseases. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2020;30(5):26-29. (In Russ.)]. https://doi.org/10.22416/1382-4376-2020-30-5-26-29 Svatkova O.A., Sheptulin A.A. Prichiny oshibok v diagnostike hronicheskih vospalitel'nyh zabolevaniy kishechnika v obschey vrachebnoy praktike. Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii. 2020;30(5):26-29. [O.A. Svatkova, A.A. Sheptulin. Sources of Bias in Common Diagnosis of Chronic Inflammatory Bowel Diseases. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2020;30(5):26-29. (In Russ.)]. https://doi.org/10.22416/1382-4376-2020-30-5-26-29 Мамаева М.И. Современные методы устранения галитоза на фоне болезни Крона : дисс. ... канд. мед. наук [ФГБОУ ВО Московский государственный медико-стоматологический университет имени А.И. Евдокимова Министерства здравоохранения Российской Федерации]. 2017:172. [M.I. Mamayeva. Modern methods of halitosis elimination against the background of Crohn's disease : diss. ... Cand. Med. Sciences. Moscow State Medical and Dental University named after A.I. Evdokimov of the Ministry of Health of the Russian Federation. 2017:172. (In Russ.)]. https://www.dissercat.com/content/sovremennye-metody-ustraneniya-galitoza-na-fone-bolezni-krona Mamaeva M.I. Sovremennye metody ustraneniya galitoza na fone bolezni Krona : diss. ... kand. med. nauk [FGBOU VO Moskovskiy gosudarstvennyy mediko-stomatologicheskiy universitet imeni A.I. Evdokimova Ministerstva zdravoohraneniya Rossiyskoy Federacii]. 2017:172. [M.I. Mamayeva. Modern methods of halitosis elimination against the background of Crohn's disease : diss. ... Cand. Med. Sciences. Moscow State Medical and Dental University named after A.I. Evdokimov of the Ministry of Health of the Russian Federation. 2017:172. (In Russ.)]. https://www.dissercat.com/content/sovremennye-metody-ustraneniya-galitoza-na-fone-bolezni-krona Робакидзе Н.С., Пихур О.Л. Состояние твердых тканей зубов пациентов с воспалительными заболеваниями кишечника в разных возрастных группах. Научные ведомости Белгородского государственного университета. Серия: Медицина. Фармация. 2015;16(213):266-271. [N.S. Robakidze, O.L. Pikhur. Condition of hard tooth tissues of patients with inflammatory intestinal diseases in different age groups. Scientific bulletin of Belgorod state university. Series: medicine. Pharmacy. 2015;16(213):266-271. (In Russ.)]. https://elibrary.ru/item.asp?id=24910369 Robakidze N.S., Pihur O.L. Sostoyanie tverdyh tkaney zubov pacientov s vospalitel'nymi zabolevaniyami kishechnika v raznyh vozrastnyh gruppah. Nauchnye vedomosti Belgorodskogo gosudarstvennogo universiteta. Seriya: Medicina. Farmaciya. 2015;16(213):266-271. [N.S. Robakidze, O.L. Pikhur. Condition of hard tooth tissues of patients with inflammatory intestinal diseases in different age groups. Scientific bulletin of Belgorod state university. Series: medicine. Pharmacy. 2015;16(213):266-271. (In Russ.)]. https://elibrary.ru/item.asp?id=24910369 Андронова Н.А. Сравнительная оценка распространенности и интенсивности кариеса зубов у пациентов, страдающих язвенным колитом. Dental Forum. 2017;4:12. [N.A. Andronova. The comparative assessment of dental caries prevalence in patients with ulcerative colitis. Dental Forum. 2017;4:12. (In Russ.)]. https://elibrary.ru/item.asp?id=30504265 Andronova N.A. Sravnitel'naya ocenka rasprostranennosti i intensivnosti kariesa zubov u pacientov, stradayuschih yazvennym kolitom. Dental Forum. 2017;4:12. [N.A. Andronova. The comparative assessment of dental caries prevalence in patients with ulcerative colitis. Dental Forum. 