Background. The problem of preventing complications of complex dental treatment is one of the main problems in modern dentistry, the solution of which is impossible without a systematic approach, including, among other things, the relationship of these complications with the general somatic status of a particular patient. The aim of the study. Identification of the features and terms of use of dentures in patients with reduced thyroid function. Methodology. The data of 304 patients who applied to a dental clinic for re-prosthetics of the dentition were studied. The distribution of patients into groups was carried out in accordance with the type of denture and the presence or absence of thyroid diseases established by the endocrinologist, leading to hypothyroidism. Standard clinical (survey, examination, etc.) and paraclinical (radiological, functional) methods of examination were used for such diagnoses. Edema of the oral mucosa was determined by palpation, and their frequency and severity were recorded. Results. Statistically significant differences in the reasons for replacement of dentures between patients of different groups were revealed. The difference in the terms of use of dentures in patients of different groups was determined. Clinical differences in the state of the tissues of the prosthetic bed and the supporting teeth of the bridge prostheses in patients, depending on the presence of hypofunction of the thyroid gland, were revealed. Conclusions. The presence of hypothyroidism in the anamnesis of patients worsens the long-term prognosis of dental orthopedic treatment. The dispensary observation of patients with hypothyroidism should differ from the observation of healthy individuals, in the direction of reducing the inter-examination intervals in order to identify early complications of dental treatment.