2017;4:12. (In Russ.)]. https://elibrary.ru/item.asp?id=30504265 Шипицына М.С., Тытюк С.Ю., Иорданишвили А.К. Стоматологическая заболеваемость при болезни крона и хроническом неспецифическом язвенном колите. Медицина: теория и практика. 2018;3(1):121. [M.S. Shipitsyna, S.Yu. Tytyuk, A.K. Iordanishvili. Dental morbidity in crohn's disease and chronic ulcerative colitis. Medicine: theory and practice. 2018;3(1):121. (In Russ.)]. https://elibrary.ru/item.asp?id=35173994 Shipicyna M.S., Tytyuk S.Yu., Iordanishvili A.K. Stomatologicheskaya zabolevaemost' pri bolezni krona i hronicheskom nespecificheskom yazvennom kolite. Medicina: teoriya i praktika. 2018;3(1):121. [M.S. Shipitsyna, S.Yu. Tytyuk, A.K. Iordanishvili. Dental morbidity in crohn's disease and chronic ulcerative colitis. Medicine: theory and practice. 2018;3(1):121. (In Russ.)]. https://elibrary.ru/item.asp?id=35173994 Трухан Л.Ю., Трухан Д.И. Cтоматологические проблемы гастроэнтерологических пациентов и возможные пути их решения. Медицинский Совет. 2016;(19):134-137. [L.Yu. Trukhan, D.I. Trukhan. Stomatoligical problems of gastroenterological patients and their possible solutions. Meditsinskiy sovet Medical Council. 2016;(19):134-137. (In Russ.)]. https://doi.org/10.21518/2079-701X-2016-19-134-137 Truhan L.Yu., Truhan D.I. Ctomatologicheskie problemy gastroenterologicheskih pacientov i vozmozhnye puti ih resheniya. Medicinskiy Sovet. 2016;(19):134-137. [L.Yu. Trukhan, D.I. Trukhan. Stomatoligical problems of gastroenterological patients and their possible solutions. Meditsinskiy sovet Medical Council. 2016;(19):134-137. (In Russ.)]. https://doi.org/10.21518/2079-701X-2016-19-134-137 Халиф И.Л., Шапина М.В., Головенко А.О. и др. Течение хронических воспалительных заболеваний кишечника и методы их лечения, применяемые в Российской Федерации (Результаты многоцентрового популяционного одномоментного наблюдательного исследования). Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2018;28(3):54-62. [I.L. Khalif, M.V. Shapina, A.O. Golovenko et al. Chronic inflammatory bowel diseases: the course and treatment methods in Russian Federation (Results of multicenter population-based one-stage observational study). Rus J Gastroenterol Hepatol Coloproctol. 2018;28(3):54-62. (In Russ.)]. https://doi.org/10.22416/1382-4376-2018-28-3-54-62 Halif I.L., Shapina M.V., Golovenko A.O. i dr. Techenie hronicheskih vospalitel'nyh zabolevaniy kishechnika i metody ih lecheniya, primenyaemye v Rossiyskoy Federacii (Rezul'taty mnogocentrovogo populyacionnogo odnomomentnogo nablyudatel'nogo issledovaniya). Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii. 2018;28(3):54-62. [I.L. Khalif, M.V. Shapina, A.O. Golovenko et al. Chronic inflammatory bowel diseases: the course and treatment methods in Russian Federation (Results of multicenter population-based one-stage observational study). Rus J Gastroenterol Hepatol Coloproctol. 2018;28(3):54-62. (In Russ.)]. https://doi.org/10.22416/1382-4376-2018-28-3-54-62 Тытюк С.Ю., Иорданишвили А.К. Характеристика твёрдых тканей зубов при хронических воспалительных заболеваниях кишечника у взрослых. Крымский терапевтический журнал. 2019;1:67-71. [S.Yu. Tytyk, A.K. Iordanishvili. Characteristics of hard dental tissues in chronic inflammatory bowel diseases in adults. Crimean Journal Of Internal Diseases. 2019;1:67-71. (In Russ.)]. https://elibrary.ru/item.asp?id=37254905 Tytyuk S.Yu., Iordanishvili A.K. Harakteristika tverdyh tkaney zubov pri hronicheskih vospalitel'nyh zabolevaniyah kishechnika u vzroslyh. Krymskiy terapevticheskiy zhurnal. 2019;1:67-71. [S.Yu. Tytyk, A.K. Iordanishvili. Characteristics of hard dental tissues in chronic inflammatory bowel diseases in adults. Crimean Journal Of Internal Diseases. 2019;1:67-71. (In Russ.)]. https://elibrary.ru/item.asp?id=37254905 Циммерман Я.C., Циммерман И.Я., Третьякова Ю.И. Язвенный колит и болезнь Крона: современные представления часть 1. Дефиниция, терминология, распространенность, этиология и патогенез, клиника, осложнения, классификация. Клиническая медицина. 2013;11:27-33. [Ya.S. Tsimmerman, I.Ya. Tsimmerman, Yu.I. Tretiakova. Ulcerative colitis and Crohn’s disease. Modern views. Part 2. Diagnostics and differential therapy. Clinical medicine. 2013;11:27-33. (In Russ.)]. https://elibrary.ru/item.asp?id=21034393 Cimmerman Ya.C., Cimmerman I.Ya., Tret'yakova Yu.I. Yazvennyy kolit i bolezn' Krona: sovremennye predstavleniya chast' 1. Definiciya, terminologiya, rasprostranennost', etiologiya i patogenez, klinika, oslozhneniya, klassifikaciya. Klinicheskaya medicina. 2013;11:27-33. [Ya.S. Tsimmerman, I.Ya. Tsimmerman, Yu.I. Tretiakova. Ulcerative colitis and Crohn’s disease. Modern views. Part 2. Diagnostics and differential therapy. Clinical medicine. 2013;11:27-33. (In Russ.)]. https://elibrary.ru/item.asp?id=21034393 Неганова О.А., Стяжкина С.Н., Николаева В.Н., Мурадова Д.М. Язвенный колит и болезнь крона: ретроспективная оценка заболеваемости за 2016-2018 годы. Здоровье и образование в XXI веке. 2019;21(6):40-43. [O.A. Neganova, S.N. Styazhkina, V.N. Nikolaeva, D.M. Muradova. Ulcerative colitis and crohn's disease: a retrospective assessment of morbidity for 2016-2018. The Journal of scientific articles “Health and Education Millennium” 2019;21(6):40-43. (In Russ.)]. http://dx.doi.org/10.26787/nydha-2226-7425-2019-21-6-40-43 Neganova O.A., Styazhkina S.N., Nikolaeva V.N., Muradova D.M. Yazvennyy kolit i bolezn' krona: retrospektivnaya ocenka zabolevaemosti za 2016-2018 gody. Zdorov'e i obrazovanie v XXI veke. 2019;21(6):40-43. [O.A. Neganova, S.N. Styazhkina, V.N. Nikolaeva, D.M. Muradova. Ulcerative colitis and crohn's disease: a retrospective assessment of morbidity for 2016-2018. The Journal of scientific articles “Health and Education Millennium” 2019;21(6):40-43. (In Russ.)]. http://dx.doi.org/10.26787/nydha-2226-7425-2019-21-6-40-43 Choon J.O., Govind K.M., Ida H., Peter R.G. et al. Asia Pacific Consensus Statements on Crohn's disease. Part 1: Definition, diagnosis, and epidemiology // Journal of Gastroenterology and Hepatology. - 2016;31:45-55. https://doi.org/10.1111 Choon J.O., Govind K.M., Ida H., Peter R.G. et al. Asia Pacific Consensus Statements on Crohn's disease. Part 1: Definition, diagnosis, and epidemiology // Journal of Gastroenterology and Hepatology. - 2016;31:45-55. https://doi.org/10.1111 Bek S., Nielsen J.V., Bojesen A.B., Franke A., Bank S., Vogel U., Andersen V. Systematic review: genetic biomarkers associated with anti-TNF treatment response in inflammatory bowel diseases // Aliment Pharmacol Ther. - 2016;44(6):554-567. https://dx.doi.org/10.1111/apt.13736 Bek S., Nielsen J.V., Bojesen A.B., Franke A., Bank S., Vogel U., Andersen V. Systematic review: genetic biomarkers associated with anti-TNF treatment response in inflammatory bowel diseases // Aliment Pharmacol Ther. - 2016;44(6):554-567. https://dx.doi.org/10.1111/apt.13736 Burisch J., Munkholm P. The epidemiology of inflammatory bowel disease // Scand J Gastroenterol. - 2015;50(8):942-951. https://dx.doi.org/10.3109/00365521.2015.1014407. Burisch J., Munkholm P. The epidemiology of inflammatory bowel disease // Scand J Gastroenterol. - 2015;50(8):942-951. https://dx.doi.org/10.3109/00365521.2015.1014407. Cosnes J., Gower-Rousseau C., Seksik P., Cortot A. Epidemiology and natural history of infl ammatory bowel diseases // Gastroenterology. - 2011;140:1785-1794. https://dx.doi.org/10.1053/j.gastro.2011.01.055. Cosnes J., Gower-Rousseau C., Seksik P., Cortot A. Epidemiology and natural history of infl ammatory bowel diseases // Gastroenterology. - 2011;140:1785-1794. https://dx.doi.org/10.1053/j.gastro.2011.01.055. Dignass A., Assche G. Van, Lindsay J.O., Lémann M. et al. The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management // J Crohns Colitis. - 2010;4(1):28-62. https://dx.doi.org/10.1016/j.crohns.2009.12.002. Dignass A., Assche G. Van, Lindsay J.O., Lémann M. et al. The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management // J Crohns Colitis. - 2010;4(1):28-62. https://dx.doi.org/10.1016/j.crohns.2009.12.002. Esser D., Cornillie F., Diamond R.H., Spiegel .R.J. On the updated ECCO consensus guidelines for medical management of Crohn's disease // J Crohns Colitis. - 2011;5(2):165-166. https://dx.doi.org/10.1016/j.crohns.2010.02.002. Esser D., Cornillie F., Diamond R.H., Spiegel .R.J. On the updated ECCO consensus guidelines for medical management of Crohn's disease // J Crohns Colitis. - 2011;5(2):165-166. https://dx.doi.org/10.1016/j.crohns.2010.02.002. Vavricka S.R., Schoepfer A., Scharl M., Lakatos P. L, Navarini A., Rogler G. Extraintestinal Manifestations of Inflammatory Bowel Disease // Inflamm Bowel Dis. - 2015;21(8):1982-1992. https://dx.doi.org/10.1097/MIB.0000000000000392. Vavricka S.R., Schoepfer A., Scharl M., Lakatos P. L, Navarini A., Rogler G. Extraintestinal Manifestations of Inflammatory Bowel Disease // Inflamm Bowel Dis. - 2015;21(8):1982-1992. https://dx.doi.org/10.1097/MIB.0000000000000392. Fiocchi C. Inflammatory bowel disease pathogenesis: where are we? // J Gastroenterol Hepatol. - 2015;1;1:12-18. https://dx.doi.org/10.1111/jgh.12751. Fiocchi C. Inflammatory bowel disease pathogenesis: where are we? // J Gastroenterol Hepatol. - 2015;1;1:12-18. https://dx.doi.org/10.1111/jgh.12751. Gafforov S.A., Fazilbekova G.A. A Scientific view of the problem of treatment and prevention of dental anomaly in children with diseases of bronchial asthma (review analysis of the literature) // Theoretical & Applied Science. - 2020;7(87):424-431. https://doi.org/10.15863/TAS.2020.07.87.81 Gafforov S.A., Fazilbekova G.A. A Scientific view of the problem of treatment and prevention of dental anomaly in children with diseases of bronchial asthma (review analysis of the literature) // Theoretical & Applied Science. - 2020;7(87):424-431. https://doi.org/10.15863/TAS.2020.07.87.81 Goodhand J., Dawson R., Hefferon M., Tshuma N., Swanson G., Wahed M., Croft N.M., Lindsay J.O. Inflammatory bowel disease in young people: the case for transitional clinics // Inflamm Bowel Dis. - 2010;16(6):947-952. https://doi.org/10.1002/ibd.21145. Goodhand J., Dawson R., Hefferon M., Tshuma N., Swanson G., Wahed M., Croft N.M., Lindsay J.O. Inflammatory bowel disease in young people: the case for transitional clinics // Inflamm Bowel Dis. - 2010;16(6):947-952. https://doi.org/10.1002/ibd.21145. Harbord M., Annese V., Vavricka S.R. et al. European Crohn’s and Colitis Organisation. The First European Evidence-based Consensus on Extraintestinal Manifestations in Inflammatory Bowel Disease // J Crohns Colitis. - 2016;10(3):239-254. https://doi.org/10.1093/ecco-jcc/jjv213 Harbord M., Annese V., Vavricka S.R. et al. European Crohn’s and Colitis Organisation. The First European Evidence-based Consensus on Extraintestinal Manifestations in Inflammatory Bowel Disease // J Crohns Colitis. - 2016;10(3):239-254. https://doi.org/10.1093/ecco-jcc/jjv213 Berkowitz L., Schultz B.M., Salazar G.A., Pardo-Roa C. Impact of Cigarette Smoking on the Gastrointestinal Tract Inflammation: Opposing Effects in Crohn’s Disease and Ulcerative Colitis // Front. Immunol. - 2018. https://doi.org/doi.org/10.3389/fimmu.2018.00074 Berkowitz L., Schultz B.M., Salazar G.A., Pardo-Roa C. Impact of Cigarette Smoking on the Gastrointestinal Tract Inflammation: Opposing Effects in Crohn’s Disease and Ulcerative Colitis // Front. Immunol. - 2018. https://doi.org/doi.org/10.3389/fimmu.2018.00074 Ingle S.B., Adgaonkar B.D., Jamadar N.P., Siddiqui S., Hinge C.R.. Crohn's disease with gastroduodenal involvement: Diagnostic approach // World J Clin Cases. - 2015;3(6):479-483. https://doi.org/10.12998/wjcc.v3.i6.479. Ingle S.B., Adgaonkar B.D., Jamadar N.P., Siddiqui S., Hinge C.R.. Crohn's disease with gastroduodenal involvement: Diagnostic approach // World J Clin Cases. - 2015;3(6):479-483. https://doi.org/10.12998/wjcc.v3.i6.479. Jajam M., Bozzolo P., Niklander S. Oral manifestations of gastrointestinal disorders // J Clin Exp Dent. - 2017;9(10):1242-1248. https://dx.doi.org/10.4317/jced.54008 Jajam M., Bozzolo P., Niklander S. Oral manifestations of gastrointestinal disorders // J Clin Exp Dent. - 2017;9(10):1242-1248. https://dx.doi.org/10.4317/jced.54008 Kaplan G.G. The global burden of IBD: from 2015 to 2025 // Nat Rev Gastroenterol Hepatol. - 2015;12(12):720-277. https://dx.doi.org/10.1038/nrgastro.2015.150 Kaplan G.G. The global burden of IBD: from 2015 to 2025 // Nat Rev Gastroenterol Hepatol. - 2015;12(12):720-277. https://dx.doi.org/10.1038/nrgastro.2015.150 Li X., Song P., Li J., Tao Y., Li G., Li X. The Disease Burden and Clinical Characteristics of Inflammatory Bowel Disease in the Chinese Population: A Systematic Review and Meta-Analysis // Int J Environ Res Public Health. - 2017;14(3):E238. https://doi.org/10.3390/ijerph14030238 Li X., Song P., Li J., Tao Y., Li G., Li X. The Disease Burden and Clinical Characteristics of Inflammatory Bowel Disease in the Chinese Population: A Systematic Review and Meta-Analysis // Int J Environ Res Public Health. - 2017;14(3):E238. https://doi.org/10.3390/ijerph14030238 Lichtenstein G.R., Loftus E.V., Isaacs K.L., Regueiro M.D., Gerson L.B., Sands B.E. ACG Clinical Guideline: Management of Crohn's Disease in Adults // Am J Gastroenterol. - 2018;113(4):481-517. https://doi.org/10.1038/ajg.2018.27. Lichtenstein G.R., Loftus E.V., Isaacs K.L., Regueiro M.D., Gerson L.B., Sands B.E. ACG Clinical Guideline: Management of Crohn's Disease in Adults // Am J Gastroenterol. - 2018;113(4):481-517. https://doi.org/10.1038/ajg.2018.27. Loftus E.V. Jr. Update on the Incidence and Prevalence of Inflammatory Bowel Disease in the United States // Gastroenterol Hepatol (NY). - 2016;12(11):704-707. PMID: 28035199 Loftus E.V. Jr. Update on the Incidence and Prevalence of Inflammatory Bowel Disease in the United States // Gastroenterol Hepatol (NY). - 2016;12(11):704-707. PMID: 28035199 Mokhtar N.M., Nawawi K.N.M., Verasingam J. et al. A four-decade analysis of the incidence trends, sociodemographic and clinical characteristics of inflammatory bowel disease patients at single tertiary centre, Kuala Lumpur, Malaysia // BMC Public Health. - 2019;19(4):550. https://doi.org/10.1186/s12889-019-6858-2 Mokhtar N.M., Nawawi K.N.M., Verasingam J. et al. A four-decade analysis of the incidence trends, sociodemographic and clinical characteristics of inflammatory bowel disease patients at single tertiary centre, Kuala Lumpur, Malaysia // BMC Public Health. - 2019;19(4):550. https://doi.org/10.1186/s12889-019-6858-2 Muhvić-Urek M., Tomac-Stojmenović M., Mijandrušić-Sinčić B. Oral pathology in inflammatory bowel disease // World J Gastroenterol. - 2016;22(25):5655-5667. https://dx.doi.org/10.3748/wjg.v22.i25.5655 Muhvić-Urek M., Tomac-Stojmenović M., Mijandrušić-Sinčić B. Oral pathology in inflammatory bowel disease // World J Gastroenterol. - 2016;22(25):5655-5667. https://dx.doi.org/10.3748/wjg.v22.i25.5655 Longo S., Chieppa M., Cossa L.G., Spinelli C.C., Greco M., Maffia M., Giudetti A.M. New Insights into Inflammatory Bowel Diseases from Proteomic and Lipidomic // Studies Proteomes. - 2020;8(3):18. https://dx.doi.org/10.3390/proteomes8030018. Longo S., Chieppa M., Cossa L.G., Spinelli C.C., Greco M., Maffia M., Giudetti A.M. New Insights into Inflammatory Bowel Diseases from Proteomic and Lipidomic // Studies Proteomes. - 2020;8(3):18. https://dx.doi.org/10.3390/proteomes8030018. Ng S.C., Shi H.Y., Hamidi N. et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies // Lancet. - 2018;390(10114):2769-2778. https://doi.org/10.1016/s0140-6736(17)32448-0 Ng S.C., Shi H.Y., Hamidi N. et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies // Lancet. - 2018;390(10114):2769-2778. https://doi.org/10.1016/s0140-6736(17)32448-0 Nijakowski K., Surdacka A. Salivary Biomarkers for Diagnosis of Inflammatory Bowel Diseases:A Systematic Review // International Journal of Molecular Sciences. - 2020;21(20):7477. https://doi.org/10.3390/ijms21207477 Nijakowski K., Surdacka A. Salivary Biomarkers for Diagnosis of Inflammatory Bowel Diseases:A Systematic Review // International Journal of Molecular Sciences. - 2020;21(20):7477. https://doi.org/10.3390/ijms21207477 Mortada I., Leone A., Gerges Geagea A., Mortada R., Matar C., Rizzo M., Hajj Hussein I., Massaad-Massade L., Jurjus A. Oral manifestations of inflammatory bowel disease // J. Biol Regul Homeost Agents. - 2017;31(3):817-821. PMID:28958141 Mortada I., Leone A., Gerges Geagea A., Mortada R., Matar C., Rizzo M., Hajj Hussein I., Massaad-Massade L., Jurjus A. Oral manifestations of inflammatory bowel disease // J. Biol Regul Homeost Agents. - 2017;31(3):817-821. PMID:28958141 Pereira M.S., Munerato M.C. Oral Manifestations of Inflammatory Bowel Diseases: Two Case Reports // Clin Med Res. - 2016;14(1):46-52. https://doi.org/10.3121/cmr.2015.1307. Epub 2016 Feb 10. Pereira M.S., Munerato M.C. Oral Manifestations of Inflammatory Bowel Diseases: Two Case Reports // Clin Med Res. - 2016;14(1):46-52. https://doi.org/10.3121/cmr.2015.1307. Epub 2016 Feb 10. Agossa K., Dendooven A., Dubuquoy L., Gower-Rousseau C., Delcourt-Debruyne E., Capron M. Periodontal manifestations of inflammatory bowel disease: emerging epidemiologic and biologic evidence // J Periodont Res. - 2017;52:313-324. https://doi.org/10.1111/jre.12422 Agossa K., Dendooven A., Dubuquoy L., Gower-Rousseau C., Delcourt-Debruyne E., Capron M. Periodontal manifestations of inflammatory bowel disease: emerging epidemiologic and biologic evidence // J Periodont Res. - 2017;52:313-324. https://doi.org/10.1111/jre.12422 Pimentel A.M., Rocha R., Santana G.O. Crohn’s disease of esophagus, stomach and duodenum // World J Gastrointest Pharmacol Ther. - 2019;10(2):35-49. https://doi.org/10.4292/wjgpt.v10.i2.35 Pimentel A.M., Rocha R., Santana G.O. Crohn’s disease of esophagus, stomach and duodenum // World J Gastrointest Pharmacol Ther. - 2019;10(2):35-49. https://doi.org/10.4292/wjgpt.v10.i2.35 Yu-Chiao Chiu, Chia-Chang Chen, Chung-Wang Ko, Szu-Chia Liao, Hong-Zen Yeh, Chung-Hsin Chang. Real-world efficacy and safety of vedolizumab among patients with inflammatory bowel disease: A single tertiary medical center experience in Central Taiwan // Adv Dig Med. - 2021;8:40-46. https://doi.org/10.1002/aid2.13188 Yu-Chiao Chiu, Chia-Chang Chen, Chung-Wang Ko, Szu-Chia Liao, Hong-Zen Yeh, Chung-Hsin Chang. Real-world efficacy and safety of vedolizumab among patients with inflammatory bowel disease: A single tertiary medical center experience in Central Taiwan // Adv Dig Med. - 2021;8:40-46. https://doi.org/10.1002/aid2.13188 Selvaratnam S., Gullino S., Shim L, Lee E., Lee A., Paramsothy S., Leong R.W. Epidemiology of inflammatory bowel disease in South America: A systematic review // World J Gastroenterol. - 2019;25(47):6866-6875. https://dx.doi.org/10.3748/wjg.v25.i47.6866 Selvaratnam S., Gullino S., Shim L, Lee E., Lee A., Paramsothy S., Leong R.W. Epidemiology of inflammatory bowel disease in South America: A systematic review // World J Gastroenterol. - 2019;25(47):6866-6875. https://dx.doi.org/10.3748/wjg.v25.i47.6866 Shelley-Fraser G., Borley N.R., Warren B.F., Shepherd N. The connective tissue changes of Crohn's disease // Histopathology. - 2012;60(7):1034-1044. https://dx.doi.org/10.1111/j.1365-2559.2011.03911.x. Shelley-Fraser G., Borley N.R., Warren B.F., Shepherd N. The connective tissue changes of Crohn's disease // Histopathology. - 2012;60(7):1034-1044. https://dx.doi.org/10.1111/j.1365-2559.2011.03911.x. Harbord M. Annese V., Vavricka S.R et al. The First European Evidence-based Consensus on Extra-intestinal Manifestations in Inflammatory Bowel Disease // J Crohns Colitis. - 2016;10(3):239-254. https://doi.org/10.1093/ecco-jcc/jjv213. Harbord M. Annese V., Vavricka S.R et al. The First European Evidence-based Consensus on Extra-intestinal Manifestations in Inflammatory Bowel Disease // J Crohns Colitis. - 2016;10(3):239-254. https://doi.org/10.1093/ecco-jcc/jjv213. Vavricka S.R., Manser C.N., Hediger S. et al. Periodontitis and gingivitis in inflammatory bowel disease: a case-control study // Inflamm Bowel Dis. - 2013;19:2768-2777. https://dx.doi.org/10.1097/01.MIB.0000438356.84263.3b Vavricka S.R., Manser C.N., Hediger S. et al. Periodontitis and gingivitis in inflammatory bowel disease: a case-control study // Inflamm Bowel Dis. - 2013;19:2768-2777. https://dx.doi.org/10.1097/01.MIB.0000438356.84263.3b Yangyang R.Y., Rodriguez J.R. Clinical presentation of Crohn’s, ulcerative colitis, and indeterminate colitis: Symptoms, extraintestinal manifestations, and disease phenotypes // Seminars in pediatric surgery. - 2017;26:349-355. https://doi.org/10.1053/j.sempedsurg.2017.10.003 Yangyang R.Y., Rodriguez J.R. Clinical presentation of Crohn’s, ulcerative colitis, and indeterminate colitis: Symptoms, extraintestinal manifestations, and disease phenotypes // Seminars in pediatric surgery. - 2017;26:349-355. https://doi.org/10.1053/j.sempedsurg.2017.10.